191 research outputs found
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Degradation of contaminants of emerging concern by UV/H2O2 for water reuse: Kinetics, mechanisms, and cytotoxicity analysis.
Advanced oxidation using UV and hydrogen peroxide (UV/H2O2) has been widely applied to degrade contaminants of emerging concern (CECs) in wastewater for water reuse. This study investigated the degradation kinetics of mixed CECs by UV/H2O2 under variable H2O2 doses, including bisphenol A, estrone, diclofenac, ibuprofen, and triclosan. Reverse osmosis (RO) treated water samples from Orange County Water District's Groundwater Replenishment System (GWRS) potable reuse project were collected on different dates and utilized as reaction matrices with spiked additions of chemicals (CECs and H2O2) to assess the application of UV/H2O2. Possible degradation pathways of selected CECs were proposed based on high resolution mass spectrometry identification of transformation products (TPs). Toxicity assessments included cytotoxicity, aryl hydrocarbon receptor-binding activity, and estrogen receptor-binding activity, in order to evaluate potential environmental impacts resulting from CEC degradation by UV/H2O2. Cytotoxicity and estrogenic activity were significantly reduced during the degradation of mixed CECs in Milli-Q water by UV/H2O2 with high UV fluence (3200 mJ cm-2). However, in GWRS RO-treated water samples collected in April 2017, the cytotoxicity and estrogen activity of spiked CEC-mixture after UV/H2O2 treatment were not significantly eliminated; this might be due to the high concentration of target CEC and their TPs, which was possibly affected by the varied quality of the secondary treatment influent at this facility such as sewer-shed and wastewater discharges. This study aimed to provide insight on the impacts of post-UV/H2O2 CECs and TPs on human and ecological health at cellular level
The Extremely Luminous Quasar Survey in the Pan-STARRS 1 Footprint (PS-ELQS)
We present the results of the Extremely Luminous Quasar Survey in the
survey of the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS;
PS1). This effort applies the successful quasar selection strategy of the
Extremely Luminous Survey in the Sloan Digital Sky Survey footprint
() to a much larger area
(). This spectroscopic survey targets the most
luminous quasars (; ) at intermediate redshifts
(). Candidates are selected based on a near-infrared JKW2 color cut
using WISE AllWISE and 2MASS photometry to mainly reject stellar contaminants.
Photometric redshifts () and star-quasar classifications for each
candidate are calculated from near-infrared and optical photometry using the
supervised machine learning technique random forests. We select 806 quasar
candidates at from a parent sample of 74318 sources. After
exclusion of known sources and rejection of candidates with unreliable
photometry, we have taken optical identification spectra for 290 of our 334
good PS-ELQS candidates. We report the discovery of 190 new quasars
and an additional 28 quasars at lower redshifts. A total of 44 good PS-ELQS
candidates remain unobserved. Including all known quasars at , our
quasar selection method has a selection efficiency of at least . At lower
declinations we approximately triple the known
population of extremely luminous quasars. We provide the PS-ELQS quasar catalog
with a total of 592 luminous quasars (, ). This unique
sample will not only be able to provide constraints on the volume density and
quasar clustering of extremely luminous quasars, but also offers valuable
targets for studies of the intergalactic medium.Comment: 34 pages, 10 figures, accepted to ApJ
A New Channel of Bulge Formation via the Destruction of Short Bars
Short (inner) bars of subkiloparsec radius have been hypothesized to be an important mechanism for driving gas inflows to small scales, thus feeding central black holes (BHs). Recent numerical simulations have shown that the growth of central BHs in galaxies can destroy short bars, when the BH reaches a mass of ∼0.1% of the total stellar mass of the galaxy. We study N-body simulations of galaxies with single and double bars to track the long-term evolution of the central stellar mass distribution. We find that the destruction of the short bar contributes significantly to the growth of the bulge. The final bulge mass is roughly equal to the sum of the masses of the initial pseudo bulge and short bar. The initially boxy/peanut-shaped bulge of Sérsic index n1 is transformed into a more massive, compact structure that bears many similarities to a classical bulge, in terms of its morphology (n≈2), kinematics (dispersion-dominated, isotropic), and location on standard scaling relations (Kormendy relation, mass-size relation, and correlations between BH mass and bulge stellar mass and velocity dispersion). Our proposed channel for forming classical bulges relies solely on the destruction of short bars without any reliance on mergers. We suggest that some of the less massive, less compact classical bulges were formed in this manner
Lyapunov Inverse Iteration for Computing a few Rightmost Eigenvalues of Large Generalized Eigenvalue Problems
In linear stability analysis of a large-scale dynamical system, we need to compute the rightmost eigenvalue(s) for a series of large generalized eigenvalue problems. Existing iterative eigenvalue solvers are not robust when no estimate of the rightmost eigenvalue(s) is available. In this study, we show that such an estimate can be obtained from Lyapunov inverse iteration applied to a special eigenvalue problem of Lyapunov structure. We also show that Lyapunov inverse iteration will always converge in only two steps if the Lyapunov equation in the first step is solved accurately enough. Furthermore, we generalize the analysis to a deflated version of this Lyapunov eigenvalue problem and propose an algorithm that computes a few rightmost eigenvalues for the eigenvalue problems arising from linear stability analysis. Numerical experiments demonstrate the robustness of the algorithm
Efficient Iterative Algorithms for Linear Stability Analysis of Incompressible Flows
Linear stability analysis of a dynamical system entails finding the rightmost eigenvalue for a series of eigenvalue problems. For large-scale systems, it is known that conventional iterative eigenvalue solvers are not reliable for computing this eigenvalue. A more robust method recently developed in Elman & Wu (2012) and Meerbergen & Spence (2010), Lyapunov inverse iteration, involves solving large-scale Lyapunov equations, which in turn requires the solution of large, sparse linear systems analogous to those arising from solving the underlying partial differential equations. This study explores the efficient implementation of Lyapunov inverse iteration when it is used for linear stability analysis of incompressible flows. Efficiencies are obtained from effective solution strategies for the Lyapunov equations and for the underlying partial differential equations. Existing solution strategies are tested and compared, and a modified version of a Lyapunov solver is proposed that achieves significant savings in computational cost
The Bright Side of Being Uncertain: The Impact of Economic Policy Uncertainty on Corporate Innovation
Purpose: This study aims to theoretically hypothesize and empirically examine the impact of economic policy uncertainty (EPU) on firms' innovation performance as well as the contingency conditions of this relationship. Design/methodology/approach: This study collects and combines secondary longitudinal data from multiple sources to test for a direct impact of EPU on firms' innovation performance. It further examines the moderating effects of firms' operational and marketing capabilities. A series of robustness checks are performed to ensure the consistency of the findings. Findings: In contrast to the common belief that EPU reduces the innovativeness of firms, the authors find an inverted-U relationship between EPU and innovation performance, indicating that a moderate level of EPU actually promotes innovation. Further analysis suggests that firms' operational and marketing capabilities make the inverted-U relationship steeper, further enhancing firms' innovation performance at a moderate level of EPU. Originality/value: This study adds to the emerging literature that investigates the operational implications of EPU, which enhances our understanding of the potential bright side of EPU and broadens the scope of operational risk management.</p
Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase
Although rhodopsin is essential for sensing light for vision, it also mediates light-induced apoptosis of photoreceptors in mouse. RPE65, which catalyzes isomerization of all-trans retinyl fatty acid esters to 11-cis-retinol (11cROL) in the visual cycle, controls the rhodopsin regeneration rate and photoreceptor susceptibility to light-induced degeneration. Mutations in RPE65 have been linked to blindness in affected children. Despite such importance, the mechanism that regulates RPE65 function remains unclear. Through unbiased expression screening of a bovine retinal pigment epithelium (RPE) cDNA library, we have identified elongation of very long-chain fatty acids-like 1 (ELOVL1) and fatty acid transport protein 4 (FATP4), which each have very long-chain fatty acid acyl-CoA synthetase (VLCFA-ACS) activity, as negative regulators of RPE65. We found that the VLCFA derivative lignoceroyl (C24:0)-CoA inhibited synthesis of 11cROL, whereas palmitoyl (C16:0)-CoA promoted synthesis of 11cROL. We further found that competition of FATP4 with RPE65 for the substrate of RPE65 was also involved in the mechanisms by which FATP4 inhibits synthesis of 11cROL. FATP4 was predominantly expressed in RPE, and the FATP4-deficient RPE showed significantly higher isomerase activity. Consistent with these results, the regeneration rate of 11-cis-retinaldehyde and the recovery rate for rod light sensitivity were faster in FATP4-deficient mice than wild-type mice. Moreover, FATP4-deficient mice displayed increased accumulation of the cytotoxic all-trans retinaldehyde and hypersusceptibility to light-induced photoreceptor degeneration. Our findings demonstrate that ELOVL1, FATP4, and their products comprise the regulatory elements of RPE65 and play important roles in protecting photoreceptors from degeneration induced by light damage
LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1
Microtubule organization and lysosomal secretion are both critical for the activation and function of osteoclasts, highly specialized polykaryons that are responsible for bone resorption and skeletal homeostasis. Here, we have identified a novel interaction between microtubule regulator LIS1 and Plekhm1, a lysosome-associated protein implicated in osteoclast secretion. Decreasing LIS1 expression by shRNA dramatically attenuated osteoclast formation and function, as shown by a decreased number of mature osteoclasts differentiated from bone marrow macrophages, diminished resorption pits formation, and reduced level of CTx-I, a bone resorption marker. The ablated osteoclast formation in LIS1-depleted macrophages was associated with a significant decrease in macrophage proliferation, osteoclast survival and differentiation, which were caused by reduced activation of ERK and AKT by M-CSF, prolonged RANKL-induced JNK activation and declined expression of NFAT-c1, a master transcription factor of osteoclast differentiation. Consistent with its critical role in microtubule organization and dynein function in other cell types, we found that LIS1 binds to and colocalizes with dynein in osteoclasts. Loss of LIS1 led to disorganized microtubules and aberrant dynein function. More importantly, the depletion of LIS1 in osteoclasts inhibited the secretion of Cathepsin K, a crucial lysosomal hydrolase for bone degradation, and reduced the motility of osteoclast precursors. These results indicate that LIS1 is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1
Disorder Dynamics in Battery Nanoparticles During Phase Transitions Revealed by Operando Single-Particle Diffraction
Structural and ion-ordering phase transitions limit the viability of
sodium-ion intercalation materials in grid scale battery storage by reducing
their lifetime. However, the combination of phenomena in nanoparticulate
electrodes creates complex behavior that is difficult to investigate,
especially on the single nanoparticle scale under operating conditions. In this
work, operando single-particle x-ray diffraction (oSP-XRD) is used to observe
single-particle rotation, interlayer spacing, and layer misorientation in a
functional sodium-ion battery. oSP-XRD is applied to
Na[NiMn]O, an archetypal P2-type sodium-ion
positive electrode material with the notorious P2-O2 phase transition induced
by sodium (de)intercalation. It is found that during sodium extraction, the
misorientation of crystalline layers inside individual particles increases
before the layers suddenly align just prior to the P2-O2 transition. The
increase in the long-range order coincides with an additional voltage plateau
signifying a phase transition prior to the P2-O2 transition. To explain the
layer alignment, a model for the phase evolution is proposed that includes a
transition from localized to correlated Jahn-Teller distortions. The model is
anticipated to guide further characterization and engineering of sodium-ion
intercalation materials with P2-O2 type transitions. oSP-XRD therefore opens a
powerful avenue for revealing complex phase behavior in heterogeneous
nanoparticulate systems.Comment: 23 pages, 4 main figures, 9 supplemental figure
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