An Efficient Representation Format for Fuzzy Intervals Based on Symmetric Membership Functions

International audienceThis paper proposes a novel implementation of fuzzy arithmetics that exploits both fuzzy intervals and hardware specificities. First, we propose and evaluate the benefit of an alternative representation format to the traditional lower-upper and midpoint-radius representation formats for intervals. Thanks to the proposed formats, we show that it is possible to halve the number of operations and memory requirements compared to conventional methods. Then, we show that operations on fuzzy intervals are sensitive to hardware specificities of accelerators such as GPU. These include static rounding, memory usage, instruction level parallelism (ILP) and thread-level parallelism (TLP). We develop a library of fuzzy arithmetic operations in CUDA and C++ over several formats. The proposed library is evaluated using compute-bound and memory-bound benchmarks on Nvidia GPUs, and shows a performance gain of 2 to 20 over traditional approaches

Apparent suppression of turbulent magnetic dynamo action by a dc magnetic field

Numerical studies of the effect of a dc magnetic field on dynamo action (development of magnetic fields with large spatial scales), due to helically-driven magnetohydrodynamic turbulence, are reported. The apparent effect of the dc magnetic field is to suppress the dynamo action, above a relatively low threshold. However, the possibility that the suppression results from an improper combination of rectangular triply spatially-periodic boundary conditions and a uniform dc magnetic field is addressed: heretofore a common and convenient computational convention in turbulence investigations. Physical reasons for the observed suppression are suggested. Other geometries and boundary conditions are offered for which the dynamo action is expected not to be suppressed by the presence of a dc magnetic field component.Comment: To appear in Physics of Plasma

Manipulation of extinction features in frequency combs through the usage of graphene

Lately, the integration of two-dimensional materials into semiconductor devices has allowed the modification of their effective index by simply applying a modest voltage (between 0 and 3 volts). In this work, we present a device composed of two evanescently coupled silicon microring resonators where both rings have a graphene layer on top. This design is aimed to produce frequency combs with transmission characteristics controlled upon voltage application to the graphene layer. We numerically analyze the device response as a function of the incident wavelength and applied voltage. The results showed a low input intensity (0.6 GW/cm2) needed and a rapid response time (0.1 μs), in comparison to devices controlled by heat injection

Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients The ROADMAP Study 2-Year Results

OBJECTIVES The authors sought to provide the pre-specified primary endpoint of the ROADMAP (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients) trial at 2 years. BACKGROUND The ROADMAP trial was a prospective nonrandomized observational study of 200 patients (97 with a left ventricular assist device [LVAD], 103 on optimal medical management [OMM]) that showed that survival with improved functional status at 1 year was better with LVADs compared with OMM in a patient population of ambulatory New York Heart Association functional class IIIb/IV patients. METHODS The primary composite endpoint was survival on original therapy with improvement in 6-min walk distance \u3e= 75 m. RESULTS Patients receiving LVAD versus OMM had lower baseline health-related quality of life, reduced Seattle Heart Failure Model 1-year survival (78% vs. 84%; p = 0.012), and were predominantly INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profile 4 (65% vs. 34%; p \u3c 0.001) versus profiles 5 to 7. More LVAD patients met the primary endpoint at 2 years: 30% LVAD versus 12% OMM (odds ratio: 3.2 [95% confidence interval: 1.3 to 7.7]; p = 0.012). Survival as treated on original therapy at 2 years was greater for LVAD versus OMM (70 +/- 5% vs. 41 +/- 5%; p \u3c 0.001), but there was no difference in intent-to-treat survival (70 +/- 5% vs. 63 +/- 5%; p = 0.307). In the OMM arm, 23 of 103 (22%) received delayed LVADs (18 within 12 months; 5 from 12 to 24 months). LVAD adverse events declined after year 1 for bleeding (primarily gastrointestinal) and arrhythmias. CONCLUSIONS Survival on original therapy with improvement in 6-min walk distance was superior with LVAD compared with OMM at 2 years. Reduction in key adverse events beyond 1 year was observed in the LVAD group. The ROADMAP trial provides risk-benefit information to guide patient- and physician-shared decision making for elective LVAD therapy as a treatment for heart failure. (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients [ROADMAP]; NCT01452802

Global warming and population change both heighten future risk of human displacement due to river floods

Every year, millions of people around the world are being displaced from their homes due to climate-related disasters. River flooding is responsible for a large part of this displacement. Previous studies have shown that river flood risk is expected to change as a result of global warming and its effects on the hydrological cycle. At the same time, future scenarios of socio-economic development imply substantial population increases in many of the areas that presently experience disaster-induced displacement. Here we show that both global warming and population change are projected to lead to substantial increases in flood-induced displacement risk over the coming decades. We use a global climate-hydrology-inundation modelling chain, including multiple alternative climate and hydrological models, to quantify the effect of global warming on displacement risk assuming either current or projected future population distributions. Keeping population fixed at present levels, we find roughly a 50% increase in global displacement risk for every degree of global warming. Adding projected population changes further exacerbates these increases globally and in most world regions, with the relative global flood displacement risk is increasing by roughly 350% at the end of the 21st century, compared to an increase of 150% without the contribution of population change. While the resolution of the global models is limited, the effect of global warming is robust across greenhouse gas concentration scenarios, climate models and hydrological models. These findings indicate a need for rapid action on both climate mitigation and adaptation agendas in order to reduce future risks to vulnerable populations

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1

The abundant, nuclear-retained, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been associated with a poorly differentiated and aggressive phenotype of mammary carcinomas. This long non-coding RNA (lncRNA) localizes to nuclear speckles, where it interacts with a subset of splicing factors and modulates their activity. In this study, we demonstrate that oncogenic splicing factor SRSF1 bridges MALAT1 to mutant p53 and ID4 proteins in breast cancer cells. Mutant p53 and ID4 delocalize MALAT1 from nuclear speckles and favor its association with chromatin. This enables aberrant recruitment of MALAT1 on VEGFA pre-mRNA and modulation of VEGFA isoforms expression. Interestingly, VEGFA-dependent expression signatures associate with ID4 expression specifically in basal-like breast cancers carrying TP53 mutations. Our results highlight the key role for MALAT1 in control of VEGFA isoforms expression in breast cancer cells expressing gain-of-function mutant p53 and ID4 proteins

East Bay Coalition for the Homeless: Branding Study and Marketing Strategy

There are a number of potential positioning strategies. The two which make the most sense for the EBCH are to “position the EBCH away from others in the category” and to “position the EBCH as unique.” These strategies have the advantage of setting the EBCH apart from the other organizations that address homelessness. Occupying its own “position” in the minds of potential and current donors is not only an effective communications/marketing strategy but also a less costly one because it avoids head-to-head competition and comparisons

A systematic multi-technique comparison of luminescence characteristics of two reference quartz samples

MB did the experiments using the equipment belonging to the Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Torun, ul. Wilenska 4, 87–100 Torun, Poland (e-mail: [email protected]) and has been financed by the grant of the National Science Centre, Poland, No. 2018/31/B/ST10/03917.International audienceFurther developments in luminescence dating, dosimetry and temperature-sensing require a deep understanding of luminescence processes and their driving parameters. Natural quartz is one of the most widely used minerals for these purposes. Still, poor reproducibility of results often hampers comparability and credibility of findings in the literature. We identified the lack of suitable natural reference samples as a pivotal problem impeding significant progression. Ideally, basic investigations involve several laboratories working on well-characterised reference quartz samples with different characteristics. Investigations should include multiple complementing methods to analyse luminescence properties and mineralogical and geochemical composition.Here, we present such a multi-technique luminescence comparison of two natural quartz samples. Next to the recently introduced Fontainebleau (FB) reference quartz, we propose another reference sample derived from the ‘Silver Sands of Morar’ (lab code ‘MR’; Scotland, UK). Our experiments confirm that both quartz samples behave fundamentally different in terms of signal composition and sensitivity. The comparative characterisation of both samples targeted electron traps via thermoluminescence (TL) and optically stimulated luminescence (OSL) techniques and luminescence centres via radioluminescence and time-resolved OSL spectrometry. In summary, we conclude that all observed differences are likely the results of divergent defect concentrations rather than variances in defects' composition (nature). The measurement data of our study are accessible open-access for inspection by others