CHALLENGES TO PRESERVING THE DIGNITY OF THE WORKER OR EMPLOYEE IN THE REPUBLIC OF BULGARIA

This article aims to analyze the Bulgarian labor law and regulations regarding the dignity of the worker or employee and the challenges to their protection in case of harassment by the employer. In the Republic of Bulgaria, many cases of disrespect for the dignity of work. Harassment in the workplace, as the most common cause of trampling on the dignity of the worker or employee, affects every aspect of their life. The Labor Code of the Republic of Bulgaria does not contain an explicit legal regulation of the concepts of “harassment” and “sexual harassment”, nor an explicit prohibition of these activities in the workplace. Sexual harassment and the harassment of certain protected characteristics are regulated in the anti-discrimination legislation, in particular the Protection Against Discrimination Act, which will be discussed in the article. In the article also discusses the Convention No. 190 of 2019 Concerning the Elimination of Violence and Harassment in the World of Work. The authors propose to ratify Convention No. 190 of 2019. The ratification of Convention No. 190/2019 by the Bulgarian state will require a subsequent addition and amendment of the Labor Code, such as the introduction of an explicit legal text in the Labor Code, through which to ensure the protection of the labor right of every worker and employee to exercise their labor rights and obligations in the workplace, without violence and harassment; introduction of an obligation for the employer to develop appropriate rules to combat violence and harassment in the workplace, as well as procedures to protect workers or employees in the event of harassment and etc. Keywords: labor rights; labor law dignity; discrimination; workplace harassment; sexual harassment; protection from discrimination; employees, employers, Republic of Bulgaria

To a holistic classification in medical theory and education

ABSTRACT Introduction: Nowadays teaching medicine is based only on structural functionalism. Thus the conventional organization of the content of functional medical sciences like physiology, pathophysiology and internal medicine is sometimes ridiculous and difficult for learning and practicing

Clofarabine and Adult Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissues that is characterized by accumulation of abnormal blast cells, principally in the marrow and impaired production of normal blood cells. The unsatisfactory clinical outcomes of AML patients urged the development of new therapy strategies, one of which includes the implementation of new nucleoside analogs. Clofarabine has offered new promising perspectives within induction and consolidation therapies. This chapter will evaluate the efficacy and tolerability of clofarabine as a single agent and in combination therapy, including hematopoietic stem cell transplantation, for AML patients

A PROCEDURE FOR SELECTING AN OPTIMAL MINING TECHNOLOGY TAKING INTO ACCOUNT THE EXTRACTION AND QUALITY CHANGE RATIOS OF THE MINED-OUT ORE

ABSTRACT A general scheme of the necessary initial data on ore extraction and processing is presented: quantity of reserves and resources, extraction and quality change ratios and cost indices. A model has been developed based on compensation of the damages caused by ore losses and impoverishment in comparing two mining technologies. When generating more than two variants, a set of contrasted pairs is formed thus enabling us to determine the variant with the best technical and economic indices. A software package TWOTECH has been designed for solving problems related to both operative planning and a preliminary survey of technologies applicable under real natural conditions

Toric moment mappings and Riemannian structures

Coadjoint orbits for the group SO(6) parametrize Riemannian G-reductions in six dimensions, and we use this correspondence to interpret symplectic fibrations between these orbits, and to analyse moment polytopes associated to the standard Hamiltonian torus action on the coadjoint orbits. The theory is then applied to describe so-called intrinsic torsion varieties of Riemannian structures on the Iwasawa manifold.Comment: 25 pages, 14 figures; Geometriae Dedicata 2012, Toric moment mappings and Riemannian structures, available at http://www.springerlink.com/content/yn86k22mv18p8ku2

Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib

Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete mass cytometry analysis pipeline for characterization of intracellular signal transduction patterns in the major leukocyte subsets of chronic phase chronic myeloid leukemia. Changes in phosphorylated Bcr-Abl1 and the signaling pathways involved were readily identifiable in peripheral blood single cells already within three hours of the patient receiving oral nilotinib. The signal transduction profiles of healthy donors were clearly distinct from those of the patients at diagnosis. Furthermore, using principal component analysis, we could show that phosphorylated transcription factors STAT3 (Y705) and CREB (S133) within seven days reflected BCR-ABL1(IS) at three and six months. Analyses of peripheral blood cells longitudinally collected from patients in the ENEST1st clinical trial showed that single cell mass cytometry appears to be highly suitable for future investigations addressing tyrosine kinase inhibitor dosing and effect. (clinicaltrials. gov identifier: 01061177)Peer reviewe