Construção de política para gestão de resíduos na Universidade de São Paulo como modelo para implementação da PNRS em IES

The actual scenario of the University of São Paulo (USP) has, in an isolated form, various environmental initiatives in diverse fronts, according to the reality of its campi. In 2010, USP designated an Environmental Management coordinator attached to the university’s rectory. The following year USP approved the its Environmental Policy, that promotes environmental sustainability in all its campi. In 2012 the Environmental Management Superintendence (SGA) was created as an office responsible for environmental management of the university, with the objective of developing norms for environmental issues in agreement to the proposed environmental policy. This superintendence created in 2012 a Working Group for dealing with issues related to solid residues generated in USP. This group, composed of specialists in this area and coordinated by an member of the SGA, developed, using participative processes, strategies and procedures for the elaboration and implementation of the Solid Residue Management Policy (PGRUSP). This policy following a previous model (PUSP-C, 2010), has as objective adequate the National Solid Residue Policy (PNRS) to the university’s environment. An initial version of the PGRUSP was presented to the academic community in a Forum promoted by the SGA. In this occasion, representatives of all the categories coming from the university’s different campi, apart from members of the external community, analyzed the document and made suggestions on its contents that were later included in the final document. PGRUSP determines the elaboration of Residue Management Plans in all the units that belong to USP. At this moment, the Working Group is elaborating directives for the training of the academic community for the execution of an ample residue diagnosis, with the objective of also mobilizing and publicizing the directives of the PGRUSP. The training and residue management plan construction presupposes learning about the practical issues of residue management. Data production and indicator construction will be the basis for the continuous and efficient implementation of this policy. For the ordering of the data a virtual platform is being developed. With such a platform, USP pretends to control generation, stocking, treatment and destination of Solid Residues produced in its academic units. It pretends with this database, to generate information that will permit the SGA to make decisions that will improve residue management in USP’s campi and, consequently, minimize environmental impacts caused in all levels of its activities. O cenário atual da Universidade de São Paulo (USP) tem, isoladamente, diversas ações ambientais em diferentes frentes, de acordo com a realidade de seus campi. Em 2010, a USP designou um coordenador de Gestão Ambiental junto à Reitoria. No ano seguinte, regulamentou a Política Ambiental da USP, que visa promover a sustentabilidade ambiental nos campi. Em 2012, foi criado um órgão institucional responsável pela gestão ambiental, a Superintendência de Gestão Ambiental (SGA), que tem como premissa ditar normas para questões ambientais em consonância com a política ambiental proposta. Esta superintendência formou, em 2012, um Grupo de Trabalho para cuidar das questões relativas aos resíduos gerados na USP. Tal grupo, composto por especialistas na área, sob a coordenação de um assessor de gabinete da própria SGA, priorizou desenvolver, através de processos participativos, estratégias e procedimentos para elaboração e implantação de uma Política de Gestão de Resíduos (PGRUSP), com base na Política Nacional de Resíduos Sólidos. A PGRUSP prevê a elaboração dos planos de gerenciamento de resíduos em todas as unidades pertencentes à USP e prevê também a capacitação da comunidade acadêmica para a realização de um diagnóstico de resíduos e sistematização dos indicadores numa plataforma virtual unificada de resíduos. Assim, pretende-se controlar tanto os insumos utilizados como a geração, o armazenamento, os tratamentos e os descartes relacionados aos resíduos gerados em nossas Unidades e, consequentemente, minimizar impactos ambientais causados em todos os níveis e atividades

Stage at presentation of breast cancer in Luanda, Angola - a retrospective study

Background: It is expected that, by 2020, 15 million new cases of cancer will occur every year in the world, one million of them in Africa. Knowledge of cancer trends in African countries is far from adequate, and improvements in cancer prevention efforts are urgently needed. The aim of this study was to characterize breast cancer clinically and pathologically at presentation in Luanda, Angola; we additionally provide quality information that will be useful for breast cancer care planning in the country. Methods: Data on breast cancer cases were retrieved from the Angolan Institute of Cancer Control, from 2006 to 2014. For women diagnosed in 2009 (5-years of follow-up), demographic, clinical and pathological information, at presentation, was collected, namely age at diagnosis, parity, methods used for pathological diagnoses, tumor pathological characteristics, stage of disease and treatment. Descriptive statistics were performed. Results: The median age of women diagnosed with breast cancer in 2009 was 47 years old (range 25–89). The most frequent clinical presentation was breast swelling with axillary lymph nodes metastasis (44.9 %), followed by a mass larger than 5 cm (14.2 %) and lump (12.9 %). Invasive ductal carcinoma was the main histologic type (81.8 %). Only 10.1 % of cancer cases had a well differentiated histological grade. Cancers were diagnosed mostly at advanced stages (66.7 % in stage III and 11.1 % in stage IV). Discussion: In this study, breast cancer was diagnosed at a very advanced stage. Although it reports data from a single cancer center in Luanda, Angola it reinforces the need for early diagnosis and increasing awareness. According to the main challenges related to breast cancer diagnosis and treatment herein presented, we propose a realistic framework that would allow for the implementation of a breast cancer care program, built under a strong network based on cooperation, teaching, audit, good practices and the organization of health services. Conclusion: Angola needs urgently a program for early diagnosis of breast cancer.We thank Susana Santos for correction of the article in English language, and a Cancer Registry Staff from IACC, particularly Pedro Luis Hernandez Gonzalez, Paulo Ernesto Alves, Xacu Parica and Alberto Sivi Lutumba for their support in data acquisition. We also thank SEMED -Portugal in support for publication

Construction of a Residue Management Policy in the University of São Paulo: A model for the implementation of the NSRP in HEI

O cenário atual da Universidade de São Paulo (USP) tem, isoladamente, diversas ações ambientais em diferentes frentes, de acordo com a realidade de seus campi. \ud Em 2010, a USP designou um coordenador de Gestão Ambiental junto à Reitoria. No ano seguinte, regulamentou a Política Ambiental da USP, que visa promover a \ud sustentabilidade ambiental nos campi. Em 2012, foi criado um órgão institucional responsável pela gestão ambiental, a Superintendência de Gestão Ambiental (SGA), \ud que tem como premissa ditar normas para questões ambientais em consonância com a política ambiental proposta. Esta superintendência formou, em 2012, um \ud Grupo de Trabalho para cuidar das questões relativas aos resíduos gerados na USP. Tal grupo, composto por especialistas na área, sob a coordenação de um assessor \ud de gabinete da própria SGA, priorizou desenvolver, através de processos participativos, estratégias e procedimentos para elaboração e implantação de uma Política de \ud Gestão de Resíduos (PGRUSP). Esta Política, aos moldes de um trabalho anterior (PUSP-C, 2010), tem como proposta adequar as especificidades contidas na Política \ud Nacional de Resíduos Sólidos, para o contexto universitário.Uma versão inicial da PGRUSP foi apresentadapara a comunidade acadêmica em um Fórum promovido \ud pela SGA. Nesta ocasião, representantes de todas as categorias advindos dos diversos campi da USP, além de outros da comunidade externa, fizeram considerações \ud sobre o conteúdo desta versão, que foi, então, reformulada. A PGRUSP prevê a elaboração dos planos de gerenciamento de resíduos em todas as unidades pertencentes \ud à USP. Neste momento, o Grupo de Trabalho está elaborando diretrizes para a capacitação da comunidade acadêmica para a realização de um diagnóstico de resíduos, \ud com intuito também de mobilizar e conscientizar sobre os ditames da PGRUSP. A partir da capacitação e da elaboração dos planos de gerenciamento de resíduos, \ud pressupõe-se um aprendizado sobre questões práticas da gestão de resíduos. A geração de dados e de indicadores fornecerá embasamento para uma implementação \ud contínua e eficaz da política. Para sistematização destes dados, está sendo desenvolvida uma plataforma virtual unificada. Assim, pretende-se controlar tanto os \ud insumos utilizados como a geração, o armazenamento, os tratamentos e os descartes relacionados aos resíduos gerados em nossas Unidades. Pretende-se, ainda, com \ud esta sistematização, fornecer informações que permitam à SGA atomar medidas norteadoras para melhora na gestão dos resíduos nos campi, e,consequentemente, \ud minimizar impactos ambientais causados em todos os níveis e atividades

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

O império dos mil anos e a arte do "tempo barroco": a águia bicéfala como emblema da Cristandade

The article reveals that between the mid-17th century and the mid-18th century, in the ecclesiastical world of the religious orders (Jesuits, franciscans, Carmelites, Cistercians, Augustinian, etc.) and the episcopate, there was the progressive adoption of the imperial symbol, the double-headed eagle, attribute of the Christian Empire, the germanic Holy Roman Empire emblem. However, in the religious field, this imperial eagle of the baroque time appears without the political insignia (sword, scepter and the imperial orb), adorning altars, monstrances, trumphal archs, facades of temples, doors, walls, domes, pulpits, sacred washbasins, sculptures and paintings of the Virgin and Child, liturgical robes, etc.; therefore related to the cult and the dogmas of the Catholic faith - in artistic works, the association between the double eagle and the flesh-spirit or human-divine unity, axial principle of the Catholic faith, represented by Virgin-Mother and Christ, is often indicated directly. The research has located and identified numerous remnants of the double eagle emblem in religious field in Portugal and Spain and in their conquests and dominions in America, Asia and Africa, and also in Italy, and the historiography on painful birth of the modern era in the West has never realized this phenomenon. Symbolizing absolute power, universal power, these works with sacred significance, as the ecclesiastical discourse of the time, demonstrate movement occurred in religious plane. With the aim to assert not only spiritual but also temporal power of Christ and his mystical body, the Church was impelled by the idea of restoring the "Republica Christiana" or Christendon - disrupted by conflicts of power and faith - and of introducing a Universal Apostolic Monarchy extended to all mankind: the Empire of the Last Days, the Empire of Christ in the world, the fifth Empire

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat