Reason and unreason in the thought of Max Horkheimer and Theodor W. Adorno

This thesis deals with the relation between reason and unreason in the thought of Max Horkheimer and Theodor W. Adorno. We extrapolate from some central categories in their writings, particularly those of subjective reason, objective reason and enlightenment, in order to elucidate the critical theory of religion that is suggested by their notion of a dialectic of enlightenment. This thesis argues that, for Horkheimer and Adorno, spiritual belief and practice stand in mutually determining relation to so-called enlightened reason. It considers unreason in the form of primitive superstition, established revealed religion, and the present-day, Western "religion industry". Unreason is held to combine elements of subjective and objective reason, and thus both to affirm and to critique domination at various stages of human history. We conclude that the dialectical conception of unreason suggested by Horkheimer and Adorno constitutes an interesting and original critique of the Enlightenment conception of reason and of the traditional Marxist treatment of religion as mere ideology. However, the notion of liberation advocated by Horkheimer and Adorno on the basis of this theory fails to satisfy

A solar metallicity galaxy at z>z > 7? Detection of the [N II] 122 μ\mum and [O III] 52 μ\mum lines

We present the first detection of the [N II] 122 $\mu$m and [O III] 52 $\mu$m lines for a reionisation-epoch galaxy. Based on these lines and previous [C II] 158 $\mu$m and [O III] 88 $\mu$m measurements, we estimate an electron density of $\lesssim$ 500 cm$^{-3}$ and a gas-phase metallicity $Z/Z_\odot \sim 1.1 \pm 0.2$ for A1689-zD1, a gravitationally-lensed, dusty galaxy at $z$ = 7.133. Other measurements or indicators of metallicity so far in galaxy ISMs at $z \gtrsim$ 6 are typically an order of magnitude lower than this. The unusually high metallicity makes A1689-zD1 inconsistent with the fundamental metallicity relation, although there is likely significant dust obscuration of the stellar mass, which may partly resolve the inconsistency. Given a solar metallicity, the dust-to-metals ratio is a factor of several lower than expected, hinting that galaxies beyond $z \sim$ 7 may have lower dust formation efficiency. Finally, the inferred nitrogen enrichment compared to oxygen, on which the metallicity measurement depends, indicates that star-formation in the system is older than about 250 Myr, pushing the beginnings of this galaxy to $z >$ 10.Comment: 10 pages, 7 figures; submitted to MNRA

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.

Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use and chronic social defeat stress. Moreover, NAc-specific manipulations that block DNA methylation potentiated cocaine reward and exerted antidepressant-like effects, whereas NAc-specific Dnmt3a overexpression attenuated cocaine reward and was pro-depressant. On a cellular level, we found that chronic cocaine use selectively increased thin dendritic spines on NAc neurons and that DNA methylation was both necessary and sufficient to mediate these effects. These data establish the importance of Dnmt3a in the NAc in regulating cellular and behavioral plasticity to emotional stimuli

RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA.</p

Cows, Sheep and Science: A Scientific Perspective on Biological Emissions from Agriculture

Biological emissions from agriculture (methane and nitrous oxide) make up almost half New Zealand’s total greenhouse gas emissions, so their importance relative to carbon dioxide is of particular policy interest. Motu Economic and Public Policy Research brought together a group of New Zealand climate change and agriculture specialists to respond to questions posed by the Parliamentary Commissioner for the Environment on the science. The paper finds that the overriding need to reduce carbon dioxide emissions is scientifically uncontentious. For the climate to stabilise, net carbon dioxide emissions must ultimately be cut to zero. There is debate about whether, when and how much action to take on other gases. Some scientists advocate a comprehensive multi-gas approach, arguing that will be more cost-effective. It may already be too late to limit warming to two degrees without mitigating agricultural greenhouse gases. Others advocate a focus on carbon dioxide or on all long-lived gases (including nitrous oxide), with concerted mitigation of methane (a short-lived gas) only once carbon dioxide emissions are falling sustainably towards zero. There is support for ‘easy wins’ on all gases, but it is unclear how easy it is for New Zealand to reduce total nitrous oxide and methane emissions while maintaining production. The report summarises current and emerging options, and discusses methods to calculate methane and nitrous oxide emissions at the paddock, farm, regional and national scale. Finally, the report considers metrics used for comparison between gases, focusing on Global Warming Potential (GWP) and Global Temperture change Potential (GTP). The authors reached a consensus that the ‘right’ value depends on the policy goal and could change substantially over time; and if the main policy goal is to cost-effectively limit global average warming to two degrees above pre-industrial levels, then the value of methane should be less than the GWP100 value of 28 until global carbon dioxide emissions have begun to decline steadily towards zero. There is no agreement beyond this on the best value to use; the arguments reflect judgments about politics, economics, and the intersection of policy and science

Phage integrases for the construction and manipulation of transgenic mammals

<p>Abstract</p> <p>Phage integrases catalyze site-specific, unidirectional recombination between two short <it>att </it>recognition sites. Recombination results in integration when the <it>att </it>sites are present on two different DNA molecules and deletion or inversion when the <it>att </it>sites are on the same molecule. Here we demonstrate the ability of the φC31 integrase to integrate DNA into endogenous sequences in the mouse genome following microinjection of donor plasmid and integrase mRNA into mouse single-cell embryos. Transgenic early embryos and a mid-gestation mouse are reported. We also demonstrate the ability of the φC31, R4, and TP901-1 phage integrases to recombine two introduced <it>att </it>sites on the same chromosome in human cells, resulting in deletion of the intervening material. We compare the frequencies of mammalian chromosomal deletion catalyzed by these three integrases in different chromosomal locations. The results reviewed here introduce these bacteriophage integrases as tools for site-specific modification of the genome for the creation and manipulation of transgenic mammals.</p

Cows, sheep and science: a scientific perspective on biological emissions from agriculture

The science is clear. &nbsp; &nbsp;&nbsp; When debating emissions, &nbsp; &nbsp;&nbsp; consider your goals.&nbsp; Biological emissions from agriculture (methane and nitrous oxide) make up almost half New Zealand’s total greenhouse gas emissions, so their importance relative to carbon dioxide is of particular policy interest. Motu Economic and Public Policy Research brought together a group of New Zealand climate change and agriculture specialists to respond to questions posed by the Parliamentary Commissioner for the Environment on the science. The paper finds that the overriding need to reduce carbon dioxide emissions is scientifically uncontentious. For the climate to stabilise, net carbon dioxide emissions must ultimately be cut to zero. There is debate about whether, when and how much action to take on other gases. Some scientists advocate a comprehensive multi-gas approach, arguing that will be more cost-effective. It may already be too late to limit warming to two degrees without mitigating agricultural greenhouse gases. Others advocate a focus on carbon dioxide or on all long-lived gases (including nitrous oxide), with concerted mitigation of methane (a short-lived gas) only once carbon dioxide emissions are falling sustainably towards zero. There is support for ‘easy wins’ on all gases, but it is unclear how easy it is for New Zealand to reduce total nitrous oxide and methane emissions while maintaining production. The report summarises current and emerging options, and discusses methods to calculate methane and nitrous oxide emissions at the paddock, farm, regional and national scale. Finally, the report considers metrics used for comparison between gases, focusing on Global Warming Potential (GWP) and Global Temperture change Potential (GTP). The authors reached a consensus that the ‘right’ value depends on the policy goal and could change substantially over time; and if the main policy goal is to cost-effectively limit global average warming to two degrees above pre-industrial levels, then the value of methane should be less than the GWP100 value of 28 until global carbon dioxide emissions have begun to decline steadily towards zero. There is no agreement beyond this on the best value to use; the arguments reflect judgments about politics, economics, and the intersection of policy and science