475 research outputs found
Accretion Processes for General Spherically Symmetric Compact Objects
We investigate the accretion process for different spherically symmetric
space-time geometries for a static fluid. We analyse this procedure using the
most general black hole metric ansatz. After that, we examine the accretion
process for specific spherically symmetric metrics obtaining the velocity of
the sound during the process and the critical speed of the flow of the fluid
around the black hole. In addition, we study the behaviour of the rate of
change of the mass for each chosen metric for a barotropic fluid.Comment: 10 pages, 15 figures, v2 accepted for publication in 'European
Physical Journal C
Tamsulosin-induced severe hypotension during general anesthesia: a case report.
Introduction: Tamsulosin, a selective alpha1-adrenergic receptor (alpha1-AR) antagonist, is a widely prescribed first-line agent for benign prostatic hypertrophy (BPH). Its interaction with anesthetic agents has not been described. Case Presentation: We report the case of 54-year-old Asian man undergoing elective left thyroid lobectomy. The only medication the Patient was taking was tamsulosin 0.4 mg for the past year for BPH. He developed persistent hypotension during the maintenance phase of anesthesia while receiving oxygen, nitrous oxide and 1% isoflurane. The hypotension could have been attributable to a possible interaction between inhalational anesthetic and tamsulosin. Conclusion: Vigilance for unexpected hypotension is important in surgical Patients who are treated with selective alpha1-AR blockers. If hypotension occurs, vasopressors that act directly on adrenergic receptors could be more effective
Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis
Neurodegeneration mediates neurological disability in inflammatory demyelinating diseases of the CNS. The role of innate immune cells in mediating this damage has remained controversial with evidence for destructive and protective effects. This has complicated efforts to develop treatment. The time sequence and dynamic evolution of the opposing functions are especially unclear. Given limits of in vivo monitoring in human diseases such as multiple sclerosis (MS), animal models are warranted to investigate the association and timing of innate immune activation with neurodegeneration. Using noninvasive in vivo retinal imaging of experimental autoimmune encephalitis (EAE) in CX3CR1GFP/+–knock-in mice followed by transcriptional profiling, we are able to show 2 distinct waves separated by a marked reduction in the number of innate immune cells and change in cell morphology. The first wave is characterized by an inflammatory phagocytic phenotype preceding the onset of EAE, whereas the second wave is characterized by a regulatory, antiinflammatory phenotype during the chronic stage. Additionally, the magnitude of the first wave is associated with neuronal loss. Two transcripts identified — growth arrest–specific protein 6 (GAS6) and suppressor of cytokine signaling 3 (SOCS3) — might be promising targets for enhancing protective effects of microglia in the chronic phase after initial injury
Accretions of Various Types of Dark Energies onto Morris-Thorne Wormhole
In this work, we have studied accretion of the dark energies onto
Morris-Thorne wormhole. For quintessence like dark energy, the mass of the
wormhole decreases and phantom like dark energy, the mass of wormhole
increases. We have assumed two types of dark energy like variable modified
Chaplygin gas (VMCG) and generalized cosmic Chaplygin gas (GCCG). We have found
the expression of wormhole mass in both cases. We have found the mass of the
wormhole at late universe and this is finite. For our choices the parameters
and the function , these models generate only quintessence dark energy
(not phantom) and so wormhole mass decreases during evolution of the universe.
Next we have assumed 5 kinds of parametrizations of well known dark energy
models. These models generate both quintessence and phantom scenarios. So if
these dark energies accrete onto the wormhole, then for quintessence stage,
wormhole mass decreases upto a certain value (finite value) and then again
increases to infinite value for phantom stage during whole evolution of the
universe. We also shown these results graphically.Comment: 9 pages, 7 figures. arXiv admin note: text overlap with
arXiv:1112.615
A molecular insight into algal-oomycete warfare : cDNA analysis of Ectocarpus siliculosus infected with the basal oomycete Eurychasma dicksonii
Peer reviewedPublisher PD
MHD models of Pulsar Wind Nebulae
Pulsar Wind Nebulae (PWNe) are bubbles or relativistic plasma that form when
the pulsar wind is confined by the SNR or the ISM. Recent observations have
shown a richness of emission features that has driven a renewed interest in the
theoretical modeling of these objects. In recent years a MHD paradigm has been
developed, capable of reproducing almost all of the observed properties of
PWNe, shedding new light on many old issues. Given that PWNe are perhaps the
nearest systems where processes related to relativistic dynamics can be
investigated with high accuracy, a reliable model of their behavior is
paramount for a correct understanding of high energy astrophysics in general. I
will review the present status of MHD models: what are the key ingredients,
their successes, and open questions that still need further investigation.Comment: 18 pages, 5 figures, Invited Review, Proceedings of the "ICREA
Workshop on The High-Energy Emission from Pulsars and their Systems", Sant
Cugat, Spain, April 12-16, 201
Binary and Millisecond Pulsars at the New Millennium
We review the properties and applications of binary and millisecond pulsars.
Our knowledge of these exciting objects has greatly increased in recent years,
mainly due to successful surveys which have brought the known pulsar population
to over 1300. There are now 56 binary and millisecond pulsars in the Galactic
disk and a further 47 in globular clusters. This review is concerned primarily
with the results and spin-offs from these surveys which are of particular
interest to the relativity community.Comment: 59 pages, 26 figures, 5 tables. Accepted for publication in Living
Reviews in Relativity (http://www.livingreviews.org
[(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma
BACKGROUND: To compare morphological gross tumor volumes (GTVs), defined as pre- and postoperative gadolinium enhancement on T1-weighted magnetic resonance imaging to biological tumor volumes (BTVs), defined by the uptake of (18)F fluoroethyltyrosine (FET) for the radiotherapy planning of high-grade glioma, using a dedicated positron emission tomography (PET)-CT scanner equipped with three triangulation lasers for patient positioning. METHODS: Nineteen patients with malignant glioma were included into a prospective protocol using FET PET-CT for radiotherapy planning. To be eligible, patients had to present with residual disease after surgery. Planning was performed using the clinical target volume (CTV = GTV union or logical sum BTV) and planning target volume (PTV = CTV + 20 mm). First, the interrater reliability for BTV delineation was assessed among three observers. Second, the BTV and GTV were quantified and compared. Finally, the geometrical relationships between GTV and BTV were assessed. RESULTS: Interrater agreement for BTV delineation was excellent (intraclass correlation coefficient 0.9). Although, BTVs and GTVs were not significantly different (p = 0.9), CTVs (mean 57.8 +/- 30.4 cm(3)) were significantly larger than BTVs (mean 42.1 +/- 24.4 cm(3); p < 0.01) or GTVs (mean 38.7 +/- 25.7 cm(3); p < 0.01). In 13 (68%) and 6 (32%) of 19 patients, FET uptake extended >or= 10 and 20 mm from the margin of the gadolinium enhancement. CONCLUSION: Using FET, the interrater reliability had excellent agreement for BTV delineation. With FET PET-CT planning, the size and geometrical location of GTVs and BTVs differed in a majority of patients
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