Integrating hydrological features and genetically validated occurrence data in occupancy modeling of an endemic and endangered semi-aquatic mammal species, Galemys pyrenaicus, in a Pyrenean catchment

As freshwater habitats are among the most endangered, there is an urgent need to identify critical areas for conservation, especially those that are home to endangered species. The Pyrenean desman (Galemys pyrenaicus) is a semi-aquatic mammal whose basic ecological requirements are largely unknown, hindering adequate conservation planning even though it is considered as a threatened species. Species distribution modelling is challenging for freshwater species. Indeed, the complexity of aquatic ecosystems (e.g., linear and hierarchical ordering) must be taken into account as well as imperfect sampling. High-quality and relevant hydrological descriptors should also be used. To understand the influence of environmental covariates on the occupancy and detection of the Pyrenean desman, we combine both a robust sign-survey data set (i.e. with genetic validation ensuring true presence information) and a hydrological model to simulate the flow regime across a whole catchment. Markovian site-occupancy analysis, taking into account sign detection and based on spatially adjacent replicates, indicated a positive influence of heterogeneity of substrate and shelters, and a negative influence of flow variability on Pyrenean desman detection. This valuable information should help to improve monitoring programs for this endangered species. Our results also highlighted a spatially clustered distribution and a positive influence of stream flow and number of tributaries on occupancy. Hence, modifications of flow regime (e.g. hydropower production, irrigation, climate change) and habitat fragmentation appear to be major threats for this species, altering the connectivity between tributaries and the mainstream river as well as between adjacent sub-catchments

Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies

Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis

Une information sur les matrices de covariance : la liaison-information

Université : Université scientifique et médicale de Grenobl

Maladie de Hodgkin chez les patients infectés par le VIH (les facteurs anatomopathologiques pronostiqués)

BORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

A Survey on Real Structural Complexity Theory

In this tutorial paper we overview research being done in the field of structural complexity and recursion theory over the real numbers and other domains following the approach by Blum, Shub, and Smale [12]

Conduire un diagnostic partagé en contexte inter-organisationnel : enseignements théoriques et pratiques

International audienc

On the expressiveness and decidability of o-minimal hybrid systems

Abstract. This paper is driven by a general motto: bisimulate a hybrid system by a finite symbolic dynamical system. In the case of o-minimal hybrid systems, the continuous and discrete components can be decoupled, and hence, the problem reduces in building a finite symbolic dynamical system for the continuous dynamics of each location. We show that this can be done for a quite general class of hybrid systems defined on o-minimal structures. In particular, we recover the main result of a paper by Lafferriere G., Pappas G.J. and Sastry S. on o-minimal hybrid systems. We also study related decidability questions. Mathematics Subject Classification: 68Q60, 03C64, 03D15.

Genetic structure of nase, Chondrostoma nasus, and common barbel, Barbus barbus (Teleostei, Cyprinidae) populations in South Belgium rivers: toward a rational management of conservation restocking

Nase (Chondrostoma nasus) and common barbel (Barbus barbus) are two rheophilic cyprinid fish naturally present in the Belgian Meuse and Rhine basins. During the last decades, the construction of dams together with changes in hydrological regimes, modifications of riverbed morphology and water pollution have caused some local dramatic declines in their populations. However, recent improvements in terms of water quality and habitat fragmentation allow considering as realistic a rational restocking plan of locally endangered patrimonial fish species such as nase and common barbel. Restocking operations for a conservation purpose have to be based on the knowledge and the use of wild type genetic strains. Therefore, the aim of this study was to characterize the genetic structure and diversity of nase and common barbel populations in South Belgium rivers. Wild common barbels (n = 313) and nases (n = 271) were sampled by electrofishing in respectively 10 and 6 different tributaries from the Meuse and Rhine rivers. Genotyping was performed on 24 microsatellite markers for each species. Preliminary results showed, for both species, a differential genetic clustering between fish originating from the Meuse basin and those originating from the Rhine basin. Detailed analysis describing the genetic structure and diversity of South Belgium populations will be presented and will serve as a management tool to set up a breeding plan for conservation restocking

Quantifier Elimination following Muchnik

This paper describes a very simple (high school level) algorithm of quantifier elimination for real closed fields and algebraically closed fields following an idea of A. Muchnik. The algorithm essentially relies on intermediate value property, pseudo-euclidean division and sign change table for univariate polynomials over R. Surprisingly this algorithm exhibits some more general feature and it can be very naturally turned into an algorithm of quantifier elimination for algebraically closed fields too