Experimental Realization of a Reconfigurable Electroacoustic Topological Insulator

A substantial challenge in guiding elastic waves is the presence of reflection and scattering at sharp edges, defects, and disorders. Recently, mechanical topological insulators have sought to overcome this challenge by supporting back-scattering resistant wave transmission. In this Letter, we propose and experimentally demonstrate the first \emph{reconfigurable electroacoustic} topological insulator exhibiting an analog to the quantum valley Hall effect (QVHE). Using programmable switches, this phononic structure allows for rapid reconfiguration of domain walls and thus the ability to control back-scattering resistant wave propagation along dynamic interfaces for phonons lying in static and finite-frequency regimes. Accordingly, a graphene-like Polyactic Acid (PLA) layer serves as the host medium, equipped with periodically arranged and bonded piezoelectric patches, resulting in two Dirac cones at the $K-$points. The PZT patches are then connected to negative capacitance external circuits to break inversion symmetry and create nontrivial topologically-protected bandgaps. As such, topologically protected interface waves are demonstrated numerically and validated experimentally for different predefined trajectories over a broad frequency range

Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation

South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This includes both communicable (e.g., HIV/AIDS and tuberculosis) and non-communicable (e.g., diabetes and cardiovascular) diseases. For example, although only 0.7% of the world’s population lives in South Africa, the country carries 17% of the global HIV/AIDS burden and 5% of the global tuberculosis burden. Nobel Peace Prize Laureate Archbishop Emeritus Desmond Tutu has coined the term Rainbow Nation, referring to a land of wealth in its many diverse peoples and cultures. It is now timely and necessary to reflect on how best to approach new genomics biotechnologies in a manner that carefully considers the public health needs and extant disease burden in the region. The aim of this paper is to document and review the advances in pharmacogenomics in South Africa and importantly, to evaluate the direction that future research should take. Previous research has shown that the populations in South Africa exhibit unique allele frequencies and novel genetic variation in pharmacogenetically relevant genes, often differing from other African and global populations. The high level of genetic diversity, low linkage disequilibrium and the presence of rare variants in these populations question the feasibility of the use of current commercially available genotyping platforms, and may partially account for genotype-phenotype discordance observed in past studies. However, the employment of high throughput technologies for genomic research, within the context of large clinical trials, combined with interdisciplinary studies and appropriate regulatory guidelines, should aid in acceleration of pharmacogenomic discoveries in high priority therapeutic areas in South Africa. Finally, we suggest that projects such as the H3Africa Initiative, the SAHGP and PGENI should play an integral role in the coordination of genomic research in South Africa, but also other African countries, by providing infrastructure and capital to local researchers, as well as providing aid in addressing the computational and statistical bottlenecks encountered at present

A four compartment epidemic model with retarded transition rates

We study an epidemic model for a constant population by taking into account four compartments of the individuals characterizing their states of health. Each individual is in one of the compartments susceptible (S); incubated - infected yet not infectious (C), infected and infectious (I), and recovered - immune (R). An infection is 'visible' only when an individual is in state I. Upon infection, an individual performs the transition pathway S to C to I to R to S remaining in each compartments C, I, and R for certain random waiting times, respectively. The waiting times for each compartment are independent and drawn from specific probability density functions (PDFs) introducing memory into the model. We derive memory evolution equations involving convolutions (time derivatives of general fractional type). We obtain formulae for the endemic equilibrium and a condition of its existence for cases when the waiting time PDFs have existing means. We analyze the stability of healthy and endemic equilibria and derive conditions for which the endemic state becomes oscillatory (Hopf) unstable. We implement a simple multiple random walker's approach (microscopic model of Brownian motion of Z independent walkers) with random SCIRS waiting times into computer simulations. Infections occur with a certain probability by collisions of walkers in compartments I and S. We compare the endemic states predicted in the macroscopic model with the numerical results of the simulations and find accordance of high accuracy. We conclude that a simple random walker's approach offers an appropriate microscopic description for the macroscopic model.Comment: 26 pages, 11 figure

Climate-based site selection for a very large telescope using GIS techniques

Astronomical research at present requires that a telescope with an aperture diameter of between 50 and 100 metres be constructed within the next 10 years or so. This new generation of telescopes will be called OWL (Overwhelmingly Large), and it represents one order of magnitude increase in size over today's telescopes. Selection of an ideal site for this giant telescope is dependent on many climatological, meteorological and geomorphological parameters (Grenon 1990). Among these are cloud cover, atmospheric humidity, aerosol content, airflow direction and strength, air temperature, topography, and seismicity. Even relatively minor changes in weather patterns can have a significant effect on seeing conditions (Beniston et al. 2002)

Resource Integration Using a Large Knowledge Base in Carnot

A method for integrating separately developed information resources that overcomes incompatibilities in syntax and semantics and permits the resources to be accessed and modified coherently is described. The method provides logical connectivity among the information resources via a semantic service layer that automates the maintenance of data integrity and provides an approximation of global data integration across systems. This layer is a fundamental part of the Carnot architecture, which provides tools for interoperability across global enterprises

Decoherence of a Pointer by a Gas Reservoir

We study the effect of the environment on the process of the measurement of a state of a microscopic spin half system. The measuring apparatus is a heavy particle, whose center of mass coordinates can be considered at the end of the measurement as approximately classical, and thus can be used as a pointer. The state of the pointer, which is the result of its interaction with the spin, is transformed into a mixed state by the coupling of the pointer to the environment. The environment is considered to be a gas reservoir, whose particles interact with the pointer. This results in a Fokker-Planck equation for the reduced density matrix of the pointer. The solution of the equation shows that the quantum coherences, which are characteristic to the entangled state between the probabilities to find the pointer in one of two positions, decays exponentially fast in time. We calculate the exponential decay function of this decoherence effect, and express it in terms of the parameters of the model.Comment: 41 pages, 1 figur