Modeling SNR Cassiopeia A from the Supernova Explosion to its Current Age: The role of post-explosion anisotropies of ejecta

The remnants of core-collapse supernovae (SNe) have complex morphologies that may reflect asymmetries and structures developed during the progenitor SN explosion. Here we investigate how the morphology of the SNR Cassiopeia A (Cas A) reflects the characteristics of the progenitor SN with the aim to derive the energies and masses of the post-explosion anisotropies responsible for the observed spatial distribution of Fe and Si/S. We model the evolution of Cas A from the immediate aftermath of the progenitor SN to the three-dimensional interaction of the remnant with the surrounding medium. The post-explosion structure of the ejecta is described by small-scale clumping of material and larger-scale anisotropies. The hydrodynamic multi-species simulations consider an appropriate post-explosion isotopic composition of the ejecta. The observed average expansion rate and shock velocities can be well reproduced by models with ejecta mass $M_{\rm ej}\approx 4M_{\odot}$ and explosion energy $E_{\rm SN}\approx 2.3\times 10^{51}$ erg. The post-explosion anisotropies (pistons) reproduce the observed distributions of Fe and Si/S if they had a total mass of $\approx 0.25\,M_{\odot}$ and a total kinetic energy of $\approx 1.5\times 10^{50}$ erg. The pistons produce a spatial inversion of ejecta layers at the epoch of Cas A, leading to the Si/S-rich ejecta physically interior to the Fe-rich ejecta. The pistons are also responsible for the development of bright rings of Si/S-rich material which form at the intersection between the reverse shock and the material accumulated around the pistons during their propagation. Our result supports the idea that the bulk of asymmetries observed in Cas A are intrinsic to the explosion.Comment: 19 pages, 14 Figures; accepted for publication on Ap

Supernova 1987A: a Template to Link Supernovae to their Remnants

The emission of supernova remnants reflects the properties of both the progenitor supernovae and the surrounding environment. The complex morphology of the remnants, however, hampers the disentanglement of the two contributions. Here we aim at identifying the imprint of SN 1987A on the X-ray emission of its remnant and at constraining the structure of the environment surrounding the supernova. We performed high-resolution hydrodynamic simulations describing SN 1987A soon after the core-collapse and the following three-dimensional expansion of its remnant between days 1 and 15000 after the supernova. We demonstrated that the physical model reproducing the main observables of SN 1987A during the first 250 days of evolution reproduces also the X-ray emission of the subsequent expanding remnant, thus bridging the gap between supernovae and supernova remnants. By comparing model results with observations, we constrained the explosion energy in the range $1.2-1.4\times 10^{51}$~erg and the envelope mass in the range $15-17 M_{\odot}$. We found that the shape of X-ray lightcurves and spectra at early epochs (<15 years) reflects the structure of outer ejecta: our model reproduces the observations if the outermost ejecta have a post-explosion radial profile of density approximated by a power law with index $\alpha = -8$. At later epochs, the shapes of X-ray lightcurves and spectra reflect the density structure of the nebula around SN 1987A. This enabled us to ascertain the origin of the multi-thermal X-ray emission, to disentangle the imprint of the supernova on the remnant emission from the effects of the remnant interaction with the environment, and to constrain the pre-supernova structure of the nebula.Comment: 16 pages, 11 Figures; accepted for publication on Ap

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.

Lipid raft membrane compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds function in establishing cell polarity and organizing signal transducers within epithelial cell junctions and neuronal synapses. Here, we elucidate a role for the MAGUK protein, Dlgh1, in polarized T cell synapse assembly and T cell function. We find that Dlgh1 translocates to the immune synapse and lipid rafts in response to T cell receptor (TCR)/CD28 engagement and that LckSH3-mediated interactions with Dlgh1 control its membrane targeting. TCR/CD28 engagement induces the formation of endogenous Lck-Dlgh1-Zap70-Wiskott-Aldrich syndrome protein (WASp) complexes in which Dlgh1 acts to facilitate interactions of Lck with Zap70 and WASp. Using small interfering RNA and overexpression approaches, we show that Dlgh1 promotes antigen-induced actin polymerization, synaptic raft and TCR clustering, nuclear factor of activated T cell activity, and cytokine production. We propose that Dlgh1 coordinates TCR/CD28-induced actin-driven T cell synapse assembly, signal transduction, and effector function. These findings highlight common molecular strategies used to regulate cell polarity, synapse assembly, and transducer organization in diverse cellular systems

Detailed study of SNR G306.3-0.9 using XMM-Newton and Chandra observations

We used combined data from XMM-Newton and Chandra observatories to study the X-ray morphology of SNR G306.3-0.9. A spatially-resolved spectral analysis was used to obtain physical and geometrical parameters of different regions of the remnant. Spitzer infrared observations were also used to constrain the progenitor supernova and study the environment in which the SNR evolved. The X-ray morphology of the remnant displays a non-uniform structure of semi-circular appearance, with a bright southwest region and very weak or almost negligible X-ray emission in its northern part. These results indicate that the remnant is propagating in a non-uniform environment as the shock fronts are encountering a high-density medium, where enhanced infrared emission is detected. The X-ray spectral analysis of the selected regions shows distinct emission-line features of several metal elements, confirming the thermal origin of the emission. The X-ray spectra are well represented by a combination of two absorbed thermal plasma models: one in equilibrium ionization with a mean temperature of ~0.19 keV, and another out of equilibrium ionization at a higher temperature of ~1.1 or 1.6-1.9 keV. For regions located in the northeast, central, and southwest part of the SNR, we found elevated abundances of Si, S, Ar, Ca, and Fe, typical of ejecta material. The outer regions located northwest and south show values of the abundances above solar but lower than to those found in the central regions. This suggests that the composition of the emitting outer parts of the SNR is a combination of ejecta and shocked material of the interstellar medium. The comparison between the S/Si, Ar/Si, and Ca/Si abundances ratios (1.75, 1.27, and 2.72 in the central region, respectively), favor a Type Ia progenitor for this SNR, a result that is also supported by an independent morphological analysis using X-ray and IR data.Comment: 8 pages, 7 figures. Accepted by Astronomy and Astrophysic

Mitral Valve Repair Techniques With Neochords: When Sizing Matters

Mitral valve (MV) repair procedures have evolved over time and multiple approaches have been proposed also for the repair with neochords implantation. This article compiles the currently available approaches for implanting and sizing neochords, to restore a proper coaptation of the MV leaflets and a good systo-dyastolic movement. The described techniques are aimed at standardizing chordal measurement, in order to reduce variability in chordal length. The placement of annuloplasty ring before chordae implantation should be avoided. Regardless of the technique chosen, it is important that the implanted chordae do not interfere with normal native chordae, to avoid the risk that neochordae may heal together or get damaged. This article aims to give an overview of the most common sizing techniques available

Sutureless and rapid deployment valves: Implantation technique from A to Z-the perceval valve

In the last two decades, sutureless (Perceval, Livallova PLC, London, UK) and rapid deployment valves (RD) (Intuity, Edwards Lifesciences, Irvine, CA, USA) were introduced to the market as an innovative alternative to traditional valves for patients requiring an aortic valve replacement (AVR). These devices have been studied extensively and in use across the last fifteen years. They have proven to not only demonstrate comparable results with conventional sutured biological valves-particularly helpful in minimally invasive cardiac surgery-but also provide an almost curative treatment to patients with intermediate-to-high surgical risk, filling the gap between transcatheter aortic valve implantation (TAVI) and traditional AVR. However, both sutureless and RD valves require special steps for implantation, resulting in a learning curve. Specific training for all surgical team members is mandatory, as recommended by the manufacturers. The aim of this review article is therefore to provide cardiac surgeons with a thorough guide on the implantation technique for each of these two prosthetic devices, from A to Z. In this first article, we will start by focusing on Perceval

Minimally invasive aortic valve surgery

Since their introduction, it has been demonstrated that minimally invasive aortic valve replacement (MIAVR) approaches are safe and effective for the treatment of aortic valve diseases. To date, the main advantage of these approaches is represented by the reduced surgical trauma, with a subsequent reduced complication rate and faster recovery. This makes such approaches an appealing choice also for frail patients [obese, aged, chronic obstructive pulmonary disease (COPD)]. The standardization of the minimally invasive techniques, together with the implementation of preoperative workup and anesthesiological intraand post-operative care, led to an amelioration of surgical results and reduction of surgical times. Moreover, the improvement of surgical technology and the introduction of new devices such as sutureless and rapid deployment (SURD) valves, has helped the achievement of comparable results to traditional surgery. However, transcatheter technologies are nowadays more and more important in the treatment of aortic valve disease, also in low risk patients. For this reason surgeons should put new efforts for further reducing the surgical trauma in the future, even taking inspiration from other disciplines. In this review, we aim to present a review of literature evidences regarding minimally invasive treatment of aortic diseases, also reflecting our personal experience with MIAVR techniques. This review could represent a tool for a well-structured patient assessment and preoperative planning, in order to safely carrying out an MIAVR procedure with satisfactory outcomes