Effects of ketosis on cocaine-induced reinstatement in male mice;

In recent years, the benefits of the ketogenic diet (KD) on different psychiatric disorders have been gaining attention, but the substance abuse field is still unexplored. Some studies have reported that palatable food can modulate the rewarding effects of cocaine, but the negative metabolic consequences rule out the recommendation of using it as a complementary treatment. Thus, the main aim of this study was to evaluate the effects of the KD on cocaine conditioned place preference (CPP) during acquisition, extinction, and reinstatement. 41 OF1 male mice were employed to assess the effects of the KD on a 10 mg/kg cocaine-induced CPP. Animals were divided into three groups: SD, KD, and KD after the Post-Conditioning test. The results revealed that, while access to the KD did not block CPP acquisition, it did significantly reduce the number of sessions required to extinguish the drug-associated memories and it blocked the priming-induced reinstatement. © 2022 The Author(s

Anthropometric and equipment characteristics in adolescent sprint kayakers

Los objetivos de este estudio fueron describir las características antropométricas y la configuración del material utilizado por 91 kayakistas españoles adolescentes de 13 y 14 años, de aguas tranquilas y buscar correlaciones entre ambas variables. Se valoraron las características antropométricas y las dimensiones del material de competición de noventa y un kayakistas de aguas tranquilas (45 hombres y 46 mujeres), de 13 y 14 años de edad. Los hombres kayakistas de 14 años presentaron valores superiores a los de 13 años en cuanto a dimensiones antropométricas y del material de competición, mientras que no se encontraron diferencias significativas entre las variables analizadas entre las mujeres kayakistas de 13 y 14 años. La talla y envergadura presentaron las mayores correlaciones con la longitud de la pala y la distancia asiento - reposapiés. La información aportada por este trabajo podría ser de utilidad para ajustar las dimensiones del material de competición, optimizando así el confort y rendimiento en kayakistas jóvenes.The aims of this study were to describe kinanthropometric characteristics and equipment set-up of male and female young kayakers and to look for correlations between both variables. Ninety one young sprint kayakers (45 males and 46 females), aged 13 and 14 years old, were assessed using a battery of 12 anthropometric and 5 equipment dimensions. Comparison between the 13- and 14-year-old kayakers showed that 14-year-old males had greater body and equipment dimensions than their 13-year-old counterparts, whereas there were no significant differences between 13- and 14-year-old female kayakers in both anthropometric and equipment set-up dimensions. Stretch stature and arm span were the variables which greater coefficient correlations showed with total paddle length and seat - feet bar distance. The data presented in this paper may provide important information to adjust equipment sep-up in order to optimise comfort and performance in young kayakers

Sagittal spinal curvatures and pelvic inclination in kayakers

El objetivo del estudio fue comparar la disposición sagital del raquis e inclinación pélvica en diferentes posiciones en kayakistas. A ciento treinta kayakistas entre 15 y 20 años (62 varones y 68 mujeres) se les evaluó, mediante un Spinal Mouse, la disposición angular del raquis torácico, lumbar e inclinación pélvica en bipedestación, sedentación relajada, máxima flexión del tronco en sedentación, test sit-and-reach, posición de base y de ataque en un kayak-ergómetro. La cifosis torácica en la piragua fue menor (p<0,001) que en bipedestación y sedentación relajada. El raquis lumbar se dispuso en inversión lumbar en las posturas de flexión del tronco y sedentación, favorecido por una posición de retroversión pélvica. Las mujeres adoptaron posturas de menor flexión lumbar y pélvica en el kayak-ergómetro. En conclusión, la posición de las mujeres en el kayak-ergómetro se caracteriza por posturas más alineadas del raquis y pelvisThe aim of this study was to compare the sagittal spinal curvatures and pelvic tilt in different positions on kayakers. One hundred and thirty kayakers between 15 and 20 years (62 males and 68 females) participated in this study. Thoracic and lumbar curvatures and pelvic position were evaluated with a Spinal Mouse system in standing position, slumped sitting, maximal trunk bending with knees flexed, sit-and-reach test, base position right entry position and left entry position in a kayak ergometer. Thoracic kyphosis in the kayak-ergometer was more reduced (p<0,001) than standing and slumped sitting. Lumbar spine adopted kyphotic postures when maximal trunk flexion was performed and in the kayak ergometer. This posture was related to posterior pelvic tilt. Females showed lower lumbar and pelvic flexion than males in the kayak ergometer. In conclusion, females adopt more aligned spinal and pelvic postures in the kayak ergometer than malesEste estudio se realizó en el marco de las ayudas de la Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia (II PCTRM 2007-2010) al proyecto nº 11951/PI/09, titulado “Evolution of sagittal spinal curvatures, hamstring extensibility, low back pain, and anthropometric characteristics in elite paddlers

Reinstatement of Morphine-Induced Conditioned Place Preference in Mice by Priming Injections

To construct a model of relapse of drug abuse in mice, the induction, we evaluated the extinction and reinstatement of morphine-induced place preference. In Experiment 1, we examined the effects of morphine (0, 2, 3, 5, 10, 20 and 40 mg/kg) in the conditioned place preference (CPP) paradigm. Mice showed CPP with 5, 10, 20 and 40 mg/kg. In Experiment 2, we evaluated the effects of two different extinction procedures. After conditioning with 40 mg/kg of morphine, the mice underwent daily extinction sessions of 60 or 15 min of duration. CPP was extinguished after seven and nine sessions, respectively. In Experiment 3, we tested the reinstating effects of several priming doses of morphine. Mice were conditioned with 40 mg/kg of morphine and underwent the daily 15 min extinction sessions until CPP was no longer evident. Then, the effects of morphine (0, 2, 3, 5, 10, 20, 40 mg/kg, i.p.) were evaluated. CPP was reinstated by doses from 5 mg/kg upward. The results show that morphine priming injections are effective in reactivating opiateseeking behavior in mice, and thus, the CPP paradigm might be useful to investigate the mechanisms underlying relapse of drug abuse

Performance assessment of ontology matching systems for FAIR data

© The Author(s). 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Ontology matching should contribute to the interoperability aspect of FAIR data (Findable, Accessible, Interoperable, and Reusable). Multiple data sources can use different ontologies for annotating their data and, thus, creating the need for dynamic ontology matching services. In this experimental study, we assessed the performance of ontology matching systems in the context of a real-life application from the rare disease domain. Additionally, we present a method for analyzing top-level classes to improve precision. Results: We included three ontologies (NCIt, SNOMED CT, ORDO) and three matching systems (AgreementMakerLight 2.0, FCA-Map, LogMap 2.0). We evaluated the performance of the matching systems against reference alignments from BioPortal and the Unified Medical Language System Metathesaurus (UMLS). Then, we analyzed the top-level ancestors of matched classes, to detect incorrect mappings without consulting a reference alignment. To detect such incorrect mappings, we manually matched semantically equivalent top-level classes of ontology pairs. AgreementMakerLight 2.0, FCA-Map, and LogMap 2.0 had F1-scores of 0.55, 0.46, 0.55 for BioPortal and 0.66, 0.53, 0.58 for the UMLS respectively. Using vote-based consensus alignments increased performance across the board. Evaluation with manually created top-level hierarchy mappings revealed that on average 90% of the mappings’ classes belonged to top-level classes that matched. Conclusions: Our findings show that the included ontology matching systems automatically produced mappings that were modestly accurate according to our evaluation. The hierarchical analysis of mappings seems promising when no reference alignments are available. All in all, the systems show potential to be implemented as part of an ontology matching service for querying FAIR data. Future research should focus on developing methods for the evaluation of mappings used in such mapping services, leading to their implementation in a FAIR data ecosystem