Introduction and overview

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26262/1/0000343.pd

Tenofovir-Associated Nephrotoxicity in Two HIV-Infected Adolescent Males

We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents. The first case, a 16-year-old African American male with an absolute CD4+ cell count of 314 cells/mm3, presented with an abrupt rise in serum creatinine leading to irreversible renal failure while on TDF-containing highly active antiretroviral therapy (HAART). While the patient had evidence of underlying kidney disease, the timing of his renal failure indicates that TDF played a central role. The second case, a 16-year-old African-American male with an absolute CD4+ cell count of 895 cells/mm3, presented with rickets and hypophosphatemia while receiving TDF-based HAART. To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients. We believe these cases highlight important and potentially irreversible side effects of this agent and emphasize the need for further studies of the renal safety of TDF in pediatric patients

STEaM Girls Activities: Flandreau Indian School, Flandreau, SD, 2016

This booklet includes tribally relevant, fun activities designed to increase interest in STEM studies and careers, particularly among Native American girls and women in South Dakota and the northern Great Plains. It is suitable for anyone to use in homes and schools, although adult supervision is recommended

A User\u27s Guide to the Encyclopedia of DNA Elements (ENCODE)

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome

Sulfidation of organic matter associated with gold mineralization, Pueblo viejo, Dominican republic

The Pueblo Viejo district is one of the largest producers of precious metals in the world, yielding more than 11,000 kg of Au annually. Gold mineralization at Pueblo Viejo is hosted in spilite, and coarse clastic and finely laminated, fine grained carbonaceous sedimentary rocks of the Lower Cretaceous Los Ranchos Formation. Mineralization was accompanied by sulfidation as evidenced by (1) the occurrence of siderite distal to mineralization and pyrite proximal to mineralization, (2) increased S/Fe ratios associated with Au mineralization, (3) the occurrence of native S in and adjacent to mineralization, and (4) the presence of sulfidized organic matter (organo-S compounds) in mineralized rocks. Organic matter in the carbonaceous sedimentary rocks comprises vitrinite and pyrobitumen. Rock-Eval pyrolysis data indicate that this organic matter is overmature (HI 2S in the mineralizing fluid would have destabilized Au bisulfide complexes and caused deposition of gold. The restriction of S-rich organic matter to rocks in which all Fe occurs as pyrite indicates that sulfidation of organic matter postdates sulfidation of ferrous Fe and therefore, deposition of much of the Au.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28847/1/0000682.pd

Gold deposition by sulfidation of ferrous Fe in the lacustrine sediments of the Pueblo Viejo district (Dominican Republic): The effect of Fe-C-S diagenesis on later hydrothermal mineralization in a Maar-Diatreme complex

The Pueblo Viejo district, located in the Cordillera Central of the Dominican Republic, contains large Au-Ag deposits associated with acid-sulfate alteration within spilites, conglomerates and carbonaceous sedimentary rocks that were deposited in a maar-diatreme complex. Much of the Au mineralization occurs in pyritic, carbonaceous siltstones of the Pueblo Viejo Maar-Diatreme Member of the Cretaceous Los Ranchos Formation. Pyrite is the only Fe-bearing phase in mineralized rock, whereas siderite is the dominant Fe-bearing phase in siltstones distal to mineralization. Disseminated pyrite occurs as framboids, cubes, pyritohedra, concretions and cement. Early framboids occur throughout the district. Au occurs as inclusions in later non-framboid disseminated pyrite (NFDP); an occurrence that is interpreted to be indicative of contemporaneous deposition. Pyrite framboids exhibit a wide range of [delta]34S-values (-17.5 to +4.8[per mille sign]) and are interpreted to have formed during biogenic reduction of pore-water sulfate. The NFDP yield restricted [delta]34S-values (, s = +/-2.4[per mille sign], n = 43) similar to those obtained from later vein pyrite (, s = +/-1.5[per mille sign], n = 12). Alunite and barite have [delta]34S-values ranging from +18.8 to +21.6[per mille sign]. The interpretation that the NFDP, vein pyrite, alunite and barite, and possibly even the framboidal pyrite share a common source of igneous sulfur is supported by the [delta]34S data. Siderite occurs as concretions and cement, contains abundant Mg (Fe0.75Mg0.19Mn0.03Ca0.02CO3) and has [delta]13C- and [delta]18O-values ranging from -2.5 to +1.1%. and +14.6 to +19.5[per mille sign], respectively. These data are consistent with the interpretation that the siderite formed in lacustrine sediments and that the carbonate in the siderite is probably methanogenic, although contributions from oxidation of organic matter during biogenic sulfate reduction, thermal decarboxylation of organic matter, or magmatic vapor cannot be ruled out.Disseminated Au mineralization in the sedimentary rocks formed when a hydrothermal fluid encountered reactive Fe2+ in diagenetic siderite. The ensuing pyrite deposition consumed H2S and destabilized the Au (HS)-2 complex, leading to precipitation of Au. The capacity of the sedimentary rocks to consume H2S and precipitate Au was controlled by the amount of non-pyrite Fe present as siderite. The abundance of siderite was controlled by the extent of pyrite formation during diagenesis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29846/1/0000193.pd

Antarctic Environmental Change and Ice Sheet Evolution through the Miocene to Pliocene ¿ A perspective from the Ross Sea and George V to Wilkes Land Coasts

We wish to acknowledge the support of National Antarctic Programmes and the International Scientific Drilling Programmes and Projects that have allowed our community to acquire the critical records of environmental change that have been discussed in this review. We thank Jenny Black, GNS Science, for her assistance with Fig. 9.2. R.L., T.N., R.M., C.O. and N.G. acknowledge funding support from the New Zealand Ministry of Business and Innovation and Employment through the Antarctic Science Platform contract (ANTA1801) Antarctic Ice Dynamics Project (ASP-021-01). C.E. acknowledges funding by the Spanish Ministry of Economy, Industry and Competitivity (grant CTM2017-89711-C2-1/2-P), co-funded by the European Union through FEDER funds. L.F.P. was funded through the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement number 792773 for the West Antarctic Margin Signatures of Ice Sheet Evolution (WAMSISE) Project

Apportioning sources of organic matter in streambed sediments: An integrated molecular and compound-specific stable isotope approach

We present a novel application for quantitatively apportioning sources of organic matter in streambed sediments via a coupled molecular and compound-specific isotope analysis (CSIA) of long-chain leaf wax n-alkane biomarkers using a Bayesian mixing model. Leaf wax extracts of 13 plant species were collected from across two environments (aquatic and terrestrial) and four plant functional types (trees, herbaceous perennials, and C3 and C4 graminoids) from the agricultural River Wensum catchment, UK. Seven isotopic (δ13C27, δ13C29, δ13C31, δ13C27–31, δ2H27, δ2H29, and δ2H27–29) and two n-alkane ratio (average chain length (ACL), carbon preference index (CPI)) fingerprints were derived, which successfully differentiated 93% of individual plant specimens by plant functional type. The δ2H values were the strongest discriminators of plants originating from different functional groups, with trees (δ2H27–29 = − 208‰ to − 164‰) and C3 graminoids (δ2H27–29 = − 259‰ to − 221‰) providing the largest contrasts. The δ13C values provided strong discrimination between C3 (δ13C27–31 = − 37.5‰ to − 33.8‰) and C4 (δ13C27–31 = − 23.5‰ to − 23.1‰) plants, but neither δ13C nor δ2H values could uniquely differentiate aquatic and terrestrial species, emphasizing a stronger plant physiological/biochemical rather than environmental control over isotopic differences. ACL and CPI complemented isotopic discrimination, with significantly longer chain lengths recorded for trees and terrestrial plants compared with herbaceous perennials and aquatic species, respectively. Application of a comprehensive Bayesian mixing model for 18 streambed sediments collected between September 2013 and March 2014 revealed considerable temporal variability in the apportionment of organic matter sources. Median organic matter contributions ranged from 22% to 52% for trees, 29% to 50% for herbaceous perennials, 17% to 34% for C3 graminoids and 3% to 7% for C4 graminoids. The results presented here clearly demonstrate the effectiveness of an integrated molecular and stable isotope analysis for quantitatively apportioning, with uncertainty, plant-specific organic matter contributions to streambed sediments via a Bayesian mixing model approach