The extraordinarily bright optical afterglow of GRB 991208 and its host galaxy

Observations of the extraordinarily bright optical afterglow (OA) of GRB 991208 started 2.1 d after the event. The flux decay constant of the OA in the R-band is -2.30 +/- 0.07 up to 5 d, which is very likely due to the jet effect, and after that it is followed by a much steeper decay with constant -3.2 +/- 0.2, the fastest one ever seen in a GRB OA. A negative detection in several all-sky films taken simultaneously to the event implies either a previous additional break prior to 2 d after the occurrence of the GRB (as expected from the jet effect). The existence of a second break might indicate a steepening in the electron spectrum or the superposition of two events. Once the afterglow emission vanished, contribution of a bright underlying SN is found, but the light curve is not sufficiently well sampled to rule out a dust echo explanation. Our determination of z = 0.706 indicates that GRB 991208 is at 3.7 Gpc, implying an isotropic energy release of 1.15 x 10E53 erg which may be relaxed by beaming by a factor > 100. Precise astrometry indicates that the GRB coincides within 0.2" with the host galaxy, thus given support to a massive star origin. The absolute magnitude is M_B = -18.2, well below the knee of the galaxy luminosity function and we derive a star-forming rate of 11.5 +/- 7.1 Mo/yr. The quasi-simultaneous broad-band photometric spectral energy distribution of the afterglow is determined 3.5 day after the burst (Dec 12.0) implying a cooling frequency below the optical band, i.e. supporting a jet model with p = -2.30 as the index of the power-law electron distribution.Comment: Accepted for publication in Astronomy and Astrophysics, 9 pages, 6 figures (Fig. 3 and Fig. 4 have been updated

CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential

In mice, the ability of naive T (TN) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8+ TN cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3+ TN cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide-HLA class I Ags.Moreover, CXCR3+ TN cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3+ TN cells were transcriptionally equivalent to murine CXCR3+ TN cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8+ T cells

Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs). To address this issue, we used a high-throughput approach to profile the αβ TCR repertoires of human naive and effector/memory CD4+ T-cell subsets, irrespective of antigen specificity. Highly conserved physicochemical and recombinatorial features were encoded on a subset-specific basis in the effector/memory compartment. Clonal tracking further identified forbidden and permitted transition pathways, mapping effector/memory subsets related by interconversion or ontogeny. Public sequences were largely confined to particular effector/memory subsets, including regulatory T cells (Tregs), which also displayed hardwired repertoire features in the naive compartment. Accordingly, these cumulative repertoire portraits establish a link between clonotype fate decisions in the complex world of CD4+ T cells and the intrinsic properties of somatically rearranged TCRs

Psilotum nudum (L.) Pal.-Beauv.

Honduras, El Paraiso, Alrededores de Quebrada Honda; por la carretera entre Manzaragua y San Lucas, más o menos 6 km. al norte de San Lucas. LAT (13°49'12' N); LONG (86°58'33' W); ALT (1100)

NOAA Data Catalog dsi 3260

NCDC Data documentation for DSI - 3260 15 Minute Precipitation Data, created April 26, 200

NOAA 15 Minute Precipitation Data: ISO-19139 Metadata

This metadata, harvested from NCEI ISO WAF refers to the original dsi-3260 from NOAA. Please note that not all information displayed in this file reflects the current status of the data; however a good majority of it may be beneficial for understanding the content available here

NOAA 15 MIN Precipitation Data

U.S. 15 Minute Precipitation Data is digital data set DSI-3260, archived at the National Centers for Environmental Information (NCEI). [Formerly NCDC] This is precipitation data. The primary source of data for this file is approximately 2,000 mostly U.S. weather stations operated or managed by the U.S. National Weather Service. Stations are primary, secondary, or cooperative observer sites that have the capability to measure precipitation at 15 minute intervals. This dataset contains 15-minute precipitation data (reported 4 times per hour, if precip occurs) for U.S. stations along with selected non-U.S. stations in U.S. territories and associated nations. It includes major city locations and many small town locations. Daily total precipitation is also included as part of the data record. NCEI has in archive data from most states as far back as 1970 or 1971, and continuing to the present day. The major parameter is precipitation amounts at 15 minute intervals, when precipitation actually occurs

NOAA Cooperative Station Information and Map File

This information corresponds to the geographic location of the cooperative stations. The two digit number in each of the data set files represents a state code. See the wiki to read more about these files