Una aproximación a los procesos de radicalización y extremismo violento (PREDEIN)

El ciclo PREDEIN (Prevención, Detección e Intervención) en los procesos de radicalización y extremismo violento se celebró entre octubre de 2019 y 2020. Fue uno de los proyectos seleccionados en la cuarta convocatoria del Palau Macaya "La Caixa", dedicados a la reflexión y diálogo de propuestas relacionadas con la divulgación, la innovación social y el debate sobre los retos de nuestras sociedades. El proyecto PREDEIN, pretende ser un riguroso espacio de intercambio, trabajo y reflexión entre profesionales, académicos, gestores de políticas públicas y sociedad civil en los ámbitos de la prevención, detección e intervención de los procesos que conducen a la radicalización y extremismo violento

Jornada de Colaboración Científica en Seguridad y Defensa

Datos técnicos: 340 minutos, color, español. Ficha técnica: Gabinete de Presidencia CSIC y Departamento de Comunicación. Emitido en directo el 31 mayo 2023El Consejo Superior de Investigaciones Científicas (CSIC) organiza una JORNADA DE COLABORACIÓN CIENTÍFICA EN SEGURIDAD Y DEFENSA el próximo día 31 de mayo. En este evento se buscará potenciar las colaboraciones del CSIC en las áreas de seguridad y defensa con socios y colaboradores externos públicos y privados. La Jornada se dividirá en cuatro cápsulas en las que investigadores presentarán la investigación que se hace en el Consejo en seguridad digital y globalizada; sensores, vigilancia y teledetección para la defensa; riesgos biológicos; y las oportunidades de financiación en proyectos colaborativos competitivos. Finalizará con un coloquio en el que diversos actores debatirán sobre el avance científico en defensa y seguridad y su impacto social.Peer reviewe

Vers una identitat col·lectiva pluricultural (IDCOL)

Aquest document és fruit d'una recerca promoguda l'any 2019 per l'Escola d'Administració Pública de Catalunya en el marc del programa EAPC motor de recerca. Forma part del projecte pilot dut a terme amb la Secretaria d'Igualtat, Migracions i Ciutadania de la Generalitat de Catalunya. Es presenta tal com va ser lliurat pels autors en la seva versió definitiv

Additional file 1 of Napping and cognitive decline: a systematic review and meta-analysis of observational studies

Additional file 1: Supplementary Table 1. PRISMA checklist. Supplementary Table 2. Search strategy for Medline. Supplementary Figure 1. Preferred Reporting Items for Systematic Reviews flowchart. Supplementary Table 3. Characteristics of the Cross-Sectional Studies Included in the Systematic Review and Meta-Analysis on the Association Between Napping and Cognition Parameters. Supplementary Table 4. Characteristics of the Longitudinal Studies Included in the Systematic Review and Meta-Analysis on the Association Between Napping and Cognition Parameters. Supplementary Table 5. Covariates used to adjust the analyses reported by the included studies. Supplementary Table 6. Risk of bias of cross-sectional and longitudinal included studies. Supplementary Table 7. Inconsistence and heterogeneity estimations for DerSimoniand and Lair and Hartung-Knapp-Sidik-Jonkman random effects methods. Supplementary Table 8. Meta-regression of napping and cognition domains by percentage of females and mean age of included studies. Supplementary Table 9. Meta-regression of napping and cognition domains by percentage of no nappers, percentage of people included in the less nighttime sleep duration category and mean night sleep time (hours) included studies. Supplementary Table 10. Sensitivity analyses by removing studies one by one for cross-sectional analysis. Supplementary Table 11. Sensitivity analyses by removing studies one by one for longitudinal analysis. Supplementary Table 12. Meta-bias for the association between IMT and cognitive function domains

Novel Blood Biomarkers for Response Prediction and Monitoring of Stereotactic Ablative Radiotherapy and Immunotherapy in Metastatic Oligoprogressive Lung Cancer

Up to 80% of patients under immune checkpoint inhibitors (ICI) face resistance. In this context, stereotactic ablative radiotherapy (SABR) can induce an immune or abscopal response. However, its molecular determinants remain unknown. We present early results of a translational study assessing biomarkers of response to combined ICI and SABR (I-SABR) in liquid biopsy from oligoprogressive patients in a prospective observational multicenter study. Cohort A includes metastatic patients in oligoprogression to ICI maintaining the same ICI due to clinical benefit and who receive concomitant SABR. B is a comparative group of oligometastatic patients receiving only SABR. Blood samples are extracted at baseline (T1), after the first (T2) and last (T3) fraction, two months post-SABR (T4) and at further progression (TP). Response is evaluated by iRECIST and defined by the objective response rate (ORR)—complete and partial responses. We assess peripheral blood mononuclear cells (PBMCs), circulating cell-free DNA (cfDNA) and small RNA from extracellular vesicles. Twenty-seven patients could be analyzed (cohort A: n = 19; B: n = 8). Most were males with non-small cell lung cancer and one progressing lesion. With a median follow-up of 6 months, the last ORR was 63% (26% complete and 37% partial response). A decrease in cfDNA from T2 to T3 correlated with a good response. At T2, CD8+PD1+ and CD8+PDL1+ cells were increased in non-responders and responders, respectively. At T2, 27 microRNAs were differentially expressed. These are potential biomarkers of response to I-SABR in oligoprogressive disease

A randomized trial of planned cesarean or vaginal delivery for twin pregnancy

Background: Twin birth is associated with a higher risk of adverse perinatal outcomes than singleton birth. It is unclear whether planned cesarean section results in a lower risk of adverse outcomes than planned vaginal delivery in twin pregnancy.\ud \ud Methods: We randomly assigned women between 32 weeks 0 days and 38 weeks 6 days of gestation with twin pregnancy and with the first twin in the cephalic presentation to planned cesarean section or planned vaginal delivery with cesarean only if indicated. Elective delivery was planned between 37 weeks 5 days and 38 weeks 6 days of gestation. The primary outcome was a composite of fetal or neonatal death or serious neonatal morbidity, with the fetus or infant as the unit of analysis for the statistical comparison.\ud \ud Results: A total of 1398 women (2795 fetuses) were randomly assigned to planned cesarean delivery and 1406 women (2812 fetuses) to planned vaginal delivery. The rate of cesarean delivery was 90.7% in the planned-cesarean-delivery group and 43.8% in the planned-vaginal-delivery group. Women in the planned-cesarean-delivery group delivered earlier than did those in the planned-vaginal-delivery group (mean number of days from randomization to delivery, 12.4 vs. 13.3; P = 0.04). There was no significant difference in the composite primary outcome between the planned-cesarean-delivery group and the planned-vaginal-delivery group (2.2% and 1.9%, respectively; odds ratio with planned cesarean delivery, 1.16; 95% confidence interval, 0.77 to 1.74; P = 0.49).\ud \ud Conclusion: In twin pregnancy between 32 weeks 0 days and 38 weeks 6 days of gestation, with the first twin in the cephalic presentation, planned cesarean delivery did not significantly decrease or increase the risk of fetal or neonatal death or serious neonatal morbidity, as compared with planned vaginal delivery