Bodily awareness in depersonalization-derealization disorder

Depersonalization-derealization disorder (DDD), a dissociative disorder encompassing disconnections from the self and from reality, remains a widely unknown and underdiagnosed condition. The broad aim of this thesis is to generate a better understanding of DDD from a body-based perspective and to present DDD as a suitable candidate for Dance Movement Therapy (DMT). In the current literature, there is a clear lack of work exploring the potential benefits of body-based therapies for DDD. I first explore DMT and the often-neglected neurocognitive concepts that may be involved including embodied cognition and interoception, with Chapter 2 presenting an in-depth review of controlled trials of DMT for clinical mental health conditions. Chapters 3 and 4 are focused on better characterizing and understanding DDD. Chapter 3 presents a latent profile analysis of psychometric measures of depersonalizationderealization, anxiety, and dissociation to determine whether symptom heterogeneity in DDD is attributable to the presence of latent subgroups. Chapter 4 presents a study examining the role of verbal suggestibility in DDD and its relationship to depersonalization-derealization symptoms, mindfulness, anxiety, and visual imagery. Both of these chapters have implications for the aetiology, mechanisms, treatment, and classification of DDD. Chapters 5 and 6 explore DMT for DDD, with Chapter 5 presenting an online intervention study and Chapter 6 presenting an in-person intervention study. Two controlled dance tasks to differentially engage with the body as a means of symptom reduction in DDD were developed: one promoting explicit body awareness and the other implicitly boosting the salience of bodily signals. Dance is presented as a bespoke and efficacious tool to reduce symptoms in DDD whilst improving a sense of body awareness. This research highlights the need for a better understanding of bodily processes in DDD and provides compelling evidence for the continued development of body-based interventions targeting both interoception and mindfulness in this population and in dissociation, more broadly

Surgical Management of Benign Adnexal Masses in the Pediatric/Adolescent Population: An 11-Year Review

Study Objective The purpose of this study was to compare ovarian conservation rates and surgical approach in benign adnexal surgeries performed by surgeons vs gynecologists at a tertiary care institution. Design A retrospective cohort review. Setting Children's and adult tertiary care university-based hospital. Participants Patients 21 years of age and younger who underwent surgery for an adnexal mass from January 2003 through December 2013. Interventions Patient age, demographic characteristics, menarchal status, clinical symptoms, radiologic imaging, timing of surgery, surgeon specialty, mode of surgery, rate of ovarian conservation, and pathology were recorded. Patients were excluded if they had a uterine anomaly or pathology-proven malignancy. Main Outcome Measures The primary outcome was the rate of ovarian conservation relative to surgical specialty; secondary outcome was surgical approach relative to surgical specialty. Results Of 310 potential cases, 194 met inclusion criteria. Gynecologists were more likely than surgeons to conserve the ovary (80% vs 63%; odds ratio, 2.28; 95% confidence interval, 1.16-4.48). After adjusting for age, body mass index, mass size, and urgency of surgery, the difference was attenuated (adjusted odds ratio, 1.84; 95% confidence interval, 0.88-3.84). Surgeons and gynecologists performed minimally invasive surgery at similar rates (62% vs 50%; P = .11). A patient was more likely to receive surgery by a gynecologist if she was older (P < .001) and postmenarchal (P = .005). Conclusion Results of our study suggest that gynecologists are more likely to perform ovarian-conserving surgery. However, our sample size precluded precise estimates in our multivariable model. Educational efforts among all pediatric and gynecologic surgeons should emphasize ovarian conservation and fertility preservation whenever possible

The Formation and Evolution of Virgo Cluster Galaxies - II. Stellar Populations

We use a combination of deep optical and near-infrared light profiles for a morphologically diverse sample of Virgo cluster galaxies to study the radially-resolved stellar populations of cluster galaxies over a wide range of galaxy structure. We find that, in the median, the age gradients of Virgo galaxies are either flat (lenticulars and Sa-Sb spirals) or positive (ellipticals, Sbc+Sc spirals, gas-rich dwarfs, and irregulars), while all galaxy types have a negative median metallicity gradient. Comparison of the galaxy stellar population diagnostics (age, metallicity, and gradients thereof) against structural and environmental parameters also reveals that the ages of gas-rich systems depend mainly on their atomic gas deficiencies. Conversely, the metallicities of Virgo gas-poor galaxies depend on their concentrations, luminosities, and surface brightnesses. The stellar population gradients of all Virgo galaxies exhibit no dependence on either their structure or environment. We interpret these stellar population data for Virgo galaxies in the context of popular formation and evolution scenarios, and suggest that gas-poor giants grew hierarchically (through dissipative starbursts), gas-poor dwarfs have descended from at least two different production channels (e.g., environmental transformation and merging), while spirals formed inside-out, but with star formation in the outskirts of a significant fraction of the population having been quenched due to ram pressure stripping. (Abridged)Comment: 54 pages, 16 figures, 3 tables, re-submitted to MNRAS (edited to reflect the referee's suggestions

In Vivo Characterization of Glutamine Metabolism Identifies Therapeutic Targets in Clear Cell Renal Cell Carcinoma

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL-mutant clear cell RCC (ccRCC) retained metabolic features of human ccRCC and engaged in oxidative and reductive glutamine metabolism. Genetic silencing of isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 impaired reductive labeling of tricarboxylic acid (TCA) cycle intermediates in vivo and suppressed growth of tumors generated from tumorgraft-derived cells. Glutaminase inhibition reduced the contribution of glutamine to the TCA cycle and resulted in modest suppression of tumorgraft growth. Infusions with [amide-15N]glutamine revealed persistent amidotransferase activity during glutaminase inhibition, and blocking these activities with the amidotransferase inhibitor JHU-083 also reduced tumor growth in both immunocompromised and immunocompetent mice. We conclude that ccRCC tumorgrafts catabolize glutamine via multiple pathways, perhaps explaining why it has been challenging to achieve therapeutic responses in patients by inhibiting glutaminase

Iconic dishes, culture and identity: the Christmas pudding and its hundred years’ journey in the USA, Australia, New Zealand and India

Asserting that recipes are textual evidences reflecting the society that produced them, this article explores the evolution of the recipes of the iconic Christmas pudding in the United States, Australia, New Zealand and India between the mid-nineteenth and the mid-twentieth centuries. Combining a micro-analysis of the recipes and the cookbook that provided them with contemporary testimonies, the article observes the dynamics revealed by the preparation and consumption of the pudding in these different societies. The findings demonstrate the relevance of national iconic dishes to the study of notions of home, migration and colonization, as well as the development of a new society and identity. They reveal how the preservation, transformation and even rejection of a traditional dish can be representative of the complex and sometimes conflicting relationships between colonists, migrants or new citizens and the places they live in

Racial and ethnic differences in epithelial ovarian cancer risk: an analysis from the Ovarian Cancer Association Consortium

Limited estimates exist on risk factors for epithelial ovarian cancer (EOC) in Asian, Hispanic, and Native Hawaiian/Pacific Islander women. Participants in this study included 1734 Asian (n&nbsp;=&nbsp;785 case and 949 control participants), 266 Native Hawaiian/Pacific Islander (n&nbsp;=&nbsp;99 case and 167 control participants), 1149 Hispanic (n&nbsp;=&nbsp;505 case and 644 control participants), and 24 189 White (n&nbsp;=&nbsp;9981 case and 14 208 control participants) from 11 studies in the Ovarian Cancer Association Consortium. Logistic regression models estimated odds ratios (ORs) and 95% CIs for risk associations by race and ethnicity. Heterogeneity in EOC risk associations by race and ethnicity (P&nbsp;≤&nbsp;.02) was observed for oral contraceptive (OC) use, parity, tubal ligation, and smoking. We observed inverse associations with EOC risk for OC use and parity across all groups; associations were strongest in Native Hawaiian/Pacific Islander and Asian women. The inverse association for tubal ligation with risk was most pronounced for Native Hawaiian/Pacific Islander participants (odds ratio (OR)&nbsp;=&nbsp;0.25; 95% CI, 0.13-0.48) compared with Asian and White participants (OR&nbsp;=&nbsp;0.68 [95% CI, 0.51-0.90] and OR&nbsp;=&nbsp;0.78 [95% CI, 0.73-0.85], respectively). Differences in EOC risk factor associations were observed across racial and ethnic groups, which could be due, in part, to varying prevalence of EOC histotypes. Inclusion of greater diversity in future studies is essential to inform prevention strategies. This article is part of a Special Collection on Gynecological Cancers

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health disparities. We present genome-wide associations for 2068 traits from 635,969 participants in the Department of Veterans Affairs Million Veteran Program, a longitudinal study of diverse United States Veterans. Systematic analysis revealed 13,672 genomic risk loci; 1608 were only significant after including non-European populations. Fine-mapping identified causal variants at 6318 signals across 613 traits. One-third (n = 2069) were identified in participants from non-European populations. This reveals a broadly similar genetic architecture across populations, highlights genetic insights gained from underrepresented groups, and presents an extensive atlas of genetic associations

Exploring the ingredients required to successfully model the placement, generation, and evolution of ice streams in the British-Irish Ice Sheet

Ice stream evolution is a major uncertainty in projections of the future of the Greenland and Antarctic Ice sheets. Accurate simulation of ice stream evolution requires an understanding of a number of “ingredients” that control the location and behaviour of ice stream flow. Here, we test the influence of geothermal heat flux, grid resolution, and bed hydrology on simulated ice streaming. The palaeo-record provides snapshots of ice stream evolution, with a particularly well constrained ice sheet being the British-Irish Ice Sheet (BIIS). We implement a new basal sliding scheme coupled with thermo-mechanics into the BISICLES ice sheet model, to simulate the evolution of the BIIS ice streams. We find that the simulated location and spacing of ice streams matches well with the empirical reconstructions of ice stream flow in terms of position and direction when simple bed hydrology is included. We show that the new basal sliding scheme allows the accurate simulation for the majority of BIIS ice streams. The extensive empirical record of the BIIS has allowed the testing of model inputs, and has helped demonstrate the skill of the ice sheet model in simulating the evolution of the location, spacing, and migration of ice streams through millennia. Simulated ice streams also prompt new empirical mapping of features indicative of streaming in the North Channel region. Ice sheet model development has allowed accurate simulation of the palaeo record, and allows for improved modelling of future ice stream behaviour

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements