393 research outputs found
Calibration of quasi-static aberrations in exoplanet direct-imaging instruments with a Zernike phase-mask sensor. II. Concept validation with ZELDA on VLT/SPHERE
Warm or massive gas giant planets, brown dwarfs, and debris disks around
nearby stars are now routinely observed by dedicated high-contrast imaging
instruments on large, ground-based observatories. These facilities include
extreme adaptive optics (ExAO) and state-of-the-art coronagraphy to achieve
unprecedented sensitivities for exoplanet detection and spectral
characterization. However, differential aberrations between the ExAO sensing
path and the science path represent a critical limitation for the detection of
giant planets with a contrast lower than a few at very small
separations (<0.3\as) from their host star. In our previous work, we proposed a
wavefront sensor based on Zernike phase contrast methods to circumvent this
issue and measure these quasi-static aberrations at a nanometric level. We
present the design, manufacturing and testing of ZELDA, a prototype that was
installed on VLT/SPHERE during its reintegration in Chile. Using the internal
light source of the instrument, we performed measurements in the presence of
Zernike or Fourier modes introduced with the deformable mirror. Our
experimental and simulation results are consistent, confirming the ability of
our sensor to measure small aberrations (<50 nm rms) with nanometric accuracy.
We then corrected the long-lived non-common path aberrations in SPHERE based on
ZELDA measurements. We estimated a contrast gain of 10 in the coronagraphic
image at 0.2\as, reaching the raw contrast limit set by the coronagraph in the
instrument. The simplicity of the design and its phase reconstruction algorithm
makes ZELDA an excellent candidate for the on-line measurements of quasi-static
aberrations during the observations. The implementation of a ZELDA-based
sensing path on the current and future facilities (ELTs, future space missions)
could ease the observation of the cold gaseous or massive rocky planets around
nearby stars.Comment: 13 pages, 12 figures, A&A accepted on June 3rd, 2016. v2 after
language editin
A patient with an uncommon complication from insertion of a central venous catheter: A case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
The Cerenkov effect revisited: from swimming ducks to zero modes in gravitational analogs
We present an interdisciplinary review of the generalized Cerenkov emission
of radiation from uniformly moving sources in the different contexts of
classical electromagnetism, superfluid hydrodynamics, and classical
hydrodynamics. The details of each specific physical systems enter our theory
via the dispersion law of the excitations. A geometrical recipe to obtain the
emission patterns in both real and wavevector space from the geometrical shape
of the dispersion law is discussed and applied to a number of cases of current
experimental interest. Some consequences of these emission processes onto the
stability of condensed-matter analogs of gravitational systems are finally
illustrated.Comment: Lecture Notes at the IX SIGRAV School on "Analogue Gravity" in Como,
Italy from May 16th-21th, 201
Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking
Rationale
GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine. We have shown previously that a deletion of the α2-subunit results in an absence of sensitisation to cocaine.
Objective
We investigated the reinforcing properties of cocaine in GABAA α2-subunit knockout (KO) mice using an intravenous self-administration procedure.
Methods
α2-subunit wildtype (WT), heterozygous (HT) and KO mice were trained to lever press for a 30 % condensed milk solution. After implantation with a jugular catheter, mice were trained to lever press for cocaine (0.5 mg/kg/infusion) during ten daily sessions. Responding was extinguished and the mice tested for cue- and cocaine-primed reinstatement. Separate groups of mice were trained to respond for decreasing doses of cocaine (0.25, 0.125, 0.06 and 0.03 mg/kg).
Results
No differences were found in acquisition of lever pressing for milk. All genotypes acquired self-administration of cocaine and did not differ in rates of self-administration, dose dependency or reinstatement. However, whilst WT and HT mice showed a dose-dependent increase in lever pressing during the cue presentation, KO mice did not.
Conclusions
Despite a reported absence of sensitisation, motivation to obtain cocaine remains unchanged in KO and HT mice. Reinstatement of cocaine seeking by cocaine and cocaine-paired cues is also unaffected. We postulate that whilst not directly involved in reward perception, the α2-subunit may be involved in modulating the “energising” aspect of cocaine’s effects on reward-seeking
Pneumatic wound compression after hip fracture surgery did not reduce postoperative blood transfusion: A randomized controlled trial involving 292 fractures
Background and purpose Patients with fracture of the proximal femur often undergo blood transfusion. A pneumatic compression bandage has been shown to reduce transfusion after primary hip arthroplasty for osteoarthritis. In this randomized trial, we evaluated the efficacy of this bandage following surgery for hip fracture
Bacteremic complications of intravascular catheter tip colonization with Gram-negative micro-organisms in patients without preceding bacteremia
Although Gram-negative micro-organisms are frequently associated with catheter-related bloodstream infections, the prognostic value and clinical implication of a positive catheter tip culture with Gram-negative micro-organisms without preceding bacteremia remains unclear. We determined the outcomes of patients with intravascular catheters colonized with these micro-organisms, without preceding positive blood cultures, and identified risk factors for the development of subsequent Gram-negative bacteremia. All patients with positive intravascular catheter tip cultures with Gram-negative micro-organisms at the University Medical Center, Utrecht, The Netherlands, between 2005 and 2009, were retrospectively studied. Patients with Gram-negative bacteremia within 48 h before catheter removal were excluded. The main outcome measure was bacteremia with Gram-negative micro-organisms. Other endpoints were length of the hospital stay, in-hospital mortality, secondary complications of Gram-negative bacteremia, and duration of intensive care admission. A total of 280 catheters from 248 patients were colonized with Gram-negative micro-organisms. Sixty-seven cases were excluded because of preceding positive blood cultures, leaving 213 catheter tips from 181 patients for analysis. In 40 (19%) cases, subsequent Gram-negative bacteremia developed. In multivariate analysis, arterial catheters were independently associated with subsequent Gram-negative bacteremia (odds ratio [OR] = 5.00, 95% confidence interval [CI]: 1.20–20.92), as was selective decontamination of the digestive tract (SDD) (OR = 2.47, 95% CI: 1.07–5.69). Gram-negative bacteremia in patients who received SDD was predominantly caused by cefotaxime (part of the SDD)-resistant organisms. Mortality was significantly higher in the group with subsequent Gram-negative bacteremia (35% versus 20%, OR = 2.12, 95% CI: 1.00–4.49). Patients with a catheter tip colonized with Gram-negative micro-organisms had a high chance of subsequent Gram-negative bacteremia from any cause. This may be clinically relevant, as starting antibiotic treatment pre-emptively in high-risk patients with Gram-negative micro-organisms cultured from arterial intravenous catheters may be beneficial
SUBARU prime focus spectrograph: integration, testing and performance for the first spectrograph
The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and
Redshifts (SuMIRe) project for Subaru telescope consists in four identical
spectrographs fed by 600 fibers each. Each spectrograph is composed by an
optical entrance unit that creates a collimated beam and distributes the light
to three channels, two visibles and one near infrared. This paper presents the
on-going effort for the tests & integration process for the first spectrograph
channel: we have developed a detailed Assembly Integration and Test (AIT) plan,
as well as the methods, detailed processes and I&T tools. We describe the tools
we designed to assemble the parts and to test the performance of the
spectrograph. We also report on the thermal acceptance tests we performed on
the first visible camera unit. We also report on and discuss the technical
difficulties that did appear during this integration phase. Finally, we detail
the important logistic process that is require to transport the components from
other country to Marseille
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Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters
Autism Spectrum Disorders (ASD) are neurodevelopmental disorders whose diagnosis relies on deficient social interaction and communication together with repetitive behaviours. Multiple studies have highlighted the potential of oxytocin (OT) to ameliorate behavioural abnormalities in animal models and subjects with ASD. Clinical trials, however, yielded disappointing results. Our study aimed at assessing the behavioural effects of different regimens of OT administration in the Oprm1 null mouse model of ASD. We assessed the effects of intranasal OT injected once at different doses (0.15, 0.3, and 0.6 IU) and time points (5, 15, and 30 min) following administration, or chronically, on ASD-related behaviours (social interaction and preference, stereotypies, anxiety, nociception) in Oprm1+/+ and Oprm1-/- mice. We then tested whether pairing intranasal OT injection with social experience would influence its outcome on ASD-like symptoms, and measured gene expression in the reward/social circuit. Acute intranasal OT at 0.3 IU improved social behaviour in Oprm1-/- mice 5 min after administration, with limited effects on non-social behaviours. Chronic (8–17 days) OT maintained rescuing effects in Oprm1 null mice but was deleterious in wild-type mice. Finally, improvements in the social behaviour of Oprm1-/- mice were greater and longer lasting when OT was administered in a social context. Under these conditions, the expression of OT and vasopressin receptor genes, as well as marker genes of striatal projection neurons, was suppressed. We detected no sex difference in OT effects. Our results highlight the importance of considering dosage and social context when evaluating the effects of OT treatment in ASD
Pseudoachondroplasia and Multiple Epiphyseal Dysplasia: A 7-Year Comprehensive Analysis of the Known Disease Genes Identify Novel and Recurrent Mutations and Provides an Accurate Assessment of Their Relative Contribution
Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are relatively common skeletal dysplasias resulting in short-limbed dwarfism, joint pain, and stiffness. PSACH and the largest proportion of autosomal dominant MED (AD-MED) results from mutations in cartilage oligomeric matrix protein (COMP); however, AD-MED is genetically heterogenous and can also result from mutations in matrilin-3 (MATN3) and type IX collagen (COL9A1, COL9A2, and COL9A3). In contrast, autosomal recessive MED (rMED) appears to result exclusively from mutations in sulphate transporter solute carrier family 26 (SLC26A2). The diagnosis of PSACH and MED can be difficult for the nonexpert due to various complications and similarities with other related diseases and often mutation analysis is requested to either confirm or exclude the diagnosis. Since 2003, the European Skeletal Dysplasia Network (ESDN) has used an on-line review system to efficiently diagnose cases referred to the network prior to mutation analysis. In this study, we present the molecular findings in 130 patients referred to ESDN, which includes the identification of novel and recurrent mutations in over 100 patients. Furthermore, this study provides the first indication of the relative contribution of each gene and confirms that they account for the majority of PSACH and MED. Hum Mutat 33:144–157, 2012. © 2011 Wiley Periodicals, Inc
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