Hermite-Hadamard type inequalities for functions whose nthn^{th} order of derivatives are ss-convex in the second sense

In this paper, we establish some Hermite-Hadamard type inequalities forfunctions whose $n^{th}$ dirivatives are $s$-convex in the second sense.Several known results are derived . Applications to special means are alsogiven

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration

Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused by hematopoietic progenitors expressing MAPK activating mutations that differentiate into senescent myeloid cells that drive lesion formation. Some patients with LCH subsequently develop progressive and incurable neurodegeneration (LCH-ND). Here, we show that LCH-ND is caused by myeloid cells that are clonal with peripheral LCH cells. We discovered that circulating BRAF V600E $^{+}$ myeloid cells cause the breakdown of the blood-brain barrier (BBB), enhancing migration into the brain parenchyma where they differentiate into senescent, inflammatory CD11a $^{+}$ macrophages that accumulate in the brainstem and cerebellum. Blocking MAPK activity and senescence programs reduced parenchymal infiltration, neuroinflammation, neuronal damage and improved neurological outcome in preclinical LCH-ND. MAPK activation and senescence programs in circulating myeloid cells represent novel and targetable mechanisms of ND

Dietary Habits and Biochemical Parameters Evolution in Type 1 Diabetic Patients after Health Care Orientations

Abstract Type 1 diabetes is a chronic illness that requires a holistic approach in terms of care to prevent longterm complications. Nutritional management is an important component of modern diabetes treatment. In this study, healthful eating practices were advised to diabetic patients recruited at the establishment of Public Health and at the endocrinology department of Tlemcen University Hospital Center (West Algeria) and beneficial effects on glucose and lipid levels and on oxidative stress parameters were evaluated after 3-years of follow-up. At baseline, the results provide evidence that glucose, lipid metabolism and oxidant/antioxidant status are altered in type 1 diabetic patients. These metabolic abnormalities were associated to at risk dietary habits such as high intakes of simple carbohydrates, fat and cholesterol and low intakes of proteins, vitamin and fiber. Nutritional management improved dietary consumption and induced a decrease in metabolic abnormalities linked to diabetes after 3 years of follow-up

Fractional Simpson-like Inequalities with Parameter for Differential <i>s</i>-<i>tgs</i>-Convex Functions

In this paper, we first prove a new parameterized identity. Based on this identity we establish some parametrized Simpson-like type symmetric inequalities, for functions whose first derivatives are s-tgs-convex via Reimann–Liouville frational operators. Some special cases are discussed. Applications to numerical quadrature are provided

Conformational modeling of the system pollutant/three-dimensional poly (2-hydroxyethyl methacrylate) (PHEMA) in aqueous medium: a new approach

International audienceThe polluted water, mixture of chemicals and dyes, discharged by various textile and paper industries, is a serious problem for the environment, peculiarly the water. Dyes are stable to light, heat and oxidizing agents and are usually biologically non-degradable, which makes them complicated environmental pollutants. To examine the removal of dye from water, a three-dimensional poly (2-hydroxyethyl methacrylate) (PHEMA) and eosin Y were used, respectively, as a dye retention support and pollutant. The study of the interaction between dye and a hydrophilic polymer networks by the conformational modeling using computer software represents the goal of the present work. Both the swelling and ultraviolet–visible spectrophotometry studies show that the pollutant was well retained by the porous polymer network PHEMA. The conformational study of the system composed of polymer network/dye shows that the interaction of the oxygen (O) and bromine (Br) of eosin Y with the hydrogen (H) of the PHEMA depends on the polymer porosity that was varied by the cross-linking rate of the three-dimensional polymer networks. The results obtained by this work can be applied to improve the retention efficiency of such material for use in wastewater application

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused by hematopoietic progenitors expressing mitogen-activated protein kinase (MAPK)-activating mutations that differentiate into senescent myeloid cells that drive lesion formation. Some individuals with LCH subsequently develop progressive and incurable neurodegeneration (LCH-ND). Here, we showed that LCH-ND was caused by myeloid cells that were clonal with peripheral LCH cells. Circulating BRAFV600E$^{+}$ myeloid cells caused the breakdown of the blood-brain barrier (BBB), enhancing migration into the brain parenchyma where they differentiated into senescent, inflammatory CD11a$^{+}$ macrophages that accumulated in the brainstem and cerebellum. Blocking MAPK activity and senescence programs reduced peripheral inflammation, brain parenchymal infiltration, neuroinflammation, neuronal damage and improved neurological outcome in preclinical LCH-ND. MAPK activation and senescence programs in circulating myeloid cells represent targetable mechanisms of LCH-ND