AIDS and the Ghana legal system: absolute ignorance or denial syndrome?

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Prenatal chromosomal diversification of leukemia in monozygotic twins

Previous studies on concordant acute lymphoblastic leukemia (ALL) in identical twins have identified the leukemia as monoclonal with MLL or ETV6-RUNX1 gene fusion as early or initiating events in utero. In the latter case, postnatal latency is associated with secondary genetic events such as ETV6 deletion. We describe here a pair of infant twins with concordant acute monoblastic leukemia (AML). They are a unique pair in that their leukemia blasts display extensive intraclonal chromosomal diversity. Comparison of the leukemic cells between the two twins by karyotype and fluorescence in situ hybridization identifies a common or shared stem line and extensive subclonal diversity for which the twins\u27 leukemic populations are divergent. This case of leukemia illustrates in utero initiation with early imposition of chromosomal instability, the progressively divergent evolution of which can be mapped in the twins into pre- and postnatal periods

Attitudes Toward the Insanity Defense: Examination of the Factor Structure of Insanity Defense Attitude-Revised (IDA-R) Scale in Ghana

Decades of research have revealed the potential of individuals to be partial toward defendants pleading insanity at the time of offense. This study examines the internal structure of the Insanity Defense Attitude-Revised (IDA-R) scale as well as predictors of insanity defense attitude in a Ghanaian sample (N = 253). Using principal component analysis, we identified three distinct latent factors, two (i.e., strict liability, unprofessional behavior and safety concerns) of which corroborate the findings of previous studies, and a unique factor- expression of sympathy. Participants who were highly involved in religious activities were more likely to be sympathetic. Views regarding the causes and treatability of mental illness did not significantly predict insanity defense attitudes.</p