Searching for axion dark matter with MeerKAT Radio Telescope

Axions provide a natural and well-motivated dark matter candidate, with the capability to convert directly to photons in the presence of an electromagnetic field. A particularly compelling observational target is the conversion of dark matter axions into photons in the magnetospheres of highly magnetised neutron stars, which is expected to produce a narrow spectral peak centred at the frequency of the axion mass. We point the MeerKAT radio telescope towards the isolated neutron star J0806.4$-$4123 for $10$-hours of observation and obtain the radio spectra in the frequency range $769$-$1051$ MHz. By modelling the conversion process of infalling axion dark matter (DM), we then compare these spectra to theoretical expectations for a given choice of axion parameters. Whilst finding no signal above $5\sigma$ in the data, we provide a unique constraint on the Primakoff coupling of axion DM, $g_{{\rm a}\gamma\gamma}\lesssim 9.3 \times 10^{-12}\,{\rm GeV}^{-1}$ at the $95\%$ confidence level, in the mass range $3.18$-$4.35\,\mu$eV. This result serves the strongest constraint in the axion mass range $4.20$-$4.35\,\mu$eV.Comment: 6 pages, 3 figures, accepted by Physical Review

Control of zeolite microenvironment for propene synthesis from methanol

Optimising the balance between propene selectivity, propene/ethene ratio and catalytic stability and unravelling the explicit mechanism on formation of the first carbon–carbon bond are challenging goals of great importance in state-of-the-art methanol-to-olefin (MTO) research. We report a strategy to finely control the nature of active sites within the pores of commercial MFI-zeolites by incorporating tantalum(V) and aluminium(III) centres into the framework. The resultant TaAlS-1 zeolite exhibits simultaneously remarkable propene selectivity (51%), propene/ethene ratio (8.3) and catalytic stability (>50 h) at full methanol conversion. In situ synchrotron X-ray powder diffraction, X-ray absorption spectroscopy and inelastic neutron scattering coupled with DFT calculations reveal that the first carbon–carbon bond is formed between an activated methanol molecule and a trimethyloxonium intermediate. The unprecedented cooperativity between tantalum(V) and Brønsted acid sites creates an optimal microenvironment for efficient conversion of methanol and thus greatly promotes the application of zeolites in the sustainable manufacturing of light olefins.We thank EPSRC (EP/P011632/1), the Royal Society, National Natural Science Foundation of China (21733011, 21890761, 21673076), and the University of Manchester for funding. We thank EPSRC for funding and the EPSRC National Service for EPR Spectroscopy at Manchester. A.M.S. is supported by a Royal Society Newton International Fellowship. We are grateful to the STFC/ISIS Facility, Oak Ridge National Laboratory (ORNL) and Diamond Light Source (DLS) for access to the beamlines TOSCA/MAPS, VISION and I11/I20, respectively. We acknowledge Dr. L. Keenan for help at I20 beamline (SP23594-1). UK Catalysis Hub is kindly thanked for resources and support provided via our membership of the UK Catalysis Hub Consortium and funded by EPSRC grant: EP/R026939/1, EP/R026815/1, EP/R026645/1, EP/R027129/1 or EP/M013219/1 (biocatalysis). We acknowledge the support of The University of Manchester’s Dalton Cumbrian Facility (DCF), a partner in the National Nuclear User Facility, the EPSRC UK National Ion Beam Centre and the Henry Royce Institute. We recognise Dr. R. Edge and Dr. K. Warren for their assistance during the 60Co γ-irradiation processes. We thank Prof. A. Jentys from the Technical University of Munich for the measurement of the INS spectrum of iso-butene. We thank C. Webb, E. Enston and G. Smith for help with GC–MS; Dr. L. Hughes for help with SEM and EDX; M. Kibble for help at TOSCA/MAPS beamlines. Computing resources (time on the SCARF compute cluster for some of the CASTEP calculations) was provided by STFC’s e-Science facility. A portion of this research used resources at the Spallation Neutron Source, a DOE Office of Science User Facility operated by ORNL. The computing resources at ORNL were made available through the VirtuES and the ICE-MAN projects, funded by Laboratory Directed Research and Development programme and Compute and Data Environment for Science (CADES

Response of Precipitation in Tianshan to Global Climate Change Based on the Berkeley Earth and ERA5 Reanalysis Products

Global climate change has readjusted a global-scale precipitation distribution in magnitude and timing. In mountainous areas, meteorological stations and observation data are very limited, making it difficult to accurately understand the response of precipitation to global climate change. Based on ECMWF Reanalysis v5 precipitation products, Berkeley Earth global temperature, and typical atmospheric circulation indexes, we integrated a gradient descent-nonlinear regression downscaling model, cross wavelet transform, and wavelet correlation method to analyze the precipitation response in Tianshan to global climate change. This study provides a high-resolution (90 m × 90 m) precipitation dataset in Tianshan and confirms that global warming, the North Pacific Pattern (NP), the Western Hemisphere Warm Pool (WHWP), and the Atlantic Multidecadal Oscillation (AMO) are related to the humidification of Tianshan over the past 40 years. The precipitation in Tianshan and global temperature have a resonance period of 8–15 months, and the correlation coefficient is above 0.9. In Tianshan, spring precipitation is determined mainly by AMO, North Tropical Atlantic Sea Level Temperature, Pacific Interdecadal Oscillation (PDO), Tropical North Atlantic Index, WHWP, NP, summer by NP, North Atlantic Oscillation, and PDO, autumn by AMO, and winter by Arctic Oscillation. This research can serve the precipitation forecast of Tianshan and help in the understanding of the regional response to global climate change

Temperature Contributes More than Precipitation to Runoff in the High Mountains of Northwest China

In alpine areas in Northwest China, such as the Tianshan Mountains, the lack of climate data (because of scarce meteorological stations) makes it difficult to assess the impact of climate change on runoff. The main contribution of this study was to develop an integrated method to assess the impact of climate change on runoff in data-scarce high mountains. Based on reanalysis products, this study firstly downscaled climate data using machine learning algorithms, then developed a Batch Gradient Descent Linear Regression to calculate the contributions of temperature and precipitation to runoff. Applying this method to six mountainous basins originating from the Tianshan Mountains, we found that climate changes in high mountains are more significant than in lowlands. In high mountains, the runoff changes are mainly affected by temperature, whereas in lowlands, precipitation contributes more than temperature to runoff. The contributions of precipitation and temperature to runoff changes were 20% and 80%, respectively, in the Kumarik River. The insights gained in this study can guide other studies on climate and hydrology in high mountain basins

How to Sustainably Use Water Resources—A Case Study for Decision Support on the Water Utilization of Xinjiang, China

Global warming has led to a serious crisis on regional water resources. Establishing a decision support system (DSS) on the sustainable utilization of water resources for arid areas is an increasingly critical problem. Selecting Xinjiang as a case study, this paper developed a system dynamics (SD) model. Through the simulation operation of the model, we achieved the decision on sustainable utilization of water resources. The extensive economic development is the main factor restricting the sustainable utilization of water resources in Xinjiang. We propose to adjust the planting structure and implement water-saving irrigation in Xinjiang, especially the Tarim Basin and Turpan-Hami Basin. This research provides the sustainable utilization plan of water resources for Xinjiang and its sub-regions in the next 30 years. By 2050, we recommend that the reuse rate of urban domestic water consumption and industrial sewage should reach 75%; the rural domestic water quota should be 70 L/(person·day); water consumption per industrial output value of ten thousand Yuan should be 28 m3; the irrigation water quota should be 5000 m3/hectare in Xinjiang. This research can provide references for the decision on sustainable utilization of water resources in arid regions around the world

Green reaction-type nucleation seed accelerator prepared from coal fly ash ground in water environment

Fly ash is the main waste generated from coal production. The application of fly ash in building materials helps reduce pollution. In the present work, a novel reaction-type nucleation seed accelerator with D50 of 512 nm was prepared from coal fly ash using wet-grinding technology, denoted as WFA seed. The physical and chemical performances of WFA seed and its promotion effect on hydration, strength and microstructure of Portland cement (PC) were studied. With the addition of WFA seed, compressive strength was significantly increased by 50% and 16% at 12 h and 28 days. The hydration heat peak was also clearly increased by WFA seed. The hydration and strength promotion by WFA seed is attributed to the dual function of secondary reaction (which occurs as early as 12 h) and nucleation induction, which is different from the single function of nucleation site effect of some existing nano-materials. Furthermore, the main chain length and Al/Si ratio of C-S-H gel were increased, and the pore structure of cement was refined by the addition of WFA seed.Web of Science306art. no. 12484

Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis

Osteoarthritis (OA) etiology is multifactorial, and its prevalence is growing globally. The Gut microbiota shapes our immune system and impacts all aspects of health and disease. The idea of utilizing probiotics to treat different conditions prevails. Concerning musculoskeletal illness and health, current data lack the link to understand the interactions between the host and microbiome. We report that S. thermophilus, L. pentosus (as probiotics), and γ-aminobutyric acid (GABA) harbour against osteoarthritis in vivo and alleviate IL-1β induced changes in chondrocytes in vitro. We examined the increased GABA concentration in mice's serum and small intestine content followed by bacterial treatment. The treatment inhibited the catabolism of cartilage and rescued mice joints from degradation. Furthermore, the anabolic markers upregulated and decreased inflammatory markers in mice knee joints and chondrocytes. This study is the first to represent GABA's chondrogenic and chondroprotective effects on joints and human chondrocytes. This data provides a foundation for future studies to elucidate the role of GABA in regulating chondrocyte cell proliferation. These findings opened future horizons to understanding the gut-joint axis and OA treatment. Thus, probiotic/GABA therapy shields OA joints in mice and could at least serve as adjuvant therapy to treat osteoarthritis

Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis

Background: The mechanism by which chondrocyte senescence aggravate OA progression has not yet been well elucidated. The aim of this study was to investigate the chondrocyte senescence related gene biosignatures in OA, and to analyze on the underlying mechanisms of senescence in OA. Materials and methods: We intersected osteoarthritis dataset GSE82107 from GEO database and senescence dataset from CellAge database of human senescence-associated genes based on genetic manipulations experiments plus gene expression profilin, and screened out 4 overlapping genes. The hub genes were verified in vitro and in human OA cartilage tissues by qRT-PCR. We further confirmed the function of mitogen-activated protein kinase 12 (MAPK12) and Fos proto-oncogene (FOS) in OA in vitro and in vivo by qRT-PCR, western blotting, Edu staining, immunofluorescence, SA-β-gal staining, HE, IHC, von frey test, and hot plate. Results: 1458 downregulated and 218 upregulated DEGs were determined from GSE82107, and 279 human senescence-associated genes were downloaded from CellAge database. After intersection assay, we screened out 4 overlapping genes, of which FOS, CYR61 and TNFSF15 were upregulated, MAPK12 was downregulated. The expression of MAPK12 was obviously downregulated, whereas the expression profiles of FOS, CYR61 and TNFSF15 were remarkedly upregulated in H2O2- or IL-1β-stimulated C28/I2 cells, human OA cartilage tissues, and knee cartilage of aging mice. Furthermore, both MAPK12 over-expression and FOS knock-down can promote cell proliferation and cartilage anabolism, inhibit cell senescence and cartilage catabolism, relieve joint pain in H2O2- or IL-1β-stimulated C28/I2 cells and mouse primary chondrocytes, destabilization of the medial meniscus (DMM) mice. Conclusion: This study explored that MAPK12 and FOS are involved in the occurrence and development of OA through modulating chondrocyte senescence. They might be biomarkers of OA chondrocyte senescence, and provides some evidence as subsequent possible therapeutic targets for OA. The translational potential of this article: The translation potential of this article is that we revealed MAPK12 and FOS can effectively alleviate OA by regulating chondrocyte senescence, and thus provided potential therapeutic targets for prevention or treatment of OA in the future

Water Environmental Capacity Calculated Based on Point and Non-Point Source Pollution Emission Intensity under Water Quality Assurance Rates in a Tidal River Network Area

A mathematical model for simulating hydrodynamics and pollutants migration in a tidal river network was constructed, which takes the temporal and spatial distribution of rainfall runoff and non-point pollutants into consideration. Under the design hydrologic conditions of a typical hydrological year, the daily concentration change process for the control section is obtained. Aiming at the uncertainty of hydrology and water quality parameters such as flow direction, flow rate and concentration change in tidal river network area, a statistical analysis method is used to obtain the maximum allowable concentration of pollutants in the control section under the condition of the water quality standard assurance rate of. Then, a formula for calculating the pollutions emission intensity of point and non-point sources is derived. The method was applied to the pollution source control in a typical region like Taihu in China

Allocating Water Environmental Capacity to Meet Water Quality Control by Considering Both Point and Non-Point Source Pollution Using a Mathematical Model: Tidal River Network Case Study

Based on the principles of fairness and feasibility, a nonlinear optimization allocation method for pollutants was developed based on controlled section water quality standards, considering the synergetic influence of point and surface sources. The maximum allowable emission of pollutants from point and surface sources were taken as the objective function. The water quality attainment rate of controlled sections, the control requirements of pollution sources, and technical parameters of pollution control engineering were taken as constraints. A nonlinear optimization allocation model was established, and a genetic algorithm was used to solve the problem. As an example, the model was applied to a certain area in the Taihu Lake basin, southern Jiangsu province, China. The analysis results showed that the annual number of days for ammonia-nitrogen and total phosphorus meeting the standard were 334 and 332 days, respectively, under maximum allowable emissions for each pollutant, and the water quality compliance rates of the control section were 91.5% and 91%, respectively. The ammonia-nitrogen and total phosphorus concentrations in the controlled section achieved related water quality compliance rate targets of 90%. These all met the water quality compliance rate requirements of the control section. The results indicate that this method reflects the feasibility of optimizing the total allocation results systematically and intuitively, overcomes the insufficiency in the feasibility of the optimized allocation method, and provides effective and reliable technical support for control and management of the total pollutant amount based on water quality improvement