395 research outputs found
Economic Evaluation of Lipid-Lowering Therapy in the Secondary Prevention Setting in the Philippines
AbstractObjectiveTo determine the cost-effectiveness of lipid-lowering therapy in the secondary prevention of cardiovascular events in the Philippines.MethodsA cost-utility analysis was performed by using Markov modeling in the secondary prevention setting. The models incorporated efficacy of lipid-lowering therapy demonstrated in randomized controlled trials and mortality rates obtained from local life tables. Average and incremental cost-effectiveness ratios were obtained for simvastatin, atorvastatin, pravastatin, and gemfibrozil. The costs of the following were included: medications, laboratory examinations, consultation and related expenses, and production losses. The costs were expressed in current or nominal prices as of the first quarter of 2010 (Philippine peso). Utility was expressed in quality-adjusted life-years gained. Sensitivity analyses were performed by using variations in the cost centers, discount rates, starting age, and differences in utility weights for stroke.ResultsIn the analysis using the lower-priced generic counterparts, therapy using 40 mg simvastatin daily was the most cost-effective option compared with the other therapies, while pravastatin 40 mg daily was the most cost-effective alternative if the higher-priced innovator drugs were used. In all sensitivity analyses, gemfibrozil was strongly dominated by the statins.ConclusionsIn secondary prevention, simvastatin or pravastatin were the most cost-effective options compared with atorvastatin and gemfibrozil in the Philippines. Gemfibrozil was strongly dominated by the statins
Economic Burden of Community-Acquired Pneumonia among Adults in the Philippines: Its Equity and Policy Implications in the Case Rate Payments of the Philippine Health Insurance Corporation
AbstractObjectivesTo determine 1) the cost of hospitalization, the 1-week postdischarge cost, the total cost, and the economic burden of community-acquired pneumonia among patients aged 19 years or older in the Philippines and 2) the difference between the estimated costs and the Philippine Health Insurance Corporation (PhilHealth) pneumonia case rate payments.MethodsThe study involved two tertiary private hospitals in the Philippines. Using the societal perspective, both health care and non–health care costs were determined. A base-case analysis and sensitivity analyses were performed, and the economic burden of pneumonia was determined using PhilHealth claims.ResultsThe estimated cost of hospitalization for community-acquired pneumonia-moderate risk (CAP-MR) ranged from Philippine peso (PHP) 36,153 to 113,633 (US 34–207). The cost of hospitalization for community-acquired pneumonia-high risk (CAP-HR) ranged from PHP104,544 to 249,695 (US 2386–5739) using invasive and noninvasive ventilation, respectively. The postdischarge cost for CAP-HR ranged from PHP1716 to 10,529 (US 354) and PHP32,000 (US $754) for CAP-MR and CAP-HR, respectively. Based on the number of PhilHealth claims for 2012 and the estimated health care cost, the economic burden of pneumonia in 2012 was PHP8.48 billion for CAP-MR and PHP643.76 million for CAP-HR.ConclusionsThe estimated health care cost of hospitalization is markedly higher than the PhilHealth case rate payments. As per the study results, the economic burden of pneumonia is, thus, significantly higher than PhilHealth estimates
Patient-cost survey for tuberculosis in the context of patient-pathway modelling.
ETTING: Eight tuberculosis treatment sites in Cavite Province, the Philippines, including two sites specialising in management of multidrug-resistant tuberculosis (MDR-TB).OBJECTIVE: To evaluate costs incurred by TB patients and to determine the proportion of households that faced catastrophic costs, then to consider cost survey responses alongside results of detailed patient-pathway modelling.DESIGN: Clustered cross-sectional survey using a field testing version of the WHO TB patient-costing tool and protocol; face-to-face interviews with 194 patients conducted in May-August 2016. Costs included direct-medical, direct non-medical and indirect costs using the human capital approach. Patients were deemed to incur catastrophic expenditure if TB-related costs exceeded 20% of annual household income. Patient pathways were modelled following multiple health staff interviews.RESULTS: Estimated mean cost incurred by patients with drug-susceptible TB was US2356 for MDR-TB patients. Catastrophic costs were suffered by 28% of drug-susceptible and 80% of MDR-TB patients, with lost income being the largest contributor. Patient-pathway modelling suggested most patients had under-reported health visits.CONCLUSION: Survey results indicate that patient costs are large for all patients in Cavite, particularly for MDR-TB patients. Patient-pathway modelling suggests these costs are an underestimate due to poor recollection of health visits, suggesting that the WHO instrument and protocol could be improved to better capture the diagnostic journey
Photoswitchable architecture transformation of a DNA-hybrid assembly at the microscopic and macroscopic scale
Molecular recognition-driven self-assembly employing single-stranded DNA (ssDNA) as a template is a promising approach to access complex architectures from simple building blocks. Oligonucleotide-based nanotechnology and soft-materials benefit from the high information storage density, self-correction, and memory function of DNA. Here we control these beneficial properties with light in a photoresponsive biohybrid hydrogel, adding an extra level of function to the system. An ssDNA template was combined with a complementary photo-responsive unit to reversibly switch between various functional states of the supramolecular assembly using a combination of light and heat. We studied the structural response of the hydrogel at both the microscopic and macroscopic scale using a combination of UV-vis absorption and CD spectroscopy, as well as fluorescence, transmission electron, and atomic force microscopy. The hydrogels grown from these supramolecular self-assembly systems show remarkable shape-memory properties and imprinting shape-behavior while the macroscopic shape of the materials obtained can be further manipulated by irradiation
Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.
Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF6. Consistent with reported roles for ARF6 in maintaining the tubular recycling endosome, MICAL-L1-positive tubules were lost from sphingolipid-treated cells. We propose that ARF6 inactivation may occur downstream of PP2A activation since: (1) sphingolipids that fail to activate PP2A did not reduce ARF6-GTP levels; (2) a structurally unrelated PP2A activator disrupted tubular recycling endosome morphology and transporter localization; and (3) overexpression of a phosphomimetic mutant of the ARF6 GEF GRP1 prevented nutrient transporter loss. ARF6 inhibition alone was not toxic; however, the ARF6 inhibitors SecinH3 and NAV2729 dramatically enhanced the killing of cancer cells by SH-BC-893 without increasing toxicity to peripheral blood mononuclear cells, suggesting that ARF6 inactivation contributes to the anti-neoplastic actions of sphingolipids. Taken together, these studies provide mechanistic insight into how ceramide and sphingolipid-like molecules limit nutrient access and suppress tumor cell growth and survival
Chemical composition of juice and antihyperglycemic studies in seed of the prehispanic fruit tunillo (Stenocereus stellatus) collected in Oaxaca, Mexico
580-584Tunillo, or pitaya of august (Stenocereus stellatus) is a prehispanic fruit, endemic to the Mixteca region in Mexico and to which a lot of medicinal properties have been associated. However, there are few scientific studies regarding its characterization and use. For these reasons, in this study we carried out a chemical characterization of the juice of four-color variants as well as determine the antihyperglycemic capacity of seed. Physical and chemical characterization were carried out in juice of fruits of Stenocereus after a preselection based on pulp color. Total soluble solids, pH, titratable acidity, organic acid and betalains were quantified in juice and antihyperglycemic capacity was measured in seed. Physicochemical parameters in juice were similar in the 4 variants; regarding the content of pigments, the red variant showed the highest values as well as the highest organic acids. However, the white, orange, and red variants showed better antihyperglycemic capacity. Red tunillo is the best candidate for obtaining pigments and its higher organic acids content correlates with its lower acceptance by the local population. The seeds of the white, orange, and red colors showed promising anhyperglycemic capacity, which suggest that they should be considered for the development of antidiabetic treatments. These results contribute to the use of compex matrices considered waste products of the fruits. This would undoubtedly increase their commercial value
Chemical composition of juice and antihyperglycemic studies in seed of the prehispanic fruit tunillo (Stenocereus stellatus) collected in Oaxaca, Mexico
Tunillo, or pitaya of august (Stenocereus stellatus) is a prehispanic fruit, endemic to the Mixteca region in Mexico and to which a lot of medicinal properties have been associated. However, there are few scientific studies regarding its characterization and use. For these reasons, in this study we carried out a chemical characterization of the juice of four-color variants as well as determine the antihyperglycemic capacity of seed. Physical and chemical characterization were carried out in juice of fruits of Stenocereus after a preselection based on pulp color. Total soluble solids, pH, titratable acidity, organic acid and betalains were quantified in juice and antihyperglycemic capacity was measured in seed. Physicochemical parameters in juice were similar in the 4 variants; regarding the content of pigments, the red variant showed the highest values as well as the highest organic acids. However, the white, orange, and red variants showed better antihyperglycemic capacity. Red tunillo is the best candidate for obtaining pigments and its higher organic acids content correlates with its lower acceptance by the local population. The seeds of the white, orange, and red colors showed promising anhyperglycemic capacity, which suggest that they should be considered for the development of antidiabetic treatments. These results contribute to the use of compex matrices considered waste products of the fruits. This would undoubtedly increase their commercial value
Measurements of differential cross sections of Z/gamma*+jets+X events in proton anti-proton collisions at sqrt{s}=1.96 TeV
We present cross section measurements for Z/gamma*+jets+X production,
differential in the transverse momenta of the three leading jets. The data
sample was collected with the D0 detector at the Fermilab Tevatron proton
anti-proton collider at a center-of-mass energy of 1.96 TeV and corresponds to
an integrated luminosity of 1 fb-1. Leading and next-to-leading order
perturbative QCD predictions are compared with the measurements, and agreement
is found within the theoretical and experimental uncertainties. We also make
comparisons with the predictions of four event generators. Two
parton-shower-based generators show significant shape and normalization
differences with respect to the data. In contrast, two generators combining
tree-level matrix elements with a parton shower give a reasonable description
of the the shapes observed in data, but the predicted normalizations show
significant differences with respect to the data, reflecting large scale
uncertainties. For specific choices of scales, the normalizations for either
generator can be made to agree with the measurements.Comment: Published in PLB. 11 pages, 3 figure
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