284 research outputs found
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin E. K.
- Aamer A.
- Aaniana K.
- Ababneh A.
- Abaliksta T.
- Abantanga F.
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
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- Abbas M
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- Abd El Hameed OS
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6Â months was conducted. Follow-up lasted 30Â days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, pâ=â0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, pâ=â0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, pâ<â0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, pâ<â0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
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- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
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- Abdelazeam AR
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- Abdelhamed R
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- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
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- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
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- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
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- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
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- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
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- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
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- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
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- Bekhet AH
- Bekhet NM
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- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
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- Bodur S
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- Boijsen M
- Bokhari S
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- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda Luque G
- Borda-Luque G
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
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- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
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- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu MR
- Bratu R-M
- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt MT
- Cabala Chiong JA
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Cakaloglu HC
- Caliman C
- Callan R
- Camacho R
- Cameron B
- Camilleri GM
- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
- Canta Calua A
- Capito C
- Capleton P
- Carabott K
- Careta MC
- Carlucci M
- Carmela Lapitan M
- Carmona JM
- Carpio J
- Carrasco N
- Carreira J-A
- Carreiro De Freitas AV
- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
- Coccolini F
- Coccolini F
- Cocker DM
- Cocorullo G
- Cohen DM
- Cohen F
- Cole S
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- Coletti M
- Colombani J-F
- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
- Coompson CL
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Corro-Diaz Gonzalez S
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
- Craus-Miguel A
- Cross K
- Cruz DH
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- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
- D'aguzan N
- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish AKZ
- Das A
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- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
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- Dayie M
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- De Franciscis S
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
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- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
- Garcia Torres CP
- Garcia-Florez L
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi DG
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy AA
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim MA
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino FR
- Giavarini L
- Giglio MC
- Gilbert R
- Gilbert RW
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo RSR
- Giuliani S
- Giuliani S
- Giuriato TF
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey JC
- GlobalSurg Collaborative
- Glover TE
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh CC
- Goh CC
- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Diminishing benefits of urban living for children and adolescentsâ growth and development
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1â6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5â19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg mâ2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
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- Barker Daniel
- Barker Darren
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- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
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- Beall Keith
- Beard Lisa
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- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
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- Clark Graham
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- Clark Sue
- Clarke Adrian
- Clarke Betty
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- Clee Chris
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- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
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- Collings Simon
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- Collins John
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- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
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- Connolly Anthony
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- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
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- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
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- Cornell Christine
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- Cui Jinhui
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- Czubayko Martin
- D\u27Souza Lisa Marie
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- Dang Michelle
- Danganan Linda
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- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
- Davies Joy
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- Davies Robert
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- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
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- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
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- Delgado Oliver
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- Deloukas Panos
- Deng Yajun
- Dennis Janet
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- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
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- Dias Jennifer
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- Dibling Catherine
- Dickson Mark
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- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
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- Ding Li
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- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
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- Dong Hui
- Dong Kimberly
- Dong Wei
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- Dong Xiaojia
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- Du Feiyu
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- Dubchak Inna
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- Dunwell Erin
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- Dutta Ireena
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- Eckenberg Ralph
- Edgar Darren
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- Edwards Karen
- Egan Amy
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- Elkin Chris
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- Garcia Ricardo M, III
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- Gardyna Steph
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- Grandbois Edward
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- Gui Qi
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- Gunning Kate
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- Hamlett John
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- Hancock Julie
- Harbes Brandy A.
- Harding Adam
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- Harley Joanne
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- Hillier LaDeana
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- Holden Jane
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- Howden Philip
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- Howell Latoya Lynette
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- Hubbard Timothy
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- Jahn Niels
- Jaklevic Joseph
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- James Kent W.
- Jareborg Niclas
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- Jeffery Grant
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- Jekosch Kerstin
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- Jia Jia
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- Jones Steven
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- Kegg Lisa
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- Kelly Susan H.
- Kershaw Joanna
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- Kohlberg Sara
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- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
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- Krawczyk Marie-Claude
- Kremitzki Colin
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- Krogh Anders
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- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
- Kuharic Patrick
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- Lad Heena
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- Laing Michael
- Laird Gavin
- Lam Edward
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- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
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- Lao Victoria
- Lapidus Alla
- Larke Ben
- Lato Bernadette
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- Lehman Karl
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- Lei Meng
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- Lindblad-Toh Kerstin
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- Lindquist K.
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- Ludeman Thom
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- Nguyen Ngoc Bich
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- Nordsiek Gabriele
- Norris Sarah Louise
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- Nusbaum Chad
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- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
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- Zhang Jingjing
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- Zhang Jiuchun
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- Zhang Li
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- Zhang Meng
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- Zhang Wei
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- Zhang Xianglin
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- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Mortality of emergency abdominal surgery in high-, middle- and low-income countries
- Author
- A A Ahmed Ata
- A A Ibrahem
- A A Maghrabi
- A A Nasir
- A A Ne'ma Abdullah
- A Abd El Galeel
- A Abdel-Rahman Al-Aarag
- A AbdelFattah
- A Abdelgelil
- A Abdelkareem
- A Abdelmotaleb Ghazy
- A Aber
- A Abo El Magd
- A Abo Elazayem
- A Aboarab
- A Abouelnasr
- A Abouzahra
- A Adebanjo
- A Adekoya
- A Adel
- A Adel
- A Ademuyiwa
- A Adeniyi
- A Adesina
- A Adesuyi
- A Adeyeye
- A Afandy
- A Agarwal
- A Ahmed
- A Al-Mallah
- A Al-Shammari
- A Aldalaq
- A Ali
- A Ali
- A Alkammash
- A Allegri
- A Almallah
- A Almoflihi
- A Alrifaie
- A Altaf
- A Altamimi
- A Althwainy
- A Arenas
- A Ashton
- A Atef Omar
- A Austraite
- A B Zerihun
- A Badr
- A Badwy
- A Baird
- A Bamicha
- A Benevento
- A Bhangu
- A Bhargava
- A Birring
- A Boddy
- A Bondurri
- A Bonnard
- A C Manchego Bautista
- A C Manchego Bautista
- A C Roslani
- A C Snaith
- A Cacurri
- A Chambers
- A Chambers
- A Chapman
- A Chowdhury
- A Chun
- A Daltri Lazzarini Cury
- A Daqeeq
- A Das
- A Diab
- A Driscoll
- A Dubois
- A Dwydar
- A E Ajao
- A E K Musa
- A E Ward
- A Echevarria Rosas Moran
- A El Gendy
- A El Kholy
- A Elbatahgy
- A Elgebaly
- A Elkelany
- A Elkelany
- A Elkelany
- A Elkelany
- A Elkholy
- A Elshafay
- A Elwaey
- A Elwan
- A Essam Elnemr
- A Eysa
- A F Palma
- A Fadel
- A Fahiem
- A Farah
- A Faraz
- A Farquharson
- A Faure
- A Fawzy
- A Fouad
- A G N Robertson
- A Gamal Toeema
- A Garland
- A Gerosa
- A Gharib
- A Gharib
- A Gheith
- A Gomaa
- A Gouda
- A Grant
- A Gudal
- A Habeebullah
- A Hafez El-Badri Kotb
- A Hagar
- A Hammad
- A Hanks
- A Haroun
- A Hasan
- A Hasheminia
- A Hashish
- A Hassan
- A Hassan
- A Hassan
- A Hegazy Khedr
- A Horobjowsky
- A Hussein
- A Huwait
- A J Fowler
- A Jabbar
- A Karim
- A Kenibar
- A Khairy Aly
- A Khalique
- A Khan
- A Khoja
- A Khyrallh
- A Kiasat
- A Kirishnan
- A Kirupagaran
- A Kjellin
- A Kolosov
- A Kyaw Tun
- A L Contreras Vergara
- A L Mclean
- A Lasheen
- A Leal
- A LeppÀniemi
- A Livesey
- A M Afifi
- A M Altwigry
- A M Attia
- A M Elkorashy
- A M Hammad
- A M Mphatsoe
- A M Saeed
- A M Shariffuddin
- A M Warwick
- A Macdonald
- A Macfarlane
- A Maffioli
- A Mahdi
- A Maniscalco
- A Marey
- A Martin
- A Mcguigan
- A Mcphee
- A Menshawy
- A Minocha
- A Mirza
- A Mistry
- A Mittal
- A Mohameden
- A Mohammad
- A Mohammed
- A Mohammed
- A Mokhtar
- A Morsi
- A Mosad
- A Munera
- A Nabawi
- A Nashaat
- A Nasr
- A Nawawi
- A Negida
- A Nesaratnam
- A Niragire
- A Nocito
- A Novak
- A Ogunyemi
- A Oluwagbemiga Lawal
- A Oosterkamp
- A Osama Elsebaaye
- A Osinowo
- A Osman Abdelaziz Elhendawy
- A P Arnaud
- A Popoola
- A Powell
- A Prabhudesai
- A R Mitul
- A Ragab Nayel
- A Ragab Soliman
- A Ramadan
- A Ramos-De La Medina
- A Rasendran
- A Rasendran
- A Rasendran
- A Rashid
- A Raslan
- A Riaz
- A Rotundo
- A Rslan
- A Rudzenskaite
- A S Mironescu
- A S North
- A Sabry
- A Sabry El-Hamouly
- A Sadek
- A Safwan Marey
- A Sakr
- A Salah Elsherbiny
- A Salleh
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- A Sayed
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- A Shah
- A Shalaby
- A Sheshe
- A SkardĆŸiukaitÄ
- A Solaiman El-Ma'doul
- A Spina
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- A Strazdas
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- A Thorell
- A Usaityte
- A Vega Carreiro De Freitas
- A VenĂąncio De Sousa
- A Vlachogiorgos
- A W Anwar
- A Watts
- A Williamson
- A Wilson
- A Zani
- A Zardab
- A Zeynel A Balkan
- A Zil-E-Ali
- Abid Bin Mahamood
- B Albeladi
- B Alghamdi
- B B Ozkan
- B B Ozkan
- B Cameron
- B F Hon Khi Chong
- B Frisk
- B Magdy
- B Mansour
- B Mijuskovic
- B Nighat
- B Odeyemi
- B Pereira
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- B S Kumar
- B Sieda
- B Skelly
- B Thompson
- B Van Duren
- B Weber
- B Wolf
- B-V Martian
- C A Arroyo Basto
- C A Azmitia Mendizabal
- C Agalianos
- C Anthoulakis
- C Beaton
- C Bode
- C Boereboom
- C Bowman
- C C Goh
- C C L Szeto
- C C RamĂŁ Rez Cabrera
- C Ceriani
- C Chandrakumar
- C Clifford
- C Currow
- C Dervenis
- C Diaz-Zorrilla
- C E Lopez
- C Fahy
- C Fairfield
- C Fairfield
- C Fermani
- C Gouldthorpe
- C Grossart
- C Hand
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- C Houlden
- C I PĂ©rez VelĂĄsquez
- C J Mcintyre
- C Jenvey
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- C Khatri
- C Koh
- C Lee
- C Leung Chong
- C Leung Chong
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- C Lopez-Arevalo
- C LĂłpez
- C M Rees
- C Magee
- C Mangan
- C Mangan
- C Marinos
- C Mason
- C Milagros Herrera Puma
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- C Normile
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- C Oliveira Felipe
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- C P GarcĂa Torres
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- C W Ho
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- C Y Chen
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- D A Amin Elsorogy
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- D A Romani Pozo
- D A Soeselo
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- D Anderson
- D Bowley
- D Brown
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- D Dabessa
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- D Du Plessis
- D Duarte Cadogan
- D E MarroquĂn RodrĂguez
- D Emadeldin
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- D Iyer
- D J Clark
- D Karousos
- D Kazanavicius
- D Kotecha
- D L Deckelbaum
- D Loughran
- D Lytras
- D M Cocker
- D M Elbendary Elsawahly
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- D Nel
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- D R L Browning
- D Roi
- D Samuel
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- D Smith
- D Stewart
- D Venskutonis
- D Venskutonis
- D Vimalachandran
- D Vinicius Dos Santos
- D Youssef
- D Ăfner
- D-C Zachariades
- E Abdallah
- E Abington
- E Adel Sayma
- E Ali Ahmed
- E Aljohani
- E Aljohani
- E Alnawam
- E Alqahtani
- E Barrios
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- E Blower
- E Borg
- E Borin
- E Brown
- E Chan
- E Court
- E D Kennedy
- E Decker
- E Dempster
- E Domini
- E E Howie
- E Elbanby
- E Etchill
- E Eyssartier
- E F Zimmermann
- E Farinella
- E G Escobar
- E G Heywood
- E Gaignard
- E Gaignard
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- E Grasset
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- E Harper
- E Hervieux
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- E Jenner
- E Jones
- E Jovine
- E Jurdell
- E Kasem
- E Kefalidi
- E Kostov
- E Laugzemys
- E M Harrison
- E M Saeed Taha
- E Macdermid
- E Macdonald
- E Mamdouh
- E Marks
- E Mcaleer
- E Monaghan
- E N W Yeung
- E Niyirera
- E Nofal
- E P Refianti Sutanto
- E Panieri
- E Preckailaite
- E Rausa
- E Schadde
- E Snyder
- E Teasdale
- E Temoche
- E Thomas
- E Upchurch
- E Veronese
- E Williams
- E Woin
- E Y A Palkhi
- F A Asele
- F A Naranjo AristizĂŁ Bal
- F Abantanga
- F Abd El-Salam
- F Alakaloko
- F Altoe
- F Coccolini
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- F Di Franco
- F Elgendy
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- F Elzowawi
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- F Sauvat
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- F Tale
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- S F Ashraf
- S Fergusson
- S G Gosling
- S Galloway
- S Germanos
- S Ghanem
- S Giuliani
- S Gokani
- S Gosling
- S Hafiz
- S Haines
- S Hallam
- S Hassan
- S Highcock
- S Hossaini
- S Hussein
- S Irtan
- S Itopa Suleiman
- S J Chapman
- S J Lim
- S Juciute
- S K D'amours
- S K Pitt
- S Karandikar
- S Khan
- S Kharsa
- S King
- S Koh
- S Kruspi
- S Kumar
- S Kushwaha
- S Limache
- S Loizides
- S M Contreras MĂ©rida
- S M Lakhani
- S M Sundstrom
- S Magdy Ahmed
- S Mahdi
- S Man Yeng Chiu
- S Mcaleer
- S Mehrez
- S Mikalauskas
- S Mitrasinovic
- S Mouttalib
- S Nadkarni
- S Ng
- S Nigo
- S O'Neill
- S Olori
- S Pai
- S Parthiban
- S Ramzi
- S Ray
- S Rayne
- S Razmdjou
- S Roncali
- S Roy
- S S Prasad
- S Saad
- S Said Elkolaly
- S Samy
- S Sani Ali
- S Sarsik
- S Sarwary
- S Satoskar
- S Shaikh
- S Shehata
- S Sheth
- S Shu
- S Sierra
- S Singh
- S Sinha
- S Sivaganesh
- S Stock
- S Tabiri
- S Talukder
- S Talukder
- S Tewari
- S Tharmalingam
- S Tou
- S V Kinnera
- S Vivekanantham
- S Ward
- S Wondimu
- S Zegarra
- S Zeidan
- S-H Kim
- S-P Hosein
- T A M Malik
- T Akeem Lawal
- T Alzayat
- T Arulampalam
- T B Wold
- T Barker
- T Boyce
- T Brogden
- T Chun
- T Clark
- T E Glover
- T Ebogo Ngwa
- T F Jones
- T Falconer Hall
- T Farooq
- T Fautz
- T Fernandes Giuriato
- T Fozard
- T Fozard
- T Khan
- T Kumar
- T M Drake
- T Mak
- T Muhammad Yaseen
- T Naqvi
- T Newton
- T Nouh
- T O'Connor
- T Pezas
- T Poskus
- T Razek B Marinkovic
- T S Hettiarachchi
- T Sherman
- T Stasinou
- T Urbonas
- T W Tilston
- T White
- T Xerri
- T Yaseen
- U Alamoudi
- U Gunnarsson
- U Gustafsson
- U Hantour
- U Karabacak
- U Walsh
- V Ambrozeviciute
- V Beisa
- V D Palomino Castillo
- V Despotidis
- V Gadhvi
- V Graffeille
- V Graffieille
- V Grassi
- V J P Nsengimana
- V Jennings
- V Jotautas
- V K Proctor
- V Kong
- V M Quintero Riaza
- V Parent
- V Patel
- V Punja
- V Sallinen
- V Shatkar
- V Summerour
- V Thanusan
- W Adham
- W Anwer
- W Beasley
- W C Ho
- W C Soon
- W Chachulski
- W Forno
- W Guo
- W Hawkins
- W Ho
- W Hutch
- W J Lossius
- W L Messa Aguilar
- W L Messa Aguilar
- W Milligan
- W Milligan
- W Pino
- W S Li
- W S M Kithsiri Janakantha Senanayake
- Y Abd El Salam
- Y Abd Elrasoul
- Y Abd-Elrasoul
- Y Aigrain
- Y Cengiz
- Y El Shoura
- Y Elfouly
- Y Hegazy
- Y Ibrahim
- Y Imorou Souaibou
- Y Macchitella
- Y N Neo
- Y P Mogan
- Y Rajjoub
- Y Reddy
- Y Salama
- Y Sinha
- Z Chan
- Z Dambrauskas
- Z Hassan
- Z Iftikhar
- Z Jaffry
- Z Mikwar
- Z Oof
- Z Urniezius
- Z Zhang
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2016
- Field of study
Background: Surgical mortality data are collected routinely in high-income countries, yet virtually no low- or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergency abdominal surgery, comparing findings across countries with a low, middle or high Human Development Index (HDI).
Methods: This was a prospective, multicentre, cohort study. Self-selected hospitals performing emergency surgery submitted prespecified data for consecutive patients from at least one 2-week interval during July to December 2014. Postoperative mortality was analysed by hierarchical multivariable logistic regression.
Results: Data were obtained for 10 745 patients from 357 centres in 58 countries; 6538 were from high-, 2889 from middle- and 1318 from low-HDI settings. The overall mortality rate was 1â
6 per cent at 24 h (high 1â
1 per cent, middle 1â
9 per cent, low 3â
4 per cent; P < 0â
001), increasing to 5â
4 per cent by 30 days (high 4â
5 per cent, middle 6â
0 per cent, low 8â
6 per cent; P < 0â
001). Of the 578 patients who died, 404 (69â
9 per cent) did so between 24 h and 30 days following surgery (high 74â
2 per cent, middle 68â
8 per cent, low 60â
5 per cent). After adjustment, 30-day mortality remained higher in middle-income (odds ratio (OR) 2â
78, 95 per cent c.i. 1â
84 to 4â
20) and low-income (OR 2â
97, 1â
84 to 4â
81) countries. Surgical safety checklist use was less frequent in low- and middle-income countries, but when used was associated with reduced mortality at 30 days.
Conclusion: Mortality is three times higher in low- compared with high-HDI countries even when adjusted for prognostic factors. Patient safety factors may have an important role. Registration number: NCT02179112 (http://www.clinicaltrials.gov)
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
- Author
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- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
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- Abantanga F
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- Abbas M
- Abbasy J
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- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader Sm
- Abdel-Wahab Nye
- Abdelaal A
- Abdelaty M
- Abdelazeam Ar
- Abdelazim G
- Abdelaziz Ma
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
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- Abdelmotaleb I
- Abdelraheim M
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- Adeniyi A
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- Decker E
- Decoud Hp
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
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- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
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- Diaz-Zorrilla C
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- Dimech T
- Din F
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- Dissanayake T
- Djivoh F
- Domini E
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- Donnelly P
- Donoghue D
- Dorani Rmnr
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- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
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- Ebrahim Os
- Eduard P
- Edwards J
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- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
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- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
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- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
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- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
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- Elmelegy R
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- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
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- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
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- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
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- Elwan A
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- Elzahed N
- Elzayat I
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- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
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- Essam A
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- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
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- Falzon M
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- Farag S
- Farah A
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- Faraz A
- Fares M
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- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
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- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
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- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
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- Gaafar S
- Gaarder T
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- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
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- Gala T
- Gala T
- Galiqi G
- Galleano R
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- Galvez Cp
- Gamal D
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- Gamal H
- Gamal S
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- Gani Ma
- Garaycochea O
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- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
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- Ghanem E
- Ghanem S
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- Ghannam M
- Gharib A
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- Ghazy Aa
- Gheith A
- Ghetia M
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- Giglio Mc
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- Giuriato Tf
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- Grassi V
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- Grizhja B
- Grobler Dc
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- Gudal A
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- Guevara R
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- Gui D
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- Gulcicek Ob
- Gulielmi A
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- Guo W
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- Gustafsson U
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- Haddad N
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- Hafiz S
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- Hagar A
- Haines M
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- Hajeh H
- Hakim H
- Halhouli O
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- Halicioglu I
- Hall E
- Hall N
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- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
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- Hany E
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- Harrison N
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- Hasan A
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- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
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- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
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- Hassan Omm
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- Hassan Z
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- Hassanain M
- Hassanein Ab
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- Helene Fc
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- Herebat A
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- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
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- Ibrahim A
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- Ibrahim A
- Ibrahim Am
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- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
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- Idris F
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- Imoro O
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- Mcphee A
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- Mehdi A
- Mehrez S
- Mejia Agv
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- Mendel H
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- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
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- Mentula P
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- Mihaljevic Al
- Mihanovic J
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- Minguez G
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- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
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- Mittal A
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- Mizzi C
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- Mlotshwa M
- Moaty M
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- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
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- Molina G
- Mollo Mc
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- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
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- Morsi A
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- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
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- Muralha N
- Murphy J
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- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
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- Mustafa Ma
- Musyoka Ck
- Mutabazi Az
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- Mutlu D
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- Muzio E
- Myers J
- Mykoniatis I
- Næ
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- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
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- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
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- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
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- Nikoloudis N
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
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- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
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- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Olaolorun A
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- Ortega-Vazquez I
- Ortiz N
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- Osei-Nketiah S
- Oshati O
- Oshodi O
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- Othman M
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- Ozben V
- Ozkan Bb
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- Pabla G
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- Padmore G
- Pagano G
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- Palma Af
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- Papaskarlatos Ia
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- Parreno-Sacdalan Md
- Parseliunas A
- Parthiban S
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- Pastora J
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- Patoulias I
- Paul M
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- Perino M
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- Pesenti G
- Petrikenas S
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- Pezas T
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- Picardo A
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- Poskus T
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- Preckailaite E
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- Prudhomme T
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- Puma Cmh
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- Rasoaherinomenjanahary F
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- Raza A
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- Razek T
- Razmdjou S
- Razuri C
- Razzaque J
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- Redota Map
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- Restrepo Im
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- Runigamugabo E
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- Saad Ha
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- Sabour Fa
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- Safa H
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- Sahel S
- Saidbadr A
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- Salama M
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- Samaniego Cs
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- Senanayake Kj
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- Sokratous A
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- Sundstrom Sm
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- Tang A
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- Tansoker I
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- Tedeschi U
- Tedjaatmadja C
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- Ubiali P
- Ugalde P
- Ukwenya Y
- Uluş
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- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
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- Urniež
- Urniezius Z
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- Valioulis I
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Recommended from our members
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
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- Rolandi GEB
- Romaguera D
- Romeo EL
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- Rusakova IA
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- Saamel M
- Saar CG
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- Westbury LD
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- Wickramasinghe K
- Widhalm K
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- Wilsgaard T
- Wirth JP
- Wojtyniak B
- Woldeyohannes M
- Wolf K
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- Wong EB
- Wong JE
- Wong NI
- Wong TY
- Wong-McClure RA
- Woo J
- Woodward M
- Wu FC
- Wu H-Y
- Wu J
- Wu LJ
- Wu S
- Wyszynska J
- Xu H
- Xu L
- Yaacob NA
- Yamborisut U
- Yan L
- Yan W
- Yang L
- Yang X
- Yang Y
- Yardim N
- Yasuharu T
- Yiallouros PK
- Yngve A
- Yoosefi M
- Yoshihara A
- Yotov Y
- You QS
- You S-L
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilova H
- Zapata ME
- Zargar AH
- Zaw KK
- Zayed AA
- Zdrojewski T
- Zeglen M
- Zejglicova K
- Zeng Y
- Zentai A
- Zhang B
- Zhang L
- Zhang Z-Y
- Zhao D
- Zhao M-H
- Zhao W
- Zhecheva YV
- Zhen S
- Zheng W
- Zheng Y
- Zholdin B
- Zhou B
- Zhou M
- Zhu D
- Zimmet P
- Zins M
- Zitt E
- Zocalo Y
- Zoghlami N
- Zuziak M
- Publication venue
- Elsevier
- Publication date
- 14/03/2024
- Field of study
Background
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods
We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age â„20 years) and school-aged children and adolescents (age 5â19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median).
Findings
From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness.
Interpretation
The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.
Funding
UK Medical Research Council, UK Research and Innovation (Research England), UK Research and Innovation (Innovate UK), and European Union
Global, regional, and national burden of disorders affecting the nervous system, 1990â2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Abate Yohannes Habtegiorgis
- Abbas Jaffar
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd-Rabu Rami
- Abdelmasseh Michael
- Abdollahi Mohammad
- Abdollahi Mozhan
- Abdollahifar Mohammad-Amin
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abedi Aidin
- Abedi Vida
- Abeldaño Zuñiga Roberto Ariel
- Abidi Hassan
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Aboyans Victor
- Abrha Woldu Aberhe
- Abu-Gharbieh Eman
- Abualhasan Ahmed
- Aburuz Salahdein
- Adamu Lawan Hassan
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adekanmbi Victor
- Adekiya Tayo Alex
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Tsion
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afzal Saira
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Sajjad
- Ahmadzade Amir Mahmoud
- Ahmed Ali
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Jivan Qasim
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akade Seyed Esma'il
- Akbari Morteza
- Akbarialiabad Hossein
- Akhlaghi Shiva
- Akinosoglou Karolina
- Akinyemi Rufus Olusola
- Akonde Maxwell
- Al Hasan Syed Mahfuz
- AL-Ahdal Tareq Mohammed Ali
- Al-amer Rasmieh Mustafa
- Al-Gheethi Adel Ali Saeed
- Al-Omari Basem
- Al-Shahi Salman Rustam
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Alahdab Fares
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldawsari Khalifah A
- Alemi Hediyeh
- Alemi Sharifullah
- Algammal Abdelazeem M
- Alhalaiqa Fadwa Alhalaiqa Naji
- Alhassan Robert Kaba
- Ali Abid
- Ali Endale Alemayehu
- Ali Liaqat
- Ali Mohammed Usman
- Ali Musa Mohammed
- Ali Rafat
- Ali Shahid
- Ali Syed Shujait Shujait
- Ali Zahid
- Alif Sheikh Mohammad
- Alimohamadi Yousef
- Aliyi Ahmednur Adem
- Aljofan Mohamad
- Aljunid Syed Mohamed
- Alladi Suvarna
- Almazan Joseph Uy
- Almustanyir Sami
- Alqahtani Jaber S
- Alqasmi Ibrahim
- Alqutaibi Ahmed Yaseen
- Altaany Zaid
- Altirkawi Khalid A
- Alvis-Guzman Nelson
- Aly Hany
- Aly Safwat
- Alzoubi Karem H
- Amani Reza
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amugsi Dickson A
- Amusa Ganiyu Adeniyi
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
- Andrei Catalina Liliana
- Androudi Sofia
- Angappan Dhanalakshmi
- Angesom Teklit W
- Anil Abhishek
- Ansari-Moghaddam Alireza
- Anwer Razique
- Arafat Mosab
- Aravkin Aleksandr Y
- Areda Demelash
- Ariffin Hany
- Arifin Hidayat
- Arkew Mesay
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Aruleba Raphael Taiwo
- Asadi-Pooya Ali A
- Asena Tilahun Ferede
- Asghari-Jafarabadi Mohammad
- Ashraf Muhammad
- Ashraf Tahira
- Atalell Kendalem Asmare
- Athari Seyyed Shamsadin
- Atinafu Bantalem Tilaye Tilaye
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Aujayeb Avinash
- Avan Abolfazl
- Ayala Quintanilla Beatriz Paulina
- Ayatollahi Haleh
- Ayinde Olatunde O
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azizi Zahra
- Azizian Khalil
- Azzam Ahmed Y
- Babaei Mahsa
- Badar Muhammad
- Badiye Ashish D
- Baghdadi Soroush
- Bagherieh Sara
- Bai Ruhai
- Baig Atif Amin
- Balakrishnan Senthilkumar
- Balalla Shivanthi
- Baltatu Ovidiu Constantin
- Banach Maciej
- Bandyopadhyay Soham
- Banerjee Indrajit
- Baran Mehmet Firat
- Barboza Miguel A
- Barchitta Martina
- Bardhan Mainak
- Barker-Collo Suzanne Lyn
- Barrow Amadou
- Bashash Davood
- Bashiri Hamideh
- Bashiru Hameed Akande
- Basiru Afisu
- Basso JoĂŁo Diogo
- Basu Sanjay
- Batiha Abdul-Monim Mohammad
- Batra Kavita
- Baune Bernhard T
- Bedi Neeraj
- Begde Ahmet
- Begum Tahmina
- Behnam Babak
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bekele Alehegn
- Belete Melaku Ashagrie
- Belgaumi Uzma Iqbal
- Bemanalizadeh Maryam
- Bender Rose G
- Benfor Bright
- Bennett Derrick A
- Bensenor Isabela M
- Berice Betyna
- Bettencourt Paulo J G
- Beyene Kebede A
- Bhadra Abhishek
- Bhagat Devidas S
- Bhangdia Kayleigh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Ajay Nagesh
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Rajbir
- Bijani Ali
- Bikbov Boris
- Bilalaga Mariah Malak
- Biswas Atanu
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- Tamuzi Jacques JL Lukenze
- Tan Ker-Kan
- Tang Haosu
- Tareke Minale
- Tarigan Ingan Ukur
- Tat Nathan Y
- Tat Vivian Y
- Tavakoli Oliaee Razieh
- Tavangar Seyed Mohammad
- Tavasol Arian
- Tefera Yibekal Manaye
- Tehrani-Banihashemi Arash
- Temesgen Worku Animaw
- Temsah Mohamad-Hani
- Teramoto Masayuki
- Tesfaye Amensisa Hailu
- Tesfaye Edosa Geta
- Tesler Riki
- Thakali Ocean
- Thangaraju Pugazhenthan
- Thapa Rajshree
- Thapar Rekha
- Thomas Nikhil Kenny
- Thrift Amanda G
- Ticoalu Jansje Henny Vera
- Tillawi Tala
- Toghroli Razie
- Tonelli Marcello
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Nghia Minh
- Tran Ngoc-Ha
- Tran Phu Van
- Tromans Samuel Joseph
- Truelsen Thomas Clement
- Truyen Thien Tan Tri Tai
- Tsatsakis Aristidis
- Tsegay Guesh Mebrahtom
- Tsermpini Evangelia Eirini
- Tualeka Abdul Rohim
- Tufa Derara Girma
- Ubah Chukwudi S
- Udoakang Aniefiok John
- Ulhaq Inam
- Umair Muhammad
- Umakanthan Srikanth
- Umapathi Krishna Kishore
- Unim Brigid
- Unnikrishnan Bhaskaran
- Vaithinathan Asokan Govindaraj
- Vakilian Alireza
- Valadan Tahbaz Sahel
- Valizadeh Rohollah
- Van den Eynde Jef
- Vart Priya
- Varthya Shoban Babu
- Vasankari Tommi Juhani
- Vaziri Siavash
- Vellingiri Balachandar
- Venketasubramanian Narayanaswamy
- Verras Georgios-Ioannis
- Vervoort Dominique
- Villafañe Jorge Hugo
- Villani Leonardo
- Vinueza Veloz Andres Fernando
- Viskadourou Maria
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Volovat Simona Ruxandra
- Vos Theo
- Vu Loc Tri
- Vujcic Isidora S
- Wagaye Birhanu
- Waheed Yasir
- Wahood Waseem
- Walde Mandaras Tariku
- Wang Fang
- Wang Shu
- Wang Yanzhong
- Wang Yuan-Pang
- Waqas Muhammad
- Waris Abdul
- Weerakoon Kosala Gayan
- Weintraub Robert G
- Weldemariam Abrha Hailay
- Westerman Ronny
- Whisnant Joanna L
- Wickramasinghe Dakshitha Praneeth
- Wickramasinghe Nuwan Darshana
- Willekens Barbara
- Wilner Lauren B
- Winkler Andrea Sylvia
- Wolfe Charles D A
- Wu Ai-Min
- Wulf Hanson Sarah
- Xu Suowen
- Xu Xiaoyue
- Yadollahpour Ali
- Yaghoubi Sajad
- Yahya Galal
- Yamagishi Kazumasa
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Yehualashet Sisay Shewasinad
- Yeshaneh Alex
- Yesiltepe Metin
- Yi Siyan
- YiÄit Arzu
- YiÄit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Yusuf Hadiza
- Zadey Siddhesh
- Zahedi Mohammad
- Zakham Fathiah
- Zaki Nazar
- Zali Alireza
- Zamagni Giulia
- Zand Ramin
- Zandieh Ghazal G Z
- Zangiabadian Moein
- Zarghami Amin
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zegeye Zelalem Banjaw
- Zeukeng Francis
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhao Yang
- Zheng Peng
- Zhou Hengxing
- Zhu Bin
- Zhumagaliuly Abzal
- ZieliĆska Magdalena
- Zikarg Yossef Teshome
- Zoladl Mohammad
- Ărnlöv Johan
- Publication venue
- Elsevier
- Publication date
- 01/04/2024
- Field of study
BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378â521), affecting 3·40 billion (3·20â3·62) individuals (43·1%, 40·5â45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7â26·7) between 1990 and 2021. Age-standardised rates of deaths per 100â000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6â38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5â32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7â2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICâHF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- AboâAuda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- AriasâMendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- BieringâSĂžrensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Böhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
- Constance Christian
- Contreras Johanna
- Corbalan Ramon
- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- CostaâVitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- CrespoâLeiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlström Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
- Dib Nabil
- Diez Mirta
- Dimov Bojidar
- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
- Donnelly Patrick
- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen HansâDirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
- Elvan Arif
- Esperon Guillermo Antonio Llamas
- Ezekowitz Justin
- Ezhov Marat
- Fang James
- Fang James C.
- Farris Neil
- Feitell Scott
- Felker G. Michael
- Fernandez Alberto
- Fernando Ronald
- Ferraz Almir
- Figal Domingo Andres Pascual
- Filho Otavio Coelho
- Filho Pedro Pimentel
- Filippatos Gerasimos
- Fisher Daniel
- Florea Viorel
- Flores Ana Maria De Leon
- Floresta Agata Marina
- Fonseca Candida
- Fonseca CĂąndida
- Forman Steven
- Forster Tamas
- Fortes Jose Augusto Ribas
- Fourie Nyda
- Franchi Francesco
- Frank Theodore
- Frankenstein Lutz
- Freire Ramon Bover
- Fremont Richard
- French John
- Friedman Keith
- Frigerio Maria
- Friz Hernan Emilio Francisco Polo
- Fu Xin
- Fucili Alessandro
- Fuente Galan Luis
- Fuente Ricardo Alfonso Leon
- Fujii Kenshi
- Fujii Shigeru
- Fujiwara Wakaya
- Fukuzawa Shigeru
- Fulop Peter
- Gabriel George
- Gajardo Victor Areli Saavedra
- Galinier Michel
- Ganeshram Vedampattu
- Ganji Jagadeesh
- Garrido Marcelo Alejandro
- Gass Alan
- Gaudet Daniel
- Geltman Edward
- Gemignani Anthony
- GenthâZotz Sabine
- Georges JeanâLouis
- Giamouzis Grigorios
- Gianfagna Robert
- Giannetti Nadia
- Gilmore Richard
- Giorgeto Flavio Eduardo
- Giraldo Clara Ines Saldarriaga
- Giuca Alina
- Giudici Vittorio
- Glover Jason
- Gogia Harinder
- Gohara Seiichiro
- Gola Zbigniew
- Goloshchekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Goncharov Ivan
- Gonsorcik Jozef
- Gonzalez Ricardo Garcia
- Gonzalez Salvador Leon
- Gordon Brian
- Gorodeski Eiran
- Gottlieb Stephen
- Goudev Assen
- Goudev Assen R.
- Gray Wayne
- Grazette Luanda
- Greco Oswaldo
- Grewal Gurinder
- Groote Pascal De
- Gueffet JeanâPierre
- Guerrero Rodolfo Andres Ahuad
- Gupta Dinesh
- Gupta Milan
- Guray Umit
- Haddad Tariq
- Haehling Stephan
- Hajko Erik
- Hal John
- Halpern Stephen
- Hametz Craig
- Hamilton Andrew
- Han Qinghua
- Han Yajun
- Handel Franklin
- Hara Hisao
- Harris John
- Hart Hamish
- Hart Terence
- Hartleib Michael
- Hasni Syed
- Hata Yoshiki
- Hattler Brack
- Hearne Steven
- Hedgepeth Chester
- Heilman Karl
- Heitner John
- Henderson David
- Herczeg Bela
- Hermans Walter
- Herzog William
- Hidaka Takayuki
- Hidalgo Mario Yanez
- Higashino Yorihiko
- Hiroi Shitoshi
- Hominal Miguel Angel
- Horacek Thomas
- Houra Marek
- Houston Brian
- Howlett Jonathan G.
- Huang He
- Huber Kurt
- Huelsmann Martin
- Hullin Roger
- Hunter Vernon
- Huynh Thao
- Ibañez Julio
- Ibrahim Hassan
- Indolfi Ciro
- Inomata Takayuki
- Iseki Harukazu
- Ishikawa Masahiro
- Isnard Richard
- Isshiki Takaaki
- Itchhaporia Dipti
- Ito Hiroshi
- Jackson Bruce
- Jacob Binu
- Jadbabaie Farid
- Jaeger Cristiano Pederneiras
- Jaffrani Naseem
- Jalaf Margarita Gertrudis Vejar
- Janik Matthew
- Jankowski Piotr
- Janmohamed Munir
- Jarasuniene Dalia
- Jattin Fernando Manzur
- Javier Julian
- Jeppesen Jorgen
- Jerabek Ondrej
- Jimenez Juan Francisco Delgado
- Jofre Christian Paolo Pincetti
- Jondeau Guillaume
- Jones Alonzo
- Joseph Susan
- Juanatey Jose Ramon Gonzalez
- Judkins Christopher
- Kadel Christoph
- Kadokami Toshiaki
- Kafara Mariusz
- Kai Hisashi
- KaiserâNielsen Peter
- Kajinami Kouji
- Kalarus Zbigniew
- KalecinskaâKrystkiewicz Ewa
- Kalra Paul
- Kaluski Edo
- Kanda Junji
- Kania Grzegorz
- Kao John
- Karavidas Apostolos
- Karim Amin
- Karlstrom Patric
- Karpenko Oleksandr
- Karvounis Haralambos
- Kasai Toshio
- Kassiotis Christos
- Katz Richard
- Kawakami Hideo
- Kawamitsu Katsunori
- Kawasaki Tomohiro
- Kazemi Navid
- Kazinczy Rita
- Kearney Leighton
- Keeling Philip
- Kellnerova Ivana
- Khalife Wissam
- Kida Keisuke
- Killat Holger
- Kindel Carlos Conejeros
- King Anthony
- Kirma Cevat
- Kitaoka Hiroaki
- Klimsa Zdenek
- Klug Eric
- Kobalava Zhanna
- Kochiadakis George
- Koga Tokushi
- Koike Akihiro
- Koizumi Tomomi
- Koldas Zehra Lale
- Koleckar Pavel
- Komiyama Nobuyuki
- Kondo Nicholas
- Konieczynska Malgorzata
- Kono Alan
- Koo Charles
- Kopaczewski Jerzy
- Korczyk Dariusz
- Koren Michael
- Korzh Oleksii
- Kosmacheva Elena
- Kostenko Viktor
- Kotelnikov Mikhail
- Kowalski Robert
- Kracz Igor
- Krantz Mori
- Krishnamoorthy Arun
- Krupicka Jiri
- Kryza Radim
- Kubota Toru
- Kulibaba Elena
- Kulynych Oleksii
- Kurtz Christopher E.
- Kwan Michael
- Lader Ellis
- Lakatos Ferenc
- Lakshminarayanan Batlagundu
- Lancellotti Patrizio
- Lanfear David E.
- Lang Chim
- Lang Christopher
- Laperche Thierry
- Laszlo Zoltan
- Leaes Paulo Ernesto
- Lefebvre JeanâMarie
- Legg Jason C.
- Leiro Maria Generosa Crespo
- Lelonek Malgorzata
- Lenartowska Lucyna
- Lenner Egon
- Leon Jose Luis Arenas
- Leonardi Sergio
- Lepor Norman
- LeWinter Martin
- Lewis Neil
- Li Dongye
- Li Jianjun
- Li Tianfa
- Li Weimin
- Li Yinjun
- Li Zhangquan
- Li Zhaoping
- Lighezan Daniel
- Lindholm CarlâJohan
- Linssen Gerardus
- Liu Feng
- Llamas Edmundo Alfredo Bayram
- Llerena Sara
- Lohr Nicole
- Londono Juan
- Lopez Gabriel Arturo Ramos
- Lopez Luis Horacio Atehortua
- Lopez Rodrigo Botero
- Lovell Charles
- Ludman Andrew
- Luengas Carlos Alberto
- Lukacova Jana
- Lukyanov Yury
- Lund Marianne
- Lund Mayanna
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo
- Lymar Yurii
- Lynch Mary
- Ma Shumei
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- Macdonald Peter
- Macdonald Peter
- Machado Gustavo Francisco Mendez
- Machova Vilma
- Macias Leonardo
- Mackinnon Ignacio
- Maejima Yasuhiro
- Magro Michael
- Mahemuti Ailiman
- Mahmood Shahid
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- Majercak Ivan
- Majul Claudio Rodolfo
- Malhotra Sanjay
- Malhotra Vinay
- Malik Adnan
- Malik Fady I.
- Mamdani Shafiq
- Mancini Donna
- Manenti Euler Roberto Fernandes
- Manita Mamoru
- Manolis Athanasios
- Mantas Ioannis
- Mareev Vyacheslav
- Mareev Vyacheslav
- Margoczy Roman
- Margonato Alberto
- Mark Laszlo
- Marquez Lilia Luz Lobo
- Martindale Jeffrey
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- Martinez Laura Jordan
- Martinez Luis
- MartinezâArraras Joaquin
- MartinezâCastrillon Melvin
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- Masuda Seigo
- Matsumoto Takashi
- Mayer Nolan
- Mayoral Alejandro Recio
- McGrew Frank
- McKelvie Robert
- McKenzie Scott
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- McMurray John J.V.
- Menck Niels
- Mendoza Jose Luis Accini
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- Merkely Bela
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- Metra Marco
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- Mi Yafei
- Michishita Ichiro
- Miekus Pawel
- Mielniczuk Lisa
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- Mitrovic Veselin
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- Mitu Florin
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- Miyamoto Nobuhide
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- Momiyama Yukihiko
- Momomura Shinâichi
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- Morita Yukiko
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- Mortara Andrea
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- Motylev Igor
- Mouhaffel Asad
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- Mueller Christian
- Murray David
- Muthumala Amal
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- Nagy Laszlo
- Nair Nandini
- Naka Katerina
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- Nakamura Kentaro
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- Nelson William
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- Nyolczas Noemi
- Nyvad Ole
- O'Brien Terrence
- O'Meara Eileen
- O'Meara Eileen
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- Oishi Shogo
- Okishige Kaoru
- Okumura Takahiro
- Okumura Yasuo
- Okuyan Ertugrul
- Oliveira Soares Manue MartinezâSelles D
- Oliveira Luis
- Olsen Stephanie
- Onoue Kenji
- Onrat Ersel
- Ooi Henry
- Orgera Marisa
- Ortiz Aurelio
- Osipova Irina
- Osorio Wilder Castaño
- Ovize Michel
- Padron Antonio Lara
- Paiva Maria Sanali
- Palomas Juan Luis Bonilla
- Pandey A Shekhar
- Paolino Bruno
- Papp Andras
- Papp Aniko
- Pareja Monica Lopez
- Parissis John
- Parkhomenko Alexander
- Parkhomenko Oleksandr
- Parody Maria Leonor
- Paszczuk Anna
- Patel Devesh
- Patsilinakos Sotirios
- Pauwaa Sunil
- Pawlowicz Lidia
- Paya Vicente Eduardo Climent
- Peart Brenda
- Peiro Maria Teresa Blasco
- Pelaez Sebastian Velez
- Perez Sonia Mirabet
- Perna Eduardo
- Perna Gianpiero
- Pesant Yves
- Peterka Karel
- Peterson Magnus
- Petrov Ivo
- Pfister Roman
- Pham Michael
- Phaneuf DenisâCarl
- Pianko Leonard
- Piatek Marek
- Picard François
- Pickett Christopher
- Piegas Leopoldo Soares
- Pijanowski Zbigniew
- Pillutla Priya
- Pimenov Leonid
- Pini Daniela
- Piovaccari Giancarlo
- Pisani Barbara
- Podoleanu Cristian Gheorghe
- Podpera Ivo
- Poelzl Gerhard
- Polasek Rostislav
- Ponikowski Piotr
- Popescu Mircea Ioachim
- Portnay Edward
- Postadzhiyan Arman
- Potthoff Sergio
- Poy Carlos
- Pozdisek Zbynek
- Prado Aldo
- Prado Jose Maria Arizon
- Price Dallas
- Prokhorov Oleksandr
- Proulx Guy
- Qu Yanling
- Radin Michael
- Radojevic Joseph
- Rafalskiy Vladimir
- Rahko Peter
- Rajagopalan Navin
- Rama Bhola
- Ramanathan Kodangudi
- Ramires Felix
- Ramires Felix J. A.
- Ramos Mark
- Ranadive Nandkishore
- Randall William
- Rao Sunder
- Rasmussen Mariela
- Rasputina Lesya
- Rassaf Tienush
- Rassi Salvador
- Rawitscher David
- Reis Gilmar
- Remmen Johannes
- Rennyson Stephen
- Repin Alexey
- Ricci Jean Etienne
- Rider James
- Rishko Mykola
- Rivero Mariel
- Robinson Shawn
- Rodriguez Alicia Contreras
- Rojas Pastor Olaya
- Rosamel Yann
- Rossi Paulo Roberto Ferreira
- Rossini Roberta
- Roth Sherryn
- Roubille Francois
- Rowan Christopher
- Roy Debashis
- Rudenko Leonid
- Rudyk Iurii
- Ruiz Alberto Esteban Bazzoni
- Rupka Dennis
- Ryabov Vyacheslav
- Ryding Alisdair
- Rynkiewicz Andrzej
- Römer Tjeerd
- Sabatier RĂ©mi
- Sahin Tayfun
- Sakagami Satoru
- Sakai Tetsuo
- Sakamoto Tomohiro
- Sakata Yasushi
- Salamon Csaba
- Salazar Dora Ines Molina
- Salazar Melchor Alpizar
- Salomone Oscar Alejandro
- Salukhov Vladimir
- Salvat Muriel
- Sampognaro Gregory
- Sandri Marcus
- Santos Luis
- Saraiva Jose Francisco
- Sarmento Pedro Morais
- Sassone Sonia
- Sato Yukihito
- Sauer Andrew
- Savard Daniel
- Sawyer Douglas
- Saxena Sanjeev
- Schaap Jeroen
- Schee Alexandr
- Schiavi Lilia
- Schmalfuss Carsten
- Schnitzler Robert
- Schultz David
- Sciborski Ryszard
- Scott Russell
- Segarra Jorge Leonardo Cobos
- Semenova Irina
- Senaratne Manohara
- Senni Michele
- Sepulveda Alex Mauricio Villablanca
- Serikawa Takeshi
- Serpytis Pranas
- Serpytis Pranas
- Seto Arnold
- Shah Amit
- Shah Anil
- Shah Keyur
- Shah Nishant
- Shandling Adrian
- Sharma Mukesh
- Sharpsten Lucie
- Shayani Steven
- Sherenkov Alexander
- Shilkina Nataliya
- Shimizu Wataru
- Shimomura Mitsuhiro
- Shin Jooyoung
- Shutemova Elena
- Shvarts Yury
- Sichrovsky Tina
- Sidor Mateusz
- Silva Neto Luis Beck
- Silva Rodrigo
- Silveira Fabio
- Simoes Marcus Vinicius
- Simon Marc
- Sinagra Gianfranco
- Sindone Andrew
- Singh Deovrat
- Singh Pradeep
- Siostrzonek Peter
- Sitnikova Maria
- Skaria Binoy
- Skonieczny Grzegorz
- Skopicki Hal
- Skrobakova Janka
- Slapikas Rimvydas
- Sliwa Karen
- Sluis Aize
- Smart Frank
- Smik Rudolf
- Smilde Tom
- Sobkowicz Bozena
- Sochor Karel
- Sokos George
- Solomon Scott D.
- Solovev Oleg
- Souza Weimar Kunz Barroso
- Spacek Rudolf
- Spinar Jindrich
- Spinar Jindrich
- Spinarova Lenka
- Spiridon Marilena Renata
- Spyra Janusz
- Stahl Llyod
- Stamate Sorin
- Stanciulescu Gabriela
- Stanislavchuk Mykola
- Stankiewicz Anna
- Starling Randall
- Stepek David
- Stets Roman
- Stevlik Jan
- Stewart Robert
- Stoddard Marcus
- StraburzynskaâMigaj Ewa
- Strader J Russell
- Styliadis Ioannis
- Störk Stefan
- Sugino Hiroshi
- Sulemanjee Nasir
- Sun Yuemin
- Sussex Bruce
- Suter Thomas
- Suter Thomas M.
- Suzuki Masahiro
- Sverdlov Aaron
- Sweitzer Nancy
- Szabo Barna
- Szakal Imre
- Szasz Gyula
- Szczasny Marcin
- Szto Gregory
- Taggeselle Jens
- Tahirkheli Naeem
- Takagi Atsutoshi
- Takahashi Natsuki
- Takaishi Hiroshi
- Takama Noriaki
- Takata Theodore
- Takeishi Yasuchika
- Takenaka Takashi
- Tallet Julio
- Tanabe Jun
- Tanaka Takahiro
- Tang Huifang
- Tarasov Nikolay
- Tartiere JeanâMichel
- Tatebe Shunsuke
- Taylor Justin
- Teerlink John R.
- Terasaki Toshiro
- Terasawa Akihiro
- Tereschenko Sergey
- Timofeev Alexander
- Tishevaâ Gospodinova Snezhanka
- Tocchetti Carlo Gabriele
- Todorov Georgi
- Tognon Alexandre
- Tomcsanyi Janos
- Tomcsanyi Janos
- Toth Kalman
- Treasure Charles
- Trebacz Jaroslaw
- Trevelyan Jasper
- Triana Miguel Urina
- Trichon Benjamin
- Trochu Jean Noel
- Tsabedze Nqoba
- Tsao Lana
- Tseluyko Vira
- Tsioufis Konstantinos
- Tsujimoto Mitsuru
- Tuncer Mustafa
- Turgut Okan Onur
- Tyl Petr
- Tzekova Maria
- Tziakas Dimitrios
- Ueda Yasunori
- Ueno Hideki
- Uhliar Rudolf
- Ujino Keiji
- Uretsky Barry
- Usui Makoto
- Utsu Noriaki
- Vaccari Christopher
- Vakaliuk Igor
- Van Eck Jacob
- Van Kesteren Henricus
- Van Zyl Louis
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhecke Thomas
- Varin Claire
- Vasallo Javier
- Vasilev Ivaylo
- Vasilyeva Larysa
- Vaz Garth
- Vazquez Eduardo Salcido
- Vega Mario
- Velikov Chavdar
- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo Nuñez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu OlgaâCristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- WozakowskaâKaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICâHF) trial. Here we describe the baseline characteristics of participants in GALACTICâHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ââ„âII, EF â€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticâguided dosing: 25, 37.5 or 50âmg bid). 8256 patients [male (79%), nonâwhite (22%), mean age 65âyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTâproBNP 1971âpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICâHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureâ<â100âmmHg (n = 1127), estimated glomerular filtration rate <â30âmL/min/1.73 m2 (n = 528), and treated with sacubitrilâvalsartan at baseline (n = 1594).
Conclusions:
GALACTICâHF enrolled a wellâtreated, highârisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
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