Extended star formation history of the star cluster NGC 2154 in the Large Magellanic Cloud

The colour-magnitude diagram (CMD) of the intermediate-age Large Magellanic Cloud star cluster NGC 2154 and its adjacent field has been analysed using Padova stellar models to determine the cluster´s fundamental parameters and its star formation history. Deep BR CCD photometry, together with synthetic CMDs and integrated luminosity functions, has allowed us to infer that the cluster experienced an extended star formation period of about 1.2 Gyr, which began approximately 2.3 Gyr ago and ended 1.1 Gyr ago. However, the physical reality of such a prolonged period of star formation is questionable, and could be the result of inadequacies in the stellar evolutionary tracks themselves. A substantial fraction of binaries (70 per cent) seems to exist in NGC 2154.Fil: Baume, Gustavo Luis. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Carraro, Giovanni. Università di Padova; ItaliaFil: Costa, E.. Universidad de Chile; ChileFil: Mendez, R. A.. Universidad de Chile; ChileFil: Girardi, L.. Osservatorio Astronomico di Padova; Itali

Prospective Minority Students\u27 Perceptions of Application Packets for Professional Psychology Programs: A Qualitative Study

This article reports the results of a qualitative study designed to determine issues salient in Black and Hispanic American students\u27 review and evaluation of program-application packets in professional psychology. The study served as an extension to the Yoshida et al. (1989) quantitative investigation. Students interested in pursuing doctoral studies in counseling or school psychology (N = 22) served as the sample. The qualitative methodology incorporated a think-aloud procedure and semistructured interviews. A theme analysis of transcribed interviews identified both major and minor themes central to participants\u27 evaluation of the packets. Major themes included financial aid, program requirements and course descriptions, demography of the student body, and the quality and clarity of application material. Specific suggestions on developing an application packet to send to inquiring prospective students are put forth. It is recommended that such a packet could serve as a cost-effective minority-recruitment strategy

Minority Student Perceptions of Professional Pscyhology Application Packets: A Qualitative Study

This article reports the results of a qualitative study designed to determine issues salient in Black and Hispanic American students\u27 review and evaluation of program-application packets in professional psychology. The study served as an extension to the Yoshida et al. (1989) quantitative investigation. Students interested in pursuing doctoral studies in counseling or school psychology (N = 22) served as the sample. The qualitative methodology incorporated a think-aloud procedure and semistructured interviews. A theme analysis of transcribed interviews identified both major and minor themes central to participants\u27 evaluation of the packets. Major themes included financial aid, program requirements and course descriptions, demography of the student body, and the quality and clarity of application material. Specific suggestions on developing an application packet to send to inquiring prospective students are put forth. It is recommended that such a packet could serve as a costeffective minority-recruitment strategy

Competencias digitales en la calidad de atención a los usuarios en una sala superior judicial de Lima, 2023

La investigación tuvo el propósito de determinar la incidencia de las competencias digitales en la calidad de atención a los usuarios judiciales en una sala superior judicial de Lima, 2023. Para el desarrollo se siguió la metodología cuantitativa, de tipología básica, con un alcance correlacional-causal, diseño no experimental - transversal; además, su población fue 79 colaboradores de donde se extrajo una muestra de 79 sujetos a quienes se aplicó la encuesta. Los hallazgos demostraron que existe una incidencia de P-Seudo R cuadrado 44.1 entre las variables con un nivel de significancia de 0.000, lo que significa que al contar con buenas competencias digitales genera mejores resultados en la calidad de la atención a los usuarios. Así también, se estableció positiva relación entre la dimensión personal, profesionalismo y privacidad, teniendo un índice de incidencia de 46.5%, 26.5% y 28.6% respectivamente entre las variables. Se concluyó que poseer buenas competencias digitales permite tener un cambio en la gestión de las instituciones al servir como apoyo para el desarrollo de las actividades propiciando un servicio más eficiente y centrado viéndose reflejado en la calidad de atención a los usuarios

The open cluster NGC 6520 and the nearby dark molecular cloud Barnard 86

Wide field BVI photometry and $^{12}$CO(1$\to$0) observations are presen ted in the region of the open cluster NGC 6520 and the dark molecular cloud Barnard~86. From the analysis of the optical data we find that the cluster is rather compact, with a radius of 1.0$\pm$0.5 arcmin, smaller than previous estimates. The cluster age is 150$\pm$50 Myr and the reddening E$_{B-V}$=0.42$\pm$0.10. The distance from the Sun is estimated to be 1900$\pm$100 pc, and it is larger than previous estimates. We finally derive basic properties of the dark nebula Barnard 86 on the assumption that it lies at the same distance of the cluster.Comment: 21 pages, 8 eps figures (a few degraded in resolution), accepted for publication in the Astronomical Journa

TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics

Microproteínas; Diferenciación neural; Formación de neuritasMicroproteïnes; Diferenciació neural; Formació de neuritesMicroproteins; Neural differentiation; Neurite formationLong noncoding RNAs (lncRNAs) are regulatory molecules which have been traditionally considered as “non-coding”. Strikingly, recent evidence has demonstrated that many non-coding regions, including lncRNAs, do in fact contain small-open reading frames that code for small proteins that have been called microproteins. Only a few of them have been characterized so far, but they display key functions in a wide variety of cellular processes. Here, we show that TUNAR lncRNA encodes an evolutionarily conserved microprotein expressed in the nervous system that we have named pTUNAR. pTUNAR deficiency in mouse embryonic stem cells improves their differentiation potential towards neural lineage both in vitro and in vivo. Conversely, pTUNAR overexpression impairs neuronal differentiation by reduced neurite formation in different model systems. At the subcellular level, pTUNAR is a transmembrane protein that localizes in the endoplasmic reticulum and interacts with the calcium transporter SERCA2. pTUNAR overexpression reduces cytoplasmatic calcium, consistent with a possible role of pTUNAR as an activator of SERCA2. Altogether, our results suggest that our newly discovered microprotein has an important role in neural differentiation and neurite formation through the regulation of intracellular calcium. From a more general point of view, our results provide a proof of concept of the role of lncRNAs-encoded microproteins in neural differentiation.Work in the Abad lab is supported by VHIO, Fero Foundation, La Caixa Foundation (HR18-00256), Asociación Española Contra el Cancer (AECC), Cellex Foundation, Mutua Madrileña Foundation and by grants from the Spanish Ministry of Science and Innovation (SAF2015-69413-R; RTI2018-102046-B-I00). M.A. was recipient of a Ramon y Cajal contract from the Spanish Ministry of Science and Innovation (RYC-2013-14747). E.S. was recipient of a AECC Postdoctoral Fellowship. L.H-M. also acknowledges funding from grants SAF2017-88019-C3-1R y PID2020-116927RB-C21 from the Spanish Government. MG is supported by the advanced ERC grant NeuroCentro and the German Research Foundation (SFB870; SPP2202; SPP2306; SYNERGY; TRR274). DT is supported by the Ramón y Cajal program (RYC-2017-23486/RTI2018-095580-A-I00). MMA acknowledges funding from the Spanish Ministry of Science and Innovation PGC2018-094091-B-I00 co-funded by FEDER

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

The multifactorial nature of Alzheimer’s disease calls for the development of multitarget agents addressing key pathogenic processes. To this end, by following a docking-assisted hybridization strategy, a number of aminocoumarins were designed, prepared, and tested as monoamine oxidases (MAOs) and acetyl- and butyryl-cholinesterase (AChE and BChE) inhibitors. Highly flexible N-benzyl-N-alkyloxy coumarins 2–12 showed good inhibitory activities at MAO-B, AChE, and BChE but low selectivity. More rigid inhibitors, bearing meta- and para-xylyl linkers, displayed good inhibitory activities and high MAO-B selectivity. Compounds 21, 24, 37, and 39, the last two featuring an improved hydrophilic/lipophilic balance, exhibited excellent activity profiles with nanomolar inhibitory potency toward hMAO-B, high hMAO-B over hMAO-A selectivity and submicromolar potency at hAChE. Cell-based assays of BBB permeation, neurotoxicity, and neuroprotection supported the potential of compound 37 as a BBB-permeant neuroprotective agent against H2O2-induced oxidative stress with poor interaction as P-gp substrate and very low cytotoxicity

Plan de responsabilidad social empresarial Constructora parque Santa María S.A.

Con la implementación de la Responsabilidad Social Empresarial las empresas están contando con mayor carácter social, al ser más responsable socialmente y por ende implicarse en los problemas económicos y sociales de los lugares donde operan y procurando el cumplimiento de las expectativas de las partes interesadas que participan en los proceso Para Constructora Parque Santa Maria S.A la RSE se ha convertido en uno de los pilares más importantes de la compañía debido a que a través de esta se está asegurando el cumplimiento de los objetivos planteados en el desarrollo de cada uno de nuestros proyectos e impactando positivamente en el entorno.With the implementation of Corporate Social Responsibility, companies are counting on a greater social character, being more socially responsible and consequently involved in the economic and social problems of the places where they operate and seeking compliance with the expectations of the stakeholders involved. in the process Constructora Parque Santa Maria SA, the Corporate Social Responsibility has become one of the most important pillars of the company because through this it is ensuring compliance with the objectives set in the development of each of our projects and positively impacting the environment

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation

Cancer; Mechanisms of diseaseCàncer; Mecanismes de la malaltiaCáncer; Mecanismos de la enfermedadThe human transcriptome contains thousands of small open reading frames (sORFs) that encode microproteins whose functions remain largely unexplored. Here, we show that TINCR lncRNA encodes pTINCR, an evolutionary conserved ubiquitin-like protein (UBL) expressed in many epithelia and upregulated upon differentiation and under cellular stress. By gain- and loss-of-function studies, we demonstrate that pTINCR is a key inducer of epithelial differentiation in vitro and in vivo. Interestingly, low expression of TINCR associates with worse prognosis in several epithelial cancers, and pTINCR overexpression reduces malignancy in patient-derived xenografts. At the molecular level, pTINCR binds to SUMO through its SUMO interacting motif (SIM) and to CDC42, a Rho-GTPase critical for actin cytoskeleton remodeling and epithelial differentiation. Moreover, pTINCR increases CDC42 SUMOylation and promotes its activation, triggering a pro-differentiation cascade. Our findings suggest that the microproteome is a source of new regulators of cell identity relevant for cancer.Work in the Abad lab is supported by VHIO, Fero Foundation, La Caixa Foundation, Asociación Española Contra el Cancer (AECC), La Mutua Foundation and by grants from the Spanish Ministry of Science and Innovation (SAF2015-69413-R; RTI2018-102046-B-I00). M.A. was recipient of a Ramón y Cajal contract from the Spanish Ministry of Science and Innovation (RYC-2013-14747). O.B. is recipient of a FPI-AGAUR fellowship from Generalitat de Catalunya. We also acknowledge funding from grant PGC2018-094091-B-I00 from the Spanish Government

Acute acalculous cholecystitis during the course of primary Epstein-Barr virus infection: a new case and a review of the literature

OBJECTIVE: The aim of this study was to describe a case of acute acalculous cholecystitis occurring in the course of primary Epstein-Barr virus (EBV) infection. METHODS: The clinical features of the case were analyzed and compared to those of three other similar cases reported in the international literature. RESULTS: All cases occurred in European females with cholestatic hepatitis, presented with gallbladder wall thickening, and recovered uneventfully without the need for surgical intervention. CONCLUSIONS: Acute acalculous cholecystitis may occur during the course of acute EBV infection, especially in patients with cholestatic hepatitis. Clinicians should be aware of the possible involvement of the gallbladder during EBV infection to avoid unnecessary invasive procedures or the overuse of antibiotics