A fundamental problem in our understanding of low-mass galaxy evolution

Recent studies have found a dramatic difference between the observed number density evolution of low-mass galaxies and that predicted by semi-analytic models. Whilst models accurately reproduce the z= 0 number density, they require that the evolution occurs rapidly at early times, which is incompatible with the strong late evolution found in observational results. We report here the same discrepancy in two state-of-the-art cosmological hydrodynamical simulations, which is evidence that the problem is fundamental. We search for the underlying cause of this problem using two complementary methods. First, we consider a narrow range in stellar mass of log (Mstar/(h−2M_)) = 9–9.5 and look for evidence of a different history of today’s low-mass galaxies in models and observations. We find that the exclusion of satellite galaxies from the analysis brings the median ages and star formation rates of galaxies into reasonable agreement. However, the models yield too few young, strongly star-forming galaxies. Secondly, we construct a toy model to link the observed evolution of specific star formation rates with the evolution of the galaxy stellar mass function. We infer from this model that a key problem in both semi-analytic and hydrodynamical models is the presence of a positive instead of a negative correlation between specific star formation rate and stellar mass. A similar positive correlation is found between the specific dark matter halo accretion rate and the halo mass, indicating that model galaxies are growing in a way that follows the growth of their host haloes too closely. It therefore appears necessary to find a mechanism that decouples the growth of low-mass galaxies, which occurs primarily at late times, from the growth of their host haloes, which occurs primarily at early times. We argue that the current form of star formation-driven feedback implemented in most galaxy formation models is unlikely to achieve this goal, owing to its fundamental dependence on host halo mass and time

A unified model for age-velocity dispersion relations in Local Group galaxies: Disentangling ISM turbulence and latent dynamical heating

We analyze age-velocity dispersion relations (AVRs) from kinematics of individual stars in eight Local Group galaxies ranging in mass from Carina ($M_{*} \sim 10^{6}$) to M31 ($M_{*} \sim 10^{11}$). Observationally the $\sigma$ vs. stellar age trends can be interpreted as dynamical heating of the stars by GMCs, bars/spiral arms, or merging subhalos; alternatively the stars could have simply been born out of a more turbulent ISM at high redshift and retain that larger velocity dispersion till present day - consistent with recent IFU studies. To ascertain the dominant mechanism and better understand the impact of instabilities and feedback, we develop models based on observed SFHs of these Local Group galaxies in order to create an evolutionary formalism which describes the ISM velocity dispersion due to a galaxy's evolving gas fraction. These empirical models relax the common assumption that the stars are born from gas which has constant velocity dispersion at all redshifts. Using only the observed SFHs as input, the ISM velocity dispersion and a mid-plane scattering model fits the observed AVRs of low mass galaxies without fine tuning. Higher mass galaxies above $M_{vir} > 10^{11}$ need a larger contribution from latent dynamical heating processes (for example minor mergers), in excess of the ISM model. Using the SFHs we also find that supernovae feedback does not appear to be a dominant driver of the gas velocity dispersion compared to gravitational instabilities - at least for dispersions $\sigma \gtrsim 25$ km/s. Together our results point to stars being born with a velocity dispersion close to that of the gas at the time of their formation, with latent dynamical heating operating with a galaxy mass-dependent efficiency. These semi-empirical relations may help constrain the efficiency of feedback and its impact on the physics of disk settling in galaxy formation simulations

A Small Conductance Calcium-Activated K⁺ Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying

In the nervous system of mice, small conductance calcium-activated potassium (SK) channels function to regulate neuronal excitability through the generation of a component of the medium afterhyperpolarization that follows action potentials. In humans, irregular action potential firing frequency underlies diseases such as ataxia, epilepsy, schizophrenia and Parkinson's disease. Due to the complexity of studying protein function in the mammalian nervous system, we sought to characterize an SK channel homologue, KCNL-2, in C. elegans, a genetically tractable system in which the lineage of individual neurons was mapped from their early developmental stages. Sequence analysis of the KCNL-2 protein reveals that the six transmembrane domains, the potassium-selective pore and the calmodulin binding domain are highly conserved with the mammalian homologues. We used widefield and confocal fluorescent imaging to show that a fusion construct of KCNL-2 with GFP in transgenic lines is expressed in the nervous system of C. elegans. We also show that a KCNL-2 null strain, kcnl-2(tm1885), demonstrates a mild egg-laying defective phenotype, a phenotype that is rescued in a KCNL-2-dependent manner. Conversely, we show that transgenic lines that overexpress KCNL-2 demonstrate a hyperactive egg-laying phenotype. In this study, we show that the vulva of transgenic hermaphrodites is highly innervated by neuronal processes and by the VC4 and VC5 neurons that express GFP-tagged KCNL-2. We propose that KCNL-2 functions in the nervous system of C. elegans to regulate the rate of egg-laying. © 2013 Chotoo et al

Cosmological evolution of metallicity correlation functions from the Auriga simulations

We study the cosmological evolution of the two-point correlation functions of galactic gas-phase metal distributions using the 28 simulated galaxies from the Auriga Project. Using mock observations of the z = 0 snapshots to mimic our past work, we show that the correlation functions of the simulated mock observations are well matched to the correlation functions measured from local galaxy surv e ys. This comparison suggests that the simulations capture the processes important for determining metal correlation lengths, the key parameter in metallicity correlation functions. We investigate the evolution of metallicity correlations o v er cosmic time using the true simulation data, showing that individual galaxies undergo no significant systematic evolution in their metal correlation functions from z ∼3 to today. In addition, the fluctuations in metal correlation length are correlated with but lag ahead fluctuations in star formation rate. This suggests that re-arrangement of metals within galaxies occurs at a higher cadence than star formation activity, and is more sensitive to the changes of environment, such as g alaxy mergers, g as inflo ws/outflo ws, and fly-bys

Transcriptional Regulation of N-Acetylglutamate Synthase

The urea cycle converts toxic ammonia to urea within the liver of mammals. At least 6 enzymes are required for ureagenesis, which correlates with dietary protein intake. The transcription of urea cycle genes is, at least in part, regulated by glucocorticoid and glucagon hormone signaling pathways. N-acetylglutamate synthase (NAGS) produces a unique cofactor, N-acetylglutamate (NAG), that is essential for the catalytic function of the first and rate-limiting enzyme of ureagenesis, carbamyl phosphate synthetase 1 (CPS1). However, despite the important role of NAGS in ammonia removal, little is known about the mechanisms of its regulation. We identified two regions of high conservation upstream of the translation start of the NAGS gene. Reporter assays confirmed that these regions represent promoter and enhancer and that the enhancer is tissue specific. Within the promoter, we identified multiple transcription start sites that differed between liver and small intestine. Several transcription factor binding motifs were conserved within the promoter and enhancer regions while a TATA-box motif was absent. DNA-protein pull-down assays and chromatin immunoprecipitation confirmed binding of Sp1 and CREB, but not C/EBP in the promoter and HNF-1 and NF-Y, but not SMAD3 or AP-2 in the enhancer. The functional importance of these motifs was demonstrated by decreased transcription of reporter constructs following mutagenesis of each motif. The presented data strongly suggest that Sp1, CREB, HNF-1, and NF-Y, that are known to be responsive to hormones and diet, regulate NAGS transcription. This provides molecular mechanism of regulation of ureagenesis in response to hormonal and dietary changes

Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort

Women with systemic lupus erythematosus (SLE) carry a substantially higher risk for preeclampsia compared to the general population [1]. Aspirin reduces the risk of preeclampsia in high-risk pregnancies by more than half [2] and thus is recommended in SLE [3-5]. The European League Against Rheumatism highlights the need for aspirin in SLE pregnancies, particularly in those with nephritis or positive antiphospholipid antibodies (aPL) [5]. Despite this, little is known about current practice. Therefore, we assessed the prevalence of aspirin use in SLE pregnancies within the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, which has been described elsewhere

ISSN exercise & sport nutrition review: research & recommendations

Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone