Эффективность и переносимость тербиназина пациентами с онихомикозом

Catedra Farmacologie şi Farmacie Clinică, USMF „Nicolae Testemiţanu”, Dispensarul Municipal Dermatovenerologic, Compania Universal-FarmThe study presents the results of a study of the efficacy and tolerance of Terbinazine on 40 patients with onychomycosis. Given the high percentage of clinical and mycological success in the treatment of dermatophytic onycomycosis with Terbinazine, the increased compliance of the patient, and its very low risk, make Terbinazine the first option in treating dermatophytic onychomycosis.Авторами представлены результаты эффективности и переносимости тербизина. Исследование проведено на 40 больных с онихомикозом. Отмечено, что тербиназин, наряду с высоким клиническим эффектом, легко переносится больными. Полученные авторами результаты свидетельствуют о том, что тербиназин является препаратом выбора в лечении дерматофитных онихомикозов

An alarm signal for the medical world addressed from the pathological anatomy service in the Republic of Moldova

Department of Morphopathology, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova, Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, RomaniaBackground: Maintaining the quality and safety of pathology services is crucial for the efficient delivery of health care. However, pathology is, perhaps, the least understood of the medical specialties. In particular, the scope of pathology and the integral role it plays in all areas of medicine are not well recognized even by some of those working in health care environments. Strategic partnerships have as the main goal the enlargement of collaborative research and partnership on national and international level, mainly, but not exclusively in European Research Area. There is a perceived need for improved management practices, use of new technologies, and increased use of some categories of the personnel. Issues with the employment program were mentioned, including tracking, matching people to jobs, training, and finding more opportunities. There was a call for greater visibility in the community (both medical and scientific). The problems facing pathology teaching and pathology teachers mirror those of most other medical disciplines, namely a lack of time and money, and competing pressures from many other sources. Conclusion: There is the danger of producing doctors who cannot explain disease to their patients, who abuse laboratories and who have no interest in pursuing pathology as a career, leading to a slow and possibly irreversible decline in pathology as a medical profession

Heteronuclear {TbxEu1-x} furoate 1D polymers presenting luminiscent properties and SMM behavior

We report the synthesis, crystal structure and photo-magnetic properties of novel Tb/Eu polymeric complexes of general formula {TbxEu1−x(α-fur)3(H2O)3}n, supported by 2-furancarboxilic acid: the homonuclear Tb(III) complex {Tb} (1), four heterodinuclear complexes, {Tb0.8Eu0.2} (2), {Tb0.7Eu0.3} (3), {Tb0.3Eu0.7} (4), and {Tb0.1Eu0.9} (5), and the homonuclear Eu(III)-only complex {Eu} (6). X-ray diffraction experiments show that the α-furoate ligands, acting in bridging mode, consolidate the 1D polymeric chains along the c-axis. Luminescence studies show the sensitization capability of the furoic acid ligand. Color tuning from green to red can be successfully achieved through the heterodinuclear strategy. We have measured Eu emission by direct excitation at the resonant 7F0 → 5L6 (395 nm), and indirectly, by excitation of the non-resonant wavelength (280 nm) which provokes ligand → Tb → Eu energy transfer. Besides, ac susceptibility measurements under varying frequencies and temperatures reveal that mixed {TbxEu1−x} complexes exhibit field-induced slow relaxation dynamics, with extremely slow relaxation times, owing to direct processes affected by the bottleneck effect. Thus, the {TbxEu1−x} complexes represent interesting low-dimensional multifunctional materials combining both luminescent and SMM magnetic properties

Heteronuclear {TbxEu1-x} furoate 1D polymers presenting luminescent properties and SMM behavior

We report the synthesis, crystal structure and photo-magnetic properties of novel Tb/Eu polymeric complexes of general formula {TbxEu1-x(a-fur)3(H2O)3}n, supported by 2-furancarboxilic acid: the homonuclear Tb(iii) complex {Tb} (1), four heterodinuclear complexes, {Tb0.8Eu0.2} (2), {Tb0.7Eu0.3} (3), {Tb0.3Eu0.7} (4), and {Tb0.1Eu0.9} (5), and the homonuclear Eu(iii)-only complex {Eu} (6). X-ray diffraction experiments show that the a-furoate ligands, acting in bridging mode, consolidate the 1D polymeric chains along the c-axis. Luminescence studies show the sensitization capability of the furoic acid ligand. Color tuning from green to red can be successfully achieved through the heterodinuclear strategy. We have measured Eu emission by direct excitation at the resonant 7F0 ¿ 5L6 (395 nm), and indirectly, by excitation of the non-resonant wavelength (280 nm) which provokes ligand ¿ Tb ¿ Eu energy transfer. Besides, ac susceptibility measurements under varying frequencies and temperatures reveal that mixed {TbxEu1-x} complexes exhibit field-induced slow relaxation dynamics, with extremely slow relaxation times, owing to direct processes affected by the bottleneck effect. Thus, the {TbxEu1-x} complexes represent interesting low-dimensional multifunctional materials combining both luminescent and SMM magnetic properties

Heteronuclear {TbxEu1−x} furoate 1D polymers presenting luminescent properties and SMM behavior

We report the synthesis, crystal structure and photo-magnetic properties of novel Tb/Eu polymeric complexes of general formula {TbxEu1−x(α-fur)3(H2O)3}n, supported by 2-furancarboxilic acid: the homonuclear Tb(III) complex {Tb} (1), four heterodinuclear complexes, {Tb0.8Eu0.2} (2), {Tb0.7Eu0.3} (3), {Tb0.3Eu0.7} (4), and {Tb0.1Eu0.9} (5), and the homonuclear Eu(III)-only complex {Eu} (6). X-ray diffraction experiments show that the α-furoate ligands, acting in bridging mode, consolidate the 1D polymeric chains along the c-axis. Luminescence studies show the sensitization capability of the furoic acid ligand. Color tuning from green to red can be successfully achieved through the heterodinuclear strategy. We have measured Eu emission by direct excitation at the resonant 7F0 → 5L6 (395 nm), and indirectly, by excitation of the non-resonant wavelength (280 nm) which provokes ligand → Tb → Eu energy transfer. Besides, ac susceptibility measurements under varying frequencies and temperatures reveal that mixed {TbxEu1−x} complexes exhibit field-induced slow relaxation dynamics, with extremely slow relaxation times, owing to direct processes affected by the bottleneck effect. Thus, the {TbxEu1−x} complexes represent interesting low-dimensional multifunctional materials combining both luminescent and SMM magnetic properties

Antiferromagnetic single-chain magnet slow relaxation in the {Tb(α-fur)3}n polymer with non-Kramers ions

We report the synthesis, crystal structure and magnetic properties of a new molecular complex based on a Tb(iii) ion supported by 2-furancarboxylic molecules: {Tb(α-fur)(HO)} (α-fur = CHOCOO). Two slightly different Tb sites (A and B) exist depending on the position of one of the dangling ligands. Ab initio calculations predict that, for both sites, the magnetic ground state is highly anisotropic (g∗ = 17.8) and consists of a quasi-doublet with a small gap, well isolated from the next excited state. The α-fur ligand forms 1D polymeric chains of Tb ions of the same type (either A or B) running along the c-axis. The crystal structure is formed by the supramolecular stacking along the a-axis of 2D layers containing parallel chains of the same type. Static magnetization and heat capacity measurements show that, magnetically, the system can be modeled as an ensemble of Ising chains of non-Kramers Tb ions with effective spin S∗ = 1/2, antiferromagnetically (AF) coupled by a weak intrachain interaction (J∗/k = -0.135 K). At very low temperatures, the static susceptibility reflects the presence of a 2-4% concentration of defects in the chains. Ac susceptibility measurements at H = 0 performed down to mK temperatures have enabled us to observe the slow relaxation of magnetization through two different pathways. They are assigned to Single-Chain-Magnet (SCM) behavior in two different types of AF chains (A and B), triggered by the existence of defects breaking the chains into segments with short-range order. At temperatures below 0.1 K this mechanism is replaced by individual relaxation of the ions through direct processes. Under the application of a magnetic field the system slowly relaxes by two distinct direct processes, strongly affected by a phonon bottleneck effect.This work has been financed by MECOM Projects MAT11/23791 and MAT11/27233-C02-02, MAT2015-68204-R, MAT2014-53921-R, DGA IMANA E34 and MOLCHIP E98 Projects. Consolider Nanoselect (CSD2007-00041) and by a grant of the Ministry of National Education, CNCS – UEFISCDI, project number PN-II-ID-PCE-2012-4-0261. D. P. thanks the Alexander von Humboldt (AvH) Foundation for financial support.Peer Reviewe

Treatment pecularities of the spleen injuries in politraumas

Clinica Chirurgie N1 “N. Anestiadi”, Laboratorul ”Chirurgie Hepato-Pancreato-Biliară, USMF „N. Testemițanu”, Chișinău, Republica Moldova, Al XI-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova și cea de-a XXXIII-a Reuniune a Chirurgilor din Moldova „Iacomi-Răzeșu” 27-30 septembrie 2011Actualitatea temei. Dilema tratamentului chirurgical în leziunile splinei în condiții de politraumă constă în necesitatea efectuării unei hemostaze sigure care deseori se asigură numai prin splenectomie, iar pentru profilaxia complicațiilor postoperatorii situația dictează efectuarea unei operații organomenajante.Scopul lucrării: Implementarea operațiilor organomenajante pe splină în condiții de politraumă. Material şi metode: Au fost supuşi studiului 155 pacienți politraumatizați cu leziuni ale splinei. Tactica medico-chirurgicală de tratament a fost următoarea: splenectomie 122 (78,71%), tratament non-operator 2 (1,29%), aplicarea TachoCombului – 5 (3,23%) suturare+TachoComb+omentopexie 3 (1,93%), suturare + TachoComb – 7 (4,52%), omentopexie – 5 (3,22%), splenorafie 11 (7,1%). Atitudinea organomenajantă a fost efectuată la pacienții hemodinamic stabili sau stabilizați cu leziune anatomica ce corespunde gradului I–III (American Assosiation for the Surgery of Trauma) în lipsa patologiei splinei şi a coagulopatiei. Repartizaerea pacienților care au beneficiat de tratament organomenajant conform gradelor leziunii splinei : grad I–6, II– 15, III–12. Rezultate: În condiții de politraumă prezervarea splinei s-a obținut în 21,29 %. Complicații hemoragice postoperatorii n-am avut. Mortalitatea în lotul de studiu a constituit 35 (22,58%). Cauzele deceselor au fost: traumatismul asociat sever (14), şocul hipovolemic ireversibil (5), sindromul CID (2), insuficiența poliorganică (11), complicații septice postoperatorii (3). Concluzii: Posibilitatea efectuării operațiilor organomenajante pe splină în condiții de politraumă se estimează la ~ 20 % şi se aplică în leziunile ce corespund gradelor I–III (American Assosiation for the Surgery of Trauma).Introduction: The dilemma of the surgical treatment with the spleen injuries in politraumas necessities a proper homeostasis which is made by a splenectomy and for the prophylaxis of the postoperative complications a save-organ operation should be made. Aim: Save-organ operations usage in politraumas. Material and methods: 155 patients with politraumas were studied. The following medico-surgical strategy was used: splenectomy – 122 (78,71%), non-operative treatment – 2 (1,29%), TachoComb application – 5 (3,23%), spleenoraphy +TachoComb+omentopexy – 3 (1,93%), spleenoraphy+TachoComb – 7 (4,52%), omentopexy – 5 (3,22%), splenoraphy – 11 (7,1%). Save–organ method was applied on the hemodynamic steady patients or established by anatomical lesion of the 3rd grade (American Association for the Surgery of Trauma) in conditions of the spleen pathology and coagolapathy lack. The classification of the patients which were treated according to the save-organ method according to the grades of the spleen lesions: I–6, II–15, III–12.Results: In conditions of politraumas the preserving of the spleen was possible 21,29 %. Postoperative hemorrhagic complications were absent. Mortality – 35 cases (22,58%). The death reasons: associate severe trauma (14), irreversible hypovelmic shock (5), CID (2), multiorgan failure (11), postoperative septic complications (3).Conclusions: The possibility of the save-organ operations on the spleen in politraumas constitutes ~20%, and must be applied on the injuries of I–III grades (American Assosiation for the Surgery of Trauma)

Rolul căpuşelor Ixodes ricinus (Ixodidae) în menţinerea riscului de contractare a borreliozei Lyme în ecosistemele Republicii Moldova

National Centre for Public Health, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaIntroducere. Borrelioza Lyme (BL) reprezintă o zooantroponoză cu tendinţă clinică de cronicizare, cauzată de Borrelia burgdorferi şi transmisă de căpuşele din genul Ixodes (familia Ixodidae Murray, 1887). Ixodidele se alimentează cu sânge în unele faze biologice de dezvoltare (larve, nimfe şi imago). Larvele şi nimfele se alimentează cu sânge, în special, pe mamifere mici (Rodentia, Insectivora), păsări şi reptile, cele adulte (imago) – pe mamifere sălbatice (căprioare), domestice (bovine, ovine, caprine) şi de campanie (pisici, câini). Omul neprotejat, nimerind în arealul ixodidelor poate fi „muşcat”, inclusiv şi de căpuşe infectate. Primele date despre existenţa focarelor de BL în Republica Moldova au fost publicate în anii 1990-1992. Însă la acel moment BL nu era inclusă în lista maladiilor raportabile în sistemul de supraveghere al bolilor infecţioase în Republica Moldova. Înregistrarea oficială a cazurilor de BL în Republica Moldova a început în anul 2000. Raportarea standardizată în sistemul naţional de supraveghere în baza definiţiei de caz «suspect», «probabil» şi «confirmat», inclusiv a criteriilor de laborator se realizează din 2007 şi continuă până în prezent. Material şi metode Ca material de studiu au servit căpuşele ixodide, colectate în perioada anilor 2009-2011, în conformitate cu metodele standard, din teritorii selectate pentru monitorizare. De pe vegetaţie s-au colectat 1 056 de exemplare căpuşe ixodide şi 1 169 de ex. de pe ovine, bovine şi caprine, fiind analizate diversitatea şi densitatea speciilor în cauză. Pentru determinarea nivelului de infectare cu borrelii au fost investigate 437 de ex. căpuşe ixodide, cercetând hemolimfa şi conţinutul intestinului prin microscopia frotiurilor cu fond negru, în conformitate cu indicaţiile metodice. Rezultatele obţinute au fost supuse unui calcul statistic, acceptat prin intermediul programului de calculator EXCEL. Rezultate obţinute Au fost identificate speciile de păşune Ixodes ricinus, Dermacentor marginatus, D.reticulatus, Haemaphysalis inermis şi H.punctata. Datorită caracteristicilor vitale de acomodare în mediul înconjurător, specia I.ricinus a fost identificată în toate cele trei zone geografice ale ţării. Indicele densităţii medii a speciei I.ricinus în perioada anilor de studiu a fost ~ de 21 de ex. la ruta standard 200 m. Pentru determinarea prezenţei borreliilor în căpuşe s-au investigat speciile I.ricinus şi D.marginatus. Prezenţa borreliilor s-a depistat la 17,9% căpuşe investigate în anul 2009, la 36,4% în anul 2010 şi 28,5% în 2011. Prezenţa borreliilor a fost determinată doar la specia I.ricinus. În condiţiile, când populaţia frecventează zonele de odihnă şi agrement, biotopuri de pădure şi agrocenoze, care sunt intens populate de căpuşele speciei I.ricinus, cu o pondere înaltă de infectare cu borrelii, nu respectă regulile comportamentale şi de protecţie contra „muşcăturilor” de căpuşe, contractarea borreliozei Lyme devine iminentă. În ultimii ani numărul îmbolnăvirilor prin borrelioza Lyme este în creştere (anii 2009 – 33 cazuri, 2010 – 117, 2011 – 171). În anul 2011 boala s-a înregistrat în 15 teritorii administrative, preponderent în mun. Chişinău (70,1%), în rândul populaţiei mature (84,2%), în lunile mai-octombrie (89,4%). Depistarea borreliozei Lyme are loc în rândul pacienţilor ce se adresează cu „muşcătură” de căpuşă, acuză prezenţa eritemului migrator la locul „muşcăturii”, unele afecţiuni ale sistemelor nervos, cardio-vascular, musculo-scheletal. Raportarea cazurilor de BL se efectuează de către medicul de familie şi alţi specialişti ce au depistat boala, în baza definiţiilor de caz «suspect», «probabil» sau «confirmat». Confirmarea de laborator al diagnosticului clinic include determinarea anticorpilor specifici IgM sau IgG către B.burgdorferi în serul sangvin sau LCR în reacţia imunoenzimatică (ELISA) sau reacţia imunofluorescentă indirectă (RIFi), urmate de confirmarea prin Western blot. Detectarea ADN-ului genospeciilor patogene de B.burgdorferi se efectuează prin reacţia de polimerizare în lanţ (PCR). Cazurile de boală sunt furnizate în sistemul electronic de supraveghere a bolilor transmisibile şi se efectuează anchetarea epidemiologică pentru identificarea circumstanţelor de molipsire şi implementarea măsurilor de răspuns. Concluzii Căpuşele din specia I. Ricinus, contaminate cu borrelii patogene menţin riscul de molipsire prin borrelioză Lyme. Gradul de expunere la risc a populaţiei poate fi diferit şi este determinat atât de aflarea în arealul căpuşelor, densitatea acestora, circulaţia borreliilor patogene la căpuşe, cât şi respectarea regulilor comportamentale şi de protecţie individuală. Suspectarea precoce a cazului de BL, diagnosticarea corectă şi administrarea unui tratament eficace va diminua frecvenţa complicaţiilor posibile, iar raportarea calitativă în sistemul de supraveghere va permite implementarea măsurilor de sănătate publică pentru a diminua răspândirea cazurilor de BL

Peculiarities of directions and causal agents’ distribution of tick-borne encephalitis in the Republic of Moldova

The aim of the study is to determine the circulation of tick-borne encephalitis (TBE) causal agents in the Ixodidae ticks population and the evaluation of the TBE threat to public health. The species of ticks Ixodes ricinus, Dermacentor reticulatus, D. marginatus and Haemaphysalis punctata can be often met in the ecosystems of the Republic of Moldova. The species I. ricinus is the most numerous and widespread one, the fact that shows its high epidemiological significance. At the same time the species D. reticulatus, D. marginatus and H. punctata are the potential directions of TBE maintaining the TBE viruses in the environment. The laboratory results got by the enzyme-linked immunosorbent assay (ELISA) have indicated the TBE virus antigen in of 25.2% of the ticks, collected in the period of 2009-2012. Using the polymerase chain reaction method it has been established that on average the RNA of TBE virus has been 8.1% of all tested tick samples. The specific antibodies to tick-borne encephalitis virus have been identified in 9 (4%) tested human specimens. The rationalization of the system of epidemiological surveillance and control of tick-born encephalitis consists in developing and implementing a definition of the case for report on the basis of clinical and laboratory criteria, as well as the communication with epidemiological station, and studying to obtain standardized and comparable data

High relaxation barrier in neodymium furoate-based field-induced SMMs

Two new neodymium molecular magnets of formula {[Nd(α-fur)3(H2O)2]·DMF}n (1) and {[Nd0.065La0.935(α-fur)3(H2O)2]}n (2), α-fur = C4H3OCOO, have been synthesized. In (1) the furoate ligands, in bidentate bridging mode, consolidate zig-zag chains running along the a-direction. Compound (2) is a magnetically diluted complex of a polymeric chain along the b-axis. Heat capacity, dc magnetization and ac susceptibility measurements have been performed from 1.8 K up to room temperature. Ab initio calculations yielded the gyromagnetic factors gx* = 0.52, gy* = 1.03, gz* = 4.41 for (1) and gx* = 1.35, gy* = 1.98, gz* = 3.88 for (2), and predicted energy gaps of Δ/kB = 125.5 K (1) and Δ/kB = 58.8 K (2). Heat capacity and magnetometry measurements agree with these predictions, and confirm the non-negligible transversal anisotropy of the Kramers doublet ground state. A weak intrachain antiferromagnetic interaction J′/kB = −3.15 × 10−3 K was found for (1). No slow relaxation is observed at H = 0, attributed to the sizable transverse anisotropy component, and/or dipolar or exchange interactions enhancing the quantum tunnelling probability. Under an external applied field as small as 80 Oe, two slow relaxation processes appear: above 3 K the first relaxation mechanism is associated to a combination of Orbach process, with a sizeable activation energy U/kB = 121 K at 1.2 kOe for (1), Raman and direct processes; the second, slowest relaxation mechanism is associated to a direct process, affected by phonon-bottleneck effect. For complex (2) a smaller U/kB = 61 K at 1.2 kOe is found, together with larger g*-transversal terms, and the low-frequency process is quenched. The reported complexes represent rare polymeric Nd single-ion magnets exhibiting high activation energies among the scarce Nd(III) family