A sensitivity analysis on the springback behavior of the Unconstrained Bending Problem

Sheet metal forming software is commonly used in the automotive and sheet metal\ud sectors to support the design stage. However, the ability of the currently available software to\ud accurately predict springback is limited. A sensitivity analysis of the springback behavior of a\ud simple product is performed to gain more knowledge into the various factors contributing to the\ud predictability of springback. The sensitivity analysis comprises both numerical and physical\ud aspects and results are reported in this article

Mogen we nog kinderen krijgen?

Political Philosophy and Ethic

Justice Between Generations

Political Philosophy and Ethic

Firms and parental justice: should firms contribute to the cost of parenthood and procreation?

Political Philosophy and Ethic

Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study

Background Asthma exacerbations are frequently triggered by rhinovirus infections. Both asthma and respiratory tract infection can activate haemostasis. Therefore we hypothesized that experimental rhinovirus-16 infection and asthmatic airway inflammation act in synergy on the haemostatic balance. Methods 28 patients (14 patients with mild allergic asthma and 14 healthy non-allergic controls) were infected with low-dose rhinovirus type 16. Venous plasma and bronchoalveolar lavage fluid (BAL fluid) were obtained before and 6 days after infection to evaluate markers of coagulation activation, thrombin-antithrombin complexes, von Willebrand factor, plasmin-antiplasmin complexes, plasminogen activator inhibitor type-1, endogenous thrombin potential and tissue factor-exposing microparticles by fibrin generation test, in plasma and/or BAL fluid. Data were analysed by nonparametric tests (Wilcoxon, Mann Whitney and Spearman correlation). Results 13 patients with mild asthma (6 females, 19-29 y) and 11 healthy controls (10 females, 19-31 y) had a documented Rhinovirus-16 infection. Rhinovirus-16 challenge resulted in a shortening of the fibrin generation test in BAL fluid of asthma patients (t = -1: 706 s vs. t = 6: 498 s; p = 0.02), but not of controls (t = -1: 693 s vs. t = 6: 636 s; p = 0.65). The fold change in tissue factor-exposing microparticles in BAL fluid inversely correlated with the fold changes in eosinophil cationic protein and myeloperoxidase in BAL fluid after virus infection (r = -0.517 and -0.528 resp., both p = 0.01). Rhinovirus-16 challenge led to increased plasminogen activator inhibitor type-1 levels in plasma in patients with asthma (26.0 ng/mL vs. 11.5 ng/mL in healthy controls, p = 0.04). Rhinovirus-16 load in BAL showed a linear correlation with the fold change in endogenous thrombin potential, plasmin-antiplasmin complexes and plasminogen activator inhibitor type-1. Conclusions Experimental rhinovirus infection induces procoagulant changes in the airways of patients with asthma through increased activity of tissue factor-exposing microparticles. These microparticle-associated procoagulant changes are associated with both neutrophilic and eosinophilic inflammation. Systemic activation of haemostasis increases with Rhinoviral load

Equality, value pluralism and relevance: Is luck egalitarianism in one way good, but not all things considered?

Some luck egalitarians argue that justice is just one value among others and is thus not necessarily what we should strive for in order to make the world better. Yet, by focusing on only one dimension of what matters – luck equality – it proves very difficult to draw political implications in cases where several values are in tension. We believe that normative political philosophy must have the ambitionto guide political action. Hence, in this paper we make a negative and a positive point. Negatively, we argue that the inability to offer recommendations on what to strive for potentially weakens Kasper Lippert-Rasmussen’s account of luck egalitarianism. In order not to be irrelevant for political practice, a more serviceable version of luck egalitarianism that would allow for all-things-considered judgments is needed. Positively, we examine two possible routes toward such a view. One would be to stick to pluralism, but to discuss possible clashes and find a rule of regulation in each case. Another would consist in giving up value pluralism by identifying an over-arching value or principle that would arbitrate between different values. We suggest that Lippert-Rasmussen’s foundation of equality carries the potential for such an overarching principle.Political Philosophy and Ethic

The effects of enhanced sea ice export from the Ross Sea on recent cooling and freshening of the Southeast Pacific

The top 2000 m of the Southern Ocean has freshened and warmed over recent decades. However, the high-latitude (south of 50°S) southeast Pacific was observed to be cooler and fresher in the years 2008-2010 compared to 2005-2007 over a wide depth range including surface, mode, and intermediate waters. The causes and impacts of this event are analyzed using the ocean—sea-ice data-assimilating Southern Ocean State Estimate (SOSE) and observationally based products. In 2008-2010, a strong positive Southern Annular Mode coincided with a negative El Niño Southern Oscillation and a deep Amundsen Sea Low. Enhanced meridional winds drove strong sea ice export from the eastern Ross Sea, bringing large amounts of ice to the Amundsen Sea ice edge. In 2008, together with increased precipitation, this introduced a strong freshwater anomaly that was advected eastward by the Antarctic Circumpolar Current (ACC), mixing along the way. This anomaly entered the ocean interior not only as Antarctic Intermediate Water, but also as lighter Southeast Pacific Subantarctic Mode Water (SEPSAMW). A numerical particle release experiment carried out in SOSE , showed that the Ross Sea sector was the dominant source of particles reaching the SEPSAMW formation region. This suggests that large-scale climate fluctuations can induce strong interannual variability of volume and properties of SEPSAMW. These fluctuations act at different time scales: instantaneously via direct forcing, and also lagged over advective time scales of several years from upstream regions