CRL Ubiquitin Ligases and DNA Damage Response

Cullin/RING ubiquitin ligases (CRL) comprise the largest subfamily of ubiquitin ligases. CRLs are involved in cell cycle regulation, DNA replication, DNA damage response (DDR), development, immune response, transcriptional regulation, circadian rhythm, viral infection, and protein quality control. One of the main functions of CRLs is to regulate the DDR, a fundamental signaling cascade that maintains genome integrity. In this review, we will discuss the regulation of CRL ubiquitin ligases and their roles in control of the DDR

PHYTOTAXA

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Quantitative spectroscopic analysis of heterogeneous mixtures: the correction of multiplicative effects caused by variations in physical properties of samples

Spectral measurements of complex heterogeneous types of mixture samples are often affected by significant multiplicative effects resulting from light scattering, due to physical variations (e.g. particle size and shape, sample packing and sample surface, etc.) inherent within the individual samples. Therefore, the separation of the spectral contributions due to variations in chemical compositions from those caused by physical variations is crucial to accurate quantitative spectroscopic analysis of heterogeneous samples. In this work, an improved strategy has been proposed to estimate the multiplicative parameters accounting for multiplicative effects in each measured spectrum, and hence mitigate the detrimental influence of multiplicative effects on the quantitative spectroscopic analysis of heterogeneous samples. The basic assumption of the proposed method is that light scattering due to physical variations has the same effects on the spectral contributions of each of the spectroscopically active chemical component in the same sample mixture. Based on this underlying assumption, the proposed method realizes the efficient estimation of the multiplicative parameters by solving a simple quadratic programming problem. The performance of the proposed method has been tested on two publicly available benchmark data sets (i.e. near-infrared total diffuse transmittance spectra of four-component suspension samples and near infrared spectral data of meat samples) and compared with some empirical approaches designed for the same purpose. It was found that the proposed method provided appreciable improvement in quantitative spectroscopic analysis of heterogeneous mixture samples. The study indicates that accurate quantitative spectroscopic analysis of heterogeneous mixture samples can be achieved through the combination of spectroscopic techniques with smart modeling methodology

Analysis of nonlinear suspension power harvest potential

Because the power consumption of a controlled suspension is huge, the power harvest potential of a nonlinear controlled suspension is analyzed. Instead of simplifying the suspension to a linear model or adopting some control strategies to solve the problem, this paper investigates the effect of the nonlinear characteristics on the power harvesting potential. A mathematic model is introduced to calculate the nonlinear vibration, and the amount of harvested power was obtained using the multi-scale method. A numerical validation is carried out at the end of this study. The results show that the investigated mechanical parameters affect both the vibration amplitude and the induced current, while the electric parameters only affect the induced current. The power harvesting potential of the nonlinear suspension is generally greater than the linear suspension because the frequency band of the actual pavement also contains bandwidth surrounding the body resonance point. The only exception occurs if the vehicle travels on a road with a particular profile, e.g. a sine curve. To optimize harvested power, it is better to consider the nonlinear characteristics rather than simplifying the suspension to a linear model

Online Time-Optimal Trajectory Generation for Two Quadrotors with Multi-Waypoints Constraints

The autonomous quadrotor's flying speed has kept increasing in the past 5 years, especially in the field of autonomous drone racing. However, the majority of the research mainly focuses on the aggressive flight of a single quadrotor. In this letter, we propose a novel method called Pairwise Model Predictive Control (PMPC) that can guide two quadrotors online to fly through the waypoints with minimum time without collisions. The flight task is first modeled as a nonlinear optimization problem and then an efficient two-step mass point velocity search method is used to provide initial values and references to improve the solving efficiency so that the method can run online with a frequency of 50 Hz and can handle dynamic waypoints. The simulation and real-world experiments validate the feasibility of the proposed method and in the real-world experiments, the two quadrotors can achieve a top speed of 8.1m/s in a 6-waypoint racing track in a compact flying arena of 6m*4m*2m