New Facile Route to Synthesize Furo[3,2-<i>e</i>][1,2,4]triazolo[4,3-<i>c</i>]pyrimidine and Furo[3,2-<i>e</i>][1,2,4]triazolo[1,5-<i>c</i>]pyrimidine Derivatives

<div><p></p><p>A new facile route for synthesis of 3-(aryl)-8,9-diphenylfuro[3,2-<i>e</i>][1,2,4]triazolo pyrimidines derivative from the same starting material, 2-amino-4,5-diphenylfuran-3-carbonitrile, has been developed through heterocyclization of the corresponding arylidene-hydrazono-5,6-diphenylfuro[2,3-<i>d</i>]pyrimidine and <i>N</i>-(arylmethylene)-4-imino-5,6-diphenylfuro[2,3-<i>d</i>]pyrimidin-3(4<i>H</i>)-amine under refluxing condition with acetic anhydride followed by air oxidation. The products were obtained in good yield with an easy workup along with the purification of products by a nonchromatographic method. This general synthetic procedure can be extended to the preparation of a wide range of isomeric triazoles using 2-amino 3-carbonitrile bifunctional derivatives.</p> </div