5 research outputs found
Total retinal detachments due to retinoblastoma: Outcomes following intra-arterial chemotherapy/ophthalmic artery chemosurgery
<div><p>Purpose</p><p>To report on the rate and timing of retinal reattachment and outcomes for retinoblastoma children who have total retinal detachments at presentation to our center and were treated with intra-arterial chemotherapy (ophthalmic artery chemosurgery, OAC).</p><p>Patients and methods</p><p>Single-center retrospective review of retinoblastoma patients who presented with total retinal detachments and were subsequently treated with OAC at MSKCC between May 2006 and July 2016. Endpoints were retinal detachment resolution, visual function, ERG amplitude, ocular survival, and patient survival from metastases.</p><p>Results</p><p>87 eyes of 84 retinoblastoma patients were included. Using a survival multistate model, by 36 months of follow-up, there was a 54% cumulative probability of complete retinal reattachment and a 76% probability of partial reattachment. 24% of eyes that completely reattached received only OAC without any prior or adjuvant treatments. Eyes that completely reattached were significantly more likely to have been diagnosed at a younger age (p<0.0001) and to have greater initial ERG values (p = 0.006). At final follow-up, 14% of eyes had gained at least 25 Ī¼V of ERG activity, and 8.0% had achieved hand motion vision or better, including one to 20/60. 13% of eyes were enucleated. No patient died from metastatic disease, and only one developed metastases.</p><p>Conclusion</p><p>OAC can successfully treat previously considered ānon-salvageableā retinoblastoma eyes with total retinal detachments, promote retinal reattachment in the majority of eyes, and preserve ocular and patient survival.</p></div
Electroretinogram (ERG) improvement after OAC.
<p>Electroretinogram (ERG) improvement after OAC.</p
Cumulative incidence of retinal reattachment by time (months).
<p>Cumulative incidence of retinal reattachment by time (months).</p
Kaplan-Meier curve of the ocular survival in OAC-treated total retinal detachment eyes, among all 87 eyes, 21 eyes treated within the first 5 years (2006ā2011), and 66 eyes treated within the most recent 5 years (2012ā2016).
<p>The dotted lines represent the 95% confidence interval for the survival curves.</p
Results of the multistate survival model.
<p>Results of the multistate survival model.</p