Bovine serum albumin as the dominant form of dietary protein reduces subcutaneous fat mass, plasma leptin and plasma corticosterone in high fat-fed C57/BL6J mice

Acknowledgements The authors thank Harriett Schellekens from the University College Cork and Paula O’Connor from Teagasc Moorepark Food Research Centre for their assistance in procuring laboratory space and equipment. The present study was funded by Teagasc. B. L. M. was funded by the Walsh Fellowship Program. J. R. S. was supported by a 1000-talents professorship from the Chinese government. The funding bodies had no input on the design of the study or in the interpretation of the data.Peer reviewedPublisher PD

A hazard model of the probability of medical school dropout in the United Kingdom

From individual level longitudinal data for two entire cohorts of medical students in UK universities, we use multilevel models to analyse the probability that an individual student will drop out of medical school. We find that academic preparedness—both in terms of previous subjects studied and levels of attainment therein—is the major influence on withdrawal by medical students. Additionally, males and more mature students are more likely to withdraw than females or younger students respectively. We find evidence that the factors influencing the decision to transfer course differ from those affecting the decision to drop out for other reasons

Shear-free, Irrotational, Geodesic, Anisotropic Fluid Cosmologies

General relativistic anisotropic fluid models whose fluid flow lines form a shear-free, irrotational, geodesic timelike congruence are examined. These models are of Petrov type D, and are assumed to have zero heat flux and an anisotropic stress tensor that possesses two distinct non-zero eigenvalues. Some general results concerning the form of the metric and the stress-tensor for these models are established. Furthermore, if the energy density and the isotropic pressure, as measured by a comoving observer, satisfy an equation of state of the form $p = p(\mu)$, with $\frac{dp}{d\mu} \neq -\frac{1}{3}$, then these spacetimes admit a foliation by spacelike hypersurfaces of constant Ricci scalar. In addition, models for which both the energy density and the anisotropic pressures only depend on time are investigated; both spatially homogeneous and spatially inhomogeneous models are found. A classification of these models is undertaken. Also, a particular class of anisotropic fluid models which are simple generalizations of the homogeneous isotropic cosmological models is studied.Comment: 13 pages LaTe

Can we predict the duration of an interglacial?

Differences in the duration of interglacials have long been apparent in palaeoclimate records of the Late and Middle Pleistocene. However, a systematic evaluation of such differences has been hampered by the lack of a metric that can be applied consistently through time and by difficulties in separating the local from the global component in various proxies. This, in turn, means that a theoretical framework with predictive power for interglacial duration has remained elusive. Here we propose that the interval between the terminal oscillation of the bipolar seesaw and three thousand years (kyr) before its first major reactivation provides an estimate that approximates the length of the sea-level highstand, a measure of interglacial duration. We apply this concept to interglacials of the last 800 kyr by using a recently-constructed record of interhemispheric variability. The onset of interglacials occurs within 2 kyr of the boreal summer insolation maximum/precession minimum and is consistent with the canonical view of Milankovitch forcing pacing the broad timing of interglacials. Glacial inception always takes place when obliquity is decreasing and never after the obliquity minimum. The phasing of precession and obliquity appears to influence the persistence of interglacial conditions over one or two insolation peaks, leading to shorter (~ 13 kyr) and longer (~ 28 kyr) interglacials. Glacial inception occurs approximately 10 kyr after peak interglacial conditions in temperature and CO2, representing a characteristic timescale of interglacial decline. Second-order differences in duration may be a function of stochasticity in the climate system, or small variations in background climate state and the magnitude of feedbacks and mechanisms contributing to glacial inception, and as such, difficult to predict. On the other hand, the broad duration of an interglacial may be determined by the phasing of astronomical parameters and the history of insolation, rather than the instantaneous forcing strength at inception

Picophytoplankton biomass distribution in the global ocean

The smallest marine phytoplankton, collectively termed picophytoplankton, have been routinely enumerated by flow cytometry since the late 1980s during cruises throughout most of the world ocean. We compiled a database of 40 946 data points, with separate abundance entries for Prochlorococcus, Synechococcus and picoeukaryotes. We use average conversion factors for each of the three groups to convert the abundance data to carbon biomass. After gridding with 1? spacing, the database covers 2.4% of the ocean surface area, with the best data coverage in the North Atlantic, the South Pacific and North Indian basins, and at least some data in all other basins. The average picophytoplankton biomass is 12 ± 22 µg Cl-1 or 1.9 g Cm-2. We estimate a total global picophytoplankton biomass of 0.53–1.32 Pg C (17–39% Prochlorococcus, 12–15% Synechococcus and 49–69% picoeukaryotes), with an intermediate/best estimate of 0.74 Pg C. Future efforts in this area of research should focus on reporting calibrated cell size and collecting data in undersampled regions

Synchronous Deglacial Overturning and Water Mass Source Changes

Understanding changes in ocean circulation during the last deglaciation is crucial to unraveling the dynamics of glacial-interglacial and millennial climate shifts. We used neodymium isotope measurements on postdepositional iron-manganese oxide coatings precipitated on planktonic foraminifera to reconstruct changes in the bottom water source of the deep western North Atlantic at the Bermuda Rise. Comparison of our deep water source record with overturning strength proxies shows that both the deep water mass source and the overturning rate shifted rapidly and synchronously during the last deglacial transition. In contrast, any freshwater perturbation caused by Heinrich event 1 could have only affected shallow overturning. These findings show how changes in upper-ocean overturning associated with millennial-scale events differ from those associated with whole-ocean deglacial climate events

Advection and scavenging controls of Pa/Th in the northern NE Atlantic

Over the last 2 decades, significant advances have been made in reconstructing past rates of ocean circulation using sedimentary proxies for the dynamics of abyssal waters. In this study we combine the use of two rate proxies, sortable silt grain size, and sedimentary ²³¹Pa/²³⁰Th, measured on a depth transect of deep-sea sediment cores from the northern NE Atlantic, to investigate ocean circulation changes during the last deglacial. We find that at two deep sites, the core-top ²³¹Pa/²³⁰Th ratios reflect Holocene circulation rates, while during Heinrich Stadial 1, the deglacial ratios peaked as the sortable silt grain size decreased, reflecting a general circulation slowdown. However, the peak ²³¹Pa/²³⁰Th significantly exceeded the production ratio in both cores, indicating that ²³¹Pa/²³⁰Th was only partially controlled by ocean circulation at these sites. This is supported by a record of ²³¹Pa/²³⁰Th from an intermediate water depth site, where values also peaked during Heinrich Stadial 1, but were consistently above the production ratio over the last 24 ka, reflecting high scavenging below productive surface waters. At our study sites, we find that preserved sediment component fluxes cannot be used to distinguish between a scavenging or circulation control, although they are consistent with a circulation influence, since the core at intermediate depth with the highest ²³¹Pa/²³⁰Th recorded the lowest particle fluxes. Reconstruction of advection rate using ²³¹Pa/²³⁰Th in this region is complicated by high productivity, but the data nevertheless contain important information on past deep ocean circulation

Persistent non-solar forcing of Holocene storm dynamics in coastal sedimentary archives

Considerable climatic variability on decadal to millennial timescales has been documented for the past 11,500 years of interglacial climate. This variability has been particularly pronounced at a frequency of about 1,500 years, with repeated cold intervals in the North Atlantic. However, there is growing evidence that these oscillations originate from a cluster of different spectral signatures, ranging from a 2,500-year cycle throughout the period to a 1,000-year cycle during the earliest millennia. Here we present a reappraisal of high-energy estuarine and coastal sedimentary records from the southern coast of the English Channel, and report evidence for five distinct periods during the Holocene when storminess was enhanced during the past 6,500 years.We find that high storm activity occurred periodically with a frequency of about 1,500 years, closely related to cold and windy periods diagnosed earlier. We show that millennial-scale storm extremes in northern Europe are phase-locked with the period of internal ocean variability in the North Atlantic of about 1,500 years. However, no consistent correlation emerges between spectral maxima in records of storminess and solar irradiation. We conclude that solar activity changes are unlikely to be a primary forcing mechanism of millennial-scale variability in storminess

Reply to comment by S. Peacock on “Glacial-interglacial circulation changes inferred from 231Pa/230Th sedimentary record in the North Atlantic region”

Peacock [2010, P10 hereafter] takes issue with several aspects of our recent article [Gherardi et al., 2009, G09hereafter]: (1) our description of the modern Atlantic meridional overturning circulation (AMOC), (2) apparent inconsistencies between modern circulation and our Holo-cene sedimentary 231Pa/230Th bathymetric profile, and (3) our use of cores for reconstructing AMOC from locations that do not lie beneath the Deep Western Boundary Current (DWBC). We welcome the comment as it affords us the opportunity to clarify important aspects of our approach to studying paleocirculation and to address any potential mis-understandings arising from the wording of our original text