Shear-free, Irrotational, Geodesic, Anisotropic Fluid Cosmologies

General relativistic anisotropic fluid models whose fluid flow lines form a shear-free, irrotational, geodesic timelike congruence are examined. These models are of Petrov type D, and are assumed to have zero heat flux and an anisotropic stress tensor that possesses two distinct non-zero eigenvalues. Some general results concerning the form of the metric and the stress-tensor for these models are established. Furthermore, if the energy density and the isotropic pressure, as measured by a comoving observer, satisfy an equation of state of the form $p = p(\mu)$, with $\frac{dp}{d\mu} \neq -\frac{1}{3}$, then these spacetimes admit a foliation by spacelike hypersurfaces of constant Ricci scalar. In addition, models for which both the energy density and the anisotropic pressures only depend on time are investigated; both spatially homogeneous and spatially inhomogeneous models are found. A classification of these models is undertaken. Also, a particular class of anisotropic fluid models which are simple generalizations of the homogeneous isotropic cosmological models is studied.Comment: 13 pages LaTe

A hazard model of the probability of medical school dropout in the United Kingdom

From individual level longitudinal data for two entire cohorts of medical students in UK universities, we use multilevel models to analyse the probability that an individual student will drop out of medical school. We find that academic preparedness—both in terms of previous subjects studied and levels of attainment therein—is the major influence on withdrawal by medical students. Additionally, males and more mature students are more likely to withdraw than females or younger students respectively. We find evidence that the factors influencing the decision to transfer course differ from those affecting the decision to drop out for other reasons

Can we predict the duration of an interglacial?

Differences in the duration of interglacials have long been apparent in palaeoclimate records of the Late and Middle Pleistocene. However, a systematic evaluation of such differences has been hampered by the lack of a metric that can be applied consistently through time and by difficulties in separating the local from the global component in various proxies. This, in turn, means that a theoretical framework with predictive power for interglacial duration has remained elusive. Here we propose that the interval between the terminal oscillation of the bipolar seesaw and three thousand years (kyr) before its first major reactivation provides an estimate that approximates the length of the sea-level highstand, a measure of interglacial duration. We apply this concept to interglacials of the last 800 kyr by using a recently-constructed record of interhemispheric variability. The onset of interglacials occurs within 2 kyr of the boreal summer insolation maximum/precession minimum and is consistent with the canonical view of Milankovitch forcing pacing the broad timing of interglacials. Glacial inception always takes place when obliquity is decreasing and never after the obliquity minimum. The phasing of precession and obliquity appears to influence the persistence of interglacial conditions over one or two insolation peaks, leading to shorter (~ 13 kyr) and longer (~ 28 kyr) interglacials. Glacial inception occurs approximately 10 kyr after peak interglacial conditions in temperature and CO2, representing a characteristic timescale of interglacial decline. Second-order differences in duration may be a function of stochasticity in the climate system, or small variations in background climate state and the magnitude of feedbacks and mechanisms contributing to glacial inception, and as such, difficult to predict. On the other hand, the broad duration of an interglacial may be determined by the phasing of astronomical parameters and the history of insolation, rather than the instantaneous forcing strength at inception

Metabolic differences in colon mucosal cells

The colonic expression of cytochromes P450 from the CYP1A, CYP3A and CYP4B subfamilies has been characterized in rabbit and human tissues using RNA blotting, immunoblotting, immunohistochemistry and hybridization histochemistry. These studies demonstrate negligible expression of the CYP1A subfamily in either rabbit or human colon. The CYP3A6 gene is expressed in rabbit colon although at markedly reduced levels relative to liver and small intestine. Whilst at least two CYP3A genes are expressed at the mRNA level in human colon tissue from some individuals, no expression was demonstrated in others. Where expression was observed, this expression was continuous throughout the length of the colon. In rabbits, CYP4B1 represents a major colon P450 enzyme, expressed at levels in colon comparable to liver and small intestine. In contrast, the human CYP4B1 gene is expressed at low levels in some individuals. These studies highlight individual differences in the expression of cytochrome P450 enzymes of importance in procarcinogen metabolism

The nature of opal burial in the equatorial atlantic during the deglaciation

Relatively high opal concentrations are measured in equatorial Atlantic sediments from the most recent deglaciation. To shed light on their causes, seven cores were analyzed for their content of siliceous (diatom, silicoflagellates, radiolarians, phytoliths, and sponge spicules) and calcareous (coccolithophores) microfossils. An early deglacial signal is detected at the time of rising boreal summer insolation ca. 18 ka by the coccolithophores. The surface freshening is likely due to the rain belt associated with the intertropical convergence zone (ITCZ), implying its southward shift relatively to its present-day average positioning. The diatom assemblages corresponding to the following increase in diatom abundances ca. 15.5 ka suggest the formation of a cold tongue of upwelled water associated with tropical instability waves propagating westward. Such conditions occur at present during boreal summer, when southerly trade winds are intensified, and the ITCZ shifts northward. The presence of the diatom Ethmodiscus rex (Wallich) Hendey and the coccolithophore Florisphera profunda indicates a deep thermocline and nutrient enrichment of the lower photic zone, revealing that Si-rich southern sourced water (SSW) likely contributed to enhanced primary productivity during this time interval. The discrepancies between the maximum opal concentrations and siliceous marine microfossils records evidence the contribution of freshwater diatoms and phytoliths, indicative of other processes. The definition of the nature of the opal record suggests successive productivity conditions associated with specific atmospheric settings determining the latitudinal ITCZ positioning and the development of oceanic processes; and major oceanic circulation changes permitting the contribution of SSW to marine productivity at this latitude.LA/P/0101/2020info:eu-repo/semantics/publishedVersio

Should applicants to Nottingham University Medical School study a non-science A-level? A cohort study

<p>Abstract</p> <p>Background</p> <p>It has been suggested that studying non-science subjects at A-level should be compulsory for medical students. Our admissions criteria specify only Biology, Chemistry and one or more additional subjects. This study aimed to determine whether studying a non-science subject for A-level is an independent predictor of achievement on the undergraduate medical course.</p> <p>Methods</p> <p>The subjects of this retrospective cohort study were 164 students from one entry-year group (October 2000), who progressed normally on the 5-year undergraduate medical course at Nottingham. Pre-admission academic and socio-demographic data and undergraduate course marks were obtained. T-test and hierarchical multiple linear regression analyses were undertaken to identify independent predictors of five course outcomes at different stages throughout the course.</p> <p>Results</p> <p>There was no evidence that the choice of science or non-science as the third or fourth A-level subject had any influence on course performance. Demographic variables (age group, sex, and fee status) had some predictive value but ethnicity did not. Pre-clinical course performance was the strongest predictor in the clinical phases (pre-clinical Themes A&B (knowledge) predicted Clinical Knowledge, p < 0.001, and pre-clinical Themes C&D (skills) predicted Clinical Skills, p = < 0.01).</p> <p>Conclusion</p> <p>This study of one year group at Nottingham Medical School provided no evidence that the admissions policy on A-level requirements should specify the choice of third or fourth subject.</p

The Formation of non-Keplerian Rings of Matter about Compact Stars

The formation of energetic rings of matter in a Kerr spacetime with an outward pointing acceleration field does not appear to have previously been noted as a relativistic effect. In this paper we show that such rings are a gravimagneto effect with no Newtonian analog, and that they do not occur in the static limit. The energy efficiency of these rings can, depending of the strength of the acceleration field, be much greater than that of Keplerian disks. The rings rotate in a direction opposite to that of compact star about which they form. The size and energy efficiency of the rings depend on the fundamental parameters of the spacetime as well as the strength the acceleration field.Comment: 19 pages, 7 figures, 1 diagram. Figures are included in the text using the "graphicx" package. If you do not have this package you can use epsfig, or another package as long as you alter the tex file appropriately. Alternatively you could print the figures out seperatel

Last glacial atmospheric CO2 decline due to widespread Pacific deep-water expansion

Ocean circulation critically affects the global climate and atmospheric carbon dioxide through redistribution of heat and carbon in the Earth system. Despite intensive research, the nature of past ocean circulation changes remains elusive. Here we present deep-water carbonate ion concentration reconstructions for widely distributed locations in the Atlantic Ocean, where low carbonate ion concentrations indicate carbon-rich waters. These data show a low-carbonate-ion water mass that extended northward up to about 20° S in the South Atlantic at 3–4 km depth during the Last Glacial Maximum. In combination with radiocarbon ages, neodymium isotopes and carbon isotopes, we conclude that this low-carbonate-ion signal reflects a widespread expansion of carbon-rich Pacific deep waters into the South Atlantic, revealing a glacial deep Atlantic circulation scheme different than commonly considered. Comparison of high-resolution carbonate ion records from different water depths in the South Atlantic indicates that this Pacific deep-water expansion developed from approximately 38,000 to 28,000 years ago. We infer that its associated carbon sequestration may have contributed critically to the contemporaneous decline in atmospheric carbon dioxide, thereby helping to initiate the glacial maximum.Australian Research Council | Ref. DP140101393Australian Research Council | Ref. DP190100894Australian Research Council | Ref. FT140100993Australian Research Council | Ref. FT180100606Australian Research Council | Ref. DP180100048Australian Research Council | Ref. FL120100050National Science Foundation of China | Ref. 41991322National Science Foundation of China | Ref. 4193086