646 research outputs found
Clinical and laboratory studies of the bacterial pathogenesis and management of Pouchitis
20-50% of patients develop pouchitis following restorative proctocolectomy for ulcerative
colitis (UC). Pre-pouch ileitis (PPI) also develops in some of these patients.
Bacteria are implicated in the pathogenesis of pouchitis and antibiotics are the mainstay of
treatment. Studies were performed to examine the role of bacteria in the pathogenesis of this
disease and to develop new treatment. Further studies examined the prevalence and
implications of PPI and the efficacy and complications associated with maintenance
antibiotic therapy.
16s rRNA sequencing demonstrated an increase in Proteobacteria and a reduction in
Bacteroidetes in the UC compared with the familial adenomatous polyposis (FAP) cohort, but
only limited differences between the UC non-pouchitis and pouchitis groups. We were unable
to identify an individual species or phylotype specifically associated with pouchitis.
Treatment with elemental diet produced a symptomatic improvement in 71% of chronic
pouchitis patients but none entered clinical remission.
Patients with PPI were identified, the prevalence, symptoms and short term outcomes of this
group were studied. PPI was identified in 5.7% of patients with UC. All patients had
associated pouchitis but not all were symptomatic. PPI was not associated with
reclassification to Crohn’s disease. A subgroup of patients with symptomatic pre-pouch ileitis
were treated with combination antibiotic therapy and 86% entered remission.
Faecal samples from patients with antibiotic resistant pouchitis were grown on agar and
sensitivity patterns identified. Following guided antibiotic therapy 80% of patients entered
remission. Stool analysis also identified the presence of extended spectrum beta-lactamase (ESBL) resistant coliforms in 35% of patients with chronic pouchitis. Not all were
symptomatic. PPI was associated with an increased risk of ESBL.
Patients treated with maintenance antibiotic therapy were identified. Pre-pouch ileitis was
associated with an increased risk of relapse. Reported side effects were rare and treatment
was associated with an improved quality of life
Discovery of two pulsars towards the Galactic Centre
We report the discovery of two highly dispersed pulsars in the direction of
the Galactic Centre made during a survey at 3.1 GHz with the Parkes radio
telescope. Both PSRs J1745-2912 and J1746-2856 have an angular separation from
the Galactic Centre of less than 0.3 degrees and dispersion measures in excess
of 1100 cm-3pc, placing them in the top 10 pulsars when ranked on this value.
The frequency dependence of the scatter-broadening in PSR J1746-2856 is much
shallower than expected from simple theory. We believe it likely that the
pulsars are located between 150 and 500 pc from the Galactic Centre on the near
side, and are part of an excess population of neutron stars associated with the
Centre itself. A second survey made at 8.4 GHz did not detect any pulsars. This
implies either that there are not many bright, long-period pulsars at the
Galactic Centre or that the scattering is more severe at high frequencies than
current models would suggest.Comment: Submitted to MNRAS Letter
Calcium channel blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors: Effectiveness in combination with diuretics or β-blockers for treating hypertension
This retrospective database analysis compared the effectiveness of dihydropyridine calcium channel blockers (DHPs), angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) added to diuretics or β-blockers. Adults with hypertension treated with diuretic or β-blocker monotherapy between 1998 and 2001 were identified from a large US electronic medical records database of primary care practices. Patients were required to have a baseline blood pressure (BP) ≥140/90 mmHg (≥130/80 mmHg for diabetes mellitus) and recorded BP measurements within 6 months before and 1–12 months following index date. Patients were matched 1:1:1 by propensity score to correct for differences in baseline characteristics. 1875 patients met study criteria and 660 (220 in each cohort) were matched based on propensity scores. Matched cohorts had no significant differences in baseline characteristics. Mean changes in systolic/diastolic BP were −17.5/−8.8, −15.7/−6.3, and −13.0/−8.0 mmHg with DHPs, ACE inhibitors, and ARBs, respectively. Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High BP 6/7 goal attainment for each regimen was 47.3%, 40.0%, and 32.2%, respectively. DHPs, ACE inhibitors, and ARBs improved BP when added to patients’ β-blocker or diuretic therapy. The greatest benefits were observed with DHPs, followed by ACE inhibitors, then ARBs
Enhanced X-ray variability from V1647 Ori, the young star in outburst illuminating McNeil's Nebula
We report a ~38 ks X-ray observation of McNeil's Nebula obtained with XMM on
2004 April 4. V1647 Ori, the young star in outburst illuminating McNeil's
Nebula, is detected with XMM and appears variable in X-rays. We investigate the
hardness ratio variability and time variations of the event energy distribution
with quantile analysis, and show that the large increase of the count rate from
V1647 Ori observed during the second half of the observation is not associated
with any large plasma temperature variations as for typical X-ray flares from
young low-mass stars. X-ray spectral fitting shows that the bulk (~75%) of the
intrinsic X-ray emission in the 0.5-8 keV energy band comes from a soft plasma
component (0.9 keV) reminiscent of the X-ray spectrum of the classical T Tauri
star TW Hya, for which X-ray emission is believed to be generated by an
accretion shock onto the photosphere of a low-mass star. The hard plasma
component (4.2 keV) contributes ~25% of the total X-ray emission, and can be
understood only in the framework of plasma heating sustained by magnetic
reconnection events. We find a hydrogen column density of NH=4.1E22 cm-2, which
points out a significant excess of hydrogen column density compared to the
value derived from optical/IR observations, consistent with the picture of the
rise of a wind/jet unveiled from ground optical spectroscopy. The X-ray flux
observed with XMM ranges from roughly the flux observed by Chandra on 2004
March 22 (~10 times greater than the pre-outburst X-ray flux) to a value two
times greater than that caught by Chandra on 2004 March 7 (~200 times greater
than the pre-outburst X-ray flux). We have investigated the possibility that
V1647 Ori displays a periodic variation in X-ray brightness as suggested by the
combined Chandra+XMM data set (abridged).Comment: 11 pages and 8 Figures. Accepted for publication by Astronomy &
Astrophysic
Misaligned spin and orbital axes cause the anomalous precession of DI Herculis
The orbits of binary stars precess as a result of general relativistic
effects, forces arising from the asphericity of the stars, and forces from
additional stars or planets in the system. For most binaries, the theoretical
and observed precession rates are in agreement. One system, however -- DI
Herculis -- has resisted explanation for 30 years. The observed precession rate
is a factor of four slower than the theoretical rate, a disagreement that once
was interpreted as evidence for a failure of general relativity. Among the
contemporary explanations are the existence of a circumbinary planet and a
large tilt of the stellar spin axes with respect to the orbit. Here we report
that both stars of DI Herculis rotate with their spin axes nearly perpendicular
to the orbital axis (contrary to the usual assumption for close binary stars).
The rotationally induced stellar oblateness causes precession in the direction
opposite to that of relativistic precession, thereby reconciling the
theoretical and observed rates.Comment: Nature, in press [11 pg
State-resolved valence shell photoionization of Be-like ions: experiment and theory
High-resolution photoionization experiments were carried out using beams of
Be-like C, N, and O ions with roughly equal populations of
the S ground-state and the P manifold of metastable components. The
energy scales of the experiments are calibrated with uncertainties of 1 to 10
meV depending on photon energy. Resolving powers beyond 20,000 were reached
allowing for the separation of contributions from the individual metastable
P, P, and P states. The measured data compare
favourably with semi-relativistic Breit-Pauli R-matrixComment: 23 figures and 3 table
Planetary nebulae in M33: probes of AGB nucleosynthesis and ISM abundances
We have obtained deep optical spectrophotometry of 16 planetary nebulae in
M33, mostly located in the central two kpc of the galaxy, with the Subaru and
Keck telescopes. We have derived electron temperatures and chemical abundances
from the detection of the [OIII]4363 line for the whole sample. We have found
one object with an extreme nitrogen abundance, 12+log(N/H)=9.20, accompanied by
a large helium content. After combining our data with those available in the
literature for PNe and HII regions, we have examined the behavior of nitrogen,
neon, oxygen and argon in relation to each other, and as a function of
galactocentric distance. We confirm the good correlation between Ne/H and O/H
for PNe in M33. Ar/H is also found to correlate with O/H. This strengthens the
idea that at the metallicity of the bright PNe analyzed in M33, which is
similar to that found in the LMC, these elements have not been significantly
modified during the dredge-up processes that take place during the AGB phase of
their progenitor stars. We find no significant oxygen abundance offset between
PNe and HII regions at any given galactocentric distance, despite the fact that
these objects represent different age groups in the evolution of the galaxy.
Combining the results from PNe and HII regions, we obtain a representative
slope of the ISM alpha-element (O, Ar, Ne) abundance gradient in M33 of -0.025
+/- 0.006 dex/kpc. Both PNe and HII regions display a large abundance
dispersion at any given distance from the galactic center. We find that the N/O
ratio in PNe is enhanced, relative to the HII regions, by approximately 0.8
dex.Comment: 21 pages, 20 figures. Accepted for publication in MNRA
The NANOGrav 11-Year Data Set: Limits on Gravitational Waves from Individual Supermassive Black Hole Binaries
Observations indicate that nearly all galaxies contain supermassive black
holes (SMBHs) at their centers. When galaxies merge, their component black
holes form SMBH binaries (SMBHBs), which emit low-frequency gravitational waves
(GWs) that can be detected by pulsar timing arrays (PTAs). We have searched the
recently-released North American Nanohertz Observatory for Gravitational Waves
(NANOGrav) 11-year data set for GWs from individual SMBHBs in circular orbits.
As we did not find strong evidence for GWs in our data, we placed 95\% upper
limits on the strength of GWs from such sources as a function of GW frequency
and sky location. We placed a sky-averaged upper limit on the GW strain of at nHz. We also developed a
technique to determine the significance of a particular signal in each pulsar
using ``dropout' parameters as a way of identifying spurious signals in
measurements from individual pulsars. We used our upper limits on the GW strain
to place lower limits on the distances to individual SMBHBs. At the
most-sensitive sky location, we ruled out SMBHBs emitting GWs with
nHz within 120 Mpc for , and
within 5.5 Gpc for . We also determined that
there are no SMBHBs with emitting
GWs in the Virgo Cluster. Finally, we estimated the number of potentially
detectable sources given our current strain upper limits based on galaxies in
Two Micron All-Sky Survey (2MASS) and merger rates from the Illustris
cosmological simulation project. Only 34 out of 75,000 realizations of the
local Universe contained a detectable source, from which we concluded it was
unsurprising that we did not detect any individual sources given our current
sensitivity to GWs.Comment: 10 pages, 11 figures. Accepted by Astrophysical Journal. Please send
any comments/questions to S. J. Vigeland ([email protected]
Assessment of Daily Life Physical Activities in Pulmonary Arterial Hypertension
Background: In pulmonary arterial hypertension (PAH), the six-minute walk test (6MWT) is believed to be representative of patient’s daily life physical activities (DLPA). Whether DLPA are decreased in PAH and whether the 6MWT is representative of patient’s DL PA remain unknown. Methods: 15 patients with idiopathic PAH (IPAH) and 10 patients with PAH associated with limited systemic sclerosis (PAH-SSc) were matched with 15 healthy control subjects and 10 patients with limited systemic sclerosis without PAH. Each subject completed a 6MWT. The mean number of daily steps and the mean energy expenditure and duration of physical activities.3 METs were assessed with a physical activity monitor for seven consecutive days and used as markers of DLPA. Results: The mean number of daily steps and the mean daily energy expenditure and duration of physical activities.3 METs were all reduced in PAH patients compared to their controls (all p,0.05). The mean number of daily steps correlated with the 6MWT distance for both IPAH and PAH-SSc patients (r = 0.76, p,0.01 and r = 0.85, p,0.01), respectively. Conclusion: DLPA are decreased in PAH and correlate with the 6MWT distance. Functional exercise capacity may thus be a useful surrogate of DL PA in PAH
A new concept for the combination of optical interferometers and high-resolution spectrographs
The combination of high spatial and spectral resolution in optical astronomy
enables new observational approaches to many open problems in stellar and
circumstellar astrophysics. However, constructing a high-resolution
spectrograph for an interferometer is a costly and time-intensive undertaking.
Our aim is to show that, by coupling existing high-resolution spectrographs to
existing interferometers, one could observe in the domain of high spectral and
spatial resolution, and avoid the construction of a new complex and expensive
instrument. We investigate in this article the different challenges which arise
from combining an interferometer with a high-resolution spectrograph. The
requirements for the different sub-systems are determined, with special
attention given to the problems of fringe tracking and dispersion. A concept
study for the combination of the VLTI (Very Large Telescope Interferometer)
with UVES (UV-Visual Echelle Spectrograph) is carried out, and several other
specific instrument pairings are discussed. We show that the proposed
combination of an interferometer with a high-resolution spectrograph is indeed
feasible with current technology, for a fraction of the cost of building a
whole new spectrograph. The impact on the existing instruments and their
ongoing programs would be minimal.Comment: 27 pages, 9 figures, Experimental Astronomy; v2: accepted versio
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