Influence of host plant, geography and pheromone strain on genomic differentiation in sympatric populations of Ostrinia nubilalis

Patterns of mating for the European corn borer (Ostrinia nubilalis) moth depend in part on variation in sex‐pheromone blend. The ratio of (E)‐11‐ and (Z)‐11‐tetradecenyl acetate (E11‐ and Z11‐14:OAc) in the pheromone blend that females produce and males respond to differs between strains of O. nubilalis. Populations also vary in female oviposition preference for and larval performance on maize (C4) and non‐maize (C3) host plants. The relative contributions of sexual and ecological trait variation to the genetic structure of O. nubilalis remains unknown. Host‐plant use (13C/14C ratios) and genetic differentiation were estimated among sympatric E and Z pheromone strain O. nubilalis males collected in sex‐pheromone baited traps at 12 locations in Pennsylvania and New York between 2007 and 2010. Among genotypes at 65 single nucleotide polymorphism marker loci, variance at a position in the pheromone gland fatty acyl‐reductase (pgfar) gene at the locus responsible for determining female pheromone ratio (Pher) explained 64% of the total genetic differentiation between males attracted to different pheromones (male response, Resp), providing evidence of sexual inter‐selection at these unlinked loci. Principal coordinate, Bayesian clustering, and distance‐based redundancy analysis (dbRDA) demonstrate that host plant history or geography does not significantly contribute to population variation or differentiation among males. In contrast, these analyses indicate that pheromone response and pgfar‐defined strain contribute significantly to population genetic differentiation. This study suggests that behavioral divergence likely plays a larger role in driving genetic variation compared to host plant‐defined ecological adaptation

Publishing ‘paper bullets’: Politics, propaganda, and Polish-English translation in wartime London

During World War 2, publishing was an important element of the war effort for both the Allies and the Axis powers. Wartime propaganda and cultural diplomacy relied primarily on books, magazines and the daily press. The exiled governments in London, including the Polish government, undertook a major effort to translate, publish and promote numerous books and pamphlets that would appeal to British readers and, thus, help sway public opinion. This paper focuses on translation as an important aspect of wartime publishing that has not yet received much scholarly attention. It offers a contribution to research into the role and place of translations in wartime publishing by discussing the Polish government-in-exile’s translation and publishing campaign. Drawing on various archival sources, it demonstrates that publishing translations was an important part of wartime cultural diplomacy and it led to the development of extensive state-private networks that brought together exiled governments and British publishers. By analysing this material in a broad cultural context, the paper highlights the historical, ideological and political relevance of translation studies research to wartime publishing and censorship

A randomized, placebo-controlled trial of prednisone in early Henoch Schönlein Purpura [ISRCTN85109383]

BACKGROUND: Henoch Schönlein Purpura (HSP) is the most common systemic vasculitis of childhood. There is considerable controversy over whether children with HSP should be treated with corticosteroids. The goal of this study was to investigate whether early corticosteroid administration could reduce the rate of renal or gastrointestinal complications in children with HSP. METHODS: Forty children with HSP, seen in the emergency room of a tertiary-care, paediatric centre, entered a randomized, double-blind, placebo controlled study. The treatment group (n = 21) received oral prednisone, 2 mg/kg/day for one week, with weaning over a second week, while the placebo group (n = 19) received an identical appearing placebo. Co-primary outcomes were the rate of renal involvement at one year and the rate of acute gastrointestinal complications. Co-primary outcomes were analysed using Fisher's Exact test. RESULTS: At one year, there was no difference in the rate of renal involvement (3/21 prednisone group vs. 2/19 placebo group, P = 1.0). There was also no statistically significant difference in the rate of acute gastrointestinal complications (2/21 prednisone group vs. 3/19 placebo group, P = 0.7). Two children in the placebo group did experience intussusceptions compared with none in the prednisone group (P = 0.2). CONCLUSIONS: Early prednisone therapy in HSP does not appear to reduce the risk of renal involvement at one year, or the risk of acute gastrointestinal complications. There may be a reduced risk of intussusception. The routine, early use of prednisone in uncomplicated HSP cannot be recommended at this time

The return of the 'Conchie': newspaper representations of conscientious objectors and pacifists in World War II

This chapter will consider the ways in which British regional and national newspapers represented conscientious objectors in the early stages of World War 11

Childhood lead exposure in France: benefit estimation and partial cost-benefit analysis of lead hazard control

<p>Abstract</p> <p>Background</p> <p>Lead exposure remains a public health concern due to its serious adverse effects, such as cognitive and behavioral impairment: children younger than six years of age being the most vulnerable population. In Europe, the lead-related economic impacts have not been examined in detail. We estimate the annual costs in France due to childhood exposure and, through a cost benefit analysis (CBA), aim to assess the expected social and economic benefits of exposure abatement.</p> <p>Methods</p> <p>Monetary benefits were assessed in terms of avoided national costs. We used results from a 2008 survey on blood-lead (B-Pb) concentrations in French children aged one to six years old. Given the absence of a threshold concentration being established, we performed a sensitivity analysis assuming different hypothetical threshold values for toxicity above 15 μg/L, 24 μg/L and 100 μg/L. Adverse health outcomes of lead exposure were translated into social burden and economic costs based on literature data from literature. Direct health benefits, social benefits and intangible avoided costs were included. Costs of pollutant exposure control were partially estimated in regard to homes lead-based paint decontamination, investments aiming at reducing industrial lead emissions and removal of all lead drinking water pipes.</p> <p>Results</p> <p>The following overall annual benefits for the three hypothetical thresholds values in 2008 are: €22.72 billion, €10.72 billion and €0.44 billion, respectively. Costs from abatement ranged from €0.9 billion to 2.95 billion/year. Finally, from a partial CBA of lead control in soils and dust the estimates of total net benefits were € 3.78 billion, € 1.88 billion and €0.25 billion respectively for the three hypothesized B-Pb effect values.</p> <p>Conclusions</p> <p>Prevention of childhood lead exposure has a high social benefit, due to reduction of B-Pb concentrations to levels below 15 μg/L or 24 μg/L, respectively. Reducing only exposures above 100 μg/L B-Pb has little economic impact due to the small number of children who now exhibit such high exposure levels. Prudent public policies would help avoiding future medical interventions, limit the need for special education and increase future productivity, and hence lifetime income for children exposed to lead.</p

&ldquo;Merrily to Hell Together&rdquo;: Threats of Self-Destruction among Golden Age Pirates

The threat of death hung over every aspect of pirate life during the Golden Age of piracy. They threatened governors and governments who dared to capture, prosecute, and hang their fellow buccaneers. They threatened their victims for running away, for fighting back, or for hiding their money. They even threatened death on each other should any of them suggest leaving off their chosen course or for betraying their company. Even the iconic skull and crossbones &ldquo;Jolly Roger&rdquo; pirate flag was a visible, physical symbol of a threat of death: for victims it was a reminder that surrender may mean mercy, but resistance would be fatal; and for the Pirates themselves, a grim reminder that capture or failure could mean their end. Many pirate crews in the Golden Age took this menace of death to the extreme by threatening to blow up their ship to avoid the noose, promising to take prisoners and pirates, captives and captors, and gold and galleon to the bottom of the ocean, going &ldquo;merrily to Hell together&rdquo;. Yet despite their boasts and despite embracing the symbols of death, when the time came to make good on their oaths, few of these crews took that final explosive step and fewer still succeeded. This paper examines twenty incidents from the Golden Age of piracy in which pirates or their victims threatened or attempted to blow up their ships and themselves to avoid capture. Witness statements, period newspaper accounts, and trial testimony reveal that the threat was frequent but the attempt was not. In the end it was often prevented by the pirates themselves after a change of heart, despite promising one another that they would &ldquo;live &amp; dye together&rdquo;

Albumin Excretion as a Measure of Glomerular Dysfunction in Children

The urine albumin/creatinine concentration ratio (U(A)/U(C)) and the albumin excretion rate per unit weight (U(A)V/Wt) have been compared with the theoretically ideal parameter for measuring glomerular damage, clearance of albumin/clearance of creatinine (C(A)/C(C)), using a simple sensitive immunochemical technique for albumin. It is shown that U(A)/U(C) on random urine specimens can be as satisfactorily used to predict C(A)/C(C) as U(A)V/Wt. Normal data over a wide range of body size of this simple parameter are presented; higher values in the newborn reflect increased permeability of the neonatal glomerulus

The reliability of strength tests performed in elevated shoulder positions using a handheld dynamometer

CONTEXT: The reliable measurement of shoulder strength is important when assessing athletes involved in overhead activities. Swimmers' shoulders are subject to repetitive humeral elevation and consequently have a high risk of developing movement-control issues and pain. Shoulder-strength tests performed in positions of elevation assist with the detection of strength deficits that may affect injury and performance. The reliability of isometric strength tests performed in positions of humeral elevation without manual stabilization, which is a typical clinical scenario, has not been established