1,520 research outputs found
A New Hybrid Framework to Efficiently Model Lines of Sight to Gravitational Lenses
In strong gravitational lens systems, the light bending is usually dominated
by one main galaxy, but may be affected by other mass along the line of sight
(LOS). Shear and convergence can be used to approximate the contributions from
less significant perturbers (e.g. those that are projected far from the lens or
have a small mass), but higher order effects need to be included for objects
that are closer or more massive. We develop a framework for multiplane lensing
that can handle an arbitrary combination of tidal planes treated with shear and
convergence and planes treated exactly (i.e., including higher order terms).
This framework addresses all of the traditional lensing observables including
image positions, fluxes, and time delays to facilitate lens modelling that
includes the non-linear effects due to mass along the LOS. It balances accuracy
(accounting for higher-order terms when necessary) with efficiency (compressing
all other LOS effects into a set of matrices that can be calculated up front
and cached for lens modelling). We identify a generalized multiplane mass sheet
degeneracy, in which the effective shear and convergence are sums over the
lensing planes with specific, redshift-dependent weighting factors.Comment: 13 pages, 2 figure
A Reconciliation between the Consumer Price Index and the Personal Consumption Expenditures Price Index
The Bureau of Labor Statistics (BLS) prepares the Consumer Price Index for All Urban Consumers (CPI-U), and the Bureau of Economic Analysis prepares the Personal Consumption Expenditures (PCE) chain-type price index. Both indexes measure the prices paid by consumers for goods and services. Because the two indexes are based on different underlying concepts, they are constructed differently, and tend to behave differently over time. From the first quarter of 2002 through the second quarter of 2007, the CPI-U increased 0.4 percentage point per year faster than the PCE price index. This paper details and quantifies the differences in growth rates between the CPI-U and the PCE price index; it provides a quarterly reconciliation of growth rates for the 2002:Q1- 2007:Q2 time period. There are several factors that explain the differences in growth rates between the CPI and the PCE price index. First, the indexes are based on difference index-number formulas. The CPI-U is based on a Laspeyres index; the PCE price index is based on a Fisher-Ideal index. Second, the relative weights assigned to the detailed item prices in each index are different because they are based on different data sources. The weights used in the CPIU are based on a household survey, while the weights used in the PCE price index are based on business surveys. Third, there are scope differences between the two indexes— that is, there are items in the CPI-U that are out-of-scope of the PCE price index, and there are items in the PCE price index that are out-of-scope of the CPI-U. And finally, there are differences in the seasonal-adjustment routines and in the detailed price indexes used to construct the two indexes. Over the 2002:Q1-2007:Q2 time period, this analysis finds that almost half of the 0.4 percentage point difference in growth rates between the CPI-U and the PCE price index was explained by differences in index-number formulas. After adjusting for formula differences, differences in relative weights—primarily “rent of shelter”—more than accounted for the remaining difference in growth rates. Net scope differences, in contrast, partly offset the effect of relative weight differences.
Comprehensive Observations of the Bright and Energetic Type Iax SN 2012Z: Interpretation as a Chandrasekhar Mass White Dwarf Explosion
We present UV through NIR broad-band photometry, and optical and NIR
spectroscopy of Type Iax supernova 2012Z. The data set consists of both early
and late-time observations, including the first late phase NIR spectrum
obtained for a spectroscopically classified SN Iax. Simple model calculations
of its bolometric light curve suggest SN 2012Z produced ~0.3 M_sun of (56)Ni,
ejected about a Chandrasekhar mass of material, and had an explosion energy of
~10^51 erg, making it one of the brightest and most energetic SN Iax yet
observed. The late phase NIR spectrum of SN 2012Z is found to broadly resemble
similar epoch spectra of normal SNe Ia; however, like other SNe Iax,
corresponding visual-wavelength spectra differ substantially compared to all
supernova types. Constraints from the distribution of IMEs, e.g. silicon and
magnesium, indicate that the outer ejecta did not experience significant mixing
during or after burning, and the late phase NIR line profiles suggests most of
the (56)Ni is produced during high density burning. The various observational
properties of SN 2012Z are found to be consistent with the theoretical
expectations of a Chandrasekhar mass white dwarf progenitor that experiences a
pulsational delayed detonation, which produced several tenths of a solar mass
of (56)Ni during the deflagration burning phase and little (or no) (56)Ni
during the detonation phase. Within this scenario only a moderate amount of
Rayleigh-Taylor mixing occurs both during the deflagration and fallback phase
of the pulsation, and the layered structure of the IMEs is a product of the
subsequent denotation phase. The fact that the SNe Iax population does not
follow a tight brightness-decline relation similar to SNe Ia can then be
understood in the framework of variable amounts of mixing during pulsational
rebound and variable amounts of (56)Ni production during the early subsonic
phase of expansion.Comment: Submitted to A&A, manuscript includes response to referee's comments.
39 pages, including 16 figures, 9 table
Supernova 2013by: A Type IIL Supernova with a IIP-like light curve drop
We present multi-band ultraviolet and optical light curves, as well as
visual-wavelength and near-infrared spectroscopy of the Type II linear (IIL)
supernova (SN) 2013by. We show that SN 2013by and other SNe IIL in the
literature, after their linear decline phase that start after maximum, have a
sharp light curve decline similar to that seen in Type II plateau (IIP)
supernovae. This light curve feature has rarely been observed in other SNe IIL
due to their relative rarity and the intrinsic faintness of this particular
phase of the light curve. We suggest that the presence of this drop could be
used as a physical parameter to distinguish between subclasses of SNe II,
rather than their light curve decline rate shortly after peak. Close inspection
of the spectra of SN 2013by indicate asymmetric line profiles and signatures of
high-velocity hydrogen. Late (less than 90 days after explosion) near-infrared
spectra of SN 2013by exhibit oxygen lines, indicating significant mixing within
the ejecta. From the late-time light curve, we estimate that 0.029 solar mass
of 56Ni was synthesized during the explosion. It is also shown that the V -band
light curve slope is responsible for part of the scatter in the luminosity (V
magnitude 50 days after explosion) vs. 56Ni relation. Our observations of SN
2013by and other SNe IIL through the onset of the nebular phase indicate that
their progenitors are similar to those of SNe IIP.Comment: submitted 2014 December 5th, accepted 2015 January 28t
SN 2015ba: A type IIP supernova with a long plateau
We present optical photometry and spectroscopy from about a week after
explosion to 272 d of an atypical Type IIP supernova, SN 2015ba, which
exploded in the edge-on galaxy IC 1029. SN 2015ba is a luminous event with an
absolute V-band magnitude of -17.10.2 mag at 50 d since explosion and has
a long plateau lasting for 123 d. The distance to the SN is estimated to
be 34.80.7 Mpc using the expanding photosphere and standard candle
methods. High-velocity H-Balmer components constant with time are observed in
the late-plateau phase spectra of SN 2015ba, which suggests a possible role of
circumstellar interaction at these phases. Both hydrodynamical and analytical
modelling suggest a massive progenitor of SN 2015ba with a pre-explosion mass
of 24-26 M. However, the nebular spectra of SN 2015ba exhibit
insignificant levels of oxygen, which is otherwise expected from a massive
progenitor. This might be suggestive of the non-monotonical link between O-core
masses and the zero-age main-sequence mass of pre-supernova stars and/or
uncertainties in the mixing scenario in the ejecta of supernovae.Comment: 42 pages, 7 pages Appendix, 20 figures, 10 tables, Accepted for
publication in MNRAS, 14-June-201
Optical and near infrared observations of SN 2014ck: an outlier among the Type Iax supernovae
We present a comprehensive set of optical and near-infrared photometric and
spectroscopic observations for SN 2014ck, extending from pre-maximum to six
months later. These data indicate that SN 2014ck is photometrically nearly
identical to SN 2002cx, which is the prototype of the class of peculiar
transients named SNe Iax. Similar to SN 2002cx, SN 2014ck reached a peak
brightness mag, with a post-maximum decline-rate mag. However, the spectroscopic sequence shows
similarities with SN 2008ha, which was three magnitudes fainter and faster
declining. In particular, SN 2014ck exhibits extremely low ejecta velocities,
km s at maximum, which are close to the value measured for
SN 2008ha and half the value inferred for SN 2002cx. The bolometric light curve
of SN 2014ck is consistent with the production of of Ni. The spectral identification of several iron-peak
features, in particular Co II lines in the NIR, provides a clear link to SNe
Ia. Also, the detection of narrow Si, S and C features in the pre-maximum
spectra suggests a thermonuclear explosion mechanism. The late-phase spectra
show a complex overlap of both permitted and forbidden Fe, Ca and Co lines. The
appearance of strong [Ca~II] 7292, 7324 again mirrors the
late-time spectra of SN 2008ha and SN 2002cx. The photometric resemblance to SN
2002cx and the spectral similarities to SN 2008ha highlight the peculiarity of
SN 2014ck, and the complexity and heterogeneity of the SNe Iax class.Comment: MNRAS Accepted 2016 March 22. Received 2016 March
The progenitor and early evolution of the Type IIb SN 2016gkg
We report initial observations and analysis on the Type IIb SN~2016gkg in the
nearby galaxy NGC~613. SN~2016gkg exhibited a clear double-peaked light curve
during its early evolution, as evidenced by our intensive photometric follow-up
campaign. SN~2016gkg shows strong similarities with other Type IIb SNe, in
particular with respect to the \he~emission features observed in both the
optical and near infrared. SN~2016gkg evolved faster than the prototypical
Type~IIb SN~1993J, with a decline similar to that of SN~2011dh after the first
peak. The analysis of archival {\it Hubble Space Telescope} images indicate a
pre-explosion source at SN~2016gkg's position, suggesting a progenitor star
with a mid F spectral type and initial mass \msun, depending on
the distance modulus adopted for NGC~613. Modeling the temperature evolution
within of explosion, we obtain a progenitor radius of
\rsun, smaller than that obtained from the analysis of the
pre-explosion images (\rsun).Comment: 7 pages, 5 figures. Submitted to ApJ Letter
Effect of P-glycoprotein modulation with cyclosporin A on cerebrospinal fluid penetration of doxorubicin in non-human primates
PURPOSE:
P-glycoprotein (Pgp) is a transmembrane drug efflux pump that is expressed in multidrug-resistant cancer cells and in a variety of normal tissues, including brain capillary endothelial cells which comprise the blood-brain barrier. We studied the effects of the Pgp inhibitor, cyclosporin A (CsA), on the cerebrospinal fluid (CSF) penetration of the Pgp substrate, doxorubicin, in non-human primates.
METHODS:
The animals received doxorubicin alone (2.0 mg/kg i.v. over 60 min) or doxorubicin (1 mg/kg i.v. over 60 min) and CsA (loading dose 4.0 mg/kg i.v. over 2 h, followed by continuous infusion of 12 mg/kg per day over 48 h). Plasma and CSF were collected over 48 h and the doxorubicin concentration was measured by reverse-phase high-pressure liquid chromatography (HPLC) with fluorescence detection (detection limit 5 nM). A two-compartment model was fitted to the plasma concentration-time data.
RESULTS:
Pgp was demonstrated to be present in the epithelium of the choroid plexus by immunohistochemical methods, indicating that CSF drug penetration could be used as a surrogate for blood-brain barrier penetration. Steady state whole blood CsA concentrations, which were measured with a fluorescence-polarization immunoassay (TDX) that detects both CsA and its metabolites, ranged from 551-1315 microg/l at 24 h. The clearance of doxorubicin in four animals was reduced by 34%, 38%, 45% and 49% when given with CsA. The doxorubicin concentration in the CSF was <5 nM in all animals, both after doxorubicin alone and doxorubicin with CsA.
CONCLUSIONS:
The Pgp inhibitor, CsA, at a concentration that alters systemic clearance of doxorubicin, does not appear to significantly increase the CSF penetration of doxorubicin
- …
