Mass flow in the interacting binary TX Ursae Majoris

Twenty-two far-ultraviolet and 23 near-ultraviolet high resolution IUE spectra of the interactive Algol-type binary TX Ursae Majoris (B8 V + F-K III-IV) were analyzed in order to determine the nature of the mass flow occurring in this system. Absorption features due to high-temperature ions of Si IV, C IV, and N V are always present. The resonance lines of Al III, Fe II, Mg II and Si IV show strong phase and secular variations indicative of gas streaming and circumstellar/circumbinary material. Radial velocities as high as 500 to 600 km/sec are present. The gas flow is particularly prominent in 1985 between phases 0.7 and 0.0. The system is more active than U Sagittae and as active as U Cephei

OAO-2 observations of beta Lyrae and a provisional interpretation

Six-color ultraviolet photoelectric observations of beta Lyrae obtained with OAO-2 are presented. These observations, made at 1380, 1500, 1920, 2460, 2980 and 3330 A, represent the first truly continual coverage of the light changes of beta Lyrae during one orbital revolution and were obtained in November 1970. The photometric data are supplemented by spectral scans in the wavelength intervals 3800-1800 A and 2000-1050 A; the latter interval was scanned at 10 A resolution once during every OAO-2 orbit, i.e., about 100 minutes. Anomalous features, such as asymmetries and short and long term variations, are present in the light curves. A tentative discussion of solutions of the light curves is given

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter

Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA damage and supra-additive toxicity to NAT-expressing cells and xenografts. This combination treatment is undergoing clinical evaluation. This present study investigated the potential of PARP-1 inhibition, in vitro and in vivo, to further enhance [131I]MIBG/topotecan efficacy

The development of the forms of responding to self-critical thoughts Scale (FoReST)

Background: Self-critical thoughts are a feature of many mental health problems. Adopting a psychologically flexible response to thoughts has been highlighted as a key determinant of wellbeing. But, the measurement of psychological flexibility (PF) in relation to self-critical thoughts is under-developed. This paper reports on the development of the Forms of Responding to Self-Critical Thoughts Scale (FoReST). Method: Study One involved the development and exploratory factor analysis of the FoReST in a convenience sample of 253 non-clinical adults. Study Two was a confirmatory factor analysis study of the FoReST in a sample of 110 University students. Study 3 explored the convergent and concurrent validity of the FoReST by examining associations with measures of similar constructs (PF, self-compassion, self-criticism) and relevant mental health measures (anxiety, depression, distress). Study 3 also explored the FoReST’s incremental validity for predicting depression and anxiety levels beyond an established measure of self-critical thinking. Results: In Study One, exploratory factor analysis produced a 9-item/2-factor solution (unworkable action and mindful acceptance). The measure demonstrated good internal consistency. In Study 2, the confirmatory factor analysis also indicated a 2-factor model (unworkable action and mindful acceptance) and overall internal consistency that was excellent. In Study Three, the FoReST demonstrated high convergent validity with similar measures, and good concurrent validity with mental health outcomes. Analyses also indicated good incremental validity for the FoReST for predicting HADS depression and anxiety scores. Conclusions: The FoReST appears to be a psychometrically sound measure suitable for measuring change processes in third wave therapies such as Acceptance and Commitment Therapy, Mindfulness-based Interventions and Compassion Focused therapy