Potential of Microwave Curing for Precast Concrete Manufacture

This paper introduces research to develop an intelligent microwave system for manufacturing concrete products. The key features of this system include the use of optical fibre Bragg grating sensors to control the temperature and humidity inside the concrete and microwave oven cavity respectively. Using this tailor-made microwave system, research is ongoing in the Advanced and Innovative Materials Group at University College London to explore the potential for curing two types of low-carbon cementitious systems: high-volume fly ash and alkali-activated fly ash. In both systems, thermal curing is essential for strength development, particularly early strength development. Results indicate that, by using the microwave curing technique, low-carbon performance can be achieved from both systems, whilst early strength was not affected. The results demonstrate the potential of microwave curing for manufacturing low-carbon precast concrete elements in future

Optimization of the accelerated curing process of concrete using a fibre Bragg grating-based control system and microwave technology

In this paper, an investigation into the suitability of using fibre Bragg gratings (FBGs) for monitoring the accelerated curing process of concrete in a microwave heating environment is presented. In this approach, the temperature data provided by the FBGs are used to regulate automatically the microwave power so that a pre-defined temperature profile is maintained to optimize the curing process, achieving early strength values comparable to those of conventional heat-curing techniques but with significantly reduced energy consumption. The immunity of the FBGs to interference from the microwave radiation used ensures stable readings in the targeted environment, unlike conventional electronic sensor probes

Application of fibre Bragg gratings for the optimization of microwave-cured concrete

In this paper, the suitability of using ‘intelligent’ fibre Bragg gratings (FBGs) as sensors for the temperature feedback control of concrete cured in a microwave environment has been presented and experimentally demonstrated. In this novel approach, the temperature data provided by the embedded FBGs are processed on the fly (using a feedback control algorithm) in order to regulate the microwave power so that an internal curing temperature of 70°C is maintained. The immunity of the FBGs to microwave radiation ensures that the embedded sensors remain stable, unlike conventional metallic/electrical probes

Potential of Microwave Curing for Precast Concrete Manufacture

In this paper, an ongoing research sponsored by Innovate UK on developing an intelligent microwave system for manufacturing concrete products is introduced. The key features of this microwave system include using optical fibre Bragg grating (FBG) sensors to control the temperature and the humidity inside concrete and microwave oven cavity, respectively. Using this tailor-made microwave system, research is ongoing in the Advanced and Innovative Materials (AIM) Group at University College London to explore the potential of curing two types of low-carbon cementitious systems, namely high-volume fly ash (HVFA) and alkali-activated fly ash (AAFA). In both systems, thermal curing is essential for the strength development, in particular, early strength development. Their results indicate that, by using the microwave curing technique, the low-carbon performance can be achieved from both systems whilst the early strength was not affected. The current results also demonstrate a good potential of microwave curing for manufacturing low-carbon precast concrete elements in the future

Densification of Fresh Concrete by Microwave

Concrete mixes with different fly ash replacement levels, namely 0%, 35% and 55% at a fixed water to binder ratio (W/B) of 0.6 were heated by a tailor-made microwave oven up to 50oC immediately after casting until initial setting in order to remove excessive free water. The compressive strengths of microwave densified samples after 7 days were 3.2%, 7.7% and 29.6% higher than those of oven heated batches. It demonstrated that higher density, lower water absorption and better microstructure were achieved after microwave heating, indicating microwave heating can be a promising technique for densifying fresh concrete

Whole-genome resequencing of two elite sires for the detection of haplotypes under selection in dairy cattle

Using a combination of whole-genome resequencing and high-density genotyping arrays, genome-wide haplotypes were reconstructed for two of the most important bulls in the history of the dairy cattle industry, Pawnee Farm Arlinda Chief (“Chief”) and his son Walkway Chief Mark (“Mark”), each accounting for ∼7% of all current genomes. We aligned 20.5 Gbp (∼7.3× coverage) and 37.9 Gbp (∼13.5× coverage) of the Chief and Mark genomic sequences, respectively. More than 1.3 million high-quality SNPs were detected in Chief and Mark sequences. The genome-wide haplotypes inherited by Mark from Chief were reconstructed using ∼1 million informative SNPs. Comparison of a set of 15,826 SNPs that overlapped in the sequence-based and BovineSNP50 SNPs showed the accuracy of the sequence-based haplotype reconstruction to be as high as 97%. By using the BovineSNP50 genotypes, the frequencies of Chief alleles on his two haplotypes then were determined in 1,149 of his descendants, and the distribution was compared with the frequencies that would be expected assuming no selection. We identified 49 chromosomal segments in which Chief alleles showed strong evidence of selection. Candidate polymorphisms for traits that have been under selection in the dairy cattle population then were identified by referencing Chief’s DNA sequence within these selected chromosome blocks. Eleven candidate genes were identified with functions related to milk-production, fertility, and disease-resistance traits. These data demonstrate that haplotype reconstruction of an ancestral proband by whole-genome resequencing in combination with high-density SNP genotyping of descendants can be used for rapid, genome-wide identification of the ancestor’s alleles that have been subjected to artificial selection

Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer

Tamoxifen is the standard-of-care treatment for estrogen receptor-positive premenopausal breast cancer. We examined tamoxifen metabolism via blood metabolite concentrations and germline variations of CYP3A5, CYP2C9, CYP2C19 and CYP2D6 in 587 premenopausal patients (Asians, Middle Eastern Arabs, Caucasian-UK; median age 39 years) and clinical outcome in 306 patients. N-desmethyltamoxifen (DM-Tam)/(Z)-endoxifen and CYP2D6 phenotype significantly correlated across ethnicities (R2: 53%, P<10?77). CYP2C19 and CYP2C9 correlated with norendoxifen and (Z)-4-hydroxytamoxifen concentrations, respectively (P<0.001). DM-Tam was influenced by body mass index (P<0.001). Improved distant relapse-free survival (DRFS) was associated with decreasing DM-Tam/(Z)-endoxifen (P=0.036) and increasing CYP2D6 activity score (hazard ratio (HR)=0.62; 95% confidence interval (CI), 0.43–0.91; P=0.013). Low (<14?nM) compared with high (>35?nM) endoxifen concentrations were associated with shorter DRFS (univariate P=0.03; multivariate HR=1.94; 95% CI, 1.04–4.14; P=0.064). Our data indicate that endoxifen formation in premenopausal women depends on CYP2D6 irrespective of ethnicity. Low endoxifen concentration/formation and decreased CYP2D6 activity predict shorter DRFS