Occupational Safety and Health Accidents among Biomedical Waste Handlers in Nairobi County

This study was conducted to investigate the reasons for prevalent increase in the number of occupational accidents among biomedical waste handlers despite the Waste Management Authority’s regulatory framework defining the laws and procedures that govern the collection, storage, processing, and disposal of biomedical waste in Nairobi County and recommend appropriate actions to counter the situation . The two areas of investigation consisted of determining the causes of occupational accidents and evaluating the attitude and knowledge of biomedical waste handlers in Nairobi County. Both, the qualitative and quantitative research paradigms were used in the study. A sample size of 168 participants from the target population of 1000 biomedical waste handlers was chosen with 160 questionnaires returned for statistical analysis. The study used a descriptive statistics approach to generate tables with the mean, standard error of the mean, t-distributions, percentages, and significance tests among other statistical measures to address the research objectives on the basis of the Petersen’s Accident/Incident and the human factors theories. On the causes of accidents, the results showed strong positive Skewness indicating problems with waste management practices, inadequate knowledge on waste classification at source, inadequate attention to rules and regulations governing the collection and handling of biomedical waste, inadequate training and awareness, poor enforcement of waste handling standards and policies, and inadequate knowledge on the classification and handling of biomedical waste. This revealed the nature of accidents to include pricks, contaminations, muscle tearing, scratches, being struck by falling objects and sustaining injuries due to falls. On knowledge and attitude of biomedical waste handlers, significant challenges were revealed showing that inadequate knowledge on safe waste handling methods with a significant number showing that their educational attainments barred them from comprehending the regulations and procedures for handling biomedical waste. A significance test at Kendall's tau coefficient statistic showed strong positive correlation between educational levels and managing biomedical waste. It was recommended that the Waste Management Authority designs a customized training program to address the problems facing biomedical waste handlers in Nairobi County. Keywords: Biomdedical waste, hazards, Accidents, Waste Management, injuries, pricks, Nairobi Count

Global Health in the Age of COVID-19: Responsive Health Systems Through a Right to Health Fund.

We propose that a Right to Health Capacity Fund (R2HCF) be created as a central institution of a reimagined global health architecture developed in the aftermath of the COVID-19 pandemic. Such a fund would help ensure the strong health systems required to prevent disease outbreaks from becoming devastating global pandemics, while ensuring genuinely universal health coverage that would encompass even the most marginalized populations. The R2HCF's mission would be to promote inclusive participation, equality, and accountability for advancing the right to health. The fund would focus its resources on civil society organizations, supporting their advocacy and strengthening mechanisms for accountability and participation. We propose an initial annual target of US$500 million for the fund, adjusted based on needs assessments. Such a financing level would be both achievable and transformative, given the limited right to health funding presently and the demonstrated potential of right to health initiatives to strengthen health systems and meet the health needs of marginalized populations-and enable these populations to be treated with dignity. We call for a civil society-led multi-stakeholder process to further conceptualize, and then launch, an R2HCF, helping create a world where, whether during a health emergency or in ordinary times, no one is left behind

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Conjugated Polymer‐Wrapped Single‐Wall Carbon Nanotubes for High‐Mobility Photonic/Electrical Fully Modulated Synaptic Transistor

Although synaptic devices have already demonstrated their operability through electric or photonic signals or a combination thereof, current challenges include developing a single hardware synaptic device that is independently fully operational through either photonic or electric signals to improve device versatility. Additionally, most previously reported devices are fabricated using multiple technical processes—which impede device implementation—while the low-output current triggered in most such devices limits the possible integration of auxiliary gadgets. Therefore, by spontaneously wrapping a conjugated block copolymer around single-walled carbon nanotubes (SWCNTs), a thin-film transistor memory device comprising single-layered poly(9,9-dioctylfluorene)-b-polyisoprene (PF-b-PI)-wrapped-SWCNTs—which function as both a semiconductor and an electret layer—to simplify the device structure and fabrication is designed. Owing to the robust SWCNT charge carrier mobility (≈11.3 cm2 V−1 s−1), a high output current (10−4 to 10−3 A) can be achieved and because PF is a photoactive conjugated polymer, the photonic signal can also be modulated. The designed memory device independently exhibits both voltage- and light-controllable switching, thereby mimicking biological synaptic behavior such as short- and long-term plasticity, spike-time, and spike-rate-dependent plasticity. This study may provide a suitable basis for developing more-convenient, economical, highly versatile synaptic devices

S2 Fig -

a. Prevalence of persistent respiratory symptoms across WHO regions. b. Prevalence of persistent respiratory symptoms across income levels. c. Prevalence of persistent respiratory symptoms across age groups. (TIF)</p

Factors associated with persisting respiratory symptoms following TB.

Factors associated with persisting respiratory symptoms following TB.</p

Prevalence of PTLD across World Health Organisation regions.

A forest plot showing subgroup meta-analysis comparing prevalence of PTLD as a composite outcome (abnormal spirometry or persistent symptoms or abnormal radiology) in all 30 studies across five WHO regions.</p

Overall prevalence of PTLD.

A forest plot showing the overall prevalence of PTLD from all 30 studies involving a pooled sample size of 6050 study participants. Studies used varying methods of post-TB assessment, for this composite model if a study used more than one method, spirometry data was adopted, symptom data if no spirometry was done, and radiology data if neither spirometry nor symptom assessment was done.</p