Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms

Introduction The autoimmune / inflammatory syndrome induced by adjuvants (ASIA) has been described by Shoenfeld and Agon-Levin (in 2011). It is an autoimmune / auto-inflammatory disease caused by adjuvants. Adjuvants are substances able to induce autoimmunity via various mechanisms such as a change in the host immune system, polyclonal activation of B cells, effects on cellular immunity, immunoregulatory cells, antibodies induced by viruses or acceleration of molecular mimicry. The aim The purpose of the work was to congregate information about ASIA useful in medical practice. State of knowledge The ASIA syndrome can be diagnosed when two main or one main and two smaller criteria are fulfil. The main criteria: External stimulus exposure Muscle pains, muscle inflammation or muscle weakness Arthralgia and / or arthritis Chronic fatigue, sleep without rest or sleep disorder Neurological symptoms Impaired cognitive function, memory loss Fever, dry mouth Removal of the inducing factor induces an improvement Result of organ biopsy Smaller criteria: Other clinical signs (irritable bowel syndrome) Presence of HLA antigens (ie HLA DRB1, HLA DQB1) Development of autoimmune disease (multiple sclerosis, systemic sclerosis). Asia syndrome may occur after implantation of silicone breast implants and cause various complications of other pain, fever and skin changes. Conclusion Autoimmune / auto-inflammatory disorders can be caused by silicone implants and vaccine adjuvants: they include the presence of autoantibodies, muscle and joint pain, lupus-like symptoms and hardened-like symptoms

The influence of SGLT2 inhibitors on oxidative stress in heart failure and chronic kidney disease in patients with type 2 diabetes

There is increasing interest in sodium-glucose cotransporter 2 inhibitors (SGLT2i) as not only a new oral glucose-lowering drug class but also one with cardio- and nephroprotective potential. Understanding the underlying mechanisms is therefore of great interest, and postulated benefits have included increased natriuresis, lower blood pressure, increased haematocrit, enhanced cardiac fatty acid utilization, reduced low-grade inflammation, and decreased oxidative stress. In particular, redox homeostasis seems to be crucial in the pathogenesis of heart and kidney disease in diabetes, and there is accumulating evidence that SGLT2i have beneficial effects in this perspective. In this review, we aimed to summarize the potential mechanisms of the influence of SGLT2i on oxidative stress parameters in animal and human studies, with a special focus on heart failure and chronic kidney disease in diabetes mellitus

Serine-Selective Bioconjugation.

This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This redox-economical approach can be used to append nearly any kind of cargo onto serine, generating a stable, benign, and hydrophilic phosphorothioate linkage. The method tolerates all other known nucleophilic functional groups of naturally occurring proteinogenic amino acids. A variety of applications can be envisaged by this expansion of the toolbox of site-selective bioconjugation methods

Reforms of the system of banking supervision in Europe after the financial crisis 2007-2009

W obliczu kryzysu finansowego lat 2007-2009, dotychczasowe praktyki nadzorcze, stosowane wobec instytucji kredytowych, okazały się niewystarczające. Niezbędne stało się wypracowanie nowych rozwiązań służących zapewnieniu stabilności i bezpieczeństwa systemu bankowego. W niniejszej pracy omówiono kolejne zmiany w systemie nadzoru banków europejskich. Celem pracy jest ocena przeprowadzonych po kryzysie reform. Z wykorzystaniem literatury przedmiotu oraz obowiązujących aktów prawnych, szczególnej analizie poddano projekt zintegrowanych ram finansowych i jego możliwe skutki dla europejskiego systemu bankowego. Rozważenie potencjalnych następstw unii bankowej pozwala wnioskować o jej znaczącym wpływie na kształt systemu nadzoru bankowego nie tylko w najbliższej przyszłości, ale również w długoterminowej perspektywie.During the financial crisis of 2007-2009, previous supervisory practices, which had been applied to financial institutions, turned out to be insufficient. It became essential to work out new solutions in order to provide safe and sound banking system. Consecutive changes in supervisory system of the European banks are described in this thesis. The purpose of the thesis is the assessment of reforms carried out after the crisis. Based on literature as well as current legislation, the analysis of the integrated financial framework was conducted and its potential impact on European banking system was taken into account. After consideration of possible banking union’s aftermath, it can be said that its influence on the system of banking supervision will be significant not only in the near future, but also in the long-term perspective

Kształtowanie się przednio-tylnych krzywizn kręgosłupa u uczniów z klas gimnazjalnych i licealnych

Introduction: Defects of posture in children and adolescents have been frequently observed for many years. The determination of the shape and size of anterior-posterior spinal curvatures is one of the elements within the examination and assessment of body posture. Aim: Characteristics of anterior-posterior spinal curvatures in the examined young people in reference to general Saunders norm. Material and method: the examinations covered 117 young people (67 girls and 50 boys), aged 13–19 years old. The measurements of the size of anterior-posterior spinal curvatures were taken using an inclinometer. The children were examinated under the following points: the medianus point of the sacrum bone (- angle), area intervertebralis Th12–L1 (0 angle) and area intervertebralis C7–Th1 (1 angle). The Wolanski method was applied to show the differences of individual types of body posture. The Statistica 7.0 program (-t-Student test and 4²test) was applied to check if statistically significant differences occured.Results: The differences of the statistically significant (p<0.05) were stated in the 1 angle amongst young people from grammar school and junior high school. The statistically significant differences were noted in the forming of thoracal kyphosis between the girls from the junior high school and the girls from the grammar school and between the boys from the junior high school and the boys from the grammar school (in both cases p<0.05). The most common type of body posture for all the teenagers was of the kyphotic type (63.2%). The most frequent defect of body posture was flat lumbar lordosis (28.2%).Conclusions: The existence of a curvature angle increase in thoracal kyphosis and angle reduction in lumbar lordosis in reference to the general Saunders norm is common in both research groups. The thoracal kyphosis is formed differently in girls and boys from grammar schools and junior high schools. It follows to form the lumbar lordosis in the correction of body posture

Efficiency of Pb(II) and Mo(VI) removal by kaolinite impregnated with zero-valent iron particles

In this work, kaolinite modified with zero-valent iron was synthesized and used as a sorbent for Pb(II) and Mo(VI) removal from aqueous solutions. The obtained material was characterized by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. The methods revealed successful modification by the Fe0 particles precipitation on the surface of well-ordered kaolinite. The sorption experiment results showed a significant increase of sorption capacity in relation to the raw kaolinite. The kaolinite with 25% content of Fe0 was found to be the best material for Pb(II) and Mo(VI) removal, resulting in approximately 500 mmol•kg-1 and 350 mmol•kg-1 sorption, respectively. The possible mechanisms responsible for metals’ removal were identified as reduction by Fe0 ‘core’ and adsorption on the iron hydroxides ‘shell’. The study indicated that the obtained material is capable of efficient Pb(II) and Mo(VI) removal and may be an interesting alternative to other methods used for heavy metals’ removal