13 research outputs found
A non-LTE spectral analysis of the 3He and 4He isotopes in the HgMn star kappa Cancri
We present a pilot study on non-local thermodynamic equilibrium (NLTE)
line-formation computations for the isotopes 3He and 4He in the
mercury-manganese star kappa Cancri. The impact of NLTE effects on the
determination of isotopic abundances and the vertical stratification of helium
in the atmosphere is investigated. Modern NLTE line-formation computations were
employed to analyse a high-resolution and high signal-to-noise ratio
ESO-VLT/UVES spectrum of kap Cnc. The atmospheric parameters were determined
from fitting the hydrogen Balmer lines and the spectral energy distribution.
Multiple HeI lines were investigated, including HeI 4921A and 6678A, which show
the widest isotopic splits. Half of the observed HeI lines in the spectrum of
kap Cnc show significant NLTE strengthening, the effects are strongest in the
red lines HeI 5875A and HeI 6678A. NLTE abundances from individual HeI lines
are up to a factor of about 3 lower than LTE values. Helium is found to be
stratified in the atmosphere of kap Cnc. While the LTE analysis indicates a
step-like profile of the helium abundance, a gradual decrease with height is
indicated by the NLTE analysis. A 3He/4He ratio of about 0.25-0.30 is found.
With the available data it cannot be decided whether the two isotopes follow
the same stratification profile, or not. This work implies that NLTE effects
may be ubiquitous in the atmospheres of HgMn stars and may have a significant
impact on abundance determinations and the interpretation of the vertical
abundance stratification of elements.Comment: 7 pages, 9 figure
Non-primate hepacivirus infection with apparent hepatitis in a horse â Short communication
Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown. This study reports the detection of natural NPHV infection in a horse with apparent hepatitis, liver damage and high-level viraemia. NPHV could be hepatotropic and associated with hepatitis in horses
First report of compounds from an Ancistrocarpus species: Triterpenoids from A. densispinosus Oliv. (Malvaceae).
Peyeino JH, Djomkam HLM, Kenmogne SB, et al. First report of compounds from an Ancistrocarpus species: Triterpenoids from A. densispinosus Oliv. (Malvaceae). Natural product research. 2020.The stem bark of Ancistrocarpus densispinosus Oliv. exhibited triterpenoids, including the rare fernane-type, fern-9(11)-ene-2alpha,3beta-diol (1) a possible chemotaxonomically distinct biomolecule for the genus. Other triterpenoids that were isolated from this plant include the ursane-type ursolic acid (2) and corosolic acid (3), friedelane-type friedelin (4) and canophyllol (5), lupane-type lupeol (6), betulin (7), betulinic acid (8) and hennadiol (9), oleanoic acid (10), maslinic acid (11) and taraxerol (12) and three sterols. This is the first report of the chemistry of a plant of the Ancistrocarpus. The structures of the compounds were elucidated based on their NMR, IR and MS techniques and by comparisons of their experimental data with those reported. The twelve triterpenoids 1-12 were found to be inactive against five bacterial strains Escherichia coli, Bacillus subtilis, Pseudomonas agarici, Micrococcus luteus and Staphylococcus warneri; inactive against KB-3-1 cervix carcinoma cancer cell line and inactive as antioxidants in the DPPH assay
Non-primate hepacivirus infection with apparent hepatitis in a horse â Short communication
Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev
Nangmou Nkouayeb BM, Maza Djomkam HL, Tabekoueng GB, et al. Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev. Chemistry & Biodiversity . 2023: e202200271.The root extract of Nauclea xanthoxylon (A.Chev.) Aubrev. displayed significant 50% inhibition concentration (IC50s) of 0.57 and 1.26 g/mL against chloroquine resistant and sensitive Plasmodium falciparum (Pf) Dd2 and 3D7 strains, respectively. Bio-guided fractionation led to an ethyl acetate fraction with IC50s of 2.68 and 1.85 g/mL and subsequently, to the new quinovic acid saponin named xanthoxyloside (1) with IC50s of 0.33 and 1.30 M, respectively against the tested strains. Further compounds obtained from ethyl acetate and hexane fractions were the known clethric acid (2), ursolic acid (3), quafrinoic acid (4), quinovic acid (5), quinovic acid 3-O-beta-D-fucopyranoside (6), oleanolic acid (7), oleanolic acid 3-acetate (8), friedelin (9), beta-sitosterol (10a), stigmasterol (10b) and stigmasterol 3-O-beta-D-glucopyranoside (11). Their structures were characterised with the aid of comprehensive spectroscopic methods (1 and 2D NMR, Mass). Bio-assays were performed using nucleic acid gel stain (SYBR green I)-based fluorescence assay with chloroquine as reference. Extracts and compounds exhibited good selectivity indices (SIs) of Ë10. Significant antiplasmodial activities measured for the crude extract, the ethyl acetate fraction and xanthoxyloside (1) from that fraction can justify the use of the root of N. xanthoxylon in ethnomedicine to treat malaria. © 2023 Wiley-VCH GmbH