15 research outputs found
Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency
- Author
- AD Kwong
- AG Evans
- AI Macrae
- AK Sheaffer
- Andrea C. Pezda
- B Ebrahimi
- B Glaunsinger
- B Glaunsinger
- Benson Yee Hin Cheng
- Britt Glaunsinger
- C Bagneris
- CM Collins
- CR Paden
- D Blaskovic
- D Martinez-Guzman
- DJ McGeoch
- E Barton
- E Flano
- E Flano
- G. Renuka Kumar
- GA Smith
- GR Kumar
- GT Rosa
- H Adler
- HW Virgin
- J Herskowitz
- J Rajcani
- J Zuo
- JA Murphy
- JB Weinberg
- JE Darnell Jr
- JM Morrison
- JM Moser
- JN Goldstein
- JS May
- Justin M. Richner
- Karen Clyde
- KE Weck
- KJ Sokoloski
- L Samady
- Laurent Coscoy
- LF van Dyk
- LI Strelow
- LS Johnson
- M Buisson
- M Korom
- M Rowe
- M van Gent
- MG Katze
- MG Wathelet
- NJ Moorman
- NJ Moorman
- NP Sunil-Chandra
- NP Sunil-Chandra
- PG Stevenson
- R Feederle
- R Martinez
- R Milho
- S Covarrubias
- S Hwang
- S Hwang
- S Iskra
- S Marques
- Samuel H. Speck
- Sergio Covarrubias
- SH Speck
- SJ Plotch
- SL Dahlroth
- SM Gregory
- SR Thompson
- T Decker
- Tina Wang
- TJ Pasieka
- TM Rickabaugh
- TT Wu
- VL Tarakanova
- W Kamitani
- YJ Lee
- Publication venue
- Public Library of Science
- Publication date
- 01/07/2011
- Field of study
During a lytic gammaherpesvirus infection, host gene expression is severely restricted by the global degradation and altered 3âČ end processing of mRNA. This host shutoff phenotype is orchestrated by the viral SOX protein, yet its functional significance to the viral lifecycle has not been elucidated, in part due to the multifunctional nature of SOX. Using an unbiased mutagenesis screen of the murine gammaherpesvirus 68 (MHV68) SOX homolog, we isolated a single amino acid point mutant that is selectively defective in host shutoff activity. Incorporation of this mutation into MHV68 yielded a virus with significantly reduced capacity for mRNA turnover. Unexpectedly, the MHV68 mutant showed little defect during the acute replication phase in the mouse lung. Instead, the virus exhibited attenuation at later stages of in vivo infections suggestive of defects in both trafficking and latency establishment. Specifically, mice intranasally infected with the host shutoff mutant accumulated to lower levels at 10 days post infection in the lymph nodes, failed to develop splenomegaly, and exhibited reduced viral DNA levels and a lower frequency of latently infected splenocytes. Decreased latency establishment was also observed upon infection via the intraperitoneal route. These results highlight for the first time the importance of global mRNA degradation during a gammaherpesvirus infection and link an exclusively lytic phenomenon with downstream latency establishment
Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders
- Author
- Adams
- Ahuja
- Ahveninen
- Amenedo
- American Psychiatric Association
- Andersson
- Andrea Tales
- Astikainen
- Astikainen
- Astikainen
- Astikainen
- Baddeley
- Baldeweg
- Baldeweg
- Barch
- Barr
- Bartholow
- Beck
- Beck
- Beck
- Benucci
- Bijl
- Bishop
- Blau
- Blumberg
- Boehnke
- Bottari
- Brockmole
- Bromet
- BrĂžnnick
- Buchanan
- Buckner
- Butler
- Button
- Carandini
- Ceponiene
- Chang
- Chang
- Chang
- Cheng
- Cheng
- Cheour
- Clark
- Cleary
- Clifford
- Cléry
- Cléry
- Cléry
- Cléry
- Cohen
- Corlett
- Corlett
- Coyle
- Coyle
- Csukly
- Csukly
- Czigler
- Czigler
- Czigler
- Czigler
- Czigler
- Czigler
- De Tommaso
- Delorme
- den Ouden
- Desimone
- Dorph-Petersen
- Dudai
- Dulude
- Egner
- Escera
- Ewbank
- Ewbank
- Farkas
- Fillmore
- Fillmore
- Fisher
- Flynn
- Folstein
- Friston
- Friston
- Friston
- Frohlich
- Fujimura
- Fusar-Poli
- Gaeta
- Garagnani
- Garrido
- Garrido
- Garrido
- Garrido
- Gayle
- Grill-Spector
- Grimm
- Grotheer
- Grotheer
- GĂĄbor Stefanics
- Haenschel
- Hart
- He
- Heekeren
- Heinrichs
- Heng
- Henson
- Herrmann
- Heslenfeld
- Hille
- Horimoto
- Hosoya
- HosĂĄk
- Houlihan
- HĂĄden
- HĂĄden
- Ibbotson
- Iijima
- Iijima
- Ioannidis
- Jacobsen
- James
- Jan KremlĂĄÄek
- Javitt
- Javitt
- Javitt
- Jessen
- JÀÀskelÀinen
- JÀÀskelÀinen
- Kairi Kreegipuu
- Kaliukhovich
- Kecskés-Kovåcs
- Kecskés-Kovåcs
- Kemner
- Kenemans
- Kenemans
- Kenemans
- Kenemans
- Keshavan
- Kessler
- Kessler
- Kessler
- Kiebel
- Kimura
- Kimura
- Kimura
- Kimura
- Kimura
- Kimura
- Kisley
- Kocsis
- Kohler
- Kohn
- Kok
- Komlosi
- Kreegipuu
- Krekelberg
- KremlĂĄÄek
- KremlĂĄÄek
- KremlĂĄÄek
- KremlĂĄÄek
- Kriegeskorte
- Kristjansson
- Kuba
- KubovĂĄ
- Kuhl
- Kujala
- Kujala
- Kuldkepp
- KÀhkönen
- LangrovĂĄ
- Lee
- Lee
- Lepistö
- Lewis
- Li
- Light
- Lindenberger
- Liu
- Lorenzo-LĂłpez
- Luck
- lv
- Maekawa
- Maekawa
- Maekawa
- Marsman
- Martin
- Martins Rosa
- Matsuyoshi
- May
- Mazza
- McDermott
- McGrath
- Meyer
- Mineka
- Mishkin
- Mo
- Moghaddam
- Morris
- Motter
- Movshon
- MĂŒller
- MĂŒller
- MĂŒller
- Nele PÔldver
- Nelken
- Nelken
- Neuhaus
- Newman
- Norcia
- Nordahl
- Norton
- Nunez
- Nyberg
- NÀÀtÀnen
- NÀÀtÀnen
- NÀÀtÀnen
- NÀÀtÀnen
- NÀÀtÀnen
- NÀÀtÀnen
- NÀÀtÀnen
- NÀÀtÀnen
- O'Shea
- Pammer
- Pang
- Park
- Pazo-Alvarez
- Peterson
- Phillips
- Piia Astikainen
- Pomarol-Clotet
- PĂ©rez-GonzĂĄlez
- Qian
- Qiu
- Ramachandran
- Rao
- Riekkinen
- Risto NÀÀtÀnen
- Rogers
- Rowe
- Ruhnau
- Ruzzoli
- Schacter
- Schröger
- Schröger
- Schulte-Körne
- Shelley
- Shepherd
- Shi
- Shimamura
- Si
- Sokolov
- Solomon
- Solomon
- Stagg
- Stahl
- Steele
- Stefanics
- Stefanics
- Stefanics
- Stefanics
- Stefanics
- Stefanics
- Stefanics
- Stefanics
- Stein
- Stephan
- Stephan
- Stephan
- Stephan
- Stothart
- Stothart
- Sulykos
- Sulykos
- Sulykos
- Summerfield
- Susac
- Susac
- Takei
- Takei
- Tales
- Tales
- Tales
- Tanaka
- Tang
- Thierry
- Thies
- Tiitinen
- Todd
- Todd
- Todd
- Tomio
- Umbricht
- Umbricht
- Urban
- Vidyasagar
- Vogels
- Wacongne
- Wang
- Wark
- Waters
- Webster
- Widmann
- Wig
- Wiggs
- Winkler
- Winkler
- Winkler
- Winkler
- Wolfe
- Wolkenstein
- Yoon
- Zhao
- Zorumski
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing
Creative destruction in science
- Author
- Abraham Ajay T.
- Adam-Troian Jais
- Adamkovic Matus
- Anand Rahul
- Arbeau Kelly J.
- Awtrey Eli C.
- Azar Ofer H.
- Bahn\uedk \u160t\u11bp\ue1n
- Ban\uedk Gabriel
- Barbosa Mendes Ana
- Barger Michael M.
- Barretto Yaranon Paolo
- Baskin Ernest
- Bavolar Jozef
- Berkers Ruud M. W. J.
- Besco Randy
- Bia\u142ek Micha\u142
- Bishop Michael M.
- Bonache Helena
- Boufkhed Sabah
- Brandt Mark J.
- Butterfield Max E.
- Byrd Nick
- Caton Neil R.
- Ceynar Michelle L.
- Corcoran Mike
- Costello Thomas H.
- Cramblet Alvarez Leslie D.
- Cummins Jamie
- Curry Oliver S.
- Daniels David P.
- Daskalo Lea L.
- Daum-Avital Liora
- Day Martin V.
- Deeg Matthew D.
- Dennehy Tara C.
- Dietl Erik
- Dimant Eugen
- Domurat Artur
- Dreber Anna
- du Plessis Christilene
- Dubrov Dmitrii
- Ebersole Charles R.
- Elena Schleu Joyce
- Elsherif Mahmoud M.
- Engel Yuval
- Fellenz Martin R.
- Field Sarahanne M.
- Firat Mustafa
- Freitag Raquel M. K.
- Friedmann Enav
- Ghasemi Omid
- Giulia Clemente Elena
- Goldberg Matthew H.
- Gordon Michael
- Gourdon-Kanhukamwe Am\ue9lie
- Graf-Vlachy Lorenz
- Griffith Jennifer A.
- Grigoryev Dmitry
- H\ufcffmeier Joachim
- Hafenbr\ue4dl Sebastian
- Hagmann David
- Hales Andrew H.
- Han Hyemin
- Hardy Jay
- Harman Jason L.
- Hartanto Andree
- Holding Benjamin C.
- Hopfensitz Astrid
- Huntsinger Jeffrey R.
- Idzikowska Katarzyna
- Innes-Ker \uc5se H.
- Jaeger Bastian
- Jankowsky Kristin
- Jarvis Shoshana N.
- Jha Nilotpal
- Jimenez-Gomez David
- Jin Pedersen Mogens
- Johannesson Magnus
- Jolles Daniel
- Jozefiakova Bibiana
- Ka\u10dm\ue1r Pavol
- Kappmeier Mariska
- Kasper Matthias
- Keller Lucas
- Kit Yeung Siu
- Knapic Viktorija
- Knutsson Mikael
- Kombeiz Olga
- Kowal Marta
- Krekels Goedele
- Laine Tei
- Lakens Daniel
- Leavitt Keith
- Li Bingjie
- Lo Ronda F.
- Ludwig Jonas
- Luis Uhlmann Eric
- Marcus James C.
- Marsh Melvin S.
- Martinoli Mario
- Marton\u10dik Marcel
- Master Allison
- Masters-Waage Theodore C.
- May Rowe Andrea
- Mayiwar Lewend
- Mazei Jens
- McCarthy Gemma S.
- McCarthy Randy J.
- Mertens Stephanie
- Micheli Leticia
- Miklikowska Marta
- Miron-Shatz Talya
- Montealegre Andres
- Moreau David
- Moret-Tatay Carmen
- Negrini Marcello
- Newall Philip W. S.
- Nilsonne Gustav
- Niszczota Pawe\u142
- Nobel Nurit
- O'Mahony Aoife
- O'Shea Deirdre
- Orhan Mehmet A.
- Oswald Flora E.
- Panning Miriam
- Pantelis Peter C.
- Paruzel-Czachura Mariola
- Pennycook Gordon
- Pfeiffer Thomas
- Plonsky Ori
- Polito Vince
- Price Paul C.
- Primbs Maximilian A.
- Protzko John
- Quayle Michael
- Rahal Rima-Maria
- Redford Liz
- Reggev Niv
- Reynolds Caleb J.
- Roczniewska Marta
- Ropovik Ivan
- Ross Robert M.
- Roulet Thomas J.
- Saccardo Silvia
- Samahita Margaret
- Schaerer Michael
- Schuetze Brendan A.
- Senftleben Ulrike
- Seri Raffaello
- Shahinoor Rahman Md.
- Shtudiner Zeev
- Shuai Jack
- Sin Ray
- Singh Aneeha
- Singh Varsha
- Siong Tey Kian
- Sokolova Tatiana
- Song Victoria
- Stafford Tom
- Stanulewicz Natalia
- Stevens Samantha M.
- Str\uf8mland Eirik
- Stronge Samantha
- Sweeney Kevin P.
- Tannenbaum David
- Tepper Stephanie J.
- Tierney Warren
- Ting Hsuchi
- Tingen Ian W.
- Todorovic Ana
- Tse Hannah M. Y.
- Tybur Joshua M.
- Viganola Domenico
- Vineyard Gerald H.
- Voslinsky Alisa
- Vranka Marek A.
- Wai Jonathan
- Walker Alexander C.
- Wallace Laura E.
- Wang Tianlin
- Werz Johanna M.
- Woike Jan K.
- Wollbrant Conny E.
- Wright Joshua D.
- Wu Sherry J.
- Xiao Qinyu
- Yoon Sangsuk
- Yu Karen
- Yucel Meltem
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Drawing on the concept of a gale of creative destruction in a capitalistic economy, we argue that initiatives to assess the robustness of findings in the organizational literature should aim to simultaneously test competing ideas operating in the same theoretical space. In other words, replication efforts should seek not just to support or question the original findings, but also to replace them with revised, stronger theories with greater explanatory power. Achieving this will typically require adding new measures, conditions, and subject populations to research designs, in order to carry out conceptual tests of multiple theories in addition to directly replicating the original findings. To illustrate the value of the creative destruction approach for theory pruning in organizational scholarship, we describe recent replication initiatives re-examining culture and work morality, working parents\u2019 reasoning about day care options, and gender discrimination in hiring decisions.
Significance statement
It is becoming increasingly clear that many, if not most, published research findings across scientific fields are not readily replicable when the same method is repeated. Although extremely valuable, failed replications risk leaving a theoretical void\u2014 reducing confidence the original theoretical prediction is true, but not replacing it with positive evidence in favor of an alternative theory. We introduce the creative destruction approach to replication, which combines theory pruning methods from the field of management with emerging best practices from the open science movement, with the aim of making replications as generative as possible. In effect, we advocate for a Replication 2.0 movement in which the goal shifts from checking on the reliability of past findings to actively engaging in competitive theory testing and theory building.
Scientific transparency statement
The materials, code, and data for this article are posted publicly on the Open Science Framework, with links provided in the article
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat RĂŒdeger
- Albert LoĂŻc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Ătienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
- Bussman Marie C.
- Böker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
- Clark Stephanie M.
- Claybrooks Edward E.
- Cleveland Keith A.
- Cohen Andrew L.
- Cohen Lester M.
- Coleman Benee L.
- Colina Luis
- ColĂłn Knicole D.
- Comber Brian J.
- Comeau Thomas M.
- Comer Thomas
- Connolly Dennis C.
- Conroy Kyle E.
- Contos Adam R.
- Contreras James
- Cook Neil J.
- Cooper James L.
- Cooper Rachel Aviva
- Correia Michael F.
- Correnti Matteo
- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
- Davies James E.
- Davis Katherine Anne
- Davis Michael S.
- Day Ratna
- de Chambure Daniel
- de Jong Pauline
- De Marchi Guido
- De Meester Wim
- de Oliveira Catarina Alves
- Dean Bruce H.
- Decker John E.
- del Pino Bruno RodrĂguez
- Delisa Amy S.
- Dell Lawrence C.
- Dellagatta Gail
- Dembinska Franciszka
- Demosthenes Sandor
- Dencheva Nadezhda M.
- Deneu Philippe
- DePriest William W.
- Deschenes Jeremy
- Dethienne Nathalie
- Detre Ărs Hunor
- Diaz Rosa Izela
- Dicken Daniel
- DiFelice Audrey S.
- Dillman Matthew
- Disharoon Maureen O.
- Dixon William V.
- Doggett Jesse B.
- Dominguez Keisha L.
- Donaldson Thomas S.
- Doria-Warner Cristina M.
- Doty Heather
- Douglas Jr. Robert E.
- Doyon René
- Dressler Alan
- Driggers Jennifer
- Driggers Phillip A.
- Dunn Jamie L.
- DuPrie Kimberly C.
- Dupuis Jean
- Durning John
- Dutta Sanghamitra B.
- Earl Nicholas M.
- Eccleston Paul
- Ecobichon Pascal
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan D.
- Eisenhower Michael
- Eisenstein Daniel J.
- Elie Michelle L.
- Elliott James
- Elliott Kyle Wesley
- Engesser Michael
- Espinoza NĂ©stor
- Etienne Odessa
- Etxaluze Mireya
- Evans Leah
- Fabreguettes Luce
- Falcolini Massimo
- Falini Patrick R.
- Fatig Curtis
- Feeney Matthew
- Feinberg Lee D.
- Fels Raymond
- Ferdous Nazma
- Ferguson Henry C.
- Ferrarese Laura
- Ferreira Marie-Héléne
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph Charles
- Firre Daniel
- Fix Mees
- Flagey Nicolas
- Flanagan Kathryn A.
- Fleming Scott W.
- Florian Michael
- Flynn James R.
- Foiadelli Luca
- Fontaine Mark R.
- Fontanella Erin Marie
- Forshay Peter Randolph
- Fortner Elizabeth A.
- Fox Ori D.
- Framarini Alexandro P.
- Francisco John I.
- Franck Randy
- Franx Marijn
- Franz David E.
- Friedman Scott D.
- Friend Katheryn E.
- Frost James R.
- Fu Henry
- Fullerton Alexander W.
- Gaillard Lionel
- Galkin Sergey
- Gallagher Ben
- Galyer Anthony D.
- Gardner Jonathan P.
- Gardner Lisa E.
- Garland Dennis
- Garrett Bruce Albert
- Gasman Danny
- Gastaud René
- Gaudreau Daniel
- Gauthier Peter Timothy
- Geers Vincent
- Geithner Paul H.
- Gennaro Mario
- Gerber John
- Gereau John C.
- Giampaoli Robert
- Giardino Giovanna
- Gibbons Paul C.
- Gilbert Karolina
- Gilman Larry
- Girard Julien H.
- Giuliano Mark E.
- Gkountis Konstantinos
- Glasse Alistair
- Glassmire Kirk Zachary
- Glauser Adrian Michael
- Glazer Stuart D.
- Goldberg Joshua
- Golimowski David A.
- Gonzaga Shireen P.
- Gordon Karl D.
- Gordon Shawn J.
- Goudfrooij Paul
- Gough Michael J.
- Graham Adrian J.
- Grau Christopher M.
- Green Joel David
- Greene Gretchen R.
- Greene Thomas P.
- Greenfield Perry E.
- Greenhouse Matthew A.
- Greve Thomas R.
- Greville Edgar M.
- Grimaldi Stefano
- Groe Frank E.
- Groebner Andrew
- Grumm David M.
- Grundy Timothy
- Guillard Pierre
- Guldalian John
- Gunn Christopher A.
- Gurule Anthony
- Gutman Irvin Meyer
- Guy Paul D.
- Guyot Benjamin
- GĂĄspĂĄr AndrĂĄs
- GĂŒdel Manuel
- Hack Warren J.
- Haderlein Peter
- Hagan James B.
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hamel Zaky El
- Hami Maryam
- Hamilton Forrest Clifford
- Hammann Jeffrey
- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
- Hardy Bruce
- Harnisch Bernd
- Harr Michael Hunter
- Harris Pamela
- Hart Jessica Ann
- Hartig George F.
- Hasan Hashima
- Hashim Kathleen Marie
- Hashimoto Ryan
- Haskins Sujee J.
- Hawkins Robert Edward
- Hayden Brian
- Hayden William L.
- Healy Mike
- Hecht Karen
- Heeg Vince J.
- Hejal Reem
- Helm Kristopher A.
- Hengemihle Nicholas J.
- Henning Thomas
- Henry Alaina
- Henry Ronald L.
- Henshaw Katherine
- Hernandez Scarlin
- Herrington Donald C.
- Heske Astrid
- Hesman Brigette Emily
- Hickey David L.
- Hilbert Bryan N.
- Hines Dean C.
- Hinz Michael R.
- Hirsch Michael
- Hitcho Robert S.
- Hodapp Klaus
- Hodge Philip E.
- Hoffman Melissa
- Holfeltz Sherie T.
- Holler Bryan Jason
- Hoppa Jennifer Rose
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- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
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- Weilert Mark
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- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
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- Wondel Amancio
- Woo Cindy
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- Worden Elaine
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- Wright Gillian S.
- Wu Carl
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- Wymer Kristen B.
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- Yan Isabelle C.
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- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Ălvarez-MĂĄrquez Javier
- Ăstlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado HĂ©ctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso JesĂșs AarĂłn MartĂnez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- BariĆĄiÄ Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos CatalĂĄ
- Bawa Ashvind
- Bawa Sayesha
- Bayhan HĂŒseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
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- Katechia Devvrat
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- Katsura Morihiro
- Kauppila Joonas H
- Kaur Amanjot
- Kausar Nabila
- Kavalakat Alfie
- Kavanagh Marcel MarjanoviÄ
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- Kealey Joshua
- Kebede Ephrem
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- Kennerton A.S.
- Kent Alistair J
- Keramati Mohammad Reza
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- Lim Yizhe
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- Lin Shuxun
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- Linero Inmaculada BenĂtez
- Ling Samuel
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- Lohmann Tibor Karl
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- Losada Manuel
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- Loubani Mahmoud
- Loureiro Luis
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- Lyra Humberto Fenner
- Mabood Waleed
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- Maffuz-Aziz Antonio
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- Magnone Stefano
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- Maguire Patrick J.
- MaheÄiÄ Tina TomiÄ
- Mahmood Fahad
- Mahmoud Abdelrahman
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- Mallmann Christoph
- Mallmann Michael R.
- Mambrilla Sara
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- Martins Claudia Pinto
- Martins Paulo N.
- MartĂnez Daniel FernĂĄndez
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- Pucher Philip
- Punjabi Prakash P
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- PĂ©rez Beatriz GĂłmez
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- Rickard Jennifer
- RincĂłn Natalia Andrea Rivera
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- Rokohl Alexander Christopher
- Roland Christina L
- Rolinger Jens
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- Sholadoye Tunde T.
- Shoukrie Shoukrie I. M.
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- Slavchev Mihail
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- Spina Alfio
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- Stevenson Andrew
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- Stijns Jasper
- Stogowski Piotr Tomasz
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- Tawalbeh Ra'Fat
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- Tebha Sameer
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- Tejero-Pintor Francisco J.
- Tellez Karla Susana Martin
- Tellez Luis Garcia-Sancho
- Thaha Mohamed Adhnan
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- Trulson Alexander
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- Turri Giulia
- Tutino Roberta
- Tuyishime Eugene
- Tzelves Lazaros
- Tzima Ioanna
- Tzimas George
- Ubiali Paolo
- Ubom Akaninyene Eseme
- Ugwu Aloy Okechukwu
- Ugwu Ebere
- Ugwu Ifeanyichukwu
- Ul Huda Maria Noor
- Ulas Ali Bilal
- Uldry Emilie
- Ulgur Hanife Seyda
- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- UlutaĆ Mehmet EĆref
- Underwood Kirk
- Unsworth Richard
- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
- Vaassen Lauretta
- Vaccara Vincenzo La
- Vagena Xanthoula
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- Valadez Tania Abigail Cueto
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- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- VelĂĄzquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
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- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
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- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Våsquez Javier Alberto Gutiérrez
- VĂĄzquez Gil
- VĂĄzquez Irene Ortega
- VÇcÇraĆu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Ăzge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- ZarĂĄnd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha HorĂĄcio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ăvila Clara Castro
- ĂlgĂ„ Andreas
- Ăakici Mehmet Ăaǧlar
- Ăelik Enes
- Ăelik Meryem Nur
- Ăzçay Necdet
- Ćevik HĂŒsnĂŒ
- Ć antak Goran
- Ć imko KristiĂĄn
- ĆœateckĂœ Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
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- Adamali H.
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- Adeyemi Oluwaseun
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- Te Amelie
- Tedd H.
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- Teixeira J
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- Thamu B
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- Vere Joanne
- Vickers Carinna
- Vinson B
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- Wainwright Tania
- Wajero Lilian O.
- Walder S
- Walker S
- Walker S.
- Wall E
- Wallis T
- Walmsley S
- Walsh J.A.
- Walsh S.
- Warburton Louise
- Ward T J C
- Warwick Katie
- Wassall Helen
- Waterson Samuel
- Watson Ekaterina
- Watson James
- Watson L.
- Webster M
- Weir-McCall Jonathan R
- Welch C
- Welch H.
- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
- Whitehead Victoria
- Whitney J.
- Whittaker S
- Whittam Beverley
- Whitworth V
- Wight A
- Wild James M
- Wilkins M.
- Wilkinson D
- Williams B
- Williams Jenny
- Williams N
- Williams Nick
- Williams-Howard S.A.
- Willicombe M.
- Willis Gemma
- Willoughby J
- Wilson Ann
- Wilson D
- Wilson Imogen
- Window Nicola
- Witham M.
- Wolf-Roberts Rebecca
- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged â„18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2â6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5â5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4â10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32â4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23â11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Shedding light on coatings: Real-time monitoring of coating quality at industrial scale
- Author
- Andrea Raffa
- Ariyasu
- Barimani
- Bernd Looser
- Bikiaris
- Boehling
- Boehling
- Cahyadi
- Dohi
- Dong
- Gendre
- Haaser
- Hattori
- Jochen Thies
- Johannes G. Khinast
- Knop
- Korasa
- Laske
- Lin
- Lin
- Lin
- Markl
- Markl
- Markl
- Matthias Wolfgang
- Maurer
- May
- Michael WeiĂensteiner
- Niblett
- Patrick Wahl
- Rowe
- Seitavuopio
- Singh
- Stephan Sacher
- Suzzi
- Vargas
- Wirges
- Yekaterina Pokhilchuk
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study
- Author
- Aanensen David M.
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Antonelli Michela
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
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- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
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- Brown Julianne R.
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- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
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- Carabelli Alessandro M.
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- Carvalho SĂlvia F.
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- Castigador Anibolina
- Catalan Jana
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- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Chen Liyuan
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- Clark Gemma
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- Connor Thomas R.
- Cook Kate F.
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- Cormie Claire
- Cortes Nicholas
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- Cottrell Simon
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- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
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- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
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- de Oliveira Martins Leonardo
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- Debebe Johnny
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- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Duncan Emma L.
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
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- Edwards Sue
- Eldirdiri Sahar
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- Elliott Scott
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- Kidd Stephen P.
- Kimuli Maimuna
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- Southgate Joel
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- Starinskij Igor
- Steves Claire J.
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
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- Sudhanva Malur
- Sudre Carole H.
- Swindells Emma
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
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- Taylor Joshua F.
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- Temperton Ben
- Templeton Kate E.
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- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
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- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
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- Wang Dennis
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- Waugh Sheila
- Webster Hermione J.
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- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
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- Wolf Jonathan
- Wolverson Paige
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- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
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- Zarebski Alex E.
- Zhang Peijun
- Ăsterdahl Marc F.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/06/2022
- Field of study
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive for SARS-CoV-2 from May 26 to July 1, 2021 (Delta overwhelmingly the predominant circulating UK variant), compared (1:1, age- and sex-matched) with individuals presenting from December 28, 2020 to May 6, 2021 (Alpha (B.1.1.7) the predominant variant). We assessed illness (symptoms, duration, presentation to hospital) during Alpha- and Delta-predominant timeframes; and transmission, reinfection, and vaccine effectiveness during the Delta-predominant period. 3581 individuals (aged 18 to 100 years) from each timeframe were assessed. The seven most frequent symptoms were common to both variants. Within the first 28 days of illness, some symptoms were more common with Delta versus Alpha infection (including fever, sore throat, and headache) and some vice versa (dyspnoea). Symptom burden in the first week was higher with Delta versus Alpha infection; however, the odds of any given symptom lastingââ„â7 days was either lower or unchanged. Illness durationââ„â28 days was lower with Delta versus Alpha infection, though unchanged in unvaccinated individuals. Hospitalisation for COVID-19 was unchanged. The Delta variant appeared more (1.49) transmissible than Alpha. Re-infections were low in all UK regions. Vaccination markedly reduced the risk of Delta infection (by 69-84%). We conclude that COVID-19 from Delta or Alpha infections is similar. The Delta variant is more transmissible than Alpha; however, current vaccines showed good efficacy against disease. This research framework can be useful for future comparisons with new emerging variants
On the Use of Transfer Entropy to Investigate the Time Horizon of Causal Influences between Signals
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- Abduallev S.
- Abhangi M.
- Abreu P.
- Afzal M.
- Aggarwal K. M.
- Agostini F. Degli
- Ahlgren T.
- Ahn J. H.
- Aho-Mantila L.
- Aiba N.
- Airila M.
- Albanese R.
- Aldred V.
- Alegre D.
- Alessi E.
- Aleynikov P.
- Alfier A.
- Alkseev A.
- Allinson M.
- Alper B.
- Alves E.
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- Bament R.
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- Zhang W.
- Zhou Y.
- Zilli E.
- Zoita V.
- Zoletnik S.
- Zychor I.
- Publication venue
- 'MDPI AG'
- Publication date
- 20/09/2019
- Field of study
Understanding the details of the correlation between time series is an essential step on the route to assessing the causal relation between systems. Traditional statistical indicators, such as the Pearson correlation coefficient and the mutual information, have some significant limitations. More recently, transfer entropy has been proposed as a powerful tool to understand the flow of information between signals. In this paper, the comparative advantages of transfer entropy, for determining the time horizon of causal influence, are illustrated with the help of synthetic data. The technique has been specifically revised for the analysis of synchronization experiments. The investigation of experimental data from thermonuclear plasma diagnostics proves the potential and limitations of the developed approach
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Adrian F. Nagle IV
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat RĂŒdeger
- Albert LoĂŻc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Ătienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bernier Antoine-Darveau
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
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- Boia John Joseph
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- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wetering Inge van de
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Ălvarez-MĂĄrquez Javier
- Ăstlin Göran
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit