Feasibility of time-lapse AVO and AVOA analysis to monitor compaction-induced seismic anisotropy

Hydrocarbon reservoir production generally results in observable time-lapse physical property changes, such as velocity increases within a compacting reservoir. However, the physical property changes that lead to velocity changes can be difficult to isolate uniquely. Thus, integrated hydro-mechanical simulation, stress-sensitive rock physics models and time-lapse seismic modelling workflows can be employed to study the influence of velocity changes and induced seismic anisotropy due to reservoir compaction. We study the influence of reservoir compaction and compartmentalization on time-lapse seismic signatures for reflection amplitude variation with offset (AVO) and azimuth (AVOA). Specifically, the time-lapse AVO and AVOA responses are predicted for two models: a laterally homogeneous four-layer dipping model and a laterally heterogeneous graben structure reservoir model. Seismic reflection coefficients for different offsets and azimuths are calculated for compressional (P–P) and converted shear (P–S) waves using an anisotropic ray tracer as well as using approximate equations for AVO and AVOA. The simulations help assess the feasibility of using time-lapse AVO and AVOA signatures to monitor reservoir compartmentalization as well as evaluate induced stress anisotropy due to changes in the effective stress field. The results of this study indicate that time-lapse AVO and AVOA analysis can be applied as a potential means for qualitatively and semi-quantitatively linking azimuthal anisotropy changes caused by reservoir production to pressure/stress changes

Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries

Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis. Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting. Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis. Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins