32 research outputs found
Characteristics of seismic survey pulses and the ambient soundscape in Baffin Bay and Melville Bay, West Greenland
- Publication venue
- 'Acoustical Society of America (ASA)'
- Publication date
- 01/12/2017
- Field of study
In 2012 a seismic survey campaign involving four vessels was conducted in Baffin Bay, West Greenland. Long-distance (150 km) pre-survey acoustic modeling was performed in accordance with regulatory requirements. Four acoustic recorders, three with hydrophones at 100, 200, and 400m depths, measured ambient and anthropogenic sound during the survey. Additional recordings without the surveys were made from September 2013 to September 2014. The results show that (1) the soundscape of Baffin Bay is typical for open ocean environments and Melville Bay's soundscape is dominated by glacial ice noise; (2) there are distinct multipath arrivals of seismic pulses 40 km from the array; (3) seismic sound levels vary little as a function of depth; (4) high fidelity pre-survey acoustic propagation modeling produced reliable results; (5) the daily SEL did not exceed regulatory thresholds and were different using Southall, Bowles, Ellison, Finneran, Gentry, Greene, Kastak, Ketten, Miller, Nachtigall, Richardson, Thomas, and Tyack [(2007) Aquat. Mamm. 33, 411-521] or NOAA weightings [National Marine Fisheries Service (2016). NOAA Technical Memorandum NMFS-OPR-55, p. 178]; (6) fluctuations of SPL with range were better described by additive models than linear regression; and (7) the survey increased the 1-min SPL by 28 dB, with most of the energy below 100 Hz; energy in the 16 000 Hz octave band was 20 dB above the ambient background 6 km from the source. (C) 2017 Acoustical Society of America
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
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- Brandriff Brigitte F.
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- Brettin Thomas
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- Brimhall Angela K.
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- Brown Margaret
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- Bruce David D.
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- Campbell Evelyn W.
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- Campo Kevin
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- Hamza Khalid
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- Hitchens Matthew Edward
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
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- Lowenstein Michael G.
- Lowry Stephen
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- Machrus Migdad
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- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
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- Mangum Brian
- Manning Jonathan
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- Mardis Elaine R.
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- Marra Marco
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- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-Hélène
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
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- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
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- Brown Cynthia
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- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
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- Carrier Marc
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- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
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- Chen Lixian
- Chen Yan
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- Chhablani Manish
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- Clark Michele
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- Clarke Jennifer
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- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ève
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
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- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-Chénard Émilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
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- Cowdrey Keri-Anne
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- Cowton Amanda
- Coyne Mark
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- Cutler Sean
- Cárcel Sheila
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- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
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- Daley Jessica
- Dalton James
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- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
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- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
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- Duffy Oscar
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- Duke Zoe
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- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
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- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
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- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
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- Godement Mathieu
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- Haider Nafeesah
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- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
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- Hall Rebecca
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- Hammonds Fiona
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- Haniffa Rashan
- Hanisch Alexis
- Hanley Joanne
- Hansen Dan
- Hanson Helen
- Hanson Jane
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- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
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- Hashmi Madhia
- Hashmi Madiha
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- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
- Hayes Anne
- Hayes Kati
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- HC Ooi
- Headdon William
- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
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- Henry Joanne
- Henry Lavinia
- Hensley Joseph
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- Hernandez Erik
- Hewitt Claire
- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
- Hills Thomas
- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
- Hird Clare
- Hodge Christopher
- Hodgson Carol
- Hodgson Helen
- Hoff Uwe
- Hoiting Oscar
- Holbrook Catherine
- Holland Andrew
- Holland Nicky
- Holland Susan
- Hollos Laszlo
- Homes Jennifer
- Honda Hitoshi
- Hope David
- Hopkins Phil
- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
- Humphrey Charlotte
- Hunt Beverley
- Hunter Stephanie
- Hurford Sally-Anne
- Hussain Mahwish
- Hussain Sajid
- Hutchinson Christina
- Hutton Paula
- Hüning Vanessa
- Ichihara Nao
- Ijaz Nazia
- Ikhena Ikhuemose
- Inskip Deborah
- Irving Ben
- Isgro Graziella
- Isguzar Agah
- Ishani Pramodya
- Ivatt Helen
- Jackson Carolyn
- Jackson Shane
- Jackson Susan
- Jacob Reni
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- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
- Jennings Stacey
- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
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- Jhanji Shaman
- Jin Xia
- Jindai Kazuaki
- John Maya
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- Johnson Toby
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- Jones Cathy
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- Jones Emily
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- Jones Samantha
- Jongebloed Katherine
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- Juffermans Nicole
- Juhaz Vera
- Kadam Umesh
- Kalamar ?iga
- Kalchko-Veyssal Selver
- Kalchthaler Kyle
- Kaliappan Agilan
- Kalla Ismail
- Kalogirou Michael
- Kamata Kazuhiro
- Kamel Toufik
- Kampschreur Linda
- Kamra Maneesha
- Kandeepan Revathi
- Kannan Santhana
- Kannan Thogulava
- Kanwal Darakhshan
- Karachi Tim
- Karim Hina
- Karki Rakshya
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kassir Sandy
- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
- Kayastha Srijana
- Kaye Callum
- Kazi Aayesha
- KC Shirish
- KC Shirsh
- Keating Liza
- Keatley Claire
- Keeler Sheryl
- Keen Alexandra
- Keen Sherbrina
- Keijzer-Timmers Nicole
- Kell Kay
- Kelly Martin
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- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
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- Arbab Hana
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- Asirifi Samuel Amoako
- Asla Amir
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- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
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- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
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- Balogun James A.
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- Borg Elaine
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- Fahim Margo Medhat Fouad
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- Farooq Muhammad
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- Fayad Elsayed A.
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- Federico Nicoletta Sveva Pipitone
- Feeney Kaylem
- Fehervari Matyas
- Fekaj Enver
- Fernandez Laura Gomez
- Fernández Julio Domenech
- Ferracci Federica
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- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
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- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Underlying Event measurements in pp collisions at s=0.9 and 7 TeV with the ALICE experiment at the LHC
- Author
- A Buckley
- A Capella
- A. Kurepin
- A.B. Kurepin
- A.K. Dutta Majumdar
- Abdiel Ramirez Reyes
- Adam Ryszard Kisiel
- Adam Tomasz Matyja
- Adam Wlodzimierz Jacholkowski
- Aditya Nath Mishra
- Adrian Sevcenco
- Adriana Telesca
- Airton Deppman
- Ajay Kumar Dash
- Ajit Kumar Mohanty
- AK Aamodt
- Alain Baldit
- Alain Michalon
- Alberica Toia
- Alberto Baldisseri
- Alberto Gago
- Alberto Masoni
- Alberto Pulvirenti
- Alejandro Szanto de Toledo
- Alessandra Fantoni
- Alessandra Maria Mazzoni
- Alessandro De Falco
- Alessandro Ferretti
- Alessandro Grelli
- Alessandro Pesci
- Alexander Akindinov
- Alexander Borissov
- Alexander Hansen
- Alexander Kluge
- Alexander Mamonov
- Alexander Nedosekin
- Alexander Ochirov
- Alexander Philipp Kalweit
- Alexander Vinogradov
- Alexander Vodopianov
- Alexander Wilk
- Alexandr Tumkin
- Alexandre Alarcon do Passo Suaide
- Alexandre Nyanin
- Alexandre Rachevski
- Alexandre Shabetai
- Alexandru Bercuci
- Alexandru Florin Dobrin
- Alexei Kaidalov
- Alexei Khanzadeev
- Alexei Pavlinov
- Alexey Bogdanov
- Alexey Kuryakin
- Alexey Vyushin
- Alexis Jean-Michel Mas
- Alfredo Musso
- Alice Zimmermann
- Alina Gabriela Grigoras
- Alla Maevskaya
- Alphonse Rademakers
- Amalia Pop
- Amaya Ofelia Casanova Diaz
- Ana Maria Marin
- Anand Kumar Dubey
- Anatoly Fedunov
- Anatoly Kolojvari
- Anders Nils Erik Oskarsson
- Andras Gabor Agocs
- Andre Augustinus
- Andre Mischke
- Andrea Agostinelli
- Andrea Alici
- Andrea Dainese
- Andrea Danu
- Andrea De Azevedo Moregula
- Andrea Rossi
- Andreas Arend
- Andreas Morsch
- Andrei George Gheata
- Andrei Ionut Herghelegiu
- Andres Sandoval
- Andrew Marshall Adare
- Andrey Ivanov
- Andrey Kazantsev
- Andrey Korneev
- Andrey Reshetin
- Andrey Vasiliev
- Andrey Zarochentsev
- Andry Malala Rakotozafindrabe
- Andrzej Deloff
- Andrzej Rybicki
- Andzhey Asryan
- Angela Badala
- Anik Gupta
- Anitha Nyatha
- Anju Bhasin
- Ankita Goswami
- Anna Piccotti
- Anna Rita Reolon
- Annalisa De Caro
- Annalisa Mastroserio
- Annika Passfeld
- Anselmo Margotti
- Ante Bilandzic
- Anthony Timmins
- Antoine Xavier Lardeux
- Anton Alkin
- Anton Andronic
- Anton Jusko
- Antonin Maire
- Antonino Zichichi
- Antonio Di Mauro
- Antonio Juan Rubio Montero
- Antonio Ortiz Velasquez
- Antonio Uras
- Ara Grigoryan
- Arian Abrahantes Quintana
- Armando Palmeri
- Arnulfo Martinez Davalos
- Arsen Hayrapetyan
- Arshad Ahmad
- Artem Konevskih
- Artur Krzysztof Szostak
- Arturo Alejandro Menchaca-Rocha
- Arturo Fernandez Tellez
- Arturo Tauro
- Arvinder Singh Palaha
- Ashok Kumar Bhati
- Aurora Diozcora Vargas
- Ayben Karasu Uysal
- B Andersson
- Baba Potukuchi
- Barbara Guerzoni
- Barthelemy von Haller
- Basanta Kumar Nandi
- Bastian Bathen
- Bedangadas Mohanty
- Benjamin Donigus
- Beomkyu Kim
- Beomsu Chang
- Bernard Hicks
- Bernd Stefan Windelband
- Bernhard Skaali
- Betty Abelev
- Bikash Sinha
- Bjarte Kileng
- Bjorn Steven Nilsen
- Blahoslav Pastircak
- Bogdan Theodor Rascanu
- Bogdan Vulpescu
- Borge Svane Nielsen
- Boris Batyunya
- Boris Grinyov
- Boris Hippolyte
- Boris Polichtchouk
- Boris Wagner
- Branislav Sitar
- Brigitte Cheynis
- Brijesh Kumar Srivastava
- Bruno Alessandro
- Bruno Alexandre Boyer
- Bruno Espagnon
- Bruno Ghidini
- Byounghee Han
- Camilo Andres Carrillo Montoya
- Camilo Ernesto Lara
- Carlos Albert Salgado
- Carlos Eugenio Perez Lara
- Carlos Pajares
- Carmelo Di Giglio
- Carsten Sogaard
- Casper Nygaard
- Catia Petta
- Cenek Zach
- Cesar Guerra Gutierrez
- Chamath Kottachchi Kankanamge Don
- Chiara Bianchin
- Chiara Oppedisano
- Chiara Zampolli
- Christelle Sophie Roy
- Christian Claude Kuhn
- Christian Holm Christensen
- Christian Joachim Schmidt
- Christian Klein-Bosing
- Christian Lippmann
- Christina Markert
- Christine Nattrass
- Christoph Blume
- Christoph Heinrich Baumann
- Christoph Mayer
- Christophe Furget
- Christophe Pierre Suire
- Christopher Daniel Anson
- Christos Tagridis
- Cinzia Luzzi
- Ciprian Mihai Mitu
- Claude Andre Pruneau
- Claudio Bortolin
- Claudio Geuna
- Claudiu Cornel Schiaua
- Constantinos Loizides
- Corrado Cicalo
- Costanza Cavicchioli
- Costin Grigoras
- Crispin Williams
- Cristian Andrei
- Cristian George Ivan
- Cristina Lazzeroni
- Cristina Terrevoli
- Csaba Soos
- Cvetan Cheshkov
- Cynthia Marie Hadjidakis
- Cyrano Bergmann
- D Acosta
- Dae Sung Hwang
- Dagmar Adamova
- Daicui Zhou
- Daniel Berenyi
- Daniel Felea
- Daniel Jesus Tapia Takaki
- Daniel Lohner
- Daniel Mayani
- Daniela Fabris
- Daniele De Gruttola
- Danilo Vranic
- Danthasinghe Piyarathna
- Dario Berzano
- Dariusz Miskowiec
- David Chinellato
- David Christopher Truesdale
- David Evans
- David Olle Rickard Silvermyr
- David Philip Emschermann
- David Rohr
- David Tlusty
- Davide Caffarri
- Davide Falchieri
- Davide Perrino
- Debasish Das
- Deepa Thomas
- Deepika Rathee
- Denise Aparecida Moreira De Godoy
- Despoina Hatzifotiadou
- Dhevan Raja Gangadharan
- Diego Perini
- Diego Stocco
- Dieter Rohrich
- Dilan Minthaka Madagodahettige-Don
- Dmitri Ivanovich Patalakha
- Dmitri Peresunko
- Dmitry Aleksandrov
- Dmitry Blau
- Dmitry Budnikov
- Dmitry Finogeev
- Dmitry Mal’Kevich
- Do Won Kim
- Domenico Colella
- Domenico Di Bari
- Domenico Elia
- Dominik Fehlker
- Don Constantin Vernekohl
- Dong Jo Kim
- Dong Wang
- Dosatsu Sakata
- Dumitru Hasegan
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- Field of study
Multiple loci on 8q24 associated with prostate cancer susceptibility
- Author
- Abrams Paul H
- Adamson Andrew
- Adeyoju A
- Afzal N
- Ahiaku Ernest K. N
- Ahmed Munir
- Al Olama Ali Amin
- Al-Samerraie
- Alcock Christopher
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Apakama Ike
- Aparcia F
- Archbold J. A. A
- Ardern-Jones Audrey T
- Ash D
- Ashford Richard F. U
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M. J
- Ball Andrew J
- Bancroft E
- Banerjee G
- Barber Jim
- Barber N
- Baria
- Barnes Douglas G
- Barwell Julian
- Basu Pradip
- Bates Christopher A
- Bax N. A
- Baxter-Smith D
- Beacock Christopher
- Beaney Ronald P
- Beard Ralph
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bellringer James
- Benson Richard
- Bhatt R. I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C. Shekhar
- Blacklock A. R. E
- Blades Rosemary
- Bloomfield David J
- Bollina Prasad
- Bonnington Sue
- Booth C. M
- Bose Pradeep
- Bottomley David
- Boucher Nigel R
- Bower Mark
- Bowsher W. G
- Boyd P. J. R
- Bramble F. James
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Brough Richard
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Butterworth Paul C
- Cahill D
- Callaghan P. S
- Calman Frances
- Campbell Alister
- Carnell Dawn M
- Carr T. W
- Carter Adam
- Carter Charles J. M
- Carter Simon
- Castle Bruce M
- Chadwick David
- Chakraborti P
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh Francis I
- Chong Irene
- Chow Wai-Man
- Christmas Timothy J
- Churn Mark J
- Clarke Noel W
- Coe M
- Cohen N. P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Cooke Peter
- Coombs L
- Cooper Colin
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
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- Corolis
- Corr John
- Costello C. B
- Cowan Richard
- Cox Robert
- Coyle C
- Crisp John C
- Cruger Dorthe
- Crundwell Malcolm
- Cummings
- Dahar Nazeer
- Daruwala Pallon
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David P
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dinneen Michael
- Dixit Sanjay
- Dobbs H. Jane
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Douglas S. Fiona
- Drake
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
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- Durkan Garrett
- Easton Douglas F
- Eccles Diana
- Eden C. D
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Ellis B. W
- Ellis R
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- Elwell Christine
- Emberton Mark
- Emmerson Louise
- English Dallas R
- Errington R. D
- Evans D. Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Feggetter Jeremy
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- Ferro Michael
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Frim Olivera
- Gallegos Christopher
- Gelister James S
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- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
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- Gower Richard L
- Graham John
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- Harper Peter
- Harrison G. S. M
- Harriss D. R
- Harvey-Hills N
- Hawkyard Simon
- Heath Catherine M
- Hehir Michael
- Hendry David
- Henley Mike
- Herbert Pippa
- Hickish Tamas
- Hindmarsh John R
- Ho Edwin T. S
- Hodgson Shirley
- Holden David
- Holding Peter
- Hollins Graham W
- Holmes Simon A. V
- Hopper John L
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Izatt Louise
- Izegbu Victor
- James Michael J
- James Michael J
- James R. Lester
- Javle Pradip
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- Jhavar Sameer
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- Jones Mandy
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- Kaisary Amir
- Karim O
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- Keeley F. X
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- Kenwrick Sue
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- Khoo Vincent
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- Kirk David
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- Koreich O
- Kote-Jarai Zsofia
- Kourah Mohamed
- Kulkarni Ravi
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- Kunkler Ian H
- Kynaston Howard
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Langley Stephen E. M
- Laniado Marc
- Larner T. R
- Lau Maurice W
- Lawrence W. T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J. O
- Lee L
- Lemburger R. John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel A
- Lester Jason
- Leung Hing
- Lewis D. Christopher
- Lewis J
- Liston Thomas
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lucas Malcolm G
- Luscombe C. J
- Lydon Anna
- Lynch Michael
- Lyons Norma
- MacDermott James P. A
- Macdonagh Ruaraidh P
- Maher E. R
- Mahmood Rana
- Mair Graeme H. M
- Malone Peter R
- Mark I
- Marsden Gemma
- Mason M. D
- Mason Robert
- Matenhelia Shyam
- Matthews Philip N
- McBride Donna
- McFarlane Jonathan
- McGrath John
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McMenemin Rhona
- McNicholas T. A
- Meddings Robert N
- Mee A. David
- Memon
- Menzes Pravin
- Mills Robert
- Mitchell S
- Mithal Natasha
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E. F
- Mokete Moeketsi
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Morley Roland
- Morris Sean B
- Morrison Jonathan
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth R
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki Jan
- Neal David E
- Neilson Donald
- Nethersell A
- Newman Hugh
- Newton R
- O'Boyle P. J
- O'Brien J
- O'Brien Tim S
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J. S
- O'Sullivan Joe
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Osborn David
- Ostler Peter
- O’Brien Lynne T
- Palfrey Edward
- Panades Miguel
- Pancharatnam M
- Pantelides Michalakis L
- Parikh Omi
- Parker Chris
- Parker Christopher C
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Patel Anup
- Patterson Helen
- Payne Heather
- Peake David
- Pedley I
- Pengelly A
- Peracha A. M
- Perry Matthew
- Persad Raj
- Philp N. H
- Philp T
- Pigott Katharine
- Plail R
- Plowman P. Nicholas
- Pocock Richard D
- Pope A. J
- Popert Rick
- Porter Tim
- Powell Christopher
- Powell Philip
- Prasad Krishna
- Prejbisz J. W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Ragavan Narasimhan
- Rankin Julia
- Rao Y
- Ravi Ramachandran
- Read Graham
- Reddy Paul J
- Rimington Peter R
- Roberts J. Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rogers P. B
- Rowbotham Carl
- Rowe Edward
- Rowley Kathryn
- Rundle John
- Russell John M
- Ryan P. G
- Saggar Anand K
- Samanci Ali
- Saunders Ed
- Sawyer Emma
- Saxby M. F
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shah Nihil
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum L
- Simcock R
- Singh Pravin
- Siva M
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Sreenivasan Thiagarajan
- Srihari Narayana N
- Srinivasan
- Sriram Rajagopalan
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M. J
- Strachan John R
- Subramonian K
- Sugden Elaine
- Sundar Santhanam
- Sundaram S. K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Syndikus Isabel
- Tahir Saad
- Taylor John W
- Terry T
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tilsley Owen
- Tindall Stuart F
- Tong
- Trembath Richard C
- Tulloch David N
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C. J
- Urwin Graeme H
- Van As Nicholas
- Vesey Sean
- Violet John
- Virdi Jaspal
- Waite Katherine
- Walker E. M
- Walker Roger
- Wallace David M. A
- Watkin Nicholas A
- Watson M. E
- Waxman J. H
- Waymont Brian
- Weaver Andrew
- Webb Ralph, J
- Wedderburn Andrew
- Wells Paula
- Wemyss-Holden G. D
- Weston P. M. T
- Wheatley Duncan
- Whelan P
- Whillis D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary A
- Williams John H
- Williams Simon
- Willis Michael
- Wilson J. R
- Wilson Richard
- Wise Marcus
- Woodhams Simon
- Woodhouse C
- Woolfenden K. A
- Worlding Jane
- Wright Mark
- Wylie James P
- Wynne Chris
- Zang Angelika
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility
Recommended from our members
A blood-based signature of cerebrospinal fluid A beta(1-42) status
- Author
- Adeli Anahita
- Aisen Paul
- Albers Colleen S.
- Albert Marilyn
- Allard Joanne
- Alzheimers Dis Metabol Consortium
- Ances Beau
- Anderson Karen
- Apostolova Liana
- Arnold Matthias
- Assaly Michele
- Asthana Sanjay
- Bachman David
- Baillie Rebecca
- Bartha Rob
- Bartzokis George
- Barupal Dinesh
- Bates Vernice
- Beccera Mauricio
- Beckett Laurel
- Belden Christine M.
- Bell Karen L.
- Bergman Howard
- Bernick Charles
- Bhattcharyya Sudeepa
- Black Colette
- Black Sandra
- Blank Karen
- Bonakdarpour Borna
- Borges-Neto Salvador
- Borrie Michael
- Brand Connie
- Brewer James
- Brockington John
- Brooks William M.
- Brosch Jared R.
- Brown Alice D.
- Budson Andrew E.
- Burke Anna
- Burns Jeffrey M.
- Caldwell Curtis
- Capote Horacio
- Carlsson Cynthia M.
- Carmichael Owen
- Carroll Maria
- Carson Richard E.
- Carter Raina
- Cellar Janet S.
- Celmins Dzintra
- Cerbone Brittany
- Chaing Gloria
- Chertkow Howard
- Chowdhury Munir
- Clark David
- Coleman Edward
- Conrad Gary
- Correia Stephen
- Creech Mary L.
- D'Agostino Daniel
- Dang Mimi
- de Leon Mony J.
- De Santi Susan
- DeCarli Charles
- deToledo-Morrell Leyla
- Dolen Sara
- Doody Rachelle S.
- Doraiswamy P. Murali
- Duara Ranjan
- Fargher Kristin
- Farlow Martin R.
- Farrer Lindsay
- Fatica Parianne
- Faux Noel G.
- Feldman Howard
- Fiehn Oliver
- Finger Elizabeth
- Flashman Laura A.
- Fleisher Adam
- Fletcher Evan
- Franklin Erin
- Fung Bowen J.
- Funk Cory
- Galvin James E.
- Garg Pradeep
- Geldmacher David
- Glodzik Lidia
- Goldstein Bonnie S.
- Gordineer Leslie
- Goudey Benjamin
- Graff-Radford Neill R.
- Green Robert C.
- Greig Maria T.
- Griffth Randall
- Grossman Hillel
- Hake Ann Marie
- Han Xianlin
- Hankemeier Thomas
- Hardy Peter
- Heidebrink Judith L.
- Heinken Almut
- Hernando Raymundo
- Herring Scott
- Honig Lawrence S.
- Hosein Chris
- Hsiung Ging-Yuek Robin
- Hunt Cynthia
- Hynes Mary L.
- Ismail M. Saleem
- Jack Clifford R.
- Jacobson Sandra A.
- Jagust William
- Jia Wei
- Jicha Greg
- Johnson Heather
- Johnson Kathleen
- Johnson Keith A.
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
- Kastsenmueller Gabi
- Kataki Maria
- Kaye Jeffrey
- Kendall Tracy
- Kertesz Andrew
- Kerwin Diana
- Kielb Stephanie
- Killiany Ronald
- Kittur Smita
- Kling Mitchel
- Knopman David
- Kowall Neil
- Kueider-Paisley Alexandra
- Lah James J.
- Lane Barton
- Lee T-Y
- Lerner Alan
- Levey Allan
- Lin Michael
- Lind Betty
- Lipowski Kristine
- Lord Joanne L.
- Love Marissa Natelson
- Lu Po H.
- MacAvoy Martha G.
- Mahmoudiandehkorki Siam
- Maillard Pauline
- Makino Kelly M.
- Malloy Paul
- Mangravite Lara
- Marshall Gad
- Marson Daniel
- Martin Kim
- Mason Sara S.
- Mathews Dana
- Matthews Brandy R.
- McAdams-Ortiz Catherine
- Meikle Peter
- Mesulam Marek-Marsel
- Michel Christina A.
- Miller Bruce L.
- Mintun Mark A.
- Mintzer Jacobo
- Mitsis Effie
- Morris John
- Morris John C.
- Moseley Arthur
- Mudge Benita
- Mulnard Ruth A.
- Munic Donna
- Nguyen Dana
- Nho Kwangsik
- Norbash Alexander
- Oates Elizabeth
- Obisesan Thomas O.
- Ogrocki Paula
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Ott Brian R.
- Parftt Francine
- Pasternack Stephen
- Pawluczyk Sonia
- Pearlson Godfrey D.
- Perry David
- Petersen Ronald
- Petrella Jeffrey R.
- Plassman Brenda
- Pogorelec Dana M.
- Pomara Nunzio
- Porsteinsson Anton P.
- Potkin Steven G.
- Preda Adrian
- Price Nathan
- Querfurth Henry
- Quiceno Mary
- Quinn Joseph
- Rachisky Irina
- Rainka Michelle
- Raj Balebail Ashok
- Ravdin Lisa
- Reeder Stephanie
- Relkin Norman
- Reynolds Brigid
- Roberson Erik
- Roberts Peggy
- Rosen Allyson
- Rosen Howard J.
- Rountree Susan
- Rusinek Henry
- Sabbagh Marwan N.
- Sadowsky Carl
- Salloway Stephen
- Santulli Robert B.
- Sarrael Antero
- Saykin Andrew
- Saykin Andrew J.
- Scharre Douglas W.
- Schieber Christine
- Schneider Lon S.
- Schneider Stacy
- Seltzer Marc
- Shah Raj C.
- Shaw Leslie
- Shaw Leslie M.
- Silbert Lisa
- Silverman Daniel H. S.
- Sinha Partha
- Sink Kaycee M.
- Sirrel Sherye A.
- Smith Amanda
- Smith Charles D.
- Spann Bryan M.
- Sperling Reisa A.
- Spicer Kenneth
- Stefanovic Bojana
- Stern Yaakov
- Swerdlow Russell H.
- Tariot Pierre
- Tatsuoka Curtis
- Taylor Joy L.
- Tenebaum Jessica
- Teodoro Liberty
- Thai Gaby
- Thiele Ines
- Thompson Will
- Tingus Kathleen
- Tinklenberg Jared
- Toga Arthur W.
- Toledo John
- Tremont Geffrey
- Trncic Nadira
- Trojanowki John Q.
- Trojanowski John
- Trost Dick
- Turner Raymond Scott
- van Duijin Cornelia
- van Dyck Christopher H.
- Vanderswag Helen
- Varma Pradeep
- Varon Daniel
- Villanueva-Meyer Javier
- Villena Teresa
- Watkins Franklin
- Weiner Michael W.
- Weintraub Sandra
- Welsh-Bohmer Kathleen
- Williamson Je D.
- Wishart David
- Wolday Saba
- Womack Kyle
- Wong Terence Z.
- Woo Ellen
- Wu Chuang-Kuo
- Wurtz Peter
- Yesavage Jerome
- Zimmerman Earl A.
- Publication venue
- Springer Nature
- Publication date
- 11/03/2019
- Field of study
It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of interventions aimed at slowing down rates of cognitive decline. Recent evidence indicates that of the two established methods for measuring amyloid, a decrease in cerebrospinal fluid (CSF) amyloid beta(1-42) (A beta(1-42)) may be an earlier indicator of Alzheimer's disease risk than measures of amyloid obtained from Positron Emission Tomography (PET). However, CSF collection is highly invasive and expensive. In contrast, blood collection is routinely performed, minimally invasive and cheap. In this work, we develop a blood-based signature that can provide a cheap and minimally invasive estimation of an individual's CSF amyloid status using a machine learning approach. We show that a Random Forest model derived from plasma analytes can accurately predict subjects as having abnormal (low) CSF A beta(1-42) levels indicative of AD risk (0.84 AUC, 0.78 sensitivity, and 0.73 specificity). Refinement of the modeling indicates that only APOE epsilon 4 carrier status and four plasma analytes (CGA, A beta(1-42), Eotaxin 3, APOE) are required to achieve a high level of accuracy. Furthermore, we show across an independent validation cohort that individuals with predicted abnormal CSF A beta(1-42) levels transitioned to an AD diagnosis over 120 months significantly faster than those with predicted normal CSF A beta(1-42) levels and that the resulting model also validates reasonably across PET A beta(1-42) status (0.78 AUC). This is the first study to show that a machine learning approach, using plasma protein levels, age and APOE epsilon 4 carrier status, is able to predict CSF A beta(1-42) status, the earliest risk indicator for AD, with high accuracy
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
- Author
- Abrams Paul H
- Adamson Andrew
- Adeyoju A
- Afzal N
- Ahiaku Ernest K. N
- Ahmed Munir
- Aitken Joanne
- Al Olama Ali Amin
- Al-Samerraie Dr
- Alcock Christopher
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Apakama Ike
- Aparcia F
- Archbold J. A. A
- Ardern-Jones Audrey T
- Arrand John
- Ash D
- Ashford Richard F. U
- Auvinen Anssi
- Badenoch David
- Bagnato Melisa
- Bahl Amit
- Bailey Karen
- Bailey M. J
- Ball Andrew J
- Bancroft E
- Banerjee G
- Banks Annette
- Barber Jim
- Barber N
- Baria Dr
- Barnes Douglas G
- Barrett Sandra
- Barwell Julian
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N. A
- Baxter-Smith D
- Beacock Christopher
- Beaney Ronald P
- Beard Ralph
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Belcheva Olga
- Bellringer James
- Benson Richard
- Bhatt R. I
- Biedermann Cédric
- Bieri Sabine
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C. Shekhar
- Blacklock A. R. E
- Blades Rosemary
- Blizzard Leigh
- Bloomfield David J
- Bollina Prasad
- Bonnington Sue
- Booth C. M
- Bose Pradeep
- Bottomley David
- Boucher Nigel R
- Bower Mark
- Bowsher W. G
- Boyd P. J. R
- Bradley Sita Ann
- Bramble F. James
- Bremer Michael
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Brough Richard
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Brugger Margot
- Butorac Kate
- Butterworth Paul C
- Cahill D
- Callaghan P. S
- Calman Frances
- Campbell Alister
- Cannon-Albright Lisa
- Cao Guangwen
- Carnell Dawn M
- Carr T. W
- Carter Adam C
- Carter Charles J. M
- Carter Simon
- Castle Bruce M
- Chadwick David
- Chakraborti P
- Challis David
- Chambers Suzanne
- Chang Wen-Jun
- Chappuis Pierre O
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F. I
- Chong Irene
- Chow Wai-Man
- Christmas Tim
- Christova Svetlana
- Churn Mark J
- Clarke Noel W
- Clements Judith
- Coe M
- Cohen N. P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Cooke Peter
- Coombs L
- Coomes Margerie
- Cooney Kathleen A
- Cooper Colin S
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P. A
- Corolis Mr
- Corr John
- Corral Roman
- Costello C. B
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crisp John C
- Cruger Dorthe
- Crundwell Malcolm
- Cummings Mr
- Cunningham Julie
- Dahar Nazeer
- Daruwala Pallon
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David P
- Defabiani Nicolas
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickinson Joanne L
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H. Jane
- Doble Andrew
- Dodds David
- Dodova Rumjana
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dork Thilo
- Douglas S. Fiona
- Drake Mr
- Dubrowinskaja Natalia
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W. D
- Durkan Garrett
- Easton Douglas F
- Eccles Diana
- Eden C. D
- Edwards Stephen M
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Ellis B. W
- Ellis R
- Elves Andrew W. S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- English Dallas R
- Errington R. D
- Evans D. Gareth
- Falconer Alison
- Farnham Jim
- Fawcett Derek
- Featherston C
- Feggetter Jeremy
- Ferguson C
- Ferguson Megan
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel M
- Flanagan Louise
- Fletcher Matthew
- Folkes A
- Foote Simon
- Ford Trevor F
- Foulkes William D
- Frim Olivera
- Gallagher Stephen
- Gallegos Christopher
- Gardiner R. A. (Frank)
- Gelister James S
- George Anne
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Girardet Christophe
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E. M
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R. L
- Gurun Riza Murat
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Hall Amanda L
- Hamdy Freddie C
- Hamel Nancy
- Hamilton C
- Hammonds John
- Hampson S. J
- Hanbury Damien C
- Hardman P. D. John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harrison G. S. M
- Harriss D. R
- Harvey-Hills N
- Hawkyard Simon
- Heath Catherine M
- Hehir Michael
- Henderson Brian E
- Hendry David
- Henley Mike
- Herbert Pippa
- Herkommer Kathleen
- Hickish Tamas
- Hillemanns Peter
- Hindmarsh John R
- Hinze Kimberly
- Ho Edwin T. S
- Hodgson Shirley
- Holden David
- Holding Peter
- Hollins Graham W
- Holmes Simon A. V
- Hopper John L
- Horwich Alan
- Hoskin Peter
- Hou Jian-Guo
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert A
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Hutter Pierre
- Iacovou John W
- Ibrahim A
- Ingles Sue A
- Inglis John A
- Irving Stuart
- Irwin C
- Isotalo Jarkko
- Izatt Louise
- Izegbu Victor
- James Michael J
- James N
- James R. Lester
- Jameson Charles
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- John Esther M
- Johnson Emilie K
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joshi Amit D
- Joss Shelagh
- Kachakova Darina
- Kaisary Amir
- Kaneva Radka
- Karim O
- Karp Stephen J
- Karstens Johann H
- Karyadi Danielle M
- Kedda Mary Anne
- Keeley F. X
- Kelham Penelope
- Kelkar Anand R
- Kelleher J. P
- Kenwrick Sue
- Khan F
- Khan Humera
- Khoo Vincent S
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Kockelbergh Roger
- Kolonel Laurence N
- Konzelmann Isabelle
- Koopmeiners Joseph S
- Koreich O
- Kotar Kimberley
- Kote-Jarai Zsofia
- Kourah Mohamed
- Kuczyk Markus
- Kuefer Rainer
- Kulkarni Ravi
- Kumar M
- Kunkler Ian H
- Kwon Erika M
- Kynaston Howard
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lange Ethan M
- Langley Stephen E. M
- Laniado Marc
- Larner T. R
- Lau Maurice W
- Lawrence W. T
- Lawson Anne
- Le Marchand Loic
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J. O
- Lee L
- Lemburger R .John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel A
- Lester Jason
- Leung Hing
- Lewis D. Christopher
- Lewis J
- Lewis Sarah J
- Liston Thomas
- Liu Jo-Fen
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lose Felicity
- Lu Yong-Jie
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C. J
- Lydon Anna
- Lynch Michael
- Lyons Norma
- MacDermott James P. A
- Macdonagh Ruaraidh P
- Machtens Stefan
- Maher E. R
- Mahmood Rana
- Maier Christiane
- Mair Graeme H. M
- Malone Peter R
- Mark I
- Marsden Gemma
- Mason M. D
- Mason Robert
- Matenhelia Shyam
- Matikainen Mika
- Matthews Philip N
- Mattila Henna
- McArdle John
- McBride Donna
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath John
- McInerney Paul
- McIntosh Gregor
- McKay James
- McKinna F
- McLaren Duncan
- McMenemin Rhona
- McNicholas T. A
- McWhirter Rebekah
- Meddings Robert N
- Mee A. David
- Meier Marie-Mathilde
- Memon Mr
- Menzes Pravin
- Meyer Andreas
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E. F
- Mokete Moeketsi
- Money-Kyrle Julian
- Montgomery Bruce
- Montie James E
- Moody Hilary
- Morley Roland
- Morris Sean B
- Morrison Jonathan
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki Jan
- Neal David E
- Neilson Donald
- Nelson Colleen
- Nethersell A
- Newman Beth
- Newman Hugh
- Newton R
- Nicol David
- Nikolov Momchil
- O'Boyle P. J
- O'Brien J
- O'Brien Lynne T
- O'Brien Tim S
- O'Donoghue E
- O'Donoghue Neil
- O'Mara Tracy
- O'Reilly P
- O'Rourke J. S
- O'Sullivan Joe
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Osborn David
- Ostler Peter
- Ostrander Elaine A
- Page Elizabeth C
- Paiss Thomas
- Pakkanen Sanna
- Palfrey Edward
- Panades Miguel
- Pancharatnam M
- Pantelides Michalakis L
- Parikh Omi
- Park Hyun Y
- Park Jong Y
- Parker Christopher C
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Patel Anup
- Patterson Briony
- Patterson Helen
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha A. M
- Perry Matthew
- Persad Raj
- Peter Hans-Ulrich
- Philp N. H
- Philp T
- Pigott Katharine
- Plail R
- Plowman P. Nicholas
- Pocock Richard D
- Polanowski Andrea
- Pope A. J
- Popert Rick
- Popov Elenko
- Porter Tim
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Prasad Krishna
- Prejbisz J. W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Radein Selina
- Ragavan Narasimhan
- Rankin Julia
- Rao Y
- Ravi Ramachandran
- Ray Anna M
- Read Graham
- Rebbeck Timothy R
- Reddy Paul J
- Rimington Peter R
- Rincon Maria
- Roberts J. Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rogers P. B
- Rowbotham Carl
- Rowe Edward
- Rowley Kathryn
- Rundle John
- Russell John M
- Ryan P. G
- Saggar Anand K
- Samanci Ali
- Saunders Edward J
- Sawyer Emma J
- Saxby M. F
- Schaid Daniel
- Schleutker Johanna
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Sellers Thomas A
- Sells Henry
- Serth Jürgen
- Sethia Krishna K
- Severi Gianluca
- Shah Nihil
- Shahabi Ahva
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum L
- Siltanen Sanna
- Simcock R
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smark Heidi
- Smith Charmaine
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Spangler Elaine
- Speakman Mark J
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan Mr
- Sriram Rajagopalan
- Stalder Michèle
- Stanford Janet L
- Stankovich James
- Stefflova Klara
- Stenman Ulf-Håkan
- Stern Mariana C
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M. J
- Strachan John R
- Subramonian K
- Sugden Elaine
- Sundar Santhanam
- Sundaram S. K
- Suresh Gokarakonda
- Surowy Harald
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Syndikus Isabel
- Tahir Saad
- Tammela Teuvo L
- Taylor John W
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thomson Russell
- Thurston A
- Tilsley Owen
- Tindall Stuart F
- Tong Dr
- Trembath Richard C
- Tulloch David N
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C. J
- Urwin Graeme H
- Van As Nicholas
- VandenBergh Patrica
- Vesey Sean
- Violet John
- Virdi Jaspal
- Vlahova Aleksandrina
- Vogel Walther
- von Klot Christoph
- Wahlfors Tiina
- Waite Katherine
- Walker Amy
- Walker E. M
- Walker Roger
- Wallace David M. A
- Wang Liang
- Watkin Nicholas A
- Watson M. E
- Waxman J. H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Weber Bärbel
- Wedderburn Andrew
- Wells Paula
- Wemyss-Holden G. D
- Weston P. M. T
- Wheatley Duncan
- Whelan P
- Whillis D
- Wiest Irina
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary A
- Williams John H
- Williams Simon
- Willis Michael
- Wilson J. R
- Wilson Richard
- Wise Marcus
- Woodhams Simon
- Woodhouse Christopher J
- Woolfenden K. A
- Worlding Jane
- Wright Mark
- Wylie James P
- Wynne Chris
- Xu Dan-Feng
- Xu Xing-Xing
- Yaxley John
- Zachariah Babu
- Zakariah Babu
- Zang Angelika
- Zeegers Maurice
- Zeigler-Johnson Charnita
- Zhang Hong-Wei
- Zuhlke Kimberly A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6×10−8 to P=2.7×10−33)
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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
- Author
- Adeli Anahita
- Aisen Paul
- Albers Colleen S.
- Albert Marilyn
- Albert Marylyn
- Allard Joanne
- Ances Beau
- Anderson Heather S.
- Anderson Karen
- Apostolova Liana
- Arfanakis Konstantinos
- Arnold Steven E.
- Ashok Raj Balebail
- Assaly Michele
- Asthana Sanjay
- Ayton Scott
- Bachman David
- Bartha Rob
- Bartzokis George
- Bates Vernice
- Beccera Mauricio
- Beckett Laurel
- Belden Christine M.
- Bell Karen L.
- Bergman Howard
- Bernick Charles
- Bernstein Matthew
- Black Sandra
- Blank Karen
- Boles Ponto Laura L.
- Borowski Bret
- Borrie Michael
- Brand Connie
- Brewer James
- Brockington John
- Brown Alice D.
- Buckholtz Neil
- Budson Andrew E.
- Burns Jeffrey M.
- Bush Ashley I.
- Cairns Nigel J.
- Caldwell Curtis
- Capote Horacio
- Carlsson Cynthia M.
- Carmichael Owen
- Carroll Maria
- Carson Richard E.
- Carter Raina
- Cellar Janet S.
- Celmins Dzintra
- Cerbone Brittany
- Chaing Gloria
- Chen Kewei
- Chertkow Howard
- Chowdhury Munir
- Clark David
- Conrad Gary
- Correia Stephen
- Crawford Karen
- D'Agostino II Daniel
- Dang Mimi
- Davies Peter
- Davis Melissa
- de Leon Mony J
- De Santi Susan
- DeCarli Charles
- deToledo-Morrell Leyla
- DeVous Michael
- Diaz-Arrastia Ramon
- Dolen Sara
- Donohue Michael
- Doody Rachelle S.
- Drost Dick
- Duara Ranjan
- Elizabeth Smith Karen
- Faber Kelley
- Fargher Kristin
- Farlow Martin R.
- Faux Noel G.
- Feldman Howard
- Figurski Michal
- Fillit Howard
- Finger Elizabether
- Finley Shannon
- Fleischman Debra
- Fleisher Adam
- Fletcher Evan
- Foroud Tatiana M.
- Foster Norm
- Fox Nick
- Frank Richard
- Frey Meghan
- Friedl Karl
- Furst Ansgar J.
- Galvin James E.
- Garg Pradeep
- Geldmacher David
- Gessert Devon
- Glodzik Lidia
- Goldstein Bonnie S.
- Graff-Radford Neill R
- Grafman Jordan
- Green Robert C.
- Greig Maria T.
- Griffith Randall
- Grossman Hillel
- Gunter Jeff
- Hake Ann Marie
- Harding Sandra
- Hardy Peter
- Harvey Danielle
- Hayes Jacqueline
- Hefti Franz
- Heidebrink Judith L.
- Hernando Raymundo
- Herring Scott
- Holtzman Davie
- Honig Lawrence S.
- Hosein Chris
- Householder Erin
- Hsiao John
- Hudson Leon
- Hunt Cynthia
- Jack Jr. Clifford R.
- Jacobson Sandra A.
- Jagust William
- James Olga
- Jay Fruehling J.
- Jicha Greg
- Jiminez Gus
- Johnson Heather
- Johnson Kathleen
- Johnson Keith A.
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
- Jones David
- Kantarci Kejal
- Karlawish Jason H.
- Kataki Maria
- Kaye Jeffrey
- Kendall Tracy
- Kertesz Andrew
- Kerwin Diana
- Khachaturian Zaven
- Kielb Stephanie
- Killiany Ronald
- Kim Sungeun
- King Richard
- Kittur Smita
- Kitzmiller Tamar J.
- Knopman David
- Koeppe Robert A.
- Korecka Magdalena
- Kowall Neil
- Kuller Lew
- Lah James J.
- Landau Susan
- Lane Barton
- Lee T-Y
- Lee Virginia
- Leon Sue
- Lerner Alan
- Levey Allan I.
- Li Gail
- Lind Betty
- Lipowski Kristine
- Lopez Oscar L.
- Lord Joanne L.
- Lu Po H.
- MacAvoy Martha G.
- Makino Kelly M.
- Malloy Paul
- Marcel Mesulam M.
- Marshall Gad
- Marson Daniel
- Martin Kim
- Martin-Cook Kristen
- Martinez Walter
- Mason Sara S.
- Massoglia Dino
- Mathews Dana
- Mathis Chet
- Matthews Brandy R.
- Mc-Adams-Ortiz Catherine
- Mesulam Marek-Marsel
- Michel Christina A.
- Miller Bruce L.
- Mintun Mark A.
- Mintzer Jacobo
- Mitsis Effie
- Montine Tom
- Morris John
- Morrison Rosemary
- Mudge Benita
- Mulnard Ruth A.
- Munic Donna
- Murali Doraiswamy P.
- Neu Scott
- Neylan Thomas
- Nguyen Dana
- Nho Kwangsik
- Norbash Alexander
- Oakley MaryAnn
- Oates Elizabeth
- Ogrocki Paula
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Ott Brian R.
- Parfitt Francine
- Pasternak Stephen
- Paul Steven
- Pawluczyk Sonia
- Pearlson Godfrey D.
- Peskind Elaine R.
- Petersen Ronald
- Petrella Jeffrey R.
- Petrie Eric C.
- Pomara Nunzio
- Porsteinsson Anton P.
- Potkin Steven
- Potkin Steven G.
- Potter William
- Preda Adrian
- Querfurth Henry
- Quiceno Mary
- Quinn Joseph
- Rachinsky Irina
- Raichle Marc
- Rainka Michelle
- Raudin Lisa
- Reeder Stephanie
- Reiman Eric M.
- Relkin Norman
- Reynolds Brigid
- Roberson Erik
- Roberts Peggy
- Robin Hsiung Ging-Yuek
- Rogers John
- Rosen Allyson
- Rosen Howard J.
- Rountree Susan
- Rusinek Henry
- Sabbagh Marwan N.
- Sadowsky Carl
- Saleem Ismail M.
- Salloway Stephen
- Santulli Robert B.
- Sarrael Antero
- Sather Tamie
- Saykin Andrew J.
- Scharre Douglas W.
- Schneider Lon S.
- Schneider Stacy
- Schuff Norbert
- Schultz Susan K.
- Schwartz Adam
- Schwartz Eben S.
- Scott Turner Raymond
- Senjem Matt
- Shah Raj C.
- Shaw Leslie M.
- Shen Li
- Shim Hyungsub
- Silverman Daniel H.S.
- Simpson Donna M.
- Sinha Partha
- Sink Kaycee M.
- Sirrel Sherye A.
- Smith Amanda
- Smith Charles D.
- Snyder Peter
- Sorensen Greg
- Spann Bryan M.
- Sperling Reisa A.
- Spicer Kenneth
- Stefanovic Bojana
- Stern Yaakov
- Swerdlow Russell H.
- Tariot Pierre
- Taylor Joy L.
- Taylor-Reinwald Lisa
- Teodoro Liberty
- Thai Gaby
- Thal Leon
- Thomas Ronald G.
- Thompson Paul
- Tingus Kathleen
- Tinklenberg Jared
- Toga Arthur W.
- Tremont Geoffrey
- Trojanowki John Q.
- van Dyck Christopher H.
- Vanderswag Helen
- Varon Daniel
- Vemuri Prashanthi
- Villanueva-Meyer Javier
- Villena Teresa
- Walter Sarah
- Ward Chad
- Watkins Franklin
- Weiner Michael W.
- Weiner Myron
- Williamson Jeff D.
- Wolk David
- Womack Kyle
- Wong Terence Z.
- Woo Ellen
- Wu Chuang-Kuo
- Yesavage Jerome A.
- Zimmerman Earl A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/07/2015
- Field of study
Brain iron elevation is implicated in Alzheimer's disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal fluid (CSF) levels of ferritin as an index, we explored whether brain iron status impacts longitudinal outcomes in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We show that baseline CSF ferritin levels were negatively associated with cognitive performance over 7 years in 91 cognitively normal, 144 mild cognitive impairment (MCI) and 67 AD subjects, and predicted MCI conversion to AD. Ferritin was strongly associated with CSF apolipoprotein E levels and was elevated by the Alzheimer's risk allele, APOE-ɛ4. These findings reveal that elevated brain iron adversely impacts on AD progression, and introduce brain iron elevation as a possible mechanism for APOE-ɛ4 being the major genetic risk factor for AD