Observations of Binary Stars with the Differential Speckle Survey Instrument. VII. Measures from 2010 September to 2012 February at the WIYN Telescope

We report on speckle observations of binary stars carried out at the WIYN Telescope over the period from September 2010 through February 2012, providing relative astrometry for 2521 observations of 883 objects, 856 of which are double stars and 27 of which are triples. The separations measured span a range of 0.01 to 1.75 arc seconds. Wavelengths of 562 nm, 692 nm, and 880 nm were used, and differential photometry at one or more of these wavelengths is presented in most cases. Sixty-six components were resolved for the first time. We also estimate detection limits at 0.2 and 1.0 arc seconds for high-quality observations in cases where no companion was seen, a total of 176 additional objects. Detection limits vary based on observing conditions and signal-to-noise ratio, but are approximately 4 magnitudes at 0.2 arc seconds and 6 magnitudes at 1.0 arc seconds on average. Analyzing the measurement precision of the data set, we find that the individual separations obtained have linear measurement uncertainties of approximately 2 mas, and photometry is uncertain to approximately 0.1 magnitudes in general. This work provides fundamental, well-calibrated data for future orbit and mass determinations, and we present three first orbits and total mass estimates of nearby K-dwarf systems as examples of this potential

The Radio Ammonia Mid-plane Survey (RAMPS) Pilot Survey

The Radio Ammonia Mid-Plane Survey (RAMPS) is a molecular line survey that aims to map a portion of the Galactic midplane in the first quadrant of the Galaxy (l = 10°–40°, | b| \leqslant 0\buildrel{\circ}\over{.} 4) using the Green Bank Telescope. We present results from the pilot survey, which has mapped approximately 6.5 square degrees in fields centered at l = 10°, 23°, 24°, 28°, 29°, 30°, 31°, 38°, 45°, and 47°. RAMPS observes the NH3 inversion transitions NH3(1,1)–(5,5), the H2O 61,6–52,3 maser line at 22.235 GHz, and several other molecular lines. We present a representative portion of the data from the pilot survey, including NH3(1,1) and NH3(2,2) integrated intensity maps, H2O maser positions, maps of NH3 velocity, NH3 line width, total NH3 column density, and NH3 rotational temperature. These data and the data cubes from which they were produced are publicly available on the RAMPS website (http://sites.bu.edu/ramps/)

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases