33 research outputs found

    A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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    Prediction of fasting gastric pH using serum biological markers

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    http://www.hepatogastroenterology.org

    Serum Nitrate/Nitrite Concentration Correlates with Gastric Juice Nitrate/Nitrite: A Possible Marker for Mutagenesis of the Proximal Stomach

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    &lt;i&gt;Background/Aims:&lt;/i&gt; In the normal acid-secreting stomach, luminally generated nitric oxide, which contributes to carcinogenesis in the proximal stomach, is associated with the concentration of nitrate plus nitrite (nitrate/nitrite) in gastric juice. We investigated whether the serum nitrate/nitrite concentration is associated with that of gastric juice and whether it can be used as a serum marker. &lt;i&gt;Methods:&lt;/i&gt; Serum and gastric juice nitrate/nitrite concentration, &lt;i&gt;Helicobacter pylori&lt;/i&gt; antibody, and gastric pH were measured in 176 patients undergoing upper endoscopy. &lt;i&gt;Results:&lt;/i&gt; Multiple regression analysis revealed that serum nitrate/nitrite concentration was the best independent predictor of gastric juice nitrate/nitrite concentration. On single regression analysis, serum and gastric juice nitrate/nitrite concentration were significantly correlated, according to the following equation: gastric juice nitrate/nitrite concentration (µmol/l) = 3.93 – 0.54 × serum nitrate/nitrite concentration (µmol/l; correlation coefficient = 0.429, p &lt; 0.001). In analyses confined to subjects with gastric pH less than 2.0, and in those with serum markers suggesting normal acid secretion (pepsinogen-I &gt;30 ng/ml and negative&lt;i&gt; H. pylori&lt;/i&gt; antibody), the serum nitrate/nitrite concentration was an independent predictor of the gastric juice nitrate/nitrite concentration (p &lt; 0.001). &lt;i&gt;Conclusion:&lt;/i&gt; Measuring the serum nitrate/nitrite concentration has potential in estimating the gastric juice nitrate/nitrite concentration. The serum nitrate/nitrite concentration could be useful as a marker for mutagenesis in the proximal stomach.</jats:p
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