A New Tensile Test for Aluminum Alloys in the Mushy State: Experimental Method and Numerical Modeling

A fairly simple experimental setup has been designed for testing the resistance of the mushy zone of alloys during solidification under tensile conditions. It has been used to study the effect of coalescence among the solid grains at a late stage of solidification. The experimental approach involves both tensile-strength measurements and scanning electron microscope (SEM) observations of fracture surfaces. Complementary information can be obtained by numerical modeling of this solidification process. The latter takes into account heat flow in the sample, rheology of the mushy alloy, liquid feeding, and porosity formation. All of the available information indicates that the transition from a granular mushy alloy to a coalesced solid-skeleton behavior starts for a solid fraction of approximately 92pc

Two-Phase Modeling of Hot Tearing in Aluminum Alloys: Applications of a Semicoupled Method

Hot tearing formation in both a classical tensile test and during direct chill (DC) casting of aluminum alloys has been modeled using a semicoupled, two-phase approach. Following a thermal calculation, the deformation of the mushy solid is computed using a compressive rheological model that neglects the pressure of the intergranular liquid. The nonzero expansion/compression of the solid and the solidification shrinkage are then introduced as source terms for the calculation of the pressure drop and pore formation in the liquid phase. A comparison between the simulation results and experimental data permits a detailed understanding of the specific conditions under which hot tears form under given conditions. It is shown that the failure modes can be quite different for these two experiments and that, as a consequence, the appropriate hot tearing criterion may differ. It is foreseen that a fully predictive theoretical tool could be obtained by coupling such a model with a granular approach. These two techniques do, indeed, permit coverage of the range of the length scales and the physical phenomena involved in hot tearin

A new tensile test for aluminum alloys in the mushy state: Experimental method and numerical modeling

A fairly simple experimental setup has been designed for testing the resistance of the mushy zone of alloys during solidification under tensile conditions. It has been used to study the effect of coalescence among the solid grains at a late stage of solidification. The experimental approach involves both tensile-strength measurements and scanning electron microscope (SEM) observations of fracture surfaces. Complementary information can be obtained by numerical modeling of this solidification process. The latter takes into account heat flow in the sample, rheology of the mushy alloy, liquid feeding, and porosity formation. All of the available information indicates that the transition from a granular mushy alloy to a coalesced solid skeleton behavior starts for a solid fraction of approximately 92 pct

Two-Phase Modeling of Hot Tearing in Aluminum Alloys: Applications of a Semicoupled Method

Hot tearing formation in both a classical tensile test and during direct chill (DC) casting of aluminum alloys has been modeled using a semicoupled, two-phase approach. Following a thermal calculation, the deformation of the mushy solid is computed using a compressive rheological model that neglects the pressure of the intergranular liquid. The nonzero expansion/compression of the solid and the solidification shrinkage are then introduced as source terms for the calculation of the pressure drop and pore formation in the liquid phase. A comparison between the simulation results and experimental data permits a detailed understanding of the specific conditions under which hot tears form under given conditions. It is shown that the failure modes can be quite different for these two experiments and that, as a consequence, the appropriate hot tearing criterion may differ. It is foreseen that a fully predictive theoretical tool could be obtained by coupling such a model with a granular approach. These two techniques do, indeed, permit coverage of the range of the length scales and the physical phenomena involved in hot tearing

HOW DOES COALESCENCE OF DENDRITE ARMS OR GRAINS INFLUENCE HOT TEARING ?

Hot tearing, a severe defect occurring during solidification, is the conjunction of tensile stresses which are transmitted to the mushy zone by the coherent solid underneath and of an insufficient liquid feeding to compensate for the volumetric change. In most recent hot tearing criteria, one of the critical issues is the definition of a coherency point which, in low-concentration alloys, corresponds to the bridging or coalescence of the primary phase. A coalescence model has been developed recently using the concept of the disruptive pressure in thin liquid films.[1] It has been shown that large-misorientation grain boundaries, which are characterized by an interfacial energy, γgb, larger than twice the solid-liquid interfacial energy, γsl, solidify at an undercooling ΔTb = (γgb - 2γsl)/(Δsfδ), where Δsf is the entropy of fusion and δ the thickness of the diffuse interface. When γgb < 2γsl (e.g., low-angle grain boundaries), dendrite arms coalesce as soon as they impinge on each other. Using such concepts and a back-diffusion model, the percolation of equiaxed, randomly oriented grains has been studied in 2D : it is shown that the grain structure gradually evolves from isolated grains separated by a continuous interdendritic liquid film, to a fully coherent solid with a few remaining wet boundaries. The implication of such findings for the hot cracking tendency of aluminum alloys are discussed

Current status and perspectives of interventional clinical trials for glioblastoma - analysis of ClinicalTrials.gov

The records of 208.777 (100%) clinical trials registered at ClinicalTrials.gov were downloaded on the 19th of February 2016. Phase II and III trials including patients with glioblastoma were selected for further classification and analysis. Based on the disease settings, trials were classified into three groups: newly diagnosed glioblastoma, recurrent disease and trials with no differentiation according to disease setting. Furthermore, we categorized trials according to the experimental interventions, the primary sponsor, the source of financial support and trial design elements. Trends were evaluated using the autoregressive integrated moving average model. Two hundred sixteen (0.1%) trials were selected for further analysis. Academic centers (investigator initiated trials) were recorded as primary sponsors in 56.9% of trials, followed by industry 25.9%. Industry was the leading source of monetary support for the selected trials in 44.4%, followed by 25% of trials with primarily academic financial support. The number of newly initiated trials between 2005 and 2015 shows a positive trend, mainly through an increase in phase II trials, whereas phase III trials show a negative trend. The vast majority of trials evaluate forms of different systemic treatments (91.2%). In total, one hundred different molecular entities or biologicals were identified. Of those, 60% were involving drugs specifically designed for central nervous system malignancies. Trials that specifically address radiotherapy, surgery, imaging and other therapeutic or diagnostic methods appear to be rare. Current research in glioblastoma is mainly driven or sponsored by industry, academic medical oncologists and neuro-oncologists, with the majority of trials evaluating forms of systemic therapies. Few trials reach phase III. Imaging, radiation therapy and surgical procedures are underrepresented in current trials portfolios. Optimization in research portfolio for glioblastoma is needed

Physical fitness in morbidly obese patients: effect of gastric bypass surgery and exercise training

Background There is a growing consensus that bariatric surgery is currently the most efficacious and long-term treatment for clinically severe obesity. However, it remains to be determined whether poor physical fitness, an important characteristic of these patients, improves as well. The purpose of this pilot study is to investigate the effect of gastric bypass surgery on physical fitness and to determine if an exercise program in the first 4 months is beneficial. Methods Fifteen morbidly obese patients (BMI 43.0 kg/m(2)) were tested before and 4 months after gastric bypass surgery. Eight of them followed a combined endurance and strength training program. Before and after 4 months the operation, anthropometrical characteristics were measured, and an extensive assessment of physical fitness (strength, aerobic, and functional capacity) was performed. Results Large-scale weight loss through gastric bypass surgery results in a decrease in dynamic and static muscle strength and no improvement of aerobic capacity. In contrast, an intensive exercise program could prevent the decrease and even induced an increase in strength of most muscle groups. Together with an improvement in aerobic capacity, functional capacity increased significantly. Both groups evolved equally with regard to body composition (decrease in fat mass and fat-free mass). Conclusions An exercise training program in the first 4 months after bariatric surgery is effective and should be promoted, considering the fact that physical fitness does not improve by weight loss only