Kunsteducatie opent de ogen

een theoretisch en empirisch onderzoek naar de theorie van Meervoudige Intelligentie (MI)in het primair onderwijs in Nederland en/of het belang van cultuureducati

Librarians on the Move: Embedded Librarians

Years ago, in the late 90’s when we had an official reference desk and students ambled their way into the library to ask for research assistance I thought it would be a good proactive idea to take the reference desk to students on their home turf in their residence hall, dining area and socializing entities. I thought, “ What better way to burst the illusion bubble that academic librarians were unhelpful, grouchy and untouchable.

Advocating for Green with Video Presence

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Submersive Learning: An Interactive Approach to Enhance Visitor Experience in a Museum Setting

Located on the Muskegon Lake Channel, Michigan, USA, the Great Lakes Naval Memorial and Museum (GLNMM0) is host to the USS Silversides a World War II submarine. In order to enhance the visitor experience at the museum and provide additional educational content the museum is implementing several integrative educational components. These components include the interactive Shipmate & ROV Oceanographer Programs and activity books, Quick Response Codes (QR codes) and increased technology for current Remotely Operated Vehicle (ROV) programs. This project is collaboration between two university management professors, the director of education at the museum, two university librarians, and three university students. Collective learning connected the museum, higher education, business, libraries, economics and the workforce

Submersive Learning: An Interactive Approach to Enhance Visitor Experience in a museum Setting

Located on the Muskegon Lake Channel, USA, the Great Lakes Naval Memorial and Museum (GLNMM) is host to the USS Silversides a World War II submarine. In order to enhance the visitor experience at the museum and provide additional educational content the museum is implementing several integrative educational components. These components include the interactive Shipmate & ROV Oceanographer Programs and activity books, Quick Response Codes (QR Codes) and increased technology for current Remotely Operated Vehicle (ROV) programs. This project is collaboration between two university management professors, the director of education at the museum, two university librarians and three university students. Collective learning connected the museum, higher education, business, libraries, economics and the workforce

Taste and speech following surgical tongue reduction in children with Beckwith-Wiedemann syndrome

Beckwith-Wiedemann syndrome (BWS) is an overgrowth disorder in which macroglossia is one of the main signs. We investigated the long-term outcome of tongue surgery reduction (TRS) on taste and speech in patients with BWS who were more than 5 years of age and had undergone surgical anterior wedge resection of the tongue. A questionnaire was used to assess medical history and to determine some aspects of speech, taste, psychological well-being, and degree of satisfaction with regard to TRS and tongue mobility. Speech sound error pattern and degree of intelligibility were measured by a speech therapist, and taste was assessed using a validated test. The degree of both intelligibility and satisfaction with the surgery was high. There were some speech errors; especially the interdental 's', addental 't', and addental 'd' were more noticed. We conclude that anterior wedge resection is an effective technique to treat macroglossia in children with BWS, and that it has no long-term consequences for intelligibility and taste perception and only limited consequences for speec

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylation-dependent substrate recognition. Screening of more than 30 representative BRDs against systematic histone-peptide arrays identifies new BRD substrates and reveals a strong influence of flanking posttranslational modifications, such as acetylation and phosphorylation, suggesting that BRDs recognize combinations of marks rather than singly acetylated sequences. We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4. These data provide a foundation for structure-based drug design of specific inhibitors for this emerging target family

COS Ambassadors

A collection of materials and resources for COS ambassadors