EEG Correlates of Consciousness During Sleep: A Pilot Study

The following is an abstract of a pilot study posted in the corollary sessions at the Lucidity Association's Conference on Higher States of Consciousness, in Chicago in July, 1990

Rapidly Rotating, X-Ray Bright Stars in the Kepler Field

We present Kepler light curves and optical spectroscopy of twenty X-ray bright stars located in the Kepler field of view. The stars, spectral type F-K, show evidence for rapid rotation including chromospheric activity 100 times or more above the Sun at maximum and flaring behavior in their light curves. Eighteen of our objects appear to be (sub)giants and may belong to the class of FK Com variables, which are evolved rapidly spinning single stars with no excretion disk and high levels of chromospheric activity. Such stars are rare and are likely the result of W UMa binary mergers, a process believed to produce the FK Com class of variable and their descendants. The FK Com stage, including the presence of an excretion disk, is short lived but leads to longer-lived stages consisting of single, rapidly rotating evolved (sub)giants with high levels of stellar activity

How do we evaluate the cost of nosocomial infection? The ECONI protocol: an incidence study with nested case-control evaluating cost and quality of life

Introduction Healthcare-associated or nosocomial infection (HAI) is distressing to patients and costly for the National Health Service (NHS). With increasing pressure to demonstrate cost-effectiveness of interventions to control HAI and notwithstanding the risk from antimicrobial-resistant infections, there is a need to understand the incidence rates of HAI and costs incurred by the health system and for patients themselves. Methods and analysis The Evaluation of Cost of Nosocomial Infection study (ECONI) is an observational incidence survey with record linkage and a nested case-control study that will include postdischarge longitudinal follow-up and qualitative interviews. ECONI will be conducted in one large teaching hospital and one district general hospital in NHS Scotland. The case mix of these hospitals reflects the majority of overnight admissions within Scotland. An incidence survey will record all HAI cases using standard case definitions. Subsequent linkage to routine data sets will provide information on an admission cohort which will be grouped into HAI and non-HAI cases. The case-control study will recruit eligible patients who develop HAI and twice that number without HAI as controls. Patients will be asked to complete five questionnaires: the first during their stay, and four others during the year following discharge from their recruitment admission (1, 3, 6 and 12 months). Multiple data collection methods will include clinical case note review; patient-reported outcome; linkage to electronic health records and qualitative interviews. Outcomes collected encompass infection types; morbidity and mortality; length of stay; quality of life; healthcare utilisation; repeat admissions and postdischarge prescribing. Ethics and dissemination The study has received a favourable ethical opinion from the Scotland A Research Ethics Committee (reference 16/SS/0199). All publications arising from this study will be published in open-access peer-reviewed journal. Lay-person summaries will be published on the ECONI website. Trial registration number NCT03253640; Pre-results

How do maternal interaction style and joint attention relate to language development in infants with Down syndrome and typically developing infants?

Down syndrome (DS) is more detrimental to language acquisition compared to other forms of learning disability. It has been shown that early social communication skills are important for language acquisition in the typical population; however few studies have examined the relationship between early social communication and language in DS. The aim of the current study is to compare the relationship between joint attention and concurrent language skills, and maternal interactive style and concurrent language skills in infants with DS and in typically developing (TD) infants matched for mental age. We also investigated if these relationships differ between children with DS and TD children. Twenty-five infants with DS (17–23 months) and 30 TD infants (9–11 months) were assessed on measures of joint attention, maternal interactive style and language. The results indicated a significant positive relationship between responding to joint attention (RJA) and concurrent language for the DS group, and a significant positive relationship between maternal positive expressed emotion (PEEM) and concurrent language for the TD group. We hypothesise that different social-communication factors are associated with language skills in DS, at least between 17 and 23 months of age compared to TD infants of similar non-verbal and general language abilities

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for > 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors

Segregation and preterm birth: The effects of neighborhood racial composition in North Carolina

Epidemiologic research suggests that racial segregation is associated with poor health among blacks in the United States (US). We used geocoded birth records and US census data to investigate whether neighborhood-level percent black is associated with preterm birth (PTB) for black and white women in two counties in the southern US, whether area-level deprivation modifies this association, and whether the association is influenced by the choice of geographic unit used to approximate a neighborhood. A 20%-point increase in tract-level percent black was found to be associated with increased PTB odds in white (OR=1.09, 95% CI: 1.01, 1.18) and black (OR=1.05, 95% CI: 0.99, 1.11) women. These small associations were similar to those observed in other US regions. Effects were robust to choice of neighborhood proxy and were not modified by area-level deprivation

The Palomar/Keck Adaptive Optics Survey of Young Solar Analogs: Evidence for a Universal Companion Mass Function

We present results from an adaptive optics survey for substellar and stellar companions to Sun-like stars. The survey targeted 266 F5-K5 stars in the 3Myr to 3Gyr age range with distances of 10-190pc. Results from the survey include the discovery of two brown dwarf companions (HD49197B and HD203030B), 24 new stellar binaries, and a triple system. We infer that the frequency of 0.012-0.072Msun brown dwarfs in 28-1590AU orbits around young solar analogs is 3.2% (+3.1%,-2.7%; 2sigma limits). The result demonstrates that the deficiency of substellar companions at wide orbital separations from Sun-like stars is less pronounced than in the radial velocity "brown dwarf desert." We infer that the mass distribution of companions in 28-1590AU orbits around solar-mass stars follows a continuous dN/dM_2 ~ M_2^(-0.4) relation over the 0.01-1.0Msun secondary mass range. While this functional form is similar to that for <0.1Msun isolated objects, over the entire 0.01-1.0Msun range the mass functions of companions and of isolated objects differ significantly. Based on this conclusion and on similar results from other direct imaging and radial velocity companion surveys in the literature, we argue that the companion mass function follows the same universal form over the entire range between 0-1590AU in orbital semi-major axis and 0.01-20Msun in companion mass. In this context, the relative dearth of substellar versus stellar secondaries at all orbital separations arises naturally from the inferred form of the companion mass function.Comment: Final version accepted by ApJ Supplements. 50 pages, including 12 tables + 16 figures. Version with full tables available at http://www.astro.sunysb.edu/metchev/PUBLICATIONS/cmf.pd