The annual cycle of the kestrel <i>Falco tinnunculus</i>:A study in behavioural energetics

Korte beschrijving: The kestrel research project of the Department of Zoology (University of Groningen) aims to evaluate the evolutionairy benefits endowed on individuals by the temporal order in their behaviour. In the tradition of the Animal Ecology Section of the department, founded by the late Prof. Dr. L. Tinbergen, the project has taken an ampiry - rather than theory-based approach to the problem of temporal organization. ... Zie: Epilogu

Development of novel small-size peptides as putative therapeutic drugs

This thesis focuses on the development of small peptide molecules with either antifungal properties or with the ability to control protein deposits that cause the characteristic brain damage in Alzheimer's disease (AD). Thus, our ultimate aim is to design putative therapeutic agents supported by computational techniques. Apropos of AD, this is a very complex disease where brain damage is associated with the degradation of the human mind and memory. Currently, researchers consent that a key role is played by a peptide called beta-amyloid. This peptide is not toxic by itself, however it becomes toxic to nerve-cells when several of its molecules clump together forming aggregates. This is the beginning of a slow but unstoppable brain deterioration, which ultimately leads to dementia. The currently available AD drugs delay, at best, the loss of memory, but do not stop the neural degradation. Its severity and the increasing number of AD patients, are the worldwide driving force to acquire more effective drugs. In our own research we focused on the development of new peptides that prevent or slow down the formation of the aggregated beta-amyloid. Computational techniques allowed us to explore the self-bound beta-amyloid molecules, as well as their interaction with new potential drugs. With this fascinating information we designed small peptides aimed at disrupting the aggregated beta-amyloid. Then, its anti-amyloid activity of was tested in vitro and in vivo. Both tests have produced not only positive but also striking and promising results indicating the potential therapeutic application of these new anti-amyloid peptides.

Pengaruh Motivasi, Dan Persepsi Terhadap Keputusan Pembelian Mobil Merek Hino Pada CV Thamrin Bersaudara Di Palembang

The goal of this experiment is to know the contribution of motivation, and perception, to consumer purchase\u27s decision of car Hino in CV Thamrin Bersaudara,Palembang. Sample are chosen using purposive sampling. And data is analysed by multiple regression. The result of this research is known that that showed that motivation, perception, and consumer\u27s attitude influence Hino purchasing with positively and significantly through purchasing decision. The benefit oh this research is used as a source of information for increasing sales of Hino in CV Thamrin,Palembang