Letter from Mary E. Stewart to John Muir, 1913 May 18.

3323 Park Hill Avenue, Milwaukee, Wisconsin.May,18,1913Dear Mr.Muir:I have read your Boyhood with so much pleasure, I wishto express it to you. I can very well understand that Scotch severity, though it came to me in a modified form.My father was this country bor ;his parents real Highlanders,using the Gaelic language.But there ismuch sturdiness in the Scotch character that stands to the good,as withness the success you have made of your life in spite of the most adverse corcumstances.I enclose a clipping of the review I made for the paper.I am so limited in space,I could not write as I would wish.The story of your inventions is not new to me as my brother,I. N.Stewart, was at the University while you were there and brought home stories of the wonders he saw of your making.Some that he told of were not mentioned in the book. A year ago we had a visit from Mr. Volney Rattan who was also at the University. While he was here Milton Griswold,now a judge of reputation and honor,spent a day and the men renewed memories of old times. Your name was frequently mentioned and all were wishing you might have been there.You crossed the plains at a time when it was a danger andhardship that can never be repeated.A history of that experience would be of value.Will you not write it? I think it should not be lost.My brother is sewing as Assemblyman in our Legislature.He has give up regular work as his health fgave out after some ten years editing on the Milwaukee Journal,the largest daioly paper in the state. I am grateful to have had opportunity to read this book and wish for more to follow.Forgive my intrusion,please and believe me,yours respectfully,[illegible

Investigating the structure of the autism-spectrum quotient using Mokken scaling

Traits similar to those shown in autism spectrum condition (ASC) are apparent in relatives of individuals with ASC, and in the general population without necessarily meeting diagnostic criteria for an ASC. We assess whether the Autism-Spectrum Quotient (AQ), a self-report measure, has hierarchical properties using Mokken scaling. Hierarchical scales allow the presence of a latent trait to be identified by discovering whether and how many specific items form an ordered array along it. Data were collected from 2 groups: (1) people with ASC (n = 449: 240 males, 209 females, M age 35.4 years, SD = 12.8) and (2) university students (n = 943: 465 males, 475 females, M age = 23.0 years, SD = 8.4). A single Mokken scale was obtained in the data from university students and 3 scales were obtained in the data from people with ASC. The scales all showed moderate Mokken scaling properties with the single scale obtained from university students showing weak invariant item ordering and 2 of the scales from people with ASC showing weak invariant item ordering. The AQ formed reliable Mokken scales. There was a large overlap between the scale from the university student sample and the sample with ASC, with the first scale, relating to social interaction, being almost identical. The present study confirms the utility of the AQ as a single instrument that can dimensionalize autistic traits in both university student and clinical samples of ASC, and confirms that items of the AQ are consistently ordered relative to one another

Transitional care in clinical networks for young people with juvenile idiopathic arthritis: current situation and challenges

Clinical networks for paediatric and adolescent rheumatology are evolving, and their effect and role in the transition process between paediatric and adult services are unknown. We therefore explored the experiences of those involved to try and understand this further. Health professionals, young people with juvenile idiopathic arthritis and their families were recruited via five national health service paediatric and adolescent rheumatology specialist centres and networks across the UK. Seventy participants took part in focus groups and one-to-one interviews. Data was analysed using coding, memoing and mapping techniques to identify features of transitional services across the sector. Variation and inequities in transitional care exist. Although transition services in networks are evolving, development has lagged behind other areas with network establishment focusing more on access to paediatric rheumatology multidisciplinary teams. Challenges include workforce shortfalls, differences in service priorities, standards and healthcare infrastructures, and managing the legacy of historic encounters. Providing equitable high-quality clinically effective services for transition across the UK has a long way to go. There is a call from within the sector for more protected time, staff and resources to develop transition roles and services, as well as streamlining of local referral pathways between paediatric and adult healthcare services. In addition, there is a need to support professionals in developing their understanding of transitional care in clinical networks, particularly around service design, organisational change and the interpersonal skills required for collaborative working

An Evaluation into Pilot Proficiency Assessment and the Current State of Training in the Industry

Pilot proficiency assessment has been a debated topic, especially in recent years. Determining effective ways to assess proficiency has been the focus of many industries, including similar high-risk industries such as health care and nuclear power industries. For the purposes of this paper, a comprehensive investigation into the current state of pilot training was conducted to analyze and compare curriculum components, proficiency levels, assessment methods and overall safety outcomes of each instructional program. This analysis includes pilot training programs from the United States, Australia and the European Union, as they relate to pilot licensing. As flight training technology and hour requirements increase, alternate methods of instruction have become more prominent in the industry worldwide. Evaluating the mechanisms that comprise the various international instructional programs, such as the training devices and hours accrued in these devices, is important in understanding how they affect and influence proficiency levels and safety

A hierarchy of happiness? Mokken scaling analysis of the Oxford Happiness Inventory

The items of the Oxford Happiness Inventory (OHI, a self-report assessment of happiness, are subjected to an analysis for hierarchy among its items. By using Mokken scaling analyses we can assess whether items can reliably be ordered between persons as severity indicators on a latent trait; in this case, a latent trait of Happiness. OHI item-level data from 1024 participants were entered into the Mokken Scaling Procedure (MSP) seeking reliable scales with H > 0.30. 12 OHI items formed a reliable and statistically significant hierarchy. However, the MSP values indicate a 'weak' scale. The 'most difficult' (happiest) item on the scale is 'feeling energetic' and the 'least difficult' (least happy) is 'I have fun'. Items in the scale are consistent with what is already known about both happiness and low mood. The reduction in the OHI's items from 29 to 12 in the Mokken scale may have utility making it more accessible to participants as well as identifying items with reliably different levels of 'difficulty'. (C) 2010 Elsevier Ltd. All rights reserved

Autistic traits are associated with enhanced working memory capacity for abstract visual stimuli

We tested whether the association between autistic traits and enhanced performance in visual-perceptual tasks extends to visual working memory capacity. We predicted that any positive effect of autistic traits on visual working memory performance would be greatest during domain-specific tasks, in which visual resources must be relied upon. We used a visual ‘matrix’ task, involving recall of black-and-white chequered patterns which increased in size, to establish participants’ capacity (span). We assessed 144 young adults’ (M = 22.0 yrs, SD = 2.5) performance on abstract, ‘low semantic’ versus ‘high semantic’ task versions. The latter offered multimodal coding due to the availability of long-term memory resources that could supplement visual working memory. Participants also completed measures of autistic traits and trait anxiety. Autistic traits, especially Attention to Detail, Attention Switching, and Communication, positively predicted visual working memory capacity, specifically in the low semantic task, which relies on visual working memory resources. Autistic traits are therefore associated with enhanced processing and recall of visual information. The benefit is removed, however, when multimodal coding may be incorporated, emphasising the visual nature of the benefit. Strengths in focused attention to detail therefore appear to benefit domain-specific visual working memory task performance

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment. There is an urgent need for greater understanding of the molecular mechanisms underlying neurodegeneration in patients to create better therapeutic options. Recently, genetic studies uncovered novel AD risk variants in the microglial receptor, triggering receptor expressed on myeloid cells 2 (TREM2). Previous studies suggested that loss of TREM2 function worsens amyloid-β (Aβ) plaque-related toxicity. In contrast, we observe TREM2 deficiency mitigates neuroinflammation and protects against brain atrophy in the context of tau pathology. These findings indicate dual roles for TREM2 and microglia in the context of amyloid versus tau pathology, which are important to consider for potential treatments targeting TREM2.</jats:p

Nurses\u27 Alumnae Association Bulletin - Volume 4 Number 7

Welcome Home Jefferson Unit Honored by Army Sincere Thanks Treasurer Report Calendar of Events Graduate Nurses\u27 Chorus Lest You Forget Attention Hi-Light of the Alumnae Association Meetings Ambitions for Alumnae Association Notice! Items to Remember Baccalaureate Service Graduating Class Private Duty News Central Dressing Room and Transfusion Unit Card Party Held The Clara Melville Scholarship Fund Staff News Notes on Urologic Nursing Capping Exercises The Poet\u27s Corner Pylephlebitis Student Nurse\u27s View Point The Transfusion Unit Improvements in the Nurses\u27 Home Jefferson Medical College Hospital School of Nursing Faculty Nurses Taking Advanced Courses Nurses in Anesthesia The Student Nurses\u27 Loan Fund A New and Improved Department for Diseases of the Chest Miscellaneous Items Jefferson\u27s Main Kitchen Activities Medical College News Purchasing Procedures Pinky Patter Flash! Class of 1932 Condolences Positions Thirty-Eighth General Hospital Nurses\u27 Reunion Engagements Marriages New Arrivals Deaths The Bulletin Committee Attention Alumnae New Addresse