O espaço e a expressão linguística

Retomando esclarecimentos de Herbert Clark a respeito da percepção que tem o homemdo espaço em que se insere no mundo e tentando correlacionar essa percepção com a sua manifestaçãolingüística, este estudo analisa, em certas expressões, especialmente naquelas que denotam a localizaçãodo homem enquanto ser social, a maneira como se realiza, na língua portuguesa, a percepção desse espaço

Comunicação atualizada na linguagem das crônicas: um exemplo de Carlos Drummond de Andrade

No presente trabalho abordamos o gênero jornalístico-literário da crônica na divulgação da cultura de uma época. Tentamos ilustrar o fenômeno através de uma análise do estilo drummondiano nas suas crônicas das décadas de 40, 50 e 70

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

10.1002/acr.23834ARTHRITIS CARE & RESEARCH715579-59

“Canção da tarde no campo”: análise estrutural / Song in the afternoon in the wilderness

A análise da “Canção da tarde no campo” busca demonstrar a importância do acoplamento na unidade e memorabilidade de um poema. The analysis of “Canção da tarde no campo” seeks to demonstrate the importance of the coupling in the unit and memorability of a poem

Comunicação atualizada na linguagem das crônicas: um exemplo de Carlos Drummond de Andrade

No presente trabalho abordamos o gênero jornalístico-literário da crônica na divulgação da cultura de uma época. Tentamos ilustrar o fenômeno através de uma análise do estilo drummondiano nas suas crônicas das décadas de 40, 50 e 70

O espaço e a expressão linguística

Retomando esclarecimentos de Herbert Clark a respeito da percepção que tem o homemdo espaço em que se insere no mundo e tentando correlacionar essa percepção com a sua manifestaçãolingüística, este estudo analisa, em certas expressões, especialmente naquelas que denotam a localizaçãodo homem enquanto ser social, a maneira como se realiza, na língua portuguesa, a percepção desse espaço

Comunicação atualizada na linguagem das crônicas: um exemplo de Carlos Drummond de Andrade

&lt;p&gt;No presente trabalho abordamos o gênero jornalístico-literário da crônica na divulgação da cultura de uma época. Tentamos ilustrar o fenômeno através de uma análise do estilo drummondiano nas suas crônicas das décadas de 40, 50 e 70.&lt;/p&gt

O espaço e a expressão linguística

Retomando esclarecimentos de Herbert Clark a respeito da percepção que tem o homemdo espaço em que se insere no mundo e tentando correlacionar essa percepção com a sua manifestaçãolingüística, este estudo analisa, em certas expressões, especialmente naquelas que denotam a localizaçãodo homem enquanto ser social, a maneira como se realiza, na língua portuguesa, a percepção desse espaço