Analisis temporal de los resultados de la calibración de ecosondas científicas en buques de investigación.

El Instituto Español de Oceanografía (IEO), en sus campañas de Evaluación Acústica de Recursos Pesqueros, utiliza ecosondas científicas para estimar la biomasa de las especies pelágicas de interés comercial, como la sardina y la anchoa. Para la utilización cuantitativa de los resultados de estas ecosondas, es fundamental la exactitud de las medidas, así como su estabilidad temporal. Por esta razón, las ecosondas son calibradas antes del comienzo de cada campaña. Este trabajo presenta un análisis temporal de las calibraciones de las ecosondas científicas de los distintos Buques de Investigación, que el IEO ha utilizado a lo largo de los años.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Formulación propuesta de acompañamiento a las familias y la comunidad

La Propuesta de acompañamiento a las familias y la comunidad Orientación a Familias en pautas de crianza para el fortalecimiento del desarrollo socioafectivo de los hijos en la comunidad del barrio Carlos Meisel de la ciudad de Barranquilla. Se presenta como resultado de un proceso de investigación realizado en contextos sociales inmediatos al ser humano, en ella se resalta la importancia de trabajar con la comunidad en la búsqueda de alternativas de solución frente a problemáticas que afectan el libre desarrollo de la vida en familia. Tiene como objetivo primordial Orientar a familias sobre la importancia de las pautas de crianzas en el desarrollo socioafectivo de los hijos a través del uso de una mitología participativa y dialogante, un método reflexivo descriptivo y el uso de técnicas de recolección de información propias del campo social. Para una mejor comprensión se contó con la participación de la comunidad desde la aplicación de las técnicas de árbol de problemas y árbol de objetivos, los formatos de descripción comunitaria y caracterización, así como la elaboración de cada una de las alternativas de solución.The Proposal of accompaniment to families and the community Orientation to Families and parenting parities to strengthen the socio-affective development of children in the community of Carlos Meisel neighborhood of the city of Barranquilla. It is presented as a result of a research process carried out in the immediate social contexts of the human being. It highlights the importance of working with the community in the search for alternative solutions to problems that affect the free development of family life. Its main objective is to guide families about the importance of parenting patterns in the socio-affective development of children through the use of participatory and dialogic methodology, a descriptive reflective method and the use of information collection techniques of the social field . For a better understanding with the participation of the community from the application of the tree techniques of the problems and the tree of the objectives, the formats of description of the community and the characterization, as well as the elaboration of each of the alternatives of the solution

SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding

Background: Protein phosphatase 2A (PP2A) is a family of conserved serine/threonine phosphatases involved in several essential aspects of cell growth and proliferation. PP2A(Cdc55) phosphatase has been extensively related to cell cycle events in budding yeast; however, few PP2A(Cdc55) substrates have been identified. Here, we performed a quantitative mass spectrometry approach to reveal new substrates of PP2A(Cdc55) phosphatase and new PP2A-related processes in mitotic arrested cells. Results: We identified 62 statistically significant PP2A(Cdc55) substrates involved mainly in actin-cytoskeleton organization. In addition, we validated new PP2A(Cdc55) substrates such as Slk19 and Lte1, involved in early and late anaphase pathways, and Zeo1, a component of the cell wall integrity pathway. Finally, we constructed docking models of Cdc55 and its substrate Mob1. We found that the predominant interface on Cdc55 is mediated by a protruding loop consisting of residues 84-90, thus highlighting the relevance of these aminoacids for substrate interaction. Conclusions: We used phosphoproteomics of Cdc55-deficient cells to uncover new PP2A(Cdc55) substrates and functions in mitosis. As expected, several hyperphosphorylated proteins corresponded to Cdk1-dependent substrates, although other kinases' consensus motifs were also enriched in our dataset, suggesting that PP2A(Cdc55) counteracts and regulates other kinases distinct from Cdk1. Indeed, Pkc1 emerged as a novel node of PP2A(Cdc55) regulation, highlighting a major role of PP2A(Cdc55) in actin cytoskeleton and cytokinesis, gene ontology terms significantly enriched in the PP2A(Cdc55)-dependent phosphoproteome

Language and ethnobiological skills decline precipitously in Papua New Guinea, the world's most linguistically diverse nation

Papua New Guinea is home to >10% of the world’s languages and rich and varied biocultural knowledge, but the future of this diversity remains unclear. We measured language skills of 6,190 students speaking 392 languages (5.5% of the global total) and modeled their future trends using individual-level variables characterizing family language use, socioeconomic conditions, students’ skills, and language traits. This approach showed that only 58% of the students, compared to 91% of their parents, were fluent in indigenous languages, while the trends in key drivers of language skills (language use at home, proportion of mixed-language families, urbanization, students’ traditional skills) predicted accelerating decline of fluency to an estimated 26% in the next generation of students. Ethnobiological knowledge declined in close parallel with language skills. Varied medicinal plant uses known to the students speaking indigenous languages are replaced by a few, mostly nonnative species for the students speaking English or Tok Pisin, the national lingua franca. Most (88%) students want to teach indigenous language to their children. While crucial for keeping languages alive, this intention faces powerful external pressures as key factors (education, cash economy, road networks, and urbanization) associated with language attrition are valued in contemporary society

Trace Metal Chemistry in the Water Column of the Angola Basin - A Contribution to the International GEOTRACES Program - Cruise No. M121, November 22, – December 27, 2015, Walvis Bay (Namibia) – Walvis Bay (Namibia)

Meteor Cruise M121 was dedicated to the investigation of the distribution of dissolved and particulate trace metals and their isotopic compositions (TEIs) in the full water column of the Angola Basin and the northernmost Cape Basin. A key aim was to determine the driving factors for the observed distributions, which includes the main external inputs, as well as internal cycling and ocean circulation. The research program of the cruise is official part of the international GEOTRACES program (www.geotraces.org) and cruise M121 corresponds to GEOTRACES cruise GA11. Subject of the cruise was the trace metal clean and contamination-free sampling of waters and particulates for subsequent analyses of the TEIs in the home laboratories of the national and international participants. Besides a standard rosette for the less contaminant prone metals, trace metal clean sampling was realized by using for the first time a new dedicated, coated trace metal clean rosette equipped with Teflon-coated GO-FLO bottles operated via a plastic coated cable from a mobile winch of GEOMAR Kiel. The particulate samples were collected under trace metal clean conditions using established in-situ pump systems operated from Meteor’s Aramid line. The cruise track led from Walvis Bay northwards along the West African margin until 3°S, then turned west until the Zero Meridian, which was followed southwards until 30°S. Then the cruise track turned east again until the Namibian margin was reached and then completed the near shore track northwards until Walvis Bay. The track crossed areas of major external inputs including dust from the Namib Desert and exchange with the west African continental margin and with the oxygen depleted shelf sediments of the Benguela upwelling, as well as with the plume of the Congo outflow, that was followed from its mouth northwards. Our investigations of internal cycling included the extremely high productivity associated with the Benguela Upwelling and the elevated productivity of the Congo plume contrasting with the extremely oligotrophic waters of the southeastern Atlantic Gyre. The links between TEI biogeochemistry and the nitrogen cycle forms an important aspect of our study. The major water masses contributing the Atlantic Meridional Overturning Circulation were sampled in order to investigate if particular TEI signatures are suitable as water mass tracers, in particular near the ocean margin and in the restricted deep Angola Basin. A total of 51 full water column stations were sampled for the different dissolved TEIs, which were in most cases accompanied by sampling for particulates and radium isotopes using the in-situ pumps. In addition, surface waters were continuously sampled under trace metal clean conditions using a towed fish and aerosol and rain samples were continuously collected

Higgs and non-universal gaugino masses: no SUSY signal expected yet?

So far, no supersymmetric particles have been detected at the Large Hadron Collider (LHC). However, the recent Higgs results have interesting implications for the SUSY parameter space. In this paper, we study the consequences of an LHC Higgs signal for a model with non-universal gaugino masses in the context of SU(5) unification. The gaugino mass ratios associated with the higher representations produce viable spectra that are largely inaccessible to the current LHC and direct dark matter detection experiments. Thus, in light of the Higgs results, the non-observation of SUSY is no surprise.Comment: supplementary file containing plots with log priors in ancillary files. v2: added some comments on more general settings and references, accepted for publication in JHE

A socially situated approach to inform ways to improve health and wellbeing

NoMainstream health psychology supports neoliberal notions of health promotion in which self-management is central. The emphasis is on models that explain behaviour as individually driven and cognitively motivated, with health beliefs framed as the favoured mechanisms to target in order to bring about change to improve health. Utilising understandings exemplified in critical health psychology, we take a more socially situated approach, focusing on practicing health, the rhetoric of modernisation in UK health care and moves toward democratisation. While recognising that within these new ways of working there are opportunities for empowerment and user-led health care, there are other implications. How these changes link to simplistic cognitive behavioural ideologies of health promotion and rational decision-making is explored. Utilising two different empirical studies, this article highlights how self-management and expected compliance with governmental authority in relation to health practices position not only communities that experience multiple disadvantage but also more seemingly privileged social actors. The article presents a challenge to self-management and informed choice, in which the importance of navigational networks is evident. Because health care can become remote and inaccessible to certain sections of the community, yet pervasive and deterministic for others, we need multiple levels of analysis and different forms of action

Many faces of low mass neutralino dark matter in the unconstrained MSSM, LHC data and new signals

If all strongly interacting sparticles (the squarks and the gluinos) in an unconstrained minimal supersymmetric standard model (MSSM) are heavier than the corresponding mass lower limits in the minimal supergravity (mSUGRA) model, obtained by the current LHC experiments, then the existing data allow a variety of electroweak (EW) sectors with light sparticles yielding dark matter (DM) relic density allowed by the WMAP data. Some of the sparticles may lie just above the existing lower bounds from LEP and lead to many novel DM producing mechanisms not common in mSUGRA. This is illustrated by revisiting the above squark-gluino mass limits obtained by the ATLAS Collaboration, with an unconstrained EW sector with masses not correlated with the strong sector. Using their selection criteria and the corresponding cross section limits, we find at the generator level using Pythia, that the changes in the mass limits, if any, are by at most 10-12% in most scenarios. In some cases, however, the relaxation of the gluino mass limits are larger ($\approx 20$). If a subset of the strongly interacting sparticles in an unconstrained MSSM are within the reach of the LHC, then signals sensitive to the EW sector may be obtained. This is illustrated by simulating the $blj$\etslash, $l= e and \mu$, and $b\tau j$\etslash signals in i) the light stop scenario and ii) the light stop-gluino scenario with various light EW sectors allowed by the WMAP data. Some of the more general models may be realized with non-universal scalar and gaugino masses.Comment: 27 pages, 1 figure, references added, minor changes in text, to appear in JHE

Insulin Signaling in Microdomains of the Plasma Membrane

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73880/1/j.1600-0854.2003.00119.x.pd

SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast

18 páginas, 5 figuras, 1 tablaBackground: Protein phosphatase 2A (PP2A) is a family of conserved serine/threonine phosphatases involved in several essential aspects of cell growth and proliferation. PP2ACdc55 phosphatase has been extensively related to cell cycle events in budding yeast; however, few PP2ACdc55 substrates have been identified. Here, we performed a quantitative mass spectrometry approach to reveal new substrates of PP2ACdc55 phosphatase and new PP2A-related processes in mitotic arrested cells. Results: We identified 62 statistically significant PP2ACdc55 substrates involved mainly in actin-cytoskeleton organization. In addition, we validated new PP2ACdc55 substrates such as Slk19 and Lte1, involved in early and late anaphase pathways, and Zeo1, a component of the cell wall integrity pathway. Finally, we constructed docking models of Cdc55 and its substrate Mob1. We found that the predominant interface on Cdc55 is mediated by a protruding loop consisting of residues 84-90, thus highlighting the relevance of these aminoacids for substrate interaction. Conclusions: We used phosphoproteomics of Cdc55-deficient cells to uncover new PP2ACdc55 substrates and functions in mitosis. As expected, several hyperphosphorylated proteins corresponded to Cdk1-dependent substrates, although other kinases' consensus motifs were also enriched in our dataset, suggesting that PP2ACdc55 counteracts and regulates other kinases distinct from Cdk1. Indeed, Pkc1 emerged as a novel node of PP2ACdc55 regulation, highlighting a major role of PP2ACdc55 in actin cytoskeleton and cytokinesis, gene ontology terms significantly enriched in the PP2ACdc55-dependent phosphoproteome.Work in our laboratory is supported by the Spanish Ministry of Science and Innovation (BFU2011–27568), Spanish Ministry of Economy and Competitively (BFU2013–43132-P and BFU2016–77975-R AEI/FEDER, UE cofounded by FEDER funds/European Regional Development Fund- a way to build Europe). MRL was supported by the Lundbeck foundation (Junior Group Leader Fellowship). This work was supported by a generous grant from the VILLUM Foundation to the VILLUM Centre for Bioanalytical Sciences at the University of Southern Denmark. SBB is a recipient of ISCIII grant 13FIS037. IDIBELL Proteomics Unit belongs to ProteoRed, PRB2-ISCIII, and is supported by grant PT13/0001/0033.Peer reviewe