What are the microscopic events of colloidal membrane fouling?

Due to the complex interplay between surface adsorption and hydrodynamic interactions, representative microscopic mechanisms of colloidal membrane fouling are still not well understood. Numerical simulations overcome experimental limitations such as the temporal and spatial resolution of microscopic events during colloidal membrane fouling: they help to gain deeper insight into fouling processes. This study uses coupled computational fluid dynamics - discrete element methods (CFD-DEM) simulations to examine mechanisms of colloidal fouling in a microfluidic architecture mimicking a porous microfiltration membrane. We pay special attention to how particles can overcome energy barriers leading to adsorption and desorption with each other and with the external and internal membrane surface. Interparticle interaction leads to a transition from the secondary to the primary minimum of the DLVO potential. Adsorbed particles can show re-entrainment or they can glide downstream. Since particles mainly re-suspend as clusters, the inner pore geometry significantly affects the fouling behavior. The findings allow a basic understanding of microscopic fouling events during colloidal filtration. The methodology enables future systematic studies on the interplay of hydrodynamic conditions and surface energy contributions represented by potentials for soft and patchy colloids

Homogeneous Catalyst Recycling and Separation of a Multicomponent Mixture Using Organic Solvent Nanofiltration

In homogeneous catalysis, the application of organic solvent nanofiltration (OSN) has become a well-known alternative to common recycling methods. Even though some OSN membranes are commercially available, their classification and the scope of application have to be determined for the specific solvent mixture. The commercial membrane Evoniks DuraMem® 300 was tested in a mixture of ethanol, ethyl acetate, and cyclohexane with magnesium triflate as possible catalyst. The cross permeate fluxes were measured for two transmembrane pressures and the hydrodynamic radii of the components were determined. Some of the components in the ternary mixture are retained, which makes the membrane also suitable for fractioning thereof. © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

A mini-module with built-in spacers for high-throughput ultrafiltration

Ultrafiltration membrane modules suffer from a permeate flow decrease arising during filtration and caused by concentration polarization and fouling in, e.g., fermentation broth purification. Such performance losses are frequently mitigated by manipulating the hydrodynamic conditions at the membrane-fluid interface using, e.g., mesh spacers acting as static mixers. This additional element increases manufacturing complexity while improving mass transport in general, yet accepting their known disadvantages such as less transport in dead zones. However, the shape of such spacers is limited to the design of commercially available spacer geometries. Here, we present a methodology to design an industrially relevant mini-module with an optimized built-in 3D spacer structure in a flat-sheet ultrafiltration membrane module to eliminate the spacer as a separate part. Therefore, the built-in structures have been conceptually implemented through an in-silico design in compliance with the specifications for an injection molding process. Ten built-in structures were investigated in a digital twin of the mini-module by 3D-CFD simulations to select two options, which were then compared to the empty feed channel regarding mass transfer. Subsequently, the simulated flux increase was experimentally verified during bovine serum albumin (BSA) filtration. The new built-in sinusoidal corrugation outperforms conventional mesh spacer inlays by up to 30% higher permeation rates. The origin of these improvements is correlated to the flow characteristics inside the mini-module as visualized online and in-situ by low-field and high-field magnetic resonance imaging velocimetry (flow-MRI) during pure water permeation

Co-generation of Ammonia and H2 from H2O Vapor and N2 Using a Membrane Electrode Assembly

The direct electrochemical synthesis of NH3 from nitrogen and water vapor without the use of a fossil carbon source is highly desired. This synthesis is a viable option to store energy and produce fertilizer precursors. Here, a new Pt-free membrane electrode assembly is presented. An electrochemical membrane reactor demonstrates the feasibility of co-generating NH3 and H2 directly from nitrogen and water vapor at ambient conditions. An unprecedented high NH3-specific current efficiency of up to 27.5% using Ti as cathodic catalyst is reported. The co-generation can be tuned by the balance of process parameters. © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics

Alveolar-capillary basement membrane (BM) is ultra-thin (<2 µm) extracellular matrix that maintains integral epithelial-endothelial cell layers. In vitro reconstructions of alveolar-capillary barrier supported on synthetic scaffolds closely resembling the fibrous and ultra-thin natural BM are essential in mimicking the lung pathophysiology. Although BM topology and dimensions are well known to significantly influence cellular behavior, conventionally used BM mimics fail to recreate this natural niche. To overcome this, electrospun ultra-thin 2 µm poly(caprolactone) (PCL) nanofibrous mesh is used to establish an alveolar-capillary barrier model of lung endothelial/epithelial cells. Transepithelial electrical resistance (TEER) and permeability studies reveal integral tight junctions and improved mass transport through the highly porous PCL meshes compared to conventional dense membranes with etched pores. The chemotaxis of neutrophils is shown across the barrier in presence of inflammatory response that is naturally impeded in confined regions. Conventional requirement of 3 µm or larger pore size can lead to barrier disruption due to epithelial/endothelial cell invasion. Despite high porosity, the interconnected BM mimic prevents barrier disruption and allows neutrophil transmigration, thereby demonstrating the physiological relevance of the thin nanofibrous meshes. It is envisioned that these bipolar cultured barriers would contribute to an organ-level in vitro model for pathological disease, environmental pollutants, and nanotoxicology. © 2021 The Authors. Advanced Biology published by Wiley-VCH Gmb

3D-printed rotating spinnerets create membranes with a twist

Round hollow fiber membranes are long-established in applications such as gas separation, ultrafiltration and blood dialysis. Yet, it is well known that geometrical topologies can introduce secondary ow patterns counteracting mass transport limitations, stemming from diffusion resistances and fouling. We present a new systematic method- ology to fabricate novel membrane architectures. We use the freedom of design by 3D-printing spinnerets, having multiple bore channels of any geometry. First, such spinnerets are stationary to fabricate straight bore channels inside a monolithic membrane. Second, in an even more complex design, a new mechanical system enables rotating the spinneret. Such rotating multibore spinnerets enable (A) the preparation of twisted channels inside a porous monolithic membrane as well as (B) a helical twist of the outside geometry. The spun material systems comprise classical polymer solutions as well as metal-polymer slurries resulting in solid porous metallic monolithic membrane after thermal post-processing. It is known that twisted spiral-type bore channel geometries are potentially superior over straight channels with respect to mass and heat polarization phenomena, however their fabrication was cumber- some in the past. Now, the described methodology enables membrane fabrication to tailor the membrane geometry to the needs of the membrane process

Fabrication and transfer print based integration of free-standing GaN membrane micro-lenses onto semiconductor chips

We demonstrate the back-end integration of broadband, high-NA GaN micro-lenses by micro-assembly onto non-native semiconductor substrates. We developed a highly parallel micro-fabrication process flow to suspend micron scale plano-convex lens platelets from 6" Si growth wafers and show their subsequent transfer-printing integration. A growth process targeted at producing unbowed epitaxial wafers was combined with optimisation of the etching volume in order to produce flat devices for printing. Lens structures were fabricated with 6 to 11 $\mu$m diameter, 2 $\mu$m height and root-mean-squared surface roughness below 2 nm. The lenses were printed in a vertically coupled geometry on a single crystalline diamond substrate and with $\mu$m-precise placement on a horizontally coupled photonic integrated circuit waveguide facet. Optical performance analysis shows that these lenses could be used to couple to diamond nitrogen vacancy centres at micron scale depths and demonstrates their potential for visible to infrared light-coupling applications.Comment: 16 pages, 14 figure

A novel microfiber wipe for delivery of active substances to human skin : clinical proof of concept

A novel technology for the delivery of active substances to the skin based on microfibers loaded with dried active substances was developed. The objective of this work was to demonstrate deposition of the active substances on the skin including concurrent cleansing properties of the wipe. As model active substance to measure deposition capacity Niacinamide was used and as parameter to measure cleansing capacities of the wipe squalene uptake was measured. Wipes loaded with niacinamide were used in the face and the forearm of 25 subjects. By means of Raman spectrometry the deposited niacinamide was analyzed before and after application. Wipes used on the face were analyzed for squalene to assess skin cleansing properties and for residual niacinamide. Forearm analysis including placebo and verum on left and right arm respectively was performed to rule out changes of the skin through application of the tissue. Measured amounts of niacinamide from face application demonstrate statistically significant results in the study population. Analysis of the wipes used show a liberation of 28.3% of niacinamide from the wipes and an uptake of 1.7 mg squalene per wipe. Results from forearm application show statistically significant differences (p < 0.05) between placebo and active for the complete study population. Sub group analyses are significant for both gender and ethnicity for face and forearm analysis respectively. Results clearly demonstrate deposition of niacinamide on the skin and the cleansing properties of the wipe. The institutional review board approved this prospective study

Laser written nitrogen vacancy centers in diamond integrated with transfer print GaN solid immersion lenses

Laser-written Nitrogen Vacancy (NV−) centers are combined with transfer-printed GaN micro-lenses to increase fluorescent light collection by reducing total internal reflection at the planar diamond interface. We find a 2x improvement of fluorescent light collection using a 0.95 NA air objective at room temperature, in agreement with FDTD simulations. The nature of the transfer print micro-lenses leads to better performance with lower Numerical Aperture (NA) collection, as confirmed by results with a 0.5NA air objective which show improvement greater than 5x. The approach is attractive for scalable integrated quantum technologies